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The map label for this gene is thyX [H]

Identifier: 220930946

GI number: 220930946

Start: 116918

End: 117604

Strand: Direct

Name: thyX [H]

Synonym: Hore_00980

Alternate gene names: 220930946

Gene position: 116918-117604 (Clockwise)

Preceding gene: 220930945

Following gene: 220930947

Centisome position: 4.53

GC content: 41.34

Gene sequence:

>687_bases
ATGGAAGTAAGACCTGAAGCAAAATTAATTGATTATACCCCCGATCCGGAAAAAAATGTCGCTATTTCGGCCAGATTGTG
TTATTCAAAAAAAGGACCGGAGCAGTTAATGGAAGAGATGAGTAGAGAGGAAATAGAAAAACTGGTAAGAAAGGTTGTCA
GTATGGGGCATCTATCAACCCTGGAGCATACCTATTTTTATTTTCATATCCAGTGTAGCCGGGTAACCAGTCATCAGCTG
GTAAGACAGAGAATCGGGGTTTCTTATAGCCAGCGTTCTCAGCGCTATGTTTCGGAGGAGGATTTTGATTATATTATTCC
CCCCTCTATTCAGAAAAATAGTGAGGCCCTGAAGGCTTTCAGGGAATATATGGAAATATCTAAAGAGGCTTATAAATCAC
TCCTCGATAAGGGTATTCCCAAGGAAGATGCCCGTTTTCTTTTACCGGCTGTTAAGACCAATCTGGTTGTGTCCTATAAT
GCCCGTTCCTTAATGCATTTTTTCAGGTTAAGATGTTGTAACCGGGCCCAGTGGGAGATAAGAAGTATTGCCAATCAGAT
GCTTTTTCAGGTGAGGAAAGTAGCCCCTGTTTTATTTGAAAAGGCAGGACCTACCTGTGAGGTAGAAGGTTACTGTCCTG
AAGGGGAATTTTCCTGTGGCCGTATTGATAATATAAAAACATCATAA

Upstream 100 bases:

>100_bases
GGCTCGAGGCCCTTTTTGGTTACCTTTATTTAAACGGTAATTATGACCGTATAAAAGAGTTATGGTCACTTCTTATAAAG
GAACTGGAGGGAGAGTAATA

Downstream 100 bases:

>100_bases
GAGGTGATATAATATTATGGCCCAGATTGAAGGCCGCAATCCAGTTATTGAAGCTATTAAAAGCGGGAGAACTATTAAAA
AAATATTTATACAGGAAGGG

Product: thymidylate synthase, flavin-dependent

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MEVRPEAKLIDYTPDPEKNVAISARLCYSKKGPEQLMEEMSREEIEKLVRKVVSMGHLSTLEHTYFYFHIQCSRVTSHQL
VRQRIGVSYSQRSQRYVSEEDFDYIIPPSIQKNSEALKAFREYMEISKEAYKSLLDKGIPKEDARFLLPAVKTNLVVSYN
ARSLMHFFRLRCCNRAQWEIRSIANQMLFQVRKVAPVLFEKAGPTCEVEGYCPEGEFSCGRIDNIKTS

Sequences:

>Translated_228_residues
MEVRPEAKLIDYTPDPEKNVAISARLCYSKKGPEQLMEEMSREEIEKLVRKVVSMGHLSTLEHTYFYFHIQCSRVTSHQL
VRQRIGVSYSQRSQRYVSEEDFDYIIPPSIQKNSEALKAFREYMEISKEAYKSLLDKGIPKEDARFLLPAVKTNLVVSYN
ARSLMHFFRLRCCNRAQWEIRSIANQMLFQVRKVAPVLFEKAGPTCEVEGYCPEGEFSCGRIDNIKTS
>Mature_228_residues
MEVRPEAKLIDYTPDPEKNVAISARLCYSKKGPEQLMEEMSREEIEKLVRKVVSMGHLSTLEHTYFYFHIQCSRVTSHQL
VRQRIGVSYSQRSQRYVSEEDFDYIIPPSIQKNSEALKAFREYMEISKEAYKSLLDKGIPKEDARFLLPAVKTNLVVSYN
ARSLMHFFRLRCCNRAQWEIRSIANQMLFQVRKVAPVLFEKAGPTCEVEGYCPEGEFSCGRIDNIKTS

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 26507; Mature: 26507

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVRPEAKLIDYTPDPEKNVAISARLCYSKKGPEQLMEEMSREEIEKLVRKVVSMGHLST
CCCCCCCCEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LEHTYFYFHIQCSRVTSHQLVRQRIGVSYSQRSQRYVSEEDFDYIIPPSIQKNSEALKAF
HHHEEEEEEEEECHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHH
REYMEISKEAYKSLLDKGIPKEDARFLLPAVKTNLVVSYNARSLMHFFRLRCCNRAQWEI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEECHHHHHHHHHHHHCCCCHHHH
RSIANQMLFQVRKVAPVLFEKAGPTCEVEGYCPEGEFSCGRIDNIKTS
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEVRPEAKLIDYTPDPEKNVAISARLCYSKKGPEQLMEEMSREEIEKLVRKVVSMGHLST
CCCCCCCCEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LEHTYFYFHIQCSRVTSHQLVRQRIGVSYSQRSQRYVSEEDFDYIIPPSIQKNSEALKAF
HHHEEEEEEEEECHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHH
REYMEISKEAYKSLLDKGIPKEDARFLLPAVKTNLVVSYNARSLMHFFRLRCCNRAQWEI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEECHHHHHHHHHHHHCCCCHHHH
RSIANQMLFQVRKVAPVLFEKAGPTCEVEGYCPEGEFSCGRIDNIKTS
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA