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The map label for this gene is murC

Identifier: 220918997

GI number: 220918997

Start: 4352355

End: 4353731

Strand: Direct

Name: murC

Synonym: A2cp1_3912

Alternate gene names: 220918997

Gene position: 4352355-4353731 (Clockwise)

Preceding gene: 220918996

Following gene: 220918998

Centisome position: 86.54

GC content: 72.4

Gene sequence:

>1377_bases
ATGAGCCTCTTCCGTTCCAGGCAGGCCAAGATCCACTTCGTGGGCGTGGGCGGCATCGGCATGAGCGGCATCGCCGAGGT
GCTGCTCAACCTCGGCTACACCGTCTCGGGCTCCGACCTGCGCGAGTCCGAGACCACCCGGCGGCTGGCCGGGCTGGGCG
GGCGCATCTCCTACGGCCACGCCGCCGAGAACGTGCTGCAGGTGGACGTGGTCGTGATCTCGTCCGCGGTGAAGCGCGAC
AACCCGGAGGTGCTGGAGGCGCGGCGCCGCAAGATCCCGGTCATCCCGCGCGCCGAGATGCTGGCCGAGCTGATGCGCCT
CAAGTACGGCGTCGCCATCGCCGGCTCGCACGGGAAGACCACCACCACCTCGATGGCGGCGCACCTGCTCGCGCACGCCG
GCCTCGACCCCACCGCGGTGGTGGGCGGCAAGGTGAACGCGTTCGGCTCGAACGCCAAGCTGGGCAAGGGCGACTACATG
GTGGTGGAGGCGGACGAGTCCGACGGCTCGTTCCTGCGCATCCCGCCCACCATCGCCATCGTCACGAACATCGACCCGGA
GCACCTCGATCACTGGAAGACCCCGGACGCGCTGCGCCGCGGCTTCGTGGACTTCGTGAACCGGGTGCCGTTCTACGGGC
TCGCCATCCTCTGCATCGACCACCCCACCGTGCAGTCGATCCTGCCCGACGTGGAGAAGCGGGCCGTCACCTACGGCGAG
AGCCACCAGGCCGACTACCGGGCCGAGGCCATCGAGCTGTCCGGCCACGCGGTCCGCTTCGACGCGTTCCGGCGCGACGA
GGCGCTGGGGCGCTTCGAGGTGGCCATGGTGGGCCGCCACAACGCGCTCAACGCGCTCGCGGTGATCGCGCTCGGCGACG
AGATGGGCATCCCGCCGCTCGTGACGCGCGAGGCGCTCCGCAGCTTCCAGGGCGTGCAGCGGCGCTTCACGGTCCGCGGC
GAGGCGGCGGGCGTGACGGTGGTGGACGACTACGGCCACCACCCGGCCGAGGTGAAGGCCACGCTGCAGGGCGCCCGCGA
GGCGTTCAAGCGGCGCGTGGTGTGCCTGTTCCAGCCGCACCGCTACACCCGCACCCGCGACCTCATGGCCGAGTTCGCCA
CCGCGTTCAACGACGCGGACGTGCTGCTGCTCACCGACATCTACGCCGCCGGCGAGGAGCCCATCCCCGGCGCCACCGCC
GCGAACCTCGCCGACGCGATCCGCGCCTGGGGCCACCGCGACGTGACGCTCGTCCCGCGCGCCGAGCTGGCCCGCGCCGC
CAGGGAGCGGGTCCGCCCGGGCGACCTGGTCCTCACGCTCGGCGCCGGCGACGTGACCGCCGCCGGCCCGGAGCTGCTGG
CGCTGCTCGAGCGATGA

Upstream 100 bases:

>100_bases
CGCCGCTGGGGCTCGCCCTTCGGCCAGGCGCGCGAGCCCGGGCAGAAGCCCGCGCGCCCGCCGGATCCCGCGTCGTAGCG
CCCGAGGAGCGTCCCGAGAC

Downstream 100 bases:

>100_bases
GCGCTCCCTCCCCCCGCCCGCGGCGCGGCCCGGCCCGCCCGGCCCCCCGCGCATGACCTGGCGCGACGAGATCGCCCGCC
GCGTCCGCGGCGAGCACCTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSLFRSRQAKIHFVGVGGIGMSGIAEVLLNLGYTVSGSDLRESETTRRLAGLGGRISYGHAAENVLQVDVVVISSAVKRD
NPEVLEARRRKIPVIPRAEMLAELMRLKYGVAIAGSHGKTTTTSMAAHLLAHAGLDPTAVVGGKVNAFGSNAKLGKGDYM
VVEADESDGSFLRIPPTIAIVTNIDPEHLDHWKTPDALRRGFVDFVNRVPFYGLAILCIDHPTVQSILPDVEKRAVTYGE
SHQADYRAEAIELSGHAVRFDAFRRDEALGRFEVAMVGRHNALNALAVIALGDEMGIPPLVTREALRSFQGVQRRFTVRG
EAAGVTVVDDYGHHPAEVKATLQGAREAFKRRVVCLFQPHRYTRTRDLMAEFATAFNDADVLLLTDIYAAGEEPIPGATA
ANLADAIRAWGHRDVTLVPRAELARAARERVRPGDLVLTLGAGDVTAAGPELLALLER

Sequences:

>Translated_458_residues
MSLFRSRQAKIHFVGVGGIGMSGIAEVLLNLGYTVSGSDLRESETTRRLAGLGGRISYGHAAENVLQVDVVVISSAVKRD
NPEVLEARRRKIPVIPRAEMLAELMRLKYGVAIAGSHGKTTTTSMAAHLLAHAGLDPTAVVGGKVNAFGSNAKLGKGDYM
VVEADESDGSFLRIPPTIAIVTNIDPEHLDHWKTPDALRRGFVDFVNRVPFYGLAILCIDHPTVQSILPDVEKRAVTYGE
SHQADYRAEAIELSGHAVRFDAFRRDEALGRFEVAMVGRHNALNALAVIALGDEMGIPPLVTREALRSFQGVQRRFTVRG
EAAGVTVVDDYGHHPAEVKATLQGAREAFKRRVVCLFQPHRYTRTRDLMAEFATAFNDADVLLLTDIYAAGEEPIPGATA
ANLADAIRAWGHRDVTLVPRAELARAARERVRPGDLVLTLGAGDVTAAGPELLALLER
>Mature_457_residues
SLFRSRQAKIHFVGVGGIGMSGIAEVLLNLGYTVSGSDLRESETTRRLAGLGGRISYGHAAENVLQVDVVVISSAVKRDN
PEVLEARRRKIPVIPRAEMLAELMRLKYGVAIAGSHGKTTTTSMAAHLLAHAGLDPTAVVGGKVNAFGSNAKLGKGDYMV
VEADESDGSFLRIPPTIAIVTNIDPEHLDHWKTPDALRRGFVDFVNRVPFYGLAILCIDHPTVQSILPDVEKRAVTYGES
HQADYRAEAIELSGHAVRFDAFRRDEALGRFEVAMVGRHNALNALAVIALGDEMGIPPLVTREALRSFQGVQRRFTVRGE
AAGVTVVDDYGHHPAEVKATLQGAREAFKRRVVCLFQPHRYTRTRDLMAEFATAFNDADVLLLTDIYAAGEEPIPGATAA
NLADAIRAWGHRDVTLVPRAELARAARERVRPGDLVLTLGAGDVTAAGPELLALLER

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=451, Percent_Identity=47.6718403547672, Blast_Score=351, Evalue=4e-98,
Organism=Escherichia coli, GI1790680, Length=461, Percent_Identity=30.1518438177874, Blast_Score=165, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ANAD2 (B8J8E9)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002494301.1
- ProteinModelPortal:   B8J8E9
- GeneID:   7297252
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_3912
- HOGENOM:   HBG476594
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49594; Mature: 49463

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFRSRQAKIHFVGVGGIGMSGIAEVLLNLGYTVSGSDLRESETTRRLAGLGGRISYGH
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCCCCCCCCCH
AAENVLQVDVVVISSAVKRDNPEVLEARRRKIPVIPRAEMLAELMRLKYGVAIAGSHGKT
HHCHHHEEHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEECCCCCC
TTTSMAAHLLAHAGLDPTAVVGGKVNAFGSNAKLGKGDYMVVEADESDGSFLRIPPTIAI
HHHHHHHHHHHHCCCCCCEEECCCEEECCCCCCCCCCCEEEEEECCCCCCEEECCCEEEE
VTNIDPEHLDHWKTPDALRRGFVDFVNRVPFYGLAILCIDHPTVQSILPDVEKRAVTYGE
EECCCHHHHHCCCCHHHHHHHHHHHHHCCCHHCEEEEEECCCHHHHHCCHHHHHHHHCCC
SHQADYRAEAIELSGHAVRFDAFRRDEALGRFEVAMVGRHNALNALAVIALGDEMGIPPL
CCCCCCHHHEEEECCCEEEEEHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCH
VTREALRSFQGVQRRFTVRGEAAGVTVVDDYGHHPAEVKATLQGAREAFKRRVVCLFQPH
HHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCC
RYTRTRDLMAEFATAFNDADVLLLTDIYAAGEEPIPGATAANLADAIRAWGHRDVTLVPR
CCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEECH
AELARAARERVRPGDLVLTLGAGDVTAAGPELLALLER
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SLFRSRQAKIHFVGVGGIGMSGIAEVLLNLGYTVSGSDLRESETTRRLAGLGGRISYGH
CCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCCCCCCCCCH
AAENVLQVDVVVISSAVKRDNPEVLEARRRKIPVIPRAEMLAELMRLKYGVAIAGSHGKT
HHCHHHEEHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEECCCCCC
TTTSMAAHLLAHAGLDPTAVVGGKVNAFGSNAKLGKGDYMVVEADESDGSFLRIPPTIAI
HHHHHHHHHHHHCCCCCCEEECCCEEECCCCCCCCCCCEEEEEECCCCCCEEECCCEEEE
VTNIDPEHLDHWKTPDALRRGFVDFVNRVPFYGLAILCIDHPTVQSILPDVEKRAVTYGE
EECCCHHHHHCCCCHHHHHHHHHHHHHCCCHHCEEEEEECCCHHHHHCCHHHHHHHHCCC
SHQADYRAEAIELSGHAVRFDAFRRDEALGRFEVAMVGRHNALNALAVIALGDEMGIPPL
CCCCCCHHHEEEECCCEEEEEHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCH
VTREALRSFQGVQRRFTVRGEAAGVTVVDDYGHHPAEVKATLQGAREAFKRRVVCLFQPH
HHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCC
RYTRTRDLMAEFATAFNDADVLLLTDIYAAGEEPIPGATAANLADAIRAWGHRDVTLVPR
CCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEECH
AELARAARERVRPGDLVLTLGAGDVTAAGPELLALLER
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA