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The map label for this gene is cbs [H]

Identifier: 220918534

GI number: 220918534

Start: 3831046

End: 3832431

Strand: Direct

Name: cbs [H]

Synonym: A2cp1_3442

Alternate gene names: 220918534

Gene position: 3831046-3832431 (Clockwise)

Preceding gene: 220918532

Following gene: 220918535

Centisome position: 76.17

GC content: 74.17

Gene sequence:

>1386_bases
ATGCCCCTTCCCCCTCCGCCCCCCGCCGCCGGCGCGCTCGAGCTCATCGGCGCGACGCCCATGGTCCGCGTGCGCCACCT
CGACACCGGCCCGTGCGAGCTGTTCCTGAAGCTCGAGAGCGCGAACCCGGGCGGCTCGATCAAGGACCGCATCGGCCTGT
CGATGATCGCGGCGGCCGAGCGCGACGGGAGCCTGGGCGGCGACCGCCGTCACCTGGTGGAGGCCACCGCGGGCAACACC
GGGCTCGGCCTCGCGCTGGTGGCCGCGCAGCGCGGGTACCGACTGACGCTCGTCATCCCCGACAAGATGAGCCGCGAGAA
GATCCTGCACCTCAAGGCGCTCGGGGCCGAGGTGGTGATGACGCGGTCCGACGTGGGCAAGGGCCACCCGGAGTACTACC
AGGACCAGGCCGAGCGGATCGCGCGCGAGGAGGGCGCGTTCTACGTGAACCAGTTCGCGAACCCGGCCAACCCGGCGGCG
CACGAGGCCGGCACCGGGCCGGAGCTCGTGGCGCAGCTCGGCGGCCGGCTCGACGCGATGGTGTGCGGCGTCGGCTCGGG
CGGCACGCTGACCGGCCTCTCGCGCCACCTGGCGAAGGCGGTCCCCGGCTGCGAGATGGTGCTGGCCGACCCGGAGGGCT
CGGTGCTCGCCGGCTACGTCGAGACCGGCACGATCGGCAAGGCGGGGAGCTGGCTGGTCGAGGGCATCGGCGAGGACTTC
CTGCCGCCGGTCGCCGACCTCTCGCGCGTCCGGCGGGCGCACCGGATCCCGGACCGCGAGAGCCTGGAGACCGCGCGCGC
GCTGCTCCGCGCCGAGGGGATCCTGGCCGGCTCGTCCACCGGCACGCTGCTCGCGGCGGCGCTGCGCCACTGCCGCGCCG
CGGACCGGCCGCTCCGCGTCTGCACGCTCGTGTGCGACTCGGGCAACAAGTACCTGTCGAAGATGTTCGACGACCTCTGG
ATGCTGGAGCAGGGGCTCTCGGACCGGCCCACCGTGGGCGACCTCACCGATCTCGTCACCCGCCGCTTCGCCGACCGCGC
GGTGGTGACCGCCGGTCCCGGCGACCCGCTGCTCGTCGCGCTGAACCGCATGAAGGCGAACGACGTCTCGCAGCTCCCGG
TGGTGGAGGACGGGCGCGTGGTGGGCATCGTGGACGAGTCCGACCTGCTGCTCGCCGCGGTGGACGACCCGTCCCGGCTC
TCGCTGCCGGTCCGCGACGTCATGACCACCCGGCTCGAGACGGTGACGCCCGCGACGCCGTTCCAGGCGCTCCTGCCGAT
GTTCGCGGCGGGCCTGGTACCCATCGTGATGGACGCCGGCCGCTTCGTCGGCCTGGTCACGCGCATGGACGTGCTGGGCG
CGCTCCGGCGCCGCGTCGCGCGCTGA

Upstream 100 bases:

>100_bases
GCCGCGGCGCCGCGCCGGCCGCTCCCTGGGCGCAACGCCGCTCGCTCCCTCGCGGGCACCCGCCTTGACACGGCACCCTC
CGTGACGGAAGAGCCGCTGC

Downstream 100 bases:

>100_bases
CCGACCGCCCGCCGGCGCCGGCGCCGGATTCGCGGGCCACCCGGCCCCGTGGCACCATGGCGCGATGGACCCGCGCGCCG
AGCTGCTGGCACGCCGCGCC

Product: Pyridoxal-5'-phosphate-dependent protein beta subunit

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MPLPPPPPAAGALELIGATPMVRVRHLDTGPCELFLKLESANPGGSIKDRIGLSMIAAAERDGSLGGDRRHLVEATAGNT
GLGLALVAAQRGYRLTLVIPDKMSREKILHLKALGAEVVMTRSDVGKGHPEYYQDQAERIAREEGAFYVNQFANPANPAA
HEAGTGPELVAQLGGRLDAMVCGVGSGGTLTGLSRHLAKAVPGCEMVLADPEGSVLAGYVETGTIGKAGSWLVEGIGEDF
LPPVADLSRVRRAHRIPDRESLETARALLRAEGILAGSSTGTLLAAALRHCRAADRPLRVCTLVCDSGNKYLSKMFDDLW
MLEQGLSDRPTVGDLTDLVTRRFADRAVVTAGPGDPLLVALNRMKANDVSQLPVVEDGRVVGIVDESDLLLAAVDDPSRL
SLPVRDVMTTRLETVTPATPFQALLPMFAAGLVPIVMDAGRFVGLVTRMDVLGALRRRVAR

Sequences:

>Translated_461_residues
MPLPPPPPAAGALELIGATPMVRVRHLDTGPCELFLKLESANPGGSIKDRIGLSMIAAAERDGSLGGDRRHLVEATAGNT
GLGLALVAAQRGYRLTLVIPDKMSREKILHLKALGAEVVMTRSDVGKGHPEYYQDQAERIAREEGAFYVNQFANPANPAA
HEAGTGPELVAQLGGRLDAMVCGVGSGGTLTGLSRHLAKAVPGCEMVLADPEGSVLAGYVETGTIGKAGSWLVEGIGEDF
LPPVADLSRVRRAHRIPDRESLETARALLRAEGILAGSSTGTLLAAALRHCRAADRPLRVCTLVCDSGNKYLSKMFDDLW
MLEQGLSDRPTVGDLTDLVTRRFADRAVVTAGPGDPLLVALNRMKANDVSQLPVVEDGRVVGIVDESDLLLAAVDDPSRL
SLPVRDVMTTRLETVTPATPFQALLPMFAAGLVPIVMDAGRFVGLVTRMDVLGALRRRVAR
>Mature_460_residues
PLPPPPPAAGALELIGATPMVRVRHLDTGPCELFLKLESANPGGSIKDRIGLSMIAAAERDGSLGGDRRHLVEATAGNTG
LGLALVAAQRGYRLTLVIPDKMSREKILHLKALGAEVVMTRSDVGKGHPEYYQDQAERIAREEGAFYVNQFANPANPAAH
EAGTGPELVAQLGGRLDAMVCGVGSGGTLTGLSRHLAKAVPGCEMVLADPEGSVLAGYVETGTIGKAGSWLVEGIGEDFL
PPVADLSRVRRAHRIPDRESLETARALLRAEGILAGSSTGTLLAAALRHCRAADRPLRVCTLVCDSGNKYLSKMFDDLWM
LEQGLSDRPTVGDLTDLVTRRFADRAVVTAGPGDPLLVALNRMKANDVSQLPVVEDGRVVGIVDESDLLLAAVDDPSRLS
LPVRDVMTTRLETVTPATPFQALLPMFAAGLVPIVMDAGRFVGLVTRMDVLGALRRRVAR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=403, Percent_Identity=38.2133995037221, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI295821200, Length=403, Percent_Identity=38.2133995037221, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4557415, Length=403, Percent_Identity=38.2133995037221, Blast_Score=241, Evalue=1e-63,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=38.2838283828383, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788754, Length=310, Percent_Identity=40.9677419354839, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=325, Percent_Identity=37.8461538461538, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17534315, Length=325, Percent_Identity=39.6923076923077, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17562970, Length=305, Percent_Identity=36.7213114754098, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI32566674, Length=305, Percent_Identity=36.3934426229508, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI115535073, Length=339, Percent_Identity=38.0530973451327, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=35.4098360655738, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17561720, Length=303, Percent_Identity=34.983498349835, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=219, Percent_Identity=35.1598173515982, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71996324, Length=346, Percent_Identity=29.4797687861272, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17539800, Length=343, Percent_Identity=24.7813411078717, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539640, Length=348, Percent_Identity=24.4252873563218, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321594, Length=497, Percent_Identity=31.7907444668008, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6321449, Length=348, Percent_Identity=33.0459770114943, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24643623, Length=414, Percent_Identity=34.0579710144928, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129101, Length=414, Percent_Identity=34.0579710144928, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 48865; Mature: 48734

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPPPPPAAGALELIGATPMVRVRHLDTGPCELFLKLESANPGGSIKDRIGLSMIAAAE
CCCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCCCHHHHCHHHHHHCC
RDGSLGGDRRHLVEATAGNTGLGLALVAAQRGYRLTLVIPDKMSREKILHLKALGAEVVM
CCCCCCCCCHHEEEECCCCCCCHHHEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEE
TRSDVGKGHPEYYQDQAERIAREEGAFYVNQFANPANPAAHEAGTGPELVAQLGGRLDAM
EECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEE
VCGVGSGGTLTGLSRHLAKAVPGCEMVLADPEGSVLAGYVETGTIGKAGSWLVEGIGEDF
EEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCCC
LPPVADLSRVRRAHRIPDRESLETARALLRAEGILAGSSTGTLLAAALRHCRAADRPLRV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCEEE
CTLVCDSGNKYLSKMFDDLWMLEQGLSDRPTVGDLTDLVTRRFADRAVVTAGPGDPLLVA
EEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEE
LNRMKANDVSQLPVVEDGRVVGIVDESDLLLAAVDDPSRLSLPVRDVMTTRLETVTPATP
EEHHCCCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCH
FQALLPMFAAGLVPIVMDAGRFVGLVTRMDVLGALRRRVAR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLPPPPPAAGALELIGATPMVRVRHLDTGPCELFLKLESANPGGSIKDRIGLSMIAAAE
CCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCCCCHHHHCHHHHHHCC
RDGSLGGDRRHLVEATAGNTGLGLALVAAQRGYRLTLVIPDKMSREKILHLKALGAEVVM
CCCCCCCCCHHEEEECCCCCCCHHHEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEE
TRSDVGKGHPEYYQDQAERIAREEGAFYVNQFANPANPAAHEAGTGPELVAQLGGRLDAM
EECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEE
VCGVGSGGTLTGLSRHLAKAVPGCEMVLADPEGSVLAGYVETGTIGKAGSWLVEGIGEDF
EEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCCC
LPPVADLSRVRRAHRIPDRESLETARALLRAEGILAGSSTGTLLAAALRHCRAADRPLRV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCEEE
CTLVCDSGNKYLSKMFDDLWMLEQGLSDRPTVGDLTDLVTRRFADRAVVTAGPGDPLLVA
EEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCEEEE
LNRMKANDVSQLPVVEDGRVVGIVDESDLLLAAVDDPSRLSLPVRDVMTTRLETVTPATP
EEHHCCCCCCCCCEECCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCH
FQALLPMFAAGLVPIVMDAGRFVGLVTRMDVLGALRRRVAR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]