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The map label for this gene is cotA [H]

Identifier: 220918532

GI number: 220918532

Start: 3827801

End: 3830200

Strand: Direct

Name: cotA [H]

Synonym: A2cp1_3440

Alternate gene names: 220918532

Gene position: 3827801-3830200 (Clockwise)

Preceding gene: 220918529

Following gene: 220918534

Centisome position: 76.11

GC content: 71.29

Gene sequence:

>2400_bases
GTGACCGTGACCCGCGCTACCCAGGTGCTCTCGCTCCTCGCGATCGCGAGCGCCGCAGTGTCCGCCGCCGCGCAGCCCGC
ACCGCTGCCGTCCGCATCGCTCACGCCGCAGACGGCGCTCCCGCCGAAGGCCATCCCGCCGTTCGTGGATCGGCTGCCGG
TGCTCTCCGCCAGCGCGGAGCCGCTCTGGTCGGCGTACCCGCGCATCGAGACCGTGGTGGACGACGGCGAGACGCCGCTC
GCCGTCCACATGTGCGAGTTCCAGACGAACGTGCTCCCCACCGGCACCTTCGCCCCCGGGCAGCGGCCCGCCACCTGGAC
CTGGGGCTACCGGCTGGGCGGATGTCCCGCCGCCGGTGCGCTCCCGCAGGACACCTTCCTCGGCCCGGTGGTCGTCGCGA
CCCGCGGCGCGCCCACCACCGTGCGCTACGTGAACGCCCTCCCCGCCTCGCCGGATCCCATCTCGACGAACCCGCTCGGC
ACGCACGTGATCGCGTACTCCGACAGCGTGGACCAGACGCTCCACTGGGCCGACGCGAACATGCAGATGTGCATGTCGAG
CATGCCGCCCGCGCTCCGCGACGTGTGCACGTACCCGTACCGCGACGCGAACGGCGCCATGGGCATCCCCGCGGCGCCGC
ACCTCCACGGCGGCGAGATCCCCGCCGAGCTCGACGGCAGCCCGGACTCCTGGTTCACCAGCACCGGCATGATGAACGGG
CCGACCTGGTACGCGAGCCCGCTGTTCTCGCCGGCGCCGAACGAGACCGTCTATCGCTACCCCAACAGCCAGGAGGCGGG
GCCGCTCTGGTTCCACGACCACACGCTCGGCGCGACCCGCCTGAACGTCTACGCCGGCCTGGCCGGCGGGTACGTGCTCG
TCGATCCCGATCAGCAGCTCCCGGCCGGCCTGGAGAACCCGGCGAACATCGTCCCGCTCATCCTGCAGGACCGAATGTTC
GACACGAACGGCGAGCTGTTCTTCACCGCGGGCACCAAGGGCGGCATCCTCTGGGCGCTCAACCCCGAGCACCCGTACTG
GAACCCGGAGTTCGTGGGCGACACGCTGCTCGTGAACGGGACGGTGTGGCCGTACCTGGAGGTCGAGCCCAAGCGCTACC
GGTTCCTGTTCGTGAACGGCTCGAACGCCCGCACCTACGAGCTGTTCCTCACCAACCCGAAGACCAAGATCAACGGGCCG
GCGATGTGGATCATCGGCACCGACGGCGGCTACGTGGACGTGGCCCGGAAGATCGATCCGACCGCGCTGAAGCCGGCGCC
GCAGCGGCTCGTGATCATGCCGGGAGAGCGCTACGAGGTCATCATCGACTTCGGCGGCCAGCCGGCGGGCACGACGCTCG
TGCTCAAGAACGTCGCGAAGACGCCGTACCCCGGCGGCGCGACGCCGGCGGGCGGCCTCTCGCAGCTGATGCAGCTCCGG
ATCGCCTGCCCTCCGGCGCCGGCGCAGTGCGGCGCCGGAGGGATCGCCTGGAACCCGGCCGTGGATCCGACCATCCGCAG
CGGCGCGGGCGCGGTGAAGCCGCTCGTCGCGTTCGACACCGGGACGCTCGGCGCGGGCGTGACCGCACAGAAGACGCGCC
TGCTCACGCTGAACGAGGTGATGGGGATGCCGGTGAACGCGGTGAACCCGATCGACGGGGTCATGACCGCGTATCCGGGC
GGACCGCTCGAGATCCTGGTCAACAACACGAAGTGGAGCGGCGCCTCGGCGCGCAACGACCCGGCCTCCGGCACCGCCTA
CCGCGGCGACTTCACCGAGCTGCCCGCGGGCGGGCTCCACTACTCCGAGCTGCCGGCGGAGGGCGAGACGGAGCTGTGGG
AGATCGCGAACCTGACGGCCGACTCGCACCCCATCCACCTGCACCTGGTGCAGTTCCAGCTCCTCAACCGCCAGGCGCTC
GACGTGCCGAAGTACGCGGCGGCGTACGCGGCCGCGTTCCCGCAGGTGAACGACCCCGCCACCGGCCAGCCGCTCATGAT
CGGCATGAACGTCTGCACCGCCGGCGCCTACTGCCCCGGCTACGGGCCGCCGCTGCATTACGACACCGGCACGCCCGGCA
AGTTCGGCGGCAATCCCGACGTCACCCGGTTCCTGAAGAGCGTGCCGGTGCCGGCCGCGGCGCAGGAGCGCGGCTGGAAG
GACACGGTGCAGGTGCCGCCGGGCACGGTGACGCGGTTCGTGGTCCGCTGGGCGCCGACCAGCGCCGACGTCGGCACCAC
CGCCGCGTTCCCGTTCGACCCGAGCGGCCAGGGCGGCGCGTTCAACTACGTGTGGCACTGCCACATCATCGACCACGAGG
ACAACGAGATGATGCGGCCGGACACCATCCTGCCCATCCCCGGCGCCAGCCGGACCTACGTGATGGGCGAGGACTACTGA

Upstream 100 bases:

>100_bases
CCCGCCCGCCGCTACGGGATCCGTCCGTCCTTTCGCGCATCTGTCCGCCTCGCATGGCGCGAGGTGGACGACCGGGCCCC
TGCCGGAAGCAGGAGATGCC

Downstream 100 bases:

>100_bases
CGGTCTGCGGCGGGGGCCGGCTCCATCCCGGGGCCGGCCCTGCGCCGCACGGCTCACTTCCCGCCGGCGGGCGGCTCCTT
GCCGGCGGCGCCGCCGCCCG

Product: multicopper oxidase type 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MTVTRATQVLSLLAIASAAVSAAAQPAPLPSASLTPQTALPPKAIPPFVDRLPVLSASAEPLWSAYPRIETVVDDGETPL
AVHMCEFQTNVLPTGTFAPGQRPATWTWGYRLGGCPAAGALPQDTFLGPVVVATRGAPTTVRYVNALPASPDPISTNPLG
THVIAYSDSVDQTLHWADANMQMCMSSMPPALRDVCTYPYRDANGAMGIPAAPHLHGGEIPAELDGSPDSWFTSTGMMNG
PTWYASPLFSPAPNETVYRYPNSQEAGPLWFHDHTLGATRLNVYAGLAGGYVLVDPDQQLPAGLENPANIVPLILQDRMF
DTNGELFFTAGTKGGILWALNPEHPYWNPEFVGDTLLVNGTVWPYLEVEPKRYRFLFVNGSNARTYELFLTNPKTKINGP
AMWIIGTDGGYVDVARKIDPTALKPAPQRLVIMPGERYEVIIDFGGQPAGTTLVLKNVAKTPYPGGATPAGGLSQLMQLR
IACPPAPAQCGAGGIAWNPAVDPTIRSGAGAVKPLVAFDTGTLGAGVTAQKTRLLTLNEVMGMPVNAVNPIDGVMTAYPG
GPLEILVNNTKWSGASARNDPASGTAYRGDFTELPAGGLHYSELPAEGETELWEIANLTADSHPIHLHLVQFQLLNRQAL
DVPKYAAAYAAAFPQVNDPATGQPLMIGMNVCTAGAYCPGYGPPLHYDTGTPGKFGGNPDVTRFLKSVPVPAAAQERGWK
DTVQVPPGTVTRFVVRWAPTSADVGTTAAFPFDPSGQGGAFNYVWHCHIIDHEDNEMMRPDTILPIPGASRTYVMGEDY

Sequences:

>Translated_799_residues
MTVTRATQVLSLLAIASAAVSAAAQPAPLPSASLTPQTALPPKAIPPFVDRLPVLSASAEPLWSAYPRIETVVDDGETPL
AVHMCEFQTNVLPTGTFAPGQRPATWTWGYRLGGCPAAGALPQDTFLGPVVVATRGAPTTVRYVNALPASPDPISTNPLG
THVIAYSDSVDQTLHWADANMQMCMSSMPPALRDVCTYPYRDANGAMGIPAAPHLHGGEIPAELDGSPDSWFTSTGMMNG
PTWYASPLFSPAPNETVYRYPNSQEAGPLWFHDHTLGATRLNVYAGLAGGYVLVDPDQQLPAGLENPANIVPLILQDRMF
DTNGELFFTAGTKGGILWALNPEHPYWNPEFVGDTLLVNGTVWPYLEVEPKRYRFLFVNGSNARTYELFLTNPKTKINGP
AMWIIGTDGGYVDVARKIDPTALKPAPQRLVIMPGERYEVIIDFGGQPAGTTLVLKNVAKTPYPGGATPAGGLSQLMQLR
IACPPAPAQCGAGGIAWNPAVDPTIRSGAGAVKPLVAFDTGTLGAGVTAQKTRLLTLNEVMGMPVNAVNPIDGVMTAYPG
GPLEILVNNTKWSGASARNDPASGTAYRGDFTELPAGGLHYSELPAEGETELWEIANLTADSHPIHLHLVQFQLLNRQAL
DVPKYAAAYAAAFPQVNDPATGQPLMIGMNVCTAGAYCPGYGPPLHYDTGTPGKFGGNPDVTRFLKSVPVPAAAQERGWK
DTVQVPPGTVTRFVVRWAPTSADVGTTAAFPFDPSGQGGAFNYVWHCHIIDHEDNEMMRPDTILPIPGASRTYVMGEDY
>Mature_798_residues
TVTRATQVLSLLAIASAAVSAAAQPAPLPSASLTPQTALPPKAIPPFVDRLPVLSASAEPLWSAYPRIETVVDDGETPLA
VHMCEFQTNVLPTGTFAPGQRPATWTWGYRLGGCPAAGALPQDTFLGPVVVATRGAPTTVRYVNALPASPDPISTNPLGT
HVIAYSDSVDQTLHWADANMQMCMSSMPPALRDVCTYPYRDANGAMGIPAAPHLHGGEIPAELDGSPDSWFTSTGMMNGP
TWYASPLFSPAPNETVYRYPNSQEAGPLWFHDHTLGATRLNVYAGLAGGYVLVDPDQQLPAGLENPANIVPLILQDRMFD
TNGELFFTAGTKGGILWALNPEHPYWNPEFVGDTLLVNGTVWPYLEVEPKRYRFLFVNGSNARTYELFLTNPKTKINGPA
MWIIGTDGGYVDVARKIDPTALKPAPQRLVIMPGERYEVIIDFGGQPAGTTLVLKNVAKTPYPGGATPAGGLSQLMQLRI
ACPPAPAQCGAGGIAWNPAVDPTIRSGAGAVKPLVAFDTGTLGAGVTAQKTRLLTLNEVMGMPVNAVNPIDGVMTAYPGG
PLEILVNNTKWSGASARNDPASGTAYRGDFTELPAGGLHYSELPAEGETELWEIANLTADSHPIHLHLVQFQLLNRQALD
VPKYAAAYAAAFPQVNDPATGQPLMIGMNVCTAGAYCPGYGPPLHYDTGTPGKFGGNPDVTRFLKSVPVPAAAQERGWKD
TVQVPPGTVTRFVVRWAPTSADVGTTAAFPFDPSGQGGAFNYVWHCHIIDHEDNEMMRPDTILPIPGASRTYVMGEDY

Specific function: Involved in brown pigmentation during sporogenesis [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To S.antibioticus phenoxazinone synthase (phsA) [H]

Homologues:

Organism=Escherichia coli, GI1789394, Length=212, Percent_Identity=31.6037735849057, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1786314, Length=233, Percent_Identity=28.3261802575107, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 85075; Mature: 84944

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTRATQVLSLLAIASAAVSAAAQPAPLPSASLTPQTALPPKAIPPFVDRLPVLSASAE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCC
PLWSAYPRIETVVDDGETPLAVHMCEFQTNVLPTGTFAPGQRPATWTWGYRLGGCPAAGA
HHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCEEECCCCCCCC
LPQDTFLGPVVVATRGAPTTVRYVNALPASPDPISTNPLGTHVIAYSDSVDQTLHWADAN
CCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCC
MQMCMSSMPPALRDVCTYPYRDANGAMGIPAAPHLHGGEIPAELDGSPDSWFTSTGMMNG
HHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
PTWYASPLFSPAPNETVYRYPNSQEAGPLWFHDHTLGATRLNVYAGLAGGYVLVDPDQQL
CCEECCCCCCCCCCCCEEECCCCCCCCCEEEECCCCCCEEEEEEEECCCCEEEECCCCCC
PAGLENPANIVPLILQDRMFDTNGELFFTAGTKGGILWALNPEHPYWNPEFVGDTLLVNG
CCCCCCCCCEEEEEEECEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCEEEECC
TVWPYLEVEPKRYRFLFVNGSNARTYELFLTNPKTKINGPAMWIIGTDGGYVDVARKIDP
EECCEEEECCCEEEEEEEECCCCEEEEEEEECCCCEECCCEEEEEECCCCEEEEEECCCC
TALKPAPQRLVIMPGERYEVIIDFGGQPAGTTLVLKNVAKTPYPGGATPAGGLSQLMQLR
CCCCCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEHHHCCCCCCCCCCCHHHHHHHHEE
IACPPAPAQCGAGGIAWNPAVDPTIRSGAGAVKPLVAFDTGTLGAGVTAQKTRLLTLNEV
ECCCCCCHHCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEHHHH
MGMPVNAVNPIDGVMTAYPGGPLEILVNNTKWSGASARNDPASGTAYRGDFTELPAGGLH
HCCCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCHHCCCCCCCC
YSELPAEGETELWEIANLTADSHPIHLHLVQFQLLNRQALDVPKYAAAYAAAFPQVNDPA
HHCCCCCCCCHHHHHHHCCCCCCCEEEEEEEEEHHCCHHCCCCHHHHHHHHHCCCCCCCC
TGQPLMIGMNVCTAGAYCPGYGPPLHYDTGTPGKFGGNPDVTRFLKSVPVPAAAQERGWK
CCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCC
DTVQVPPGTVTRFVVRWAPTSADVGTTAAFPFDPSGQGGAFNYVWHCHIIDHEDNEMMRP
CEEECCCCCEEEEEEEECCCCCCCCCEEECCCCCCCCCCEEEEEEEEEEEECCCCCCCCC
DTILPIPGASRTYVMGEDY
CEEEECCCCCEEEEECCCC
>Mature Secondary Structure 
TVTRATQVLSLLAIASAAVSAAAQPAPLPSASLTPQTALPPKAIPPFVDRLPVLSASAE
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCC
PLWSAYPRIETVVDDGETPLAVHMCEFQTNVLPTGTFAPGQRPATWTWGYRLGGCPAAGA
HHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEECCEEECCCCCCCC
LPQDTFLGPVVVATRGAPTTVRYVNALPASPDPISTNPLGTHVIAYSDSVDQTLHWADAN
CCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCC
MQMCMSSMPPALRDVCTYPYRDANGAMGIPAAPHLHGGEIPAELDGSPDSWFTSTGMMNG
HHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
PTWYASPLFSPAPNETVYRYPNSQEAGPLWFHDHTLGATRLNVYAGLAGGYVLVDPDQQL
CCEECCCCCCCCCCCCEEECCCCCCCCCEEEECCCCCCEEEEEEEECCCCEEEECCCCCC
PAGLENPANIVPLILQDRMFDTNGELFFTAGTKGGILWALNPEHPYWNPEFVGDTLLVNG
CCCCCCCCCEEEEEEECEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCEEEECC
TVWPYLEVEPKRYRFLFVNGSNARTYELFLTNPKTKINGPAMWIIGTDGGYVDVARKIDP
EECCEEEECCCEEEEEEEECCCCEEEEEEEECCCCEECCCEEEEEECCCCEEEEEECCCC
TALKPAPQRLVIMPGERYEVIIDFGGQPAGTTLVLKNVAKTPYPGGATPAGGLSQLMQLR
CCCCCCCCEEEEECCCCEEEEEEECCCCCCCEEEEEHHHCCCCCCCCCCCHHHHHHHHEE
IACPPAPAQCGAGGIAWNPAVDPTIRSGAGAVKPLVAFDTGTLGAGVTAQKTRLLTLNEV
ECCCCCCHHCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEHHHH
MGMPVNAVNPIDGVMTAYPGGPLEILVNNTKWSGASARNDPASGTAYRGDFTELPAGGLH
HCCCCCCCCCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCHHCCCCCCCC
YSELPAEGETELWEIANLTADSHPIHLHLVQFQLLNRQALDVPKYAAAYAAAFPQVNDPA
HHCCCCCCCCHHHHHHHCCCCCCCEEEEEEEEEHHCCHHCCCCHHHHHHHHHCCCCCCCC
TGQPLMIGMNVCTAGAYCPGYGPPLHYDTGTPGKFGGNPDVTRFLKSVPVPAAAQERGWK
CCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCC
DTVQVPPGTVTRFVVRWAPTSADVGTTAAFPFDPSGQGGAFNYVWHCHIIDHEDNEMMRP
CEEECCCCCEEEEEEEECCCCCCCCCEEECCCCCCCCCCEEEEEEEEEEEECCCCCCCCC
DTILPIPGASRTYVMGEDY
CEEEECCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969499; 9455482; 9384377; 2821284; 3135411 [H]