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The map label for this gene is atoC [H]

Identifier: 220917599

GI number: 220917599

Start: 2759186

End: 2760532

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_2499

Alternate gene names: 220917599

Gene position: 2759186-2760532 (Clockwise)

Preceding gene: 220917598

Following gene: 220917604

Centisome position: 54.86

GC content: 75.13

Gene sequence:

>1347_bases
ATGTCCCGGCTGCTGCTGGTCGATGACGAGCCCGCCGTGCTCTACGCGCTGAAGGAGCTGGCGCGCTCGAACGGTCACGA
GCCGGTCACCGCGCGCTCCGGCGCCGAGGCGCTGGAGCGCCTGGAGGGCGTGGACGCCGTCGTCACGGACTACGCCATGC
CCGAGATGGACGGGCTGCAGCTCCTCCAGGCCATCCACGAGCGCGACGCGTCGCTCCCGGTGGTGGTCCTCACCGCCCAG
GGATCGGAGCGCGTGGCGGTGCGCGCCATGAAGGCCGGCGCGTACGAGTACGTGACCAAGCCCTTCGACATCGACGAGAT
GACGCTGGTGCTGGACCGCGCGCTCGAGACCCGCGCGCTGCGCGTGCAGAACCGGCGCCTCGCCGTCGAGAAGGCGCTCG
GCCGCAGCATCGTGGGCGACGCGCCGGCCATGCAGCGGCTGCTCGACGCGGTGGCGCGGGTCGCGCCGAAGGACGTGACG
GTGCTGGTGCGCGGCGAGACCGGCACCGGCAAGGAGCTGATCGCGTCGCTGCTCCACGCCCAGAGCCGCCGCGCGTCCGG
TCCGCTCGTCCGCTTCAACTGCGCGGCCATCCCCGCAGAGCTGGCCGAGGCGGAGCTGTTCGGCCACGCGCGCGGCGCGT
TCACCGGGGCGGTGCAGGCGCGGCAGGGCTTCTTCGCCCAGGCCGACGGCGGGACGCTGGTGCTGGACGAGGTGGGCGAG
CTGCCGCTGCCGCTCCAGGCCAAGCTGCTCCGGGCCCTACAGGAGGGCGAGATCCAGCCGGTCGGCGCCGGCCGCGTCGA
GCGCGTGGACGTGCGCCTCGTGGCCGCCACGCACCGCGATCTCGCCGAGGAGGCGCGCGCGGGGCGGTTCCGCGAGGACC
TGTACTACCGGCTCGCGGTGGTGGAGCTGGTGGTCCCGCCGCTCCGCGAGCACCGCGAGGACATCCCGGCCCTTGCGAAG
GAGTTCGCGCGGCGCTTCGGCGCGCGCTTCGGCGTGGACGACGTCCGGCTCTCGCCGCCGCTGCTCGAGCGCCTCGCGGC
CGCGGAGTGGCCGGGCAACGTGCGCCAGCTCGAGAACCAGGTGGCGCGCCTGGTCGCGCTGAGCAACGGCGGGGAGCTCG
GCCCGGAGGCGCTCGAGGCGGGGGCCGCCCCCGCGGCGCGCGAGCCGGGCGTGGAGGCGCCGCCGGAGGGCGCGCTCACG
CTCCACGAGCACCTCGACGCCGTCGAGCGGAACATCATCGCGAAGACGCTGGCCGCGACCGGCGGCAACCAGTCGGAGAC
CGCGCGCCGCCTCGGGGTGAGCCGCGGCGCGCTCATCGACCGGCTGAAGAAGTACGGGTTCGCGTAG

Upstream 100 bases:

>100_bases
TTCGTCCAGCACGGCGGCGCGCTCGAGTACGCGAGCGCGCCCGACGCGGGCACCACCGCTACCGGCACCCTTCCCCGGGT
GCACCAGGAGGCCACCGAGA

Downstream 100 bases:

>100_bases
CCGGGGGCGGACCGGCTCGCGACCCTCGCGCGGTCGCCTAGGGGACCTCGGCGTACGCCGGATCCGTCGCGCCGCGCGCG
GTCGCGGACGCCTCCTTGCT

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSRLLLVDDEPAVLYALKELARSNGHEPVTARSGAEALERLEGVDAVVTDYAMPEMDGLQLLQAIHERDASLPVVVLTAQ
GSERVAVRAMKAGAYEYVTKPFDIDEMTLVLDRALETRALRVQNRRLAVEKALGRSIVGDAPAMQRLLDAVARVAPKDVT
VLVRGETGTGKELIASLLHAQSRRASGPLVRFNCAAIPAELAEAELFGHARGAFTGAVQARQGFFAQADGGTLVLDEVGE
LPLPLQAKLLRALQEGEIQPVGAGRVERVDVRLVAATHRDLAEEARAGRFREDLYYRLAVVELVVPPLREHREDIPALAK
EFARRFGARFGVDDVRLSPPLLERLAAAEWPGNVRQLENQVARLVALSNGGELGPEALEAGAAPAAREPGVEAPPEGALT
LHEHLDAVERNIIAKTLAATGGNQSETARRLGVSRGALIDRLKKYGFA

Sequences:

>Translated_448_residues
MSRLLLVDDEPAVLYALKELARSNGHEPVTARSGAEALERLEGVDAVVTDYAMPEMDGLQLLQAIHERDASLPVVVLTAQ
GSERVAVRAMKAGAYEYVTKPFDIDEMTLVLDRALETRALRVQNRRLAVEKALGRSIVGDAPAMQRLLDAVARVAPKDVT
VLVRGETGTGKELIASLLHAQSRRASGPLVRFNCAAIPAELAEAELFGHARGAFTGAVQARQGFFAQADGGTLVLDEVGE
LPLPLQAKLLRALQEGEIQPVGAGRVERVDVRLVAATHRDLAEEARAGRFREDLYYRLAVVELVVPPLREHREDIPALAK
EFARRFGARFGVDDVRLSPPLLERLAAAEWPGNVRQLENQVARLVALSNGGELGPEALEAGAAPAAREPGVEAPPEGALT
LHEHLDAVERNIIAKTLAATGGNQSETARRLGVSRGALIDRLKKYGFA
>Mature_447_residues
SRLLLVDDEPAVLYALKELARSNGHEPVTARSGAEALERLEGVDAVVTDYAMPEMDGLQLLQAIHERDASLPVVVLTAQG
SERVAVRAMKAGAYEYVTKPFDIDEMTLVLDRALETRALRVQNRRLAVEKALGRSIVGDAPAMQRLLDAVARVAPKDVTV
LVRGETGTGKELIASLLHAQSRRASGPLVRFNCAAIPAELAEAELFGHARGAFTGAVQARQGFFAQADGGTLVLDEVGEL
PLPLQAKLLRALQEGEIQPVGAGRVERVDVRLVAATHRDLAEEARAGRFREDLYYRLAVVELVVPPLREHREDIPALAKE
FARRFGARFGVDDVRLSPPLLERLAAAEWPGNVRQLENQVARLVALSNGGELGPEALEAGAAPAAREPGVEAPPEGALTL
HEHLDAVERNIIAKTLAATGGNQSETARRLGVSRGALIDRLKKYGFA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=42.0479302832244, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=42.8571428571429, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1788905, Length=450, Percent_Identity=43.3333333333333, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=40.1709401709402, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1789087, Length=395, Percent_Identity=40.5063291139241, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI87082152, Length=300, Percent_Identity=47.6666666666667, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082117, Length=379, Percent_Identity=40.8970976253298, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=39.0625, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=39.1025641025641, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1786524, Length=327, Percent_Identity=37.9204892966361, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=38.1987577639752, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI1789828, Length=337, Percent_Identity=34.1246290801187, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081858, Length=317, Percent_Identity=32.1766561514196, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=38.3177570093458, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=108, Percent_Identity=39.8148148148148, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788713, Length=158, Percent_Identity=27.8481012658228, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=109, Percent_Identity=32.1100917431193, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48294; Mature: 48163

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLLLVDDEPAVLYALKELARSNGHEPVTARSGAEALERLEGVDAVVTDYAMPEMDGLQ
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCHHHH
LLQAIHERDASLPVVVLTAQGSERVAVRAMKAGAYEYVTKPFDIDEMTLVLDRALETRAL
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHH
RVQNRRLAVEKALGRSIVGDAPAMQRLLDAVARVAPKDVTVLVRGETGTGKELIASLLHA
HHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHH
QSRRASGPLVRFNCAAIPAELAEAELFGHARGAFTGAVQARQGFFAQADGGTLVLDEVGE
HHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCC
LPLPLQAKLLRALQEGEIQPVGAGRVERVDVRLVAATHRDLAEEARAGRFREDLYYRLAV
CCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHH
VELVVPPLREHREDIPALAKEFARRFGARFGVDDVRLSPPLLERLAAAEWPGNVRQLENQ
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
VARLVALSNGGELGPEALEAGAAPAAREPGVEAPPEGALTLHEHLDAVERNIIAKTLAAT
HHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GGNQSETARRLGVSRGALIDRLKKYGFA
CCCHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRLLLVDDEPAVLYALKELARSNGHEPVTARSGAEALERLEGVDAVVTDYAMPEMDGLQ
CCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCHHHH
LLQAIHERDASLPVVVLTAQGSERVAVRAMKAGAYEYVTKPFDIDEMTLVLDRALETRAL
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHH
RVQNRRLAVEKALGRSIVGDAPAMQRLLDAVARVAPKDVTVLVRGETGTGKELIASLLHA
HHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHH
QSRRASGPLVRFNCAAIPAELAEAELFGHARGAFTGAVQARQGFFAQADGGTLVLDEVGE
HHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCC
LPLPLQAKLLRALQEGEIQPVGAGRVERVDVRLVAATHRDLAEEARAGRFREDLYYRLAV
CCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHH
VELVVPPLREHREDIPALAKEFARRFGARFGVDDVRLSPPLLERLAAAEWPGNVRQLENQ
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
VARLVALSNGGELGPEALEAGAAPAAREPGVEAPPEGALTLHEHLDAVERNIIAKTLAAT
HHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GGNQSETARRLGVSRGALIDRLKKYGFA
CCCHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]