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The map label for this gene is clcA [H]

Identifier: 220917604

GI number: 220917604

Start: 2762873

End: 2764777

Strand: Direct

Name: clcA [H]

Synonym: A2cp1_2504

Alternate gene names: 220917604

Gene position: 2762873-2764777 (Clockwise)

Preceding gene: 220917599

Following gene: 220917605

Centisome position: 54.94

GC content: 78.01

Gene sequence:

>1905_bases
ATGTCGGACCCCGGACCGGACGAACGAAGCCCCCTCACGGCCCGCGCGCTGCGCGCGGGCATGGCGTGGATGACGCCGCT
GGGCGGCCCGCTCGACCTCCGGCTCCTGGGCCGGACGCTGCTGCACACCGCGGTGCTGGGCTGCGTGGCCGGCCTGGTGG
GCGCGGGCTTCTTCGCCGCGCTCGAGCTGGGGCAGCGCCTGCTGCTGGGCGGGCTCGCCGGGTACCTGCCGCTGCGCGCC
GCGGGCGAGCTGGTGTTCGGGAGGGAGCCGGCCGGCCCGCTGCGCCCCTGGGTGCTGGTGCTGCTCCCCGCGCTCGGAGG
GCTGGCGAGCGGCCTGGTCACCGCGAAGCTCGCGCCCGAGTGCGGGGGCGGCGGCGGCGACGCGACCATCGACGCGTACC
ACCTCCACGGTGCGCGCATGCGCGCGCGGGTGGCGCCGGTGAAGGCGCTCGCCTCGGTGCTGACGCTCGCCACCGGCGGC
GCGGGCGGCCGCGAGGGGCCGACCATGCAGATCGGCGGCGCGCTCGGCGCGCTCACCGGACGGCTGCTGCCGACCAGCCC
GCGCGAGCGGCGCATCCTGATGGTGGCCGGGGTGGCGGCCGGCATCTCGGCGGTGTTCCGGACGCCGCTCGGCGCCGCGC
TGCTCGCGGTCGAGATGCTGTACCGCGACGACTTCGAGTCCGACGCGCTCGTCCCGGCCATCCTGGCGAGCGTGGTGGCG
TACTCGCTGGTCGCGTCGATCTACGGCGAGGCCACGCTGTTCGGCCGCCTGCCGGCGTTCCCGTTCGTGCCGCGCCACCT
CCCGCTGTACGCGCTGCTCTCGCTGCTCGTCTCGCTCGGCGCGGTCGCGTTCGCGGTGAGCCTGCGCACGGTGGCGCGGG
GGTTCCGCCGGCTGCCCGGGCCCGCCTGGCTGCGGCCGGGGCTGGGCGGGCTGCTCATGGGCGGGTTCGCCACCGCCATC
ATCCTGCTGGTCGGCCACCTGTACGGCGCCGAGGACCGCGGCATCGGGCTCCTGGGCGGCGGCTACGGCGCGGTGCAGGC
CGCCATCGCCGGCTCCCCGGGCATGCAGCCGGGCTGGTCGCTGGTGGTCCTCCTGCTCGGCCTCGCCGCCGCGAAGGTCG
TGGCGGCCTCGCTCACCATCGGCTCGGGCGGCTCCGCCGGCGACTTCGCCCCGGCGCTCACCATCGGCGGCCTGCTCGGC
GCCGCGTTCGGCCACGGGGCGGCGCTGGTCACCGGCGATCCGACGCTCCAGCCGGCCGCGTTCGTGCTGGTGGGCATGGG
CACGCTCTACGGCGGGCTCGCGCACGTGCCGCTGTCGGCGCTGGTGCTGGTGTCCGAGCTGGCCGGCAGCTACGACCTGC
TCGTCCCGATGATGCTCTCCATCGGCGTGGCGTACGTGGCGCTGCGGCGCTGGACGCTCTACCCGGCGCAGCCGCGCAAC
CAGCGCGAGTCGCCGGCGCACCCCGAGCTCCGCGCGCGCGACCTGCTCACCCGCATCACGGTCAGGGACGTGGCGGTGCC
GGCCGAGGCGGGGCCGGCCGAGGCGGCGGCGCGGCTCGCCGACGGGCTGGCCGCCGCGGGGAAGACCTCGCGCCAGCGCG
TGCTGCCGCTGCTCGGCCCCGCCGGCGCCTGGGCGGGCCTCGCCGACGTGGACGCGATCCGCGCGGCGGCCGCCGACCCG
CACCTCGGCTGGGCGGTCCTCGCCGACGTGGCGGCGCGGTGGACGGCCGTCGCGCCCGAGACCTCCCTCGCGCGCGTGGG
CGAGCTGCTGGTGGACAGCGGGCTGCGCCAGCTCCCGGTGCTCGAGGGCGGCCGGGTGACGGGCTACGTCGGCGAGGCGG
AGATCGCGCGGGTGTTCCTGGCGGCGATCGCCGATCCGCCCGCGCAGCATCGCGCGGGCGCGTAG

Upstream 100 bases:

>100_bases
GCCGGGCGCCACGCCCCATATGGTACGTAGACAAGAAAGTTCGCGGGGTTGAGCAGCAGGCTCGCCCCCCGACCGGCCGC
GAATAGAATGCCCGGCACGC

Downstream 100 bases:

>100_bases
CGCCCGTCCGCCTACCCCCGTCTTGCGGCGCGCACCGGTCCGACGCCGGGCACATCCATGAGGATGGGTGCGAGGGCGGA
GCGCACCGGCGCCGCGACGG

Product: Chloride channel core

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MSDPGPDERSPLTARALRAGMAWMTPLGGPLDLRLLGRTLLHTAVLGCVAGLVGAGFFAALELGQRLLLGGLAGYLPLRA
AGELVFGREPAGPLRPWVLVLLPALGGLASGLVTAKLAPECGGGGGDATIDAYHLHGARMRARVAPVKALASVLTLATGG
AGGREGPTMQIGGALGALTGRLLPTSPRERRILMVAGVAAGISAVFRTPLGAALLAVEMLYRDDFESDALVPAILASVVA
YSLVASIYGEATLFGRLPAFPFVPRHLPLYALLSLLVSLGAVAFAVSLRTVARGFRRLPGPAWLRPGLGGLLMGGFATAI
ILLVGHLYGAEDRGIGLLGGGYGAVQAAIAGSPGMQPGWSLVVLLLGLAAAKVVAASLTIGSGGSAGDFAPALTIGGLLG
AAFGHGAALVTGDPTLQPAAFVLVGMGTLYGGLAHVPLSALVLVSELAGSYDLLVPMMLSIGVAYVALRRWTLYPAQPRN
QRESPAHPELRARDLLTRITVRDVAVPAEAGPAEAAARLADGLAAAGKTSRQRVLPLLGPAGAWAGLADVDAIRAAAADP
HLGWAVLADVAARWTAVAPETSLARVGELLVDSGLRQLPVLEGGRVTGYVGEAEIARVFLAAIADPPAQHRAGA

Sequences:

>Translated_634_residues
MSDPGPDERSPLTARALRAGMAWMTPLGGPLDLRLLGRTLLHTAVLGCVAGLVGAGFFAALELGQRLLLGGLAGYLPLRA
AGELVFGREPAGPLRPWVLVLLPALGGLASGLVTAKLAPECGGGGGDATIDAYHLHGARMRARVAPVKALASVLTLATGG
AGGREGPTMQIGGALGALTGRLLPTSPRERRILMVAGVAAGISAVFRTPLGAALLAVEMLYRDDFESDALVPAILASVVA
YSLVASIYGEATLFGRLPAFPFVPRHLPLYALLSLLVSLGAVAFAVSLRTVARGFRRLPGPAWLRPGLGGLLMGGFATAI
ILLVGHLYGAEDRGIGLLGGGYGAVQAAIAGSPGMQPGWSLVVLLLGLAAAKVVAASLTIGSGGSAGDFAPALTIGGLLG
AAFGHGAALVTGDPTLQPAAFVLVGMGTLYGGLAHVPLSALVLVSELAGSYDLLVPMMLSIGVAYVALRRWTLYPAQPRN
QRESPAHPELRARDLLTRITVRDVAVPAEAGPAEAAARLADGLAAAGKTSRQRVLPLLGPAGAWAGLADVDAIRAAAADP
HLGWAVLADVAARWTAVAPETSLARVGELLVDSGLRQLPVLEGGRVTGYVGEAEIARVFLAAIADPPAQHRAGA
>Mature_633_residues
SDPGPDERSPLTARALRAGMAWMTPLGGPLDLRLLGRTLLHTAVLGCVAGLVGAGFFAALELGQRLLLGGLAGYLPLRAA
GELVFGREPAGPLRPWVLVLLPALGGLASGLVTAKLAPECGGGGGDATIDAYHLHGARMRARVAPVKALASVLTLATGGA
GGREGPTMQIGGALGALTGRLLPTSPRERRILMVAGVAAGISAVFRTPLGAALLAVEMLYRDDFESDALVPAILASVVAY
SLVASIYGEATLFGRLPAFPFVPRHLPLYALLSLLVSLGAVAFAVSLRTVARGFRRLPGPAWLRPGLGGLLMGGFATAII
LLVGHLYGAEDRGIGLLGGGYGAVQAAIAGSPGMQPGWSLVVLLLGLAAAKVVAASLTIGSGGSAGDFAPALTIGGLLGA
AFGHGAALVTGDPTLQPAAFVLVGMGTLYGGLAHVPLSALVLVSELAGSYDLLVPMMLSIGVAYVALRRWTLYPAQPRNQ
RESPAHPELRARDLLTRITVRDVAVPAEAGPAEAAARLADGLAAAGKTSRQRVLPLLGPAGAWAGLADVDAIRAAAADPH
LGWAVLADVAARWTAVAPETSLARVGELLVDSGLRQLPVLEGGRVTGYVGEAEIARVFLAAIADPPAQHRAGA

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=376, Percent_Identity=29.2553191489362, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI87081943, Length=326, Percent_Identity=27.3006134969325, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 64320; Mature: 64189

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPGPDERSPLTARALRAGMAWMTPLGGPLDLRLLGRTLLHTAVLGCVAGLVGAGFFAA
CCCCCCCCCCCHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LELGQRLLLGGLAGYLPLRAAGELVFGREPAGPLRPWVLVLLPALGGLASGLVTAKLAPE
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCC
CGGGGGDATIDAYHLHGARMRARVAPVKALASVLTLATGGAGGREGPTMQIGGALGALTG
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHC
RLLPTSPRERRILMVAGVAAGISAVFRTPLGAALLAVEMLYRDDFESDALVPAILASVVA
CCCCCCCCCCEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YSLVASIYGEATLFGRLPAFPFVPRHLPLYALLSLLVSLGAVAFAVSLRTVARGFRRLPG
HHHHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAWLRPGLGGLLMGGFATAIILLVGHLYGAEDRGIGLLGGGYGAVQAAIAGSPGMQPGWS
CCHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCCCCCCHHH
LVVLLLGLAAAKVVAASLTIGSGGSAGDFAPALTIGGLLGAAFGHGAALVTGDPTLQPAA
HHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
FVLVGMGTLYGGLAHVPLSALVLVSELAGSYDLLVPMMLSIGVAYVALRRWTLYPAQPRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
QRESPAHPELRARDLLTRITVRDVAVPAEAGPAEAAARLADGLAAAGKTSRQRVLPLLGP
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCHHCCC
AGAWAGLADVDAIRAAAADPHLGWAVLADVAARWTAVAPETSLARVGELLVDSGLRQLPV
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCC
LEGGRVTGYVGEAEIARVFLAAIADPPAQHRAGA
CCCCCEEEECCHHHHHHHHHHHHCCCCHHCCCCC
>Mature Secondary Structure 
SDPGPDERSPLTARALRAGMAWMTPLGGPLDLRLLGRTLLHTAVLGCVAGLVGAGFFAA
CCCCCCCCCCHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LELGQRLLLGGLAGYLPLRAAGELVFGREPAGPLRPWVLVLLPALGGLASGLVTAKLAPE
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCC
CGGGGGDATIDAYHLHGARMRARVAPVKALASVLTLATGGAGGREGPTMQIGGALGALTG
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHC
RLLPTSPRERRILMVAGVAAGISAVFRTPLGAALLAVEMLYRDDFESDALVPAILASVVA
CCCCCCCCCCEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YSLVASIYGEATLFGRLPAFPFVPRHLPLYALLSLLVSLGAVAFAVSLRTVARGFRRLPG
HHHHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAWLRPGLGGLLMGGFATAIILLVGHLYGAEDRGIGLLGGGYGAVQAAIAGSPGMQPGWS
CCHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCCCCCCHHH
LVVLLLGLAAAKVVAASLTIGSGGSAGDFAPALTIGGLLGAAFGHGAALVTGDPTLQPAA
HHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
FVLVGMGTLYGGLAHVPLSALVLVSELAGSYDLLVPMMLSIGVAYVALRRWTLYPAQPRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
QRESPAHPELRARDLLTRITVRDVAVPAEAGPAEAAARLADGLAAAGKTSRQRVLPLLGP
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCHHCCC
AGAWAGLADVDAIRAAAADPHLGWAVLADVAARWTAVAPETSLARVGELLVDSGLRQLPV
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCC
LEGGRVTGYVGEAEIARVFLAAIADPPAQHRAGA
CCCCCEEEECCHHHHHHHHHHHHCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA