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The map label for this gene is kinA [H]

Identifier: 220917598

GI number: 220917598

Start: 2757856

End: 2759211

Strand: Direct

Name: kinA [H]

Synonym: A2cp1_2498

Alternate gene names: 220917598

Gene position: 2757856-2759211 (Clockwise)

Preceding gene: 220917594

Following gene: 220917599

Centisome position: 54.84

GC content: 75.15

Gene sequence:

>1356_bases
ATGGAGATGCCGATCGCCCAGGGCCCGGATCTTGCGAAGGATCGGGGCATGGGCACCCATGCGCAGCAGGAGCACCTGCG
CCGCTCGAACCTGGCCGCGGCGGACGAGCGGTGGCGCCGGAGCCGGCCCGCGCTCGTGGTGGCCCTCTACGCCTCCTGGA
TCAGCTTCGTCGTGCTGCTCTGGTTCCAGGGCTACCCGCGCTGGCGCGTGCTCGCGCTCCTCGGCATCCTGGGGCTCGCG
CTGGCGATGCACGCCGCGCGCGCGTGCGTCCGCGCGAACGGTCCCTTCTGCGCCGCGGTGACCGCCGCCGACATCCGCCT
GCCGCTCGCCATGTCGCTCGCGGCCGTCGCGCTGACCGGGGGCCTGCACAGCCCGCTGCTCGTCGCCCTCCCCCCCACGG
TCTCGGTGCTGGTGGTCCGCTGCGGCTGGAGGCGGGAGACCGCGGGAGCGCTCTGGGCCCTGGCCGCCGCCGGCCTGGTC
ATGCTGCTCGCGCCGGGCTGGATGGGGCCGCCGGTCCCGGAGCGCACGTTCGCGCTCGTCGCGCTGGTGGCGCTCGTCGG
GACGGTGGCGGTCCACGCCGACTACGTGGTCATCCTCGGGGAGACGGTCGCCGACTCGGTCCGCGGGATGCTGCGGGCCC
GCGACGAGGTGGCGAGCCAGGCGCTCACCCGCGCCCGCGAGCTCGAGCTGATGAGCTCGCAGATCTCGCACGAGCTGAAG
AACCCGCTCGGCGCCATCAAGGCGCTGGTCCAGATCAGCGCCCGCGGCTCCTCCGACGGCGACACGTGCGAGCGGCTCAA
GGTGGTCTCGTCCGAGGTCGAGCGCATGCGCGAGATCCTCGACGGCTACCTGTCGTTCTCGCGGCCGCTCGAGTGCCTGC
AGCGCGAGGACCTCTCGCTGGGCGAGCTCGCCGACGAGGTGCTCTCGGTGCTGCAGGGGCGCGCCGCGGCCGCCGGTGTC
GGCCTGCACCGGCGCGGCGACGCGCGCGTCGAGGCCGACCCGCGCCGCCTCAAGGAGGCGCTGCTGAACCTGGTCGCGAA
CGCGGTGGAGGCGAGCCGCCGGGGCGACCGGGTCGAGGTGCTGGTCGCCGATCACGGCGGCACCGTCGAGGTGGCGGTCC
GGGACACCGGCCGCGGCATGCCGCCGGCGGTGGTCGCGCGCCTGGGCACCCCGTTCTTCACCACCCGCGACCAGGGCACC
GGGCTGGGCGTCCTGCTCGCCCGGCGCGCGTTCGTCCAGCACGGCGGCGCGCTCGAGTACGCGAGCGCGCCCGACGCGGG
CACCACCGCTACCGGCACCCTTCCCCGGGTGCACCAGGAGGCCACCGAGAATGTCCCGGCTGCTGCTGGTCGATGA

Upstream 100 bases:

>100_bases
GTCGCCGCCGTGTCGGGTCCGTGGACAGGAGCCACCCCGATTGTCGGCTCGACGTACAGGCGGGGTGGCCGGCGAGCCCG
GACCCGCAGATAATCGGGCC

Downstream 100 bases:

>100_bases
CGAGCCCGCCGTGCTCTACGCGCTGAAGGAGCTGGCGCGCTCGAACGGTCACGAGCCGGTCACCGCGCGCTCCGGCGCCG
AGGCGCTGGAGCGCCTGGAG

Product: histidine kinase

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MEMPIAQGPDLAKDRGMGTHAQQEHLRRSNLAAADERWRRSRPALVVALYASWISFVVLLWFQGYPRWRVLALLGILGLA
LAMHAARACVRANGPFCAAVTAADIRLPLAMSLAAVALTGGLHSPLLVALPPTVSVLVVRCGWRRETAGALWALAAAGLV
MLLAPGWMGPPVPERTFALVALVALVGTVAVHADYVVILGETVADSVRGMLRARDEVASQALTRARELELMSSQISHELK
NPLGAIKALVQISARGSSDGDTCERLKVVSSEVERMREILDGYLSFSRPLECLQREDLSLGELADEVLSVLQGRAAAAGV
GLHRRGDARVEADPRRLKEALLNLVANAVEASRRGDRVEVLVADHGGTVEVAVRDTGRGMPPAVVARLGTPFFTTRDQGT
GLGVLLARRAFVQHGGALEYASAPDAGTTATGTLPRVHQEATENVPAAAGR

Sequences:

>Translated_451_residues
MEMPIAQGPDLAKDRGMGTHAQQEHLRRSNLAAADERWRRSRPALVVALYASWISFVVLLWFQGYPRWRVLALLGILGLA
LAMHAARACVRANGPFCAAVTAADIRLPLAMSLAAVALTGGLHSPLLVALPPTVSVLVVRCGWRRETAGALWALAAAGLV
MLLAPGWMGPPVPERTFALVALVALVGTVAVHADYVVILGETVADSVRGMLRARDEVASQALTRARELELMSSQISHELK
NPLGAIKALVQISARGSSDGDTCERLKVVSSEVERMREILDGYLSFSRPLECLQREDLSLGELADEVLSVLQGRAAAAGV
GLHRRGDARVEADPRRLKEALLNLVANAVEASRRGDRVEVLVADHGGTVEVAVRDTGRGMPPAVVARLGTPFFTTRDQGT
GLGVLLARRAFVQHGGALEYASAPDAGTTATGTLPRVHQEATENVPAAAGR
>Mature_451_residues
MEMPIAQGPDLAKDRGMGTHAQQEHLRRSNLAAADERWRRSRPALVVALYASWISFVVLLWFQGYPRWRVLALLGILGLA
LAMHAARACVRANGPFCAAVTAADIRLPLAMSLAAVALTGGLHSPLLVALPPTVSVLVVRCGWRRETAGALWALAAAGLV
MLLAPGWMGPPVPERTFALVALVALVGTVAVHADYVVILGETVADSVRGMLRARDEVASQALTRARELELMSSQISHELK
NPLGAIKALVQISARGSSDGDTCERLKVVSSEVERMREILDGYLSFSRPLECLQREDLSLGELADEVLSVLQGRAAAAGV
GLHRRGDARVEADPRRLKEALLNLVANAVEASRRGDRVEVLVADHGGTVEVAVRDTGRGMPPAVVARLGTPFFTTRDQGT
GLGVLLARRAFVQHGGALEYASAPDAGTTATGTLPRVHQEATENVPAAAGR

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=211, Percent_Identity=33.6492890995261, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=28.6324786324786, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1790300, Length=204, Percent_Identity=29.9019607843137, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=216, Percent_Identity=26.8518518518519, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=27.3858921161826, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI48994928, Length=249, Percent_Identity=26.5060240963855, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789808, Length=242, Percent_Identity=25.2066115702479, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=206, Percent_Identity=29.126213592233, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47983; Mature: 47983

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMPIAQGPDLAKDRGMGTHAQQEHLRRSNLAAADERWRRSRPALVVALYASWISFVVLL
CCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
WFQGYPRWRVLALLGILGLALAMHAARACVRANGPFCAAVTAADIRLPLAMSLAAVALTG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHC
GLHSPLLVALPPTVSVLVVRCGWRRETAGALWALAAAGLVMLLAPGWMGPPVPERTFALV
CCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALVALVGTVAVHADYVVILGETVADSVRGMLRARDEVASQALTRARELELMSSQISHELK
HHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NPLGAIKALVQISARGSSDGDTCERLKVVSSEVERMREILDGYLSFSRPLECLQREDLSL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GELADEVLSVLQGRAAAAGVGLHRRGDARVEADPRRLKEALLNLVANAVEASRRGDRVEV
HHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
LVADHGGTVEVAVRDTGRGMPPAVVARLGTPFFTTRDQGTGLGVLLARRAFVQHGGALEY
EEECCCCEEEEEEECCCCCCCHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCCEEE
ASAPDAGTTATGTLPRVHQEATENVPAAAGR
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEMPIAQGPDLAKDRGMGTHAQQEHLRRSNLAAADERWRRSRPALVVALYASWISFVVLL
CCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
WFQGYPRWRVLALLGILGLALAMHAARACVRANGPFCAAVTAADIRLPLAMSLAAVALTG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHC
GLHSPLLVALPPTVSVLVVRCGWRRETAGALWALAAAGLVMLLAPGWMGPPVPERTFALV
CCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALVALVGTVAVHADYVVILGETVADSVRGMLRARDEVASQALTRARELELMSSQISHELK
HHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NPLGAIKALVQISARGSSDGDTCERLKVVSSEVERMREILDGYLSFSRPLECLQREDLSL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GELADEVLSVLQGRAAAAGVGLHRRGDARVEADPRRLKEALLNLVANAVEASRRGDRVEV
HHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
LVADHGGTVEVAVRDTGRGMPPAVVARLGTPFFTTRDQGTGLGVLLARRAFVQHGGALEY
EEECCCCEEEEEEECCCCCCCHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCCEEE
ASAPDAGTTATGTLPRVHQEATENVPAAAGR
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]