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The map label for this gene is bfmBAA [H]

Identifier: 220917206

GI number: 220917206

Start: 2344981

End: 2346174

Strand: Direct

Name: bfmBAA [H]

Synonym: A2cp1_2103

Alternate gene names: 220917206

Gene position: 2344981-2346174 (Clockwise)

Preceding gene: 220917205

Following gene: 220917207

Centisome position: 46.63

GC content: 72.78

Gene sequence:

>1194_bases
ATGCGCCGAGAGCACGTGGTGGGTCCGCCGACGAGGCATCACCCGCGCGAGGCACGGGACTACGAGCCCGGCCGGTTCCT
GAAGGAGTTCCCGCTCCACACGGTCATCCGTGAGGACGGCTCCGCGGATCCGGACGAGGTGGTCCTGCCGGACGCGGAGG
CGCTGCGGCTGTACCGGTGGATGGTGCTGAACCGCGCGCTCGACGAGCGGATGATCACGCTCCAGCGCCAGGGGCGGATC
GGCTTCTACATCGGGTCGATCGGCGAGGAGGCCACCGTGCTCGGCACGGCGGCGGCGATGGACGAGCGCGACTGGATCTA
CCCGTGCTACCGCGAGCACGGGGCCGCGCTGCTGCGCGGGATGCCGCTCGTCACGTTCGTCTGCGACCTGTTCGGCAACG
GCGGGGACGCCATGAAGGGCCGGCAGATGCCCTGCCACGAGGCGTGGCGGCCGGGCCGCTTCACCTCGATCAGCTCGCCC
ATCGCCACCCAGGTCTCGCAGGCGATGGGCGGCGCCTGGGCGGCGAAGCTGAAGGGCGAGGAGATGGTCGCCATCACCTA
CTTCGGCGAGGGCGCCACCAGCGCGCACGACTTCCACACCGGCCTGAACTTCGCGGCGGTGCGGAAGATCCCGGTGGTGT
TCGTGTGCCGCAACAACGGCTGGGCCATCAGCGTGCCGCGCGAGCGGCAGACCGCCTCCGAGACCATCGCGCAGAAGGCG
ATCGCGTACGGCATGCGCGGCGAGCGCGTCGATGGGAACGACCTGCTCGCGGTGTACGCCGCCACCCGCCGGGCGCGGGC
GCGCGCCGCCGCCGGCGAGGGCCCGACGCTGCTCGAGTGCGTGACCTACCGCATCGAGGGGCACTCGACCTCCGACGACC
CGCGCGCGTACCGGCCGGCCGAGCTGGTCGAGCCCTGGAAGCGCAAGGACCCGATCCTGCGCATGCGCCGCTACCTCTCG
CGGCGCGGCGCGCTCGACGAGGCGCAGGACGCCGCGCTCCGCGACGAGCTGCGCGAGCAGATCCAGGCGGCGCTGAAGGA
GGCCGAGGCGTTCCCGGCCAAGCCGTCCATCGAGACGCTGTTCGCCGACGTGTACGAGGAGCCGCTCTGGCAGCAGCGCG
AGCAGCTGGCCGAGATCGAGGCGGCGGTCGCCGCGGACCCGCGCGCGGCGAACCCGCGCCACTCCGACGCGTGA

Upstream 100 bases:

>100_bases
CGAGCGGCCCGCTGGTCCGGTCGTCGTACCGCGCGGCGGAGCTGTTCCTGCGCGGCGAGATCGAGTCGAGGACGAAGCCC
CGCTGACGACAGGAGCGAGC

Downstream 100 bases:

>100_bases
TACAGGGGGCCGCATGCCCACCATGAACATCATCCAGGCGGTCAACGACGCGCTCCGGATCGAGATGCGCAAGGATCCGG
ACGTGGTGGTGCTGGGCGAG

Product: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MRREHVVGPPTRHHPREARDYEPGRFLKEFPLHTVIREDGSADPDEVVLPDAEALRLYRWMVLNRALDERMITLQRQGRI
GFYIGSIGEEATVLGTAAAMDERDWIYPCYREHGAALLRGMPLVTFVCDLFGNGGDAMKGRQMPCHEAWRPGRFTSISSP
IATQVSQAMGGAWAAKLKGEEMVAITYFGEGATSAHDFHTGLNFAAVRKIPVVFVCRNNGWAISVPRERQTASETIAQKA
IAYGMRGERVDGNDLLAVYAATRRARARAAAGEGPTLLECVTYRIEGHSTSDDPRAYRPAELVEPWKRKDPILRMRRYLS
RRGALDEAQDAALRDELREQIQAALKEAEAFPAKPSIETLFADVYEEPLWQQREQLAEIEAAVAADPRAANPRHSDA

Sequences:

>Translated_397_residues
MRREHVVGPPTRHHPREARDYEPGRFLKEFPLHTVIREDGSADPDEVVLPDAEALRLYRWMVLNRALDERMITLQRQGRI
GFYIGSIGEEATVLGTAAAMDERDWIYPCYREHGAALLRGMPLVTFVCDLFGNGGDAMKGRQMPCHEAWRPGRFTSISSP
IATQVSQAMGGAWAAKLKGEEMVAITYFGEGATSAHDFHTGLNFAAVRKIPVVFVCRNNGWAISVPRERQTASETIAQKA
IAYGMRGERVDGNDLLAVYAATRRARARAAAGEGPTLLECVTYRIEGHSTSDDPRAYRPAELVEPWKRKDPILRMRRYLS
RRGALDEAQDAALRDELREQIQAALKEAEAFPAKPSIETLFADVYEEPLWQQREQLAEIEAAVAADPRAANPRHSDA
>Mature_397_residues
MRREHVVGPPTRHHPREARDYEPGRFLKEFPLHTVIREDGSADPDEVVLPDAEALRLYRWMVLNRALDERMITLQRQGRI
GFYIGSIGEEATVLGTAAAMDERDWIYPCYREHGAALLRGMPLVTFVCDLFGNGGDAMKGRQMPCHEAWRPGRFTSISSP
IATQVSQAMGGAWAAKLKGEEMVAITYFGEGATSAHDFHTGLNFAAVRKIPVVFVCRNNGWAISVPRERQTASETIAQKA
IAYGMRGERVDGNDLLAVYAATRRARARAAAGEGPTLLECVTYRIEGHSTSDDPRAYRPAELVEPWKRKDPILRMRRYLS
RRGALDEAQDAALRDELREQIQAALKEAEAFPAKPSIETLFADVYEEPLWQQREQLAEIEAAVAADPRAANPRHSDA

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=357, Percent_Identity=45.3781512605042, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI258645172, Length=357, Percent_Identity=45.3781512605042, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI4885543, Length=326, Percent_Identity=31.5950920245399, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI291084742, Length=341, Percent_Identity=31.0850439882698, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI4505685, Length=341, Percent_Identity=31.0850439882698, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI291084744, Length=348, Percent_Identity=29.8850574712644, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI291084757, Length=343, Percent_Identity=27.9883381924198, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=348, Percent_Identity=43.1034482758621, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI86563357, Length=348, Percent_Identity=43.1034482758621, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=31.5950920245399, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=31.5950920245399, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6321026, Length=319, Percent_Identity=31.3479623824451, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21355903, Length=377, Percent_Identity=38.1962864721485, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24639740, Length=342, Percent_Identity=30.1169590643275, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24639744, Length=342, Percent_Identity=30.1169590643275, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI28571106, Length=342, Percent_Identity=30.1169590643275, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24639746, Length=283, Percent_Identity=30.0353356890459, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639748, Length=327, Percent_Identity=28.1345565749235, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 44394; Mature: 44394

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRREHVVGPPTRHHPREARDYEPGRFLKEFPLHTVIREDGSADPDEVVLPDAEALRLYRW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCCCCCCCEECCCHHHHHHHHH
MVLNRALDERMITLQRQGRIGFYIGSIGEEATVLGTAAAMDERDWIYPCYREHGAALLRG
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHEEEHHHHCCCCCCCCHHHHHHHHHHHHC
MPLVTFVCDLFGNGGDAMKGRQMPCHEAWRPGRFTSISSPIATQVSQAMGGAWAAKLKGE
CHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHCCHHEEEECCC
EMVAITYFGEGATSAHDFHTGLNFAAVRKIPVVFVCRNNGWAISVPRERQTASETIAQKA
EEEEEEEECCCCCCCHHHHCCCCHHEEECCCEEEEEECCCEEEECCHHHHHHHHHHHHHH
IAYGMRGERVDGNDLLAVYAATRRARARAAAGEGPTLLECVTYRIEGHSTSDDPRAYRPA
HHHCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCHHEEEHEEEECCCCCCCCCCCCCCH
ELVEPWKRKDPILRMRRYLSRRGALDEAQDAALRDELREQIQAALKEAEAFPAKPSIETL
HHHCCHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
FADVYEEPLWQQREQLAEIEAAVAADPRAANPRHSDA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRREHVVGPPTRHHPREARDYEPGRFLKEFPLHTVIREDGSADPDEVVLPDAEALRLYRW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCCCCCCCEECCCHHHHHHHHH
MVLNRALDERMITLQRQGRIGFYIGSIGEEATVLGTAAAMDERDWIYPCYREHGAALLRG
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHEEEHHHHCCCCCCCCHHHHHHHHHHHHC
MPLVTFVCDLFGNGGDAMKGRQMPCHEAWRPGRFTSISSPIATQVSQAMGGAWAAKLKGE
CHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHCCHHEEEECCC
EMVAITYFGEGATSAHDFHTGLNFAAVRKIPVVFVCRNNGWAISVPRERQTASETIAQKA
EEEEEEEECCCCCCCHHHHCCCCHHEEECCCEEEEEECCCEEEECCHHHHHHHHHHHHHH
IAYGMRGERVDGNDLLAVYAATRRARARAAAGEGPTLLECVTYRIEGHSTSDDPRAYRPA
HHHCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCCHHEEEHEEEECCCCCCCCCCCCCCH
ELVEPWKRKDPILRMRRYLSRRGALDEAQDAALRDELREQIQAALKEAEAFPAKPSIETL
HHHCCHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
FADVYEEPLWQQREQLAEIEAAVAADPRAANPRHSDA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]