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The map label for this gene is moaA [H]

Identifier: 220917203

GI number: 220917203

Start: 2341663

End: 2342667

Strand: Reverse

Name: moaA [H]

Synonym: A2cp1_2100

Alternate gene names: 220917203

Gene position: 2342667-2341663 (Counterclockwise)

Preceding gene: 220917204

Following gene: 220917198

Centisome position: 46.58

GC content: 75.52

Gene sequence:

>1005_bases
GTGCTCCAGCAACCCCCCTCCCCCGCCGCCGCGCCGCTCGTGGACGGCCAGGGCCGCCGGATCGTCTACCTCCGGCTCTC
CCTCACCGACCGCTGCAACTTCCGGTGCAGCTACTGCTCGCCGGCCGCACCGGAGACGCACGAGGATCCGCTCGCCCGCG
ACGAGGTCGCGCGGCTGGTCCGCATCTTCGGCGGCCTGGGCATCCGGCGCGTGCGCCTGACCGGCGGTGAGCCCACGCTC
CGCCGCGACGTGCTGGACGTGATCCGCGAGGTGGCGCGCGCCCCCGGCATCGAGGAGGTGGCGCTCACCACGAACGGCCA
CCTGCTCCAGGCGCTCGCCGGCCCGCTCCGCGAGGCGGGCGTCACGCGGCTCAACGTCTCGCTCGACACGCTCGACGCGG
AGAAGCTGCACCGCATCGCCGGCCGCGCCGCGACGCTGGAGCGGATCGTGGCCGGGATCGAGGCCGCCTACCGCGCCGGC
TTCGCCTCGGTGAAGCTGAACGTGGTGGTGGTGCGCGGGCAGAACGACGACGAGCTGGGCGCGCTGGCCCGCTTCGCCTG
GGGGTTCGGGGCCACCGCGCGGTTCATCGAGCTGATGCCGTTCGGCCCCGGGAAGCCGGTGCCCACCGCCGAGGTGAAGC
GGCTGCTCGAGGCGCAGGGCATCCGGCTCGAGCCCGACGCGACGCGCGGCTGGGGGCCCGCCTACCACATGCGCGGCACC
TCCGAGCACGAGGGACGGACCGTCACCGGCCTGGTCGGCTTCATCGGGGCCATGACCGAGAACTTCTGCGACGGCTGCAA
CCGCGTGCGGGTGGGCGCCGACGGCTCGCTGCGCGCCTGCCTCGGCGGCCGCGAGCGGCTCGGGCTGAAGGAGCTGCTGC
GCGGCGCCGCCAGCGACGCGGACATCGCCGCGGCCATCCGCGCGGCGCTGCTCGGCAAGGGCGAGCGCCACGACATGGAG
CGCGGCGGCGACGGGCTGCTGCCCATGATCGGCACCGGCGGGTAG

Upstream 100 bases:

>100_bases
GCGGCCCATCTGACGCTCCGCGCGGCGGGCGGCGCTGCGCGGGCCCGCGCAGGCGTCCCGGTGGCTTTCTCCTCCCCCCG
CGGTGGTGGTATGAGGCGCC

Downstream 100 bases:

>100_bases
CGCGGTCGTCAGTCTCGCAGCTCGAAGCGGAGCGGCGGGGTGCGCACCGAGCGGAGCCCGCCCCGGCGGAGCGGATCCGG
CTCGTCGCGCTCGAAGAACG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLQQPPSPAAAPLVDGQGRRIVYLRLSLTDRCNFRCSYCSPAAPETHEDPLARDEVARLVRIFGGLGIRRVRLTGGEPTL
RRDVLDVIREVARAPGIEEVALTTNGHLLQALAGPLREAGVTRLNVSLDTLDAEKLHRIAGRAATLERIVAGIEAAYRAG
FASVKLNVVVVRGQNDDELGALARFAWGFGATARFIELMPFGPGKPVPTAEVKRLLEAQGIRLEPDATRGWGPAYHMRGT
SEHEGRTVTGLVGFIGAMTENFCDGCNRVRVGADGSLRACLGGRERLGLKELLRGAASDADIAAAIRAALLGKGERHDME
RGGDGLLPMIGTGG

Sequences:

>Translated_334_residues
MLQQPPSPAAAPLVDGQGRRIVYLRLSLTDRCNFRCSYCSPAAPETHEDPLARDEVARLVRIFGGLGIRRVRLTGGEPTL
RRDVLDVIREVARAPGIEEVALTTNGHLLQALAGPLREAGVTRLNVSLDTLDAEKLHRIAGRAATLERIVAGIEAAYRAG
FASVKLNVVVVRGQNDDELGALARFAWGFGATARFIELMPFGPGKPVPTAEVKRLLEAQGIRLEPDATRGWGPAYHMRGT
SEHEGRTVTGLVGFIGAMTENFCDGCNRVRVGADGSLRACLGGRERLGLKELLRGAASDADIAAAIRAALLGKGERHDME
RGGDGLLPMIGTGG
>Mature_334_residues
MLQQPPSPAAAPLVDGQGRRIVYLRLSLTDRCNFRCSYCSPAAPETHEDPLARDEVARLVRIFGGLGIRRVRLTGGEPTL
RRDVLDVIREVARAPGIEEVALTTNGHLLQALAGPLREAGVTRLNVSLDTLDAEKLHRIAGRAATLERIVAGIEAAYRAG
FASVKLNVVVVRGQNDDELGALARFAWGFGATARFIELMPFGPGKPVPTAEVKRLLEAQGIRLEPDATRGWGPAYHMRGT
SEHEGRTVTGLVGFIGAMTENFCDGCNRVRVGADGSLRACLGGRERLGLKELLRGAASDADIAAAIRAALLGKGERHDME
RGGDGLLPMIGTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=37.0030581039755, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=37.0030581039755, Blast_Score=201, Evalue=5e-52,
Organism=Escherichia coli, GI1786999, Length=334, Percent_Identity=37.4251497005988, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32566331, Length=325, Percent_Identity=37.8461538461538, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32566329, Length=341, Percent_Identity=37.8299120234604, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17561210, Length=340, Percent_Identity=38.2352941176471, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI28574490, Length=318, Percent_Identity=37.7358490566038, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI28574488, Length=318, Percent_Identity=37.7358490566038, Blast_Score=201, Evalue=7e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35664; Mature: 35664

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQQPPSPAAAPLVDGQGRRIVYLRLSLTDRCNFRCSYCSPAAPETHEDPLARDEVARLV
CCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHH
RIFGGLGIRRVRLTGGEPTLRRDVLDVIREVARAPGIEEVALTTNGHLLQALAGPLREAG
HHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCC
VTRLNVSLDTLDAEKLHRIAGRAATLERIVAGIEAAYRAGFASVKLNVVVVRGQNDDELG
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHH
ALARFAWGFGATARFIELMPFGPGKPVPTAEVKRLLEAQGIRLEPDATRGWGPAYHMRGT
HHHHHHHCCCCHHHHEEEEECCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCC
SEHEGRTVTGLVGFIGAMTENFCDGCNRVRVGADGSLRACLGGRERLGLKELLRGAASDA
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCHHCCCHHHHHHCCCCCH
DIAAAIRAALLGKGERHDMERGGDGLLPMIGTGG
HHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLQQPPSPAAAPLVDGQGRRIVYLRLSLTDRCNFRCSYCSPAAPETHEDPLARDEVARLV
CCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHH
RIFGGLGIRRVRLTGGEPTLRRDVLDVIREVARAPGIEEVALTTNGHLLQALAGPLREAG
HHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCC
VTRLNVSLDTLDAEKLHRIAGRAATLERIVAGIEAAYRAGFASVKLNVVVVRGQNDDELG
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHH
ALARFAWGFGATARFIELMPFGPGKPVPTAEVKRLLEAQGIRLEPDATRGWGPAYHMRGT
HHHHHHHCCCCHHHHEEEEECCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCC
SEHEGRTVTGLVGFIGAMTENFCDGCNRVRVGADGSLRACLGGRERLGLKELLRGAASDA
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCHHCCCHHHHHHCCCCCH
DIAAAIRAALLGKGERHDMERGGDGLLPMIGTGG
HHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA