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The map label for this gene is tdh

Identifier: 220916966

GI number: 220916966

Start: 2085090

End: 2086127

Strand: Reverse

Name: tdh

Synonym: A2cp1_1862

Alternate gene names: 220916966

Gene position: 2086127-2085090 (Counterclockwise)

Preceding gene: 220916967

Following gene: 220916965

Centisome position: 41.48

GC content: 69.94

Gene sequence:

>1038_bases
ATGAAGGCACTCGTCAAGGCGAAGCGCGAGGAAGGCATCTGGATGCAGCACGACGTGCCGGTCCCCGAGGTCGGGGTCCA
CGACGTGATGATCCGGGTCACGAAGAGCGCCATCTGCGGCACCGACGTGCACATCTACAACTGGGACGAGTGGAGCCAGA
AGACCGTCCCGGTGCCCATGGTGGTGGGGCACGAGTACGTGGGCCGGGTGGAGAAGGTCGGGGCCGAGGTGGAGGCGTTC
CGGCCCGGCGAGCGGGTGAGCGGCGAGGGCCACGTCACCTGCGGCTTCTGCCGCAACTGCCGCGCCGGCCGCCGGCACCT
CTGCCGGCACACGGTGGGCGTGGGCGTGAACCGGCCCGGATCCTTCGCCGAGTACGTGGTGATCCCGGCCGACAACGTCT
ACCGCATCCCGGACGACATCCCCGACGACATCGCCGCCATCTTCGACCCGTTCGGCAACGCCACGCACACCGCGCTCTCG
TTCGACCTGGTGGGCGAGGACGTGCTCGTCACCGGCGCCGGGCCCATCGGCGTCATGGCGGCCGCCATCGCGCGGCACGT
GGGCGCGCGGCACGTGGTCGTCACCGACGTGAACGACTACCGGCTCGACCTGGCCCGCCGGATGGGCGCGTCGCGGGCGG
TGAACGTGGCGAAGGAGGACCTGCGCGCGGTCATGTCCGAGCTGGGCATGCGCGAGGGCTTCGACGTGGGGCTGGAGATG
AGCGGGAACGGCCGCGCCTTCCGCCAGCTCCTCGAGGTCATGAACCACGGCGGCAAGGTCGCCCTGCTCGGCATCATGGC
CGGGCCGGAGCCGATCGACTGGAGCCAGGTGGTGTTCAAGGGGCTCCAGCTCAAGGGCGTGTACGGCCGGGAGATGTACG
AGACCTGGTACAAGATGGTCGCGATGCTGCAGAGCGGGCTCGACCTCACCGCGGTCGTCACGCACCGCTTCTCCATCGAC
GACTTCCAGCAGGGCTTCGACGTCATGCGCAGCGGGCGCTCCGGCAAGGTGGTCCTGGACTGGGGCGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
ACTCGCGCGAGGACCTCGACCACGCCGTGGCGGCGTTCGAGAAGGTCGGCCGCGCGCTGGGCGTCATCCAGGGACGTTGA
CCGAGAGGAAACATCACGCG

Downstream 100 bases:

>100_bases
CCGCTTCACCGACCGTGATCTGACACCGCGCGTGCGGCGCGCCCGCGCCGCGCGGCAACAAGCCGCGCGCCGGTCGCACC
CGCACGCGGGGTGCGACGCC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKALVKAKREEGIWMQHDVPVPEVGVHDVMIRVTKSAICGTDVHIYNWDEWSQKTVPVPMVVGHEYVGRVEKVGAEVEAF
RPGERVSGEGHVTCGFCRNCRAGRRHLCRHTVGVGVNRPGSFAEYVVIPADNVYRIPDDIPDDIAAIFDPFGNATHTALS
FDLVGEDVLVTGAGPIGVMAAAIARHVGARHVVVTDVNDYRLDLARRMGASRAVNVAKEDLRAVMSELGMREGFDVGLEM
SGNGRAFRQLLEVMNHGGKVALLGIMAGPEPIDWSQVVFKGLQLKGVYGREMYETWYKMVAMLQSGLDLTAVVTHRFSID
DFQQGFDVMRSGRSGKVVLDWGAAR

Sequences:

>Translated_345_residues
MKALVKAKREEGIWMQHDVPVPEVGVHDVMIRVTKSAICGTDVHIYNWDEWSQKTVPVPMVVGHEYVGRVEKVGAEVEAF
RPGERVSGEGHVTCGFCRNCRAGRRHLCRHTVGVGVNRPGSFAEYVVIPADNVYRIPDDIPDDIAAIFDPFGNATHTALS
FDLVGEDVLVTGAGPIGVMAAAIARHVGARHVVVTDVNDYRLDLARRMGASRAVNVAKEDLRAVMSELGMREGFDVGLEM
SGNGRAFRQLLEVMNHGGKVALLGIMAGPEPIDWSQVVFKGLQLKGVYGREMYETWYKMVAMLQSGLDLTAVVTHRFSID
DFQQGFDVMRSGRSGKVVLDWGAAR
>Mature_345_residues
MKALVKAKREEGIWMQHDVPVPEVGVHDVMIRVTKSAICGTDVHIYNWDEWSQKTVPVPMVVGHEYVGRVEKVGAEVEAF
RPGERVSGEGHVTCGFCRNCRAGRRHLCRHTVGVGVNRPGSFAEYVVIPADNVYRIPDDIPDDIAAIFDPFGNATHTALS
FDLVGEDVLVTGAGPIGVMAAAIARHVGARHVVVTDVNDYRLDLARRMGASRAVNVAKEDLRAVMSELGMREGFDVGLEM
SGNGRAFRQLLEVMNHGGKVALLGIMAGPEPIDWSQVVFKGLQLKGVYGREMYETWYKMVAMLQSGLDLTAVVTHRFSID
DFQQGFDVMRSGRSGKVVLDWGAAR

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=29.3939393939394, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501929, Length=354, Percent_Identity=25.1412429378531, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI34577061, Length=356, Percent_Identity=25.561797752809, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4501933, Length=356, Percent_Identity=24.7191011235955, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=24.1573033707865, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501939, Length=350, Percent_Identity=24.2857142857143, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI71743840, Length=366, Percent_Identity=24.3169398907104, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI262073058, Length=366, Percent_Identity=24.3169398907104, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=361, Percent_Identity=24.3767313019391, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=73.0205278592375, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1788075, Length=361, Percent_Identity=30.4709141274238, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788073, Length=316, Percent_Identity=29.746835443038, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787863, Length=332, Percent_Identity=29.5180722891566, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI226510992, Length=331, Percent_Identity=26.8882175226586, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87082125, Length=342, Percent_Identity=29.8245614035088, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788407, Length=364, Percent_Identity=26.3736263736264, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786825, Length=384, Percent_Identity=27.34375, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790718, Length=266, Percent_Identity=26.3157894736842, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786552, Length=359, Percent_Identity=28.133704735376, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081918, Length=265, Percent_Identity=28.6792452830189, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786518, Length=268, Percent_Identity=27.9850746268657, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=316, Percent_Identity=31.3291139240506, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=328, Percent_Identity=30.1829268292683, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25146526, Length=350, Percent_Identity=26.8571428571429, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=348, Percent_Identity=26.7241379310345, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=184, Percent_Identity=32.6086956521739, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=274, Percent_Identity=25.1824817518248, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=122, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=321, Percent_Identity=29.595015576324, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=374, Percent_Identity=27.5401069518717, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=319, Percent_Identity=26.9592476489028, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=319, Percent_Identity=26.6457680250784, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320033, Length=362, Percent_Identity=27.6243093922652, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6319257, Length=283, Percent_Identity=28.2685512367491, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=206, Percent_Identity=28.6407766990291, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=277, Percent_Identity=26.7148014440433, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=210, Percent_Identity=29.0476190476191, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=204, Percent_Identity=29.4117647058824, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319949, Length=288, Percent_Identity=27.4305555555556, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737897, Length=327, Percent_Identity=27.217125382263, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI17137530, Length=324, Percent_Identity=26.5432098765432, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17737895, Length=362, Percent_Identity=24.585635359116, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221457811, Length=188, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550770, Length=188, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551930, Length=188, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_ANAD2 (B8J714)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492270.1
- ProteinModelPortal:   B8J714
- SMR:   B8J714
- GeneID:   7296388
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1862
- HOGENOM:   HBG753318
- ProtClustDB:   PRK05396
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR00692

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37887; Mature: 37887

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVKAKREEGIWMQHDVPVPEVGVHDVMIRVTKSAICGTDVHIYNWDEWSQKTVPVPM
CCCHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEE
VVGHEYVGRVEKVGAEVEAFRPGERVSGEGHVTCGFCRNCRAGRRHLCRHTVGVGVNRPG
EECCHHHHHHHHHCCCCEECCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCC
SFAEYVVIPADNVYRIPDDIPDDIAAIFDPFGNATHTALSFDLVGEDVLVTGAGPIGVMA
CCEEEEEECCCCEEECCCCCCHHHHHHHCCCCCCCHHEEEEEECCCEEEEECCCHHHHHH
AAIARHVGARHVVVTDVNDYRLDLARRMGASRAVNVAKEDLRAVMSELGMREGFDVGLEM
HHHHHHCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
SGNGRAFRQLLEVMNHGGKVALLGIMAGPEPIDWSQVVFKGLQLKGVYGREMYETWYKMV
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEEECCCCHHHHHHHHHHH
AMLQSGLDLTAVVTHRFSIDDFQQGFDVMRSGRSGKVVLDWGAAR
HHHHCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCC
>Mature Secondary Structure
MKALVKAKREEGIWMQHDVPVPEVGVHDVMIRVTKSAICGTDVHIYNWDEWSQKTVPVPM
CCCHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEE
VVGHEYVGRVEKVGAEVEAFRPGERVSGEGHVTCGFCRNCRAGRRHLCRHTVGVGVNRPG
EECCHHHHHHHHHCCCCEECCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCC
SFAEYVVIPADNVYRIPDDIPDDIAAIFDPFGNATHTALSFDLVGEDVLVTGAGPIGVMA
CCEEEEEECCCCEEECCCCCCHHHHHHHCCCCCCCHHEEEEEECCCEEEEECCCHHHHHH
AAIARHVGARHVVVTDVNDYRLDLARRMGASRAVNVAKEDLRAVMSELGMREGFDVGLEM
HHHHHHCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
SGNGRAFRQLLEVMNHGGKVALLGIMAGPEPIDWSQVVFKGLQLKGVYGREMYETWYKMV
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEEECCCCHHHHHHHHHHH
AMLQSGLDLTAVVTHRFSIDDFQQGFDVMRSGRSGKVVLDWGAAR
HHHHCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA