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The map label for this gene is fps [H]

Identifier: 220916330

GI number: 220916330

Start: 1373708

End: 1374589

Strand: Direct

Name: fps [H]

Synonym: A2cp1_1224

Alternate gene names: 220916330

Gene position: 1373708-1374589 (Clockwise)

Preceding gene: 220916329

Following gene: 220916331

Centisome position: 27.31

GC content: 77.55

Gene sequence:

>882_bases
TTGACGACCCCGTTCCCGATCGAGGCGTACCTGCGCAGCGTGGCGGAGCGCGTCGAGCCGCGCCTGGCCGCGCTGGCCGA
CGCCCGCGCGCCGGGCGGCCCGCCGCGGCTGGTGGAGGCGATGCGCTACGCGCTGCTGGGCGGCGGCAAGCGCATGCGCC
CGGCGCTGGTGCTCGCCGCGTGCGAGGCGCACGGCGGCGACGCGTCCGACGCCTCGCTGGCGATGCGCTTCGCGGTGGCG
CTCGAGGCCATCCACACCTACTCGCTCGTCCACGACGACCTGCCCGCCATGGACGACGACGACCTGCGCCGCGGCCGGCC
CACCGTGCACAAGGCGTACGACGAGCCGACGGCGGTGCTGGTGGGCGACGGGCTGCAGTCGCTCGCGTTCGCGCACCTCC
TCGCCTCGCCCGACCCCGCGGCGGCACCGCTCGCGCGCCTGCTCGCCGAGAACGCGCAGCTCATGGTCGAGGGCCAGGCC
CGCGACATGGCCGGCGAGCACGCGCGCCTCGGTGAGGCCGAGGTCATGGAGCTGATGCGGACCAAGACCGGCGCGCTGCT
CGCGGCCGCGGTCGCGGGCGGCGCGCGCTGCGCCGGGGTCCCCGTCGAGGCGGCGTACCCGGTGGGCCTGAAGCTCGGGC
TCGCGTTCCAGATCGCCGACGACCTGCTCGACCTCACCGCCGACGCGGCCACCCTGGGCAAGCGCGCCGGCAAGGACGCC
GCCGCCGGGAAGTCCACGCTGCACGCGGTGGTCGGGGTGGAGGAGGCCCGCCGCCGCGCCGAGGCGCTGCTCGCCGAGGC
GCTCGCGGCCATCGAGCCGCTCGGGCCCCGCGGCGAGGCGCTGCGCGCGCTGGCGCGCTTCGTCCTCGCCCGCAAGAAGT
GA

Upstream 100 bases:

>100_bases
GGCGCCGTTCCGACGCCGGCCTAGGCCACCCCGCCGCGCCCCGCTCGCGGGCGCCGGCGGGCGATCCGTCCGCGCCGCTT
GTGCTAAAAGGTCCGTCACC

Downstream 100 bases:

>100_bases
CGGAAGGGAAGGAGAGCCCATGGGCCGCCTGCTGGACACGATCGACTCGCCGACCGACCTGAAGAAGGTGCCGGTCGAGC
AGCTCCCCGCGCTCTGCCAG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTTPFPIEAYLRSVAERVEPRLAALADARAPGGPPRLVEAMRYALLGGGKRMRPALVLAACEAHGGDASDASLAMRFAVA
LEAIHTYSLVHDDLPAMDDDDLRRGRPTVHKAYDEPTAVLVGDGLQSLAFAHLLASPDPAAAPLARLLAENAQLMVEGQA
RDMAGEHARLGEAEVMELMRTKTGALLAAAVAGGARCAGVPVEAAYPVGLKLGLAFQIADDLLDLTADAATLGKRAGKDA
AAGKSTLHAVVGVEEARRRAEALLAEALAAIEPLGPRGEALRALARFVLARKK

Sequences:

>Translated_293_residues
MTTPFPIEAYLRSVAERVEPRLAALADARAPGGPPRLVEAMRYALLGGGKRMRPALVLAACEAHGGDASDASLAMRFAVA
LEAIHTYSLVHDDLPAMDDDDLRRGRPTVHKAYDEPTAVLVGDGLQSLAFAHLLASPDPAAAPLARLLAENAQLMVEGQA
RDMAGEHARLGEAEVMELMRTKTGALLAAAVAGGARCAGVPVEAAYPVGLKLGLAFQIADDLLDLTADAATLGKRAGKDA
AAGKSTLHAVVGVEEARRRAEALLAEALAAIEPLGPRGEALRALARFVLARKK
>Mature_292_residues
TTPFPIEAYLRSVAERVEPRLAALADARAPGGPPRLVEAMRYALLGGGKRMRPALVLAACEAHGGDASDASLAMRFAVAL
EAIHTYSLVHDDLPAMDDDDLRRGRPTVHKAYDEPTAVLVGDGLQSLAFAHLLASPDPAAAPLARLLAENAQLMVEGQAR
DMAGEHARLGEAEVMELMRTKTGALLAAAVAGGARCAGVPVEAAYPVGLKLGLAFQIADDLLDLTADAATLGKRAGKDAA
AGKSTLHAVVGVEEARRRAEALLAEALAAIEPLGPRGEALRALARFVLARKK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=312, Percent_Identity=29.8076923076923, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1786623, Length=311, Percent_Identity=41.4790996784566, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789578, Length=306, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505681, Length=253, Percent_Identity=28.4584980237154, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651612, Length=229, Percent_Identity=29.2576419213974, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30550; Mature: 30418

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPFPIEAYLRSVAERVEPRLAALADARAPGGPPRLVEAMRYALLGGGKRMRPALVLAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
CEAHGGDASDASLAMRFAVALEAIHTYSLVHDDLPAMDDDDLRRGRPTVHKAYDEPTAVL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHCCCCCEEE
VGDGLQSLAFAHLLASPDPAAAPLARLLAENAQLMVEGQARDMAGEHARLGEAEVMELMR
ECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCHHHHCCHHHHCCHHHHHHHHH
TKTGALLAAAVAGGARCAGVPVEAAYPVGLKLGLAFQIADDLLDLTADAATLGKRAGKDA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AAGKSTLHAVVGVEEARRRAEALLAEALAAIEPLGPRGEALRALARFVLARKK
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTPFPIEAYLRSVAERVEPRLAALADARAPGGPPRLVEAMRYALLGGGKRMRPALVLAA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
CEAHGGDASDASLAMRFAVALEAIHTYSLVHDDLPAMDDDDLRRGRPTVHKAYDEPTAVL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHCCCCCEEE
VGDGLQSLAFAHLLASPDPAAAPLARLLAENAQLMVEGQARDMAGEHARLGEAEVMELMR
ECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCHHHHCCHHHHCCHHHHHHHHH
TKTGALLAAAVAGGARCAGVPVEAAYPVGLKLGLAFQIADDLLDLTADAATLGKRAGKDA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AAGKSTLHAVVGVEEARRRAEALLAEALAAIEPLGPRGEALRALARFVLARKK
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]