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The map label for this gene is dxs

Identifier: 220916331

GI number: 220916331

Start: 1374609

End: 1376519

Strand: Direct

Name: dxs

Synonym: A2cp1_1225

Alternate gene names: 220916331

Gene position: 1374609-1376519 (Clockwise)

Preceding gene: 220916330

Following gene: 220916332

Centisome position: 27.33

GC content: 72.16

Gene sequence:

>1911_bases
ATGGGCCGCCTGCTGGACACGATCGACTCGCCGACCGACCTGAAGAAGGTGCCGGTCGAGCAGCTCCCCGCGCTCTGCCA
GGAGATCCGCGAGCAGATCATCCAGACCTGCGCCCGGAACGGCGGCCACCTCGGCTCGTCGCTCGGCGCGGTGGAGATCA
ACGTCGCGCTGCACCACGTGTTCTCCTCGCCGCAGGACAAGCTCGTCTGGGACGTGGGGCACCAGGCGTACGCGCACAAG
CTGCTCACCGGCCGGCGCGAGGCGTTCCGGACCATCCGCACCGAGGGTGGCCTGGCGGGCTTCCCCGAGCGGCACGAGTC
GGCGCACGACGCGTTCGGCGTGGGGCACGCCTCCACCGCGATCAGCGCCGCGCTCGGCATGATCGAGGCGAAGCGCGTCA
CCGGCGAGCCGGGCAAGGTGGTGGCGGTGGTGGGCGACGGCGCCATGACCGGCGGCGTGGCCTTCGAGGGCCTGAACCAG
GCCGGCTACCTCGGGCGCAACCTGCTGGTGGTGCTGAACGACAACGAGATGTCGATCTCGCCCAACGTGGGCGCGCTGTC
GGAGTGGTTCTCGAAGAAGTTCGCCTCGCGCACGTACAACCGCTGGCGCCGCCAGGTGAAGGAGTTCCTGGAGAGCGTGC
CCAAGGGGCCGGAGGCGATCGAGATCATCCGCCACGGCATCAACGCCACCAAGGCGCTCGTCACCCCCGGCATCCTGTTC
GAGGGGCTCGGCTTCCACTACGTCGGCCCGGTGGACGGGCACGACGTGAAGGGGCTGGTGGAGACGTTCCAGAAGCTCGC
CATCTTCGACGGCCCGGTGCTGCTGCACGCCATCACCACCAAGGGCAAGGGCTATCACCCGGCGGAGTCGGACAAGGCCA
CGCGCGGCCACGGCCTGTCCTTCTTCGACGTGGCCACCGGCAAGCCGGTGAAGAAGTCGCCCGGGGCGAAGGCCTACACC
GACCTGTTCGCCGAGGCGCTCTGCGAGGAGATGGAGCACGACCCCAGGGTCGTGGCCATCACCGCGGCGATGCTCGAGGG
CACCGGGCTCATCAAGGCGAAGCAGCGCTTCCCGGACCGCACCTACGACGTCGGCATCGCCGAGCAGCACGCGGTGACGT
TCGCGGCGGGCCTGGCGTGCGAGGGGATCCGGCCGGTGGTGGCCATCTACTCGACGTTCCTGCAGCGCGCCTACGACCAG
ATCATCCACGACGTGGCGCTGCAGAAGCTGCCGGTGACGTTCGCGCTCGACCGCGGTGGCCTCGTGGGCGCCGACGGCAA
GACGCACCAGGGCGCGTTCGACCTCGCCTACCTGCGCTGCGTGCCGGGGCTGGTGGTCATGGCCCCGTCGGACGAGAACG
AGCTGCGCCACATGCTGCACACCTCGCTGCAGCACGACGGGCCGGCGGCCCTCCGCTACCCGCGCGGCGCCGGCGAGGGG
GTGGCGCTCGAGCCCGCGCGCGTGCTGGAGATCGGCAAGGGGCGGCTGGCGCGGAACGTCCCGGGCAAGCCGGACGTGTG
CGTGGTCGCGGCCGGCACCACGCTGAAGGCCGCGCTCGCCGCCGCCGAGGCGCTCGCCGCCGAGGGCGTGGCGGCCACGG
TCGTCGATCCGCGGTTCGTGAAGCCGCTCGACGAGGAGCTGATCTGCGCCGAGGCGGGCCGCGCGAAGCGCGTGGTCACG
GTGGAGGAGGGGTGCCTCGCCGGCGGCTTCGGCACCGCCTGCCTGGAGGCGTTCGAGCGCCGCGGGCTGCTCGAGGCCGG
CCTGGGCGTGCGGCGCCTCGGCATCCCCGACGAGTTCATCACCCACGCCGAGCAGGCGAAGCAGCGCGCCTGGGTGGGCA
TCGACGCCGACGCGATCGCCGCGGCCTGCCGCGCCCTGGTGGGCGACCGCAAGGCGCGCGGCGTGGCGTAG

Upstream 100 bases:

>100_bases
CTCGCGGCCATCGAGCCGCTCGGGCCCCGCGGCGAGGCGCTGCGCGCGCTGGCGCGCTTCGTCCTCGCCCGCAAGAAGTG
ACGGAAGGGAAGGAGAGCCC

Downstream 100 bases:

>100_bases
GCGGTGAGCGCGTTGCCAGCGCCGGTCGCAGTTCTCGATCGCGCGCCGTCAGGCGCGCCCGCGGGGACCTCGCGCGAGCC
CGCGAACGCGGGCGCGCGAG

Product: deoxyxylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MGRLLDTIDSPTDLKKVPVEQLPALCQEIREQIIQTCARNGGHLGSSLGAVEINVALHHVFSSPQDKLVWDVGHQAYAHK
LLTGRREAFRTIRTEGGLAGFPERHESAHDAFGVGHASTAISAALGMIEAKRVTGEPGKVVAVVGDGAMTGGVAFEGLNQ
AGYLGRNLLVVLNDNEMSISPNVGALSEWFSKKFASRTYNRWRRQVKEFLESVPKGPEAIEIIRHGINATKALVTPGILF
EGLGFHYVGPVDGHDVKGLVETFQKLAIFDGPVLLHAITTKGKGYHPAESDKATRGHGLSFFDVATGKPVKKSPGAKAYT
DLFAEALCEEMEHDPRVVAITAAMLEGTGLIKAKQRFPDRTYDVGIAEQHAVTFAAGLACEGIRPVVAIYSTFLQRAYDQ
IIHDVALQKLPVTFALDRGGLVGADGKTHQGAFDLAYLRCVPGLVVMAPSDENELRHMLHTSLQHDGPAALRYPRGAGEG
VALEPARVLEIGKGRLARNVPGKPDVCVVAAGTTLKAALAAAEALAAEGVAATVVDPRFVKPLDEELICAEAGRAKRVVT
VEEGCLAGGFGTACLEAFERRGLLEAGLGVRRLGIPDEFITHAEQAKQRAWVGIDADAIAAACRALVGDRKARGVA

Sequences:

>Translated_636_residues
MGRLLDTIDSPTDLKKVPVEQLPALCQEIREQIIQTCARNGGHLGSSLGAVEINVALHHVFSSPQDKLVWDVGHQAYAHK
LLTGRREAFRTIRTEGGLAGFPERHESAHDAFGVGHASTAISAALGMIEAKRVTGEPGKVVAVVGDGAMTGGVAFEGLNQ
AGYLGRNLLVVLNDNEMSISPNVGALSEWFSKKFASRTYNRWRRQVKEFLESVPKGPEAIEIIRHGINATKALVTPGILF
EGLGFHYVGPVDGHDVKGLVETFQKLAIFDGPVLLHAITTKGKGYHPAESDKATRGHGLSFFDVATGKPVKKSPGAKAYT
DLFAEALCEEMEHDPRVVAITAAMLEGTGLIKAKQRFPDRTYDVGIAEQHAVTFAAGLACEGIRPVVAIYSTFLQRAYDQ
IIHDVALQKLPVTFALDRGGLVGADGKTHQGAFDLAYLRCVPGLVVMAPSDENELRHMLHTSLQHDGPAALRYPRGAGEG
VALEPARVLEIGKGRLARNVPGKPDVCVVAAGTTLKAALAAAEALAAEGVAATVVDPRFVKPLDEELICAEAGRAKRVVT
VEEGCLAGGFGTACLEAFERRGLLEAGLGVRRLGIPDEFITHAEQAKQRAWVGIDADAIAAACRALVGDRKARGVA
>Mature_635_residues
GRLLDTIDSPTDLKKVPVEQLPALCQEIREQIIQTCARNGGHLGSSLGAVEINVALHHVFSSPQDKLVWDVGHQAYAHKL
LTGRREAFRTIRTEGGLAGFPERHESAHDAFGVGHASTAISAALGMIEAKRVTGEPGKVVAVVGDGAMTGGVAFEGLNQA
GYLGRNLLVVLNDNEMSISPNVGALSEWFSKKFASRTYNRWRRQVKEFLESVPKGPEAIEIIRHGINATKALVTPGILFE
GLGFHYVGPVDGHDVKGLVETFQKLAIFDGPVLLHAITTKGKGYHPAESDKATRGHGLSFFDVATGKPVKKSPGAKAYTD
LFAEALCEEMEHDPRVVAITAAMLEGTGLIKAKQRFPDRTYDVGIAEQHAVTFAAGLACEGIRPVVAIYSTFLQRAYDQI
IHDVALQKLPVTFALDRGGLVGADGKTHQGAFDLAYLRCVPGLVVMAPSDENELRHMLHTSLQHDGPAALRYPRGAGEGV
ALEPARVLEIGKGRLARNVPGKPDVCVVAAGTTLKAALAAAEALAAEGVAATVVDPRFVKPLDEELICAEAGRAKRVVTV
EEGCLAGGFGTACLEAFERRGLLEAGLGVRRLGIPDEFITHAEQAKQRAWVGIDADAIAAACRALVGDRKARGVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=666, Percent_Identity=24.7747747747748, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4507521, Length=666, Percent_Identity=24.7747747747748, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI133778974, Length=632, Percent_Identity=24.5253164556962, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI225637463, Length=378, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI225637459, Length=378, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI225637461, Length=378, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1786622, Length=624, Percent_Identity=48.3974358974359, Blast_Score=587, Evalue=1e-168,
Organism=Escherichia coli, GI1788808, Length=175, Percent_Identity=31.4285714285714, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=633, Percent_Identity=24.3285939968404, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17538422, Length=275, Percent_Identity=26.5454545454545, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=267, Percent_Identity=27.3408239700375, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24666278, Length=591, Percent_Identity=27.9187817258883, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45551847, Length=640, Percent_Identity=26.71875, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45550715, Length=640, Percent_Identity=26.71875, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24645119, Length=401, Percent_Identity=30.9226932668329, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358145, Length=305, Percent_Identity=28.8524590163934, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650940, Length=305, Percent_Identity=28.8524590163934, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ANAD2 (B8JFY1)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491635.1
- ProteinModelPortal:   B8JFY1
- SMR:   B8JFY1
- GeneID:   7299091
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1225
- HOGENOM:   HBG571647
- ProtClustDB:   CLSK2465121
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67742; Mature: 67611

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLLDTIDSPTDLKKVPVEQLPALCQEIREQIIQTCARNGGHLGSSLGAVEINVALHHV
CCCHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHH
FSSPQDKLVWDVGHQAYAHKLLTGRREAFRTIRTEGGLAGFPERHESAHDAFGVGHASTA
HCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHCCCCHHHHH
ISAALGMIEAKRVTGEPGKVVAVVGDGAMTGGVAFEGLNQAGYLGRNLLVVLNDNEMSIS
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCCCCCCCCCCEEEEECCCCEEEC
PNVGALSEWFSKKFASRTYNRWRRQVKEFLESVPKGPEAIEIIRHGINATKALVTPGILF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCHHH
EGLGFHYVGPVDGHDVKGLVETFQKLAIFDGPVLLHAITTKGKGYHPAESDKATRGHGLS
HCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCE
FFDVATGKPVKKSPGAKAYTDLFAEALCEEMEHDPRVVAITAAMLEGTGLIKAKQRFPDR
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCHHHHHCCCC
TYDVGIAEQHAVTFAAGLACEGIRPVVAIYSTFLQRAYDQIIHDVALQKLPVTFALDRGG
CEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
LVGADGKTHQGAFDLAYLRCVPGLVVMAPSDENELRHMLHTSLQHDGPAALRYPRGAGEG
EECCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCC
VALEPARVLEIGKGRLARNVPGKPDVCVVAAGTTLKAALAAAEALAAEGVAATVVDPRFV
EEECCHHHHHHCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCHHH
KPLDEELICAEAGRAKRVVTVEEGCLAGGFGTACLEAFERRGLLEAGLGVRRLGIPDEFI
CCCCHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHHCCCEEECCCCHHHH
THAEQAKQRAWVGIDADAIAAACRALVGDRKARGVA
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GRLLDTIDSPTDLKKVPVEQLPALCQEIREQIIQTCARNGGHLGSSLGAVEINVALHHV
CCHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHH
FSSPQDKLVWDVGHQAYAHKLLTGRREAFRTIRTEGGLAGFPERHESAHDAFGVGHASTA
HCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHCCCCHHHHH
ISAALGMIEAKRVTGEPGKVVAVVGDGAMTGGVAFEGLNQAGYLGRNLLVVLNDNEMSIS
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCCCCCCCCCCEEEEECCCCEEEC
PNVGALSEWFSKKFASRTYNRWRRQVKEFLESVPKGPEAIEIIRHGINATKALVTPGILF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCHHH
EGLGFHYVGPVDGHDVKGLVETFQKLAIFDGPVLLHAITTKGKGYHPAESDKATRGHGLS
HCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCE
FFDVATGKPVKKSPGAKAYTDLFAEALCEEMEHDPRVVAITAAMLEGTGLIKAKQRFPDR
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCHHHHHCCCC
TYDVGIAEQHAVTFAAGLACEGIRPVVAIYSTFLQRAYDQIIHDVALQKLPVTFALDRGG
CEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
LVGADGKTHQGAFDLAYLRCVPGLVVMAPSDENELRHMLHTSLQHDGPAALRYPRGAGEG
EECCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCC
VALEPARVLEIGKGRLARNVPGKPDVCVVAAGTTLKAALAAAEALAAEGVAATVVDPRFV
EEECCHHHHHHCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCHHH
KPLDEELICAEAGRAKRVVTVEEGCLAGGFGTACLEAFERRGLLEAGLGVRRLGIPDEFI
CCCCHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHHCCCEEECCCCHHHH
THAEQAKQRAWVGIDADAIAAACRALVGDRKARGVA
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA