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The map label for this gene is mprA [H]

Identifier: 220916329

GI number: 220916329

Start: 1373233

End: 1373631

Strand: Direct

Name: mprA [H]

Synonym: A2cp1_1223

Alternate gene names: 220916329

Gene position: 1373233-1373631 (Clockwise)

Preceding gene: 220916328

Following gene: 220916330

Centisome position: 27.3

GC content: 68.42

Gene sequence:

>399_bases
ATGCGCAAGCCCAAGGTCATCATCGTCGACGACGACCGCGACACGCGCGAGATGCTGACGCTCGCGCTGGAGCTGGAGGG
GTTCGACGTGGGCCAGGCGGCGAACGGCCTGCGGCTCATCTCCGCCATGCACGTGGACCGGCCGGACGTGATCCTGCTCG
ACGTGATGATGTCCTGGATCGACGGCTTCGAGCTGTGCCGCGCCATCAAGAAGAACCCGACGTTCGGGGACATCCCGGTG
ATCTTCATCTCGGCGCGCAAGAGCGCCGACGACGAGCGCGCCGGGATCGAGGCGGGCGCGGTGGACTACTTCCCCAAGCC
CCTCGACATGGACCGGCTGGTGGCCCGGATCCGCGAGATCCTCGATCAGCGCGCGGGCGCCGTTCCGACGCCGGCCTAG

Upstream 100 bases:

>100_bases
GTGGAGCTCCTGGTGCGCGGCGCGGACGGCGACGACGAGGCGGTTCCGTTCGAGCCCGAGGGCGGCCGGGGCCCGTGACC
CGATGACGGCCGAGCCACGC

Downstream 100 bases:

>100_bases
GCCACCCCGCCGCGCCCCGCTCGCGGGCGCCGGCGGGCGATCCGTCCGCGCCGCTTGTGCTAAAAGGTCCGTCACCTTGA
CGACCCCGTTCCCGATCGAG

Product: response regulator receiver protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MRKPKVIIVDDDRDTREMLTLALELEGFDVGQAANGLRLISAMHVDRPDVILLDVMMSWIDGFELCRAIKKNPTFGDIPV
IFISARKSADDERAGIEAGAVDYFPKPLDMDRLVARIREILDQRAGAVPTPA

Sequences:

>Translated_132_residues
MRKPKVIIVDDDRDTREMLTLALELEGFDVGQAANGLRLISAMHVDRPDVILLDVMMSWIDGFELCRAIKKNPTFGDIPV
IFISARKSADDERAGIEAGAVDYFPKPLDMDRLVARIREILDQRAGAVPTPA
>Mature_132_residues
MRKPKVIIVDDDRDTREMLTLALELEGFDVGQAANGLRLISAMHVDRPDVILLDVMMSWIDGFELCRAIKKNPTFGDIPV
IFISARKSADDERAGIEAGAVDYFPKPLDMDRLVARIREILDQRAGAVPTPA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=127, Percent_Identity=33.8582677165354, Blast_Score=77, Evalue=5e-16,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1790860, Length=133, Percent_Identity=35.3383458646617, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI1788394, Length=118, Percent_Identity=33.0508474576271, Blast_Score=71, Evalue=3e-14,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=35.6521739130435, Blast_Score=70, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=34.8214285714286, Blast_Score=70, Evalue=4e-14,
Organism=Escherichia coli, GI87082012, Length=126, Percent_Identity=30.1587301587302, Blast_Score=68, Evalue=2e-13,
Organism=Escherichia coli, GI1786911, Length=127, Percent_Identity=35.4330708661417, Blast_Score=68, Evalue=2e-13,
Organism=Escherichia coli, GI2367329, Length=117, Percent_Identity=41.8803418803419, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1786784, Length=124, Percent_Identity=31.4516129032258, Blast_Score=67, Evalue=4e-13,
Organism=Escherichia coli, GI1787229, Length=117, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1790863, Length=123, Percent_Identity=27.6422764227642, Blast_Score=64, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=32.4786324786325, Blast_Score=60, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 14692; Mature: 14692

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPKVIIVDDDRDTREMLTLALELEGFDVGQAANGLRLISAMHVDRPDVILLDVMMSWI
CCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
DGFELCRAIKKNPTFGDIPVIFISARKSADDERAGIEAGAVDYFPKPLDMDRLVARIREI
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
LDQRAGAVPTPA
HHHHCCCCCCCC
>Mature Secondary Structure
MRKPKVIIVDDDRDTREMLTLALELEGFDVGQAANGLRLISAMHVDRPDVILLDVMMSWI
CCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
DGFELCRAIKKNPTFGDIPVIFISARKSADDERAGIEAGAVDYFPKPLDMDRLVARIREI
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
LDQRAGAVPTPA
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA