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The map label for this gene is hisB

Identifier: 220915867

GI number: 220915867

Start: 842842

End: 843468

Strand: Direct

Name: hisB

Synonym: A2cp1_0750

Alternate gene names: 220915867

Gene position: 842842-843468 (Clockwise)

Preceding gene: 220915866

Following gene: 220915868

Centisome position: 16.76

GC content: 73.68

Gene sequence:

>627_bases
ATGAGCCGGCGGGCGGCGGTGAAGACCCCGCGCGCGGGGGCGGCCGCGCGCCGCGGGGCGGTGGCGCGGCGGACCAAGGA
GACCGACGTCGCGGTGGAGCTCCGGCTCGAGCCGGGCGAGGCGGCGATCTCGACCGGGCTCCCGTTCTTCGACCACATGC
TCGACCAGATCTCGCGCCACGGCGGCATGGCGCTCACGGTGCGGGCGAAGGGCGACCTGCAGGTGGACGCGCACCACACC
GTCGAGGACGTGGGCATCGGCCTGGGCGAGGCGCTGCGGCAGGCGCTCGAGGACAAGGCCGGGCTGGCGCGCTACGGGCA
CGCGGTGGTGCCGCTCGACGAGGCGCTGGTGGAGGCGGTGGTGGACCTCTCCGGCCGCCCGCACCTCACGTTCAACGCGA
AGCTGCCGAGCGGCAAGAAGTTCATCGGCGGCTACGACGTGGACCTGACGCAGGACTTCCTGCAGGCGCTCGTGAACCAC
GCGCGCATCTGCGTGCACGTGAACGTCCGCTACGGCCGCAACCTGCACCACGTGGTCGAGGCGATCTTCAAGGCGACCGC
GCGCGCGCTCCGCGCCGCGACCGCGCGCGAGGGGACCGCGCTGCCCAGCACCAAGGGAACGCTGTGA

Upstream 100 bases:

>100_bases
GCGCGTCCGCGCGGGCCCGCCGGGTGGCGCCGGCGAAGGCGAAGGCGGCCGGCGCGTCGGGGGCGCCCCGCGCGCGCGCC
GCGGCCGGGGGGGCGCGTCG

Downstream 100 bases:

>100_bases
GCCGCCCGGCCGGCACCGTCGCGCTGGTGGACTACGGCGCCGGCAACCTGCGCTCGGTGGAGAACGCGCTGCGCGAGGTG
GGCGCGGCGGTGGTGGTCAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSRRAAVKTPRAGAAARRGAVARRTKETDVAVELRLEPGEAAISTGLPFFDHMLDQISRHGGMALTVRAKGDLQVDAHHT
VEDVGIGLGEALRQALEDKAGLARYGHAVVPLDEALVEAVVDLSGRPHLTFNAKLPSGKKFIGGYDVDLTQDFLQALVNH
ARICVHVNVRYGRNLHHVVEAIFKATARALRAATAREGTALPSTKGTL

Sequences:

>Translated_208_residues
MSRRAAVKTPRAGAAARRGAVARRTKETDVAVELRLEPGEAAISTGLPFFDHMLDQISRHGGMALTVRAKGDLQVDAHHT
VEDVGIGLGEALRQALEDKAGLARYGHAVVPLDEALVEAVVDLSGRPHLTFNAKLPSGKKFIGGYDVDLTQDFLQALVNH
ARICVHVNVRYGRNLHHVVEAIFKATARALRAATAREGTALPSTKGTL
>Mature_207_residues
SRRAAVKTPRAGAAARRGAVARRTKETDVAVELRLEPGEAAISTGLPFFDHMLDQISRHGGMALTVRAKGDLQVDAHHTV
EDVGIGLGEALRQALEDKAGLARYGHAVVPLDEALVEAVVDLSGRPHLTFNAKLPSGKKFIGGYDVDLTQDFLQALVNHA
RICVHVNVRYGRNLHHVVEAIFKATARALRAATAREGTALPSTKGTL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=210, Percent_Identity=42.8571428571429, Blast_Score=169, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324776, Length=184, Percent_Identity=41.304347826087, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_ANAD2 (B8JDL0)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491171.1
- ProteinModelPortal:   B8JDL0
- SMR:   B8JDL0
- GeneID:   7299135
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_0750
- HOGENOM:   HBG289010
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22305; Mature: 22174

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRAAVKTPRAGAAARRGAVARRTKETDVAVELRLEPGEAAISTGLPFFDHMLDQISRH
CCCCCCCCCCCCCHHHHHCHHHHCCCCCCEEEEEEECCCCHHHHCCCHHHHHHHHHHHHC
GGMALTVRAKGDLQVDAHHTVEDVGIGLGEALRQALEDKAGLARYGHAVVPLDEALVEAV
CCEEEEEEECCCEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHH
VDLSGRPHLTFNAKLPSGKKFIGGYDVDLTQDFLQALVNHARICVHVNVRYGRNLHHVVE
HHCCCCCCEEEECCCCCCCEECCCCCCHHHHHHHHHHHHCCEEEEEEEEHHCCCHHHHHH
AIFKATARALRAATAREGTALPSTKGTL
HHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SRRAAVKTPRAGAAARRGAVARRTKETDVAVELRLEPGEAAISTGLPFFDHMLDQISRH
CCCCCCCCCCCCHHHHHCHHHHCCCCCCEEEEEEECCCCHHHHCCCHHHHHHHHHHHHC
GGMALTVRAKGDLQVDAHHTVEDVGIGLGEALRQALEDKAGLARYGHAVVPLDEALVEAV
CCEEEEEEECCCEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHH
VDLSGRPHLTFNAKLPSGKKFIGGYDVDLTQDFLQALVNHARICVHVNVRYGRNLHHVVE
HHCCCCCCEEEECCCCCCCEECCCCCCHHHHHHHHHHHHCCEEEEEEEEHHCCCHHHHHH
AIFKATARALRAATAREGTALPSTKGTL
HHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA