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The map label for this gene is hisD [H]

Identifier: 220915866

GI number: 220915866

Start: 841439

End: 842845

Strand: Direct

Name: hisD [H]

Synonym: A2cp1_0749

Alternate gene names: 220915866

Gene position: 841439-842845 (Clockwise)

Preceding gene: 220915863

Following gene: 220915867

Centisome position: 16.73

GC content: 78.82

Gene sequence:

>1407_bases
GTGCTGAAGCTCGATTCCCGCGATCCTGGCTTCCAAGAAGCGTGGGCCCGCGTCTGCGCCCGTGGGTCGGACGAGGACGA
GGCGCCGGTGCGCGAGGCCGCCGCCACCATCGTGGCCGACGTCCGCGCCCGCGGCGACCTGGCGCTGCTCGAGCACACCC
GCCGCCACGACGCCTGGGACCCGGGCTCCGCCGCCGGCCTGGCGCTCGGCCCGGCCGACTTCGCCGCCGCGTACCGCGGC
CTCCCCGCCGCGGCGCGTCGTGCGCTCTCGCTCGCCGCCCGGCGCATCGCCGACTTCCATCGCCGCGAGACCGACGCCCG
GGTGCCGGCCCGTCGCGACGCCGCGGGTGCGACGCTGTCGCAGGTCGTCCGCCCGCTGGAGCGCGTCGGCCTGTACGTTC
CGGGGGGGACGGCCCGCTATCCCTCCTCGGTGCTGATGACCGCCGTTCCGGCCCGCGTGGCCGGCGTCCGGGAGATCGTC
GTGACGTCCCCCGGCGTGAAGGGCAGCGGCGAGATGGACCGCTGGACGCTCGCCGCCTGCCACGTGGCCGGGGTGGCGCG
CCTGTTCAAGGTCGGCGGCGCGCAGGCGGTGGCGGCGCTGGCGTACGGCACCGCCACGGTGCCGGCGGTGGACAAGATCT
GCGGGCCGGGCAACGCGTACGTGGCCGCCGCGAAGCGGCTGGTGTTCGGGCGCGTGGACATCGACATGATCGCCGGGCCG
AGCGAGATCCTGGTGCTCGCGGACGCGGCGGCGGATCCGGCCGAGGTGGCGAGCGACCTGCTCGCGCAGGCCGAGCACGA
CGTGCGGGCCGTGTCGGTGCTGGTGACGCCGTCGGCCGCGCTGGCGCGGGCGGCGCTGGCGGCGGTGGAGCGCCAGCTCG
CCGACCTGCCGCGCCGGGAGATCGCCGGGCGGTCGATCGAGGAGCGCGGCGCGGTGGTGGTGACGCGCGGCCTCTCCGAG
GCGGTGCGGCTCGCCGACGCGTTCGCGCCCGAGCACCTGGCGCTGCACGCCCGCGGCGCGGCCGGCCTCGTGAAGCGGAT
CTCGCGCGCCGGCGCGGTGTTCGTGGGCAGCTCCACCCCGGAGGCGGTCGGCGACTACCTGGCCGGCCCGAGCCACGTGC
TCCCGACCGCCGGCACCGCCCGGTTCGCCTCGCCGCTGTCGGTGGCGACGTTCCGCCGCCGCATGAGCGTGCTCGACCTG
ACGCCCGCGGCGCTCGCCGCGCTGGCACCGTCGGTCGAGGCGCTGGCGCGGGCCGAGGGGCTGGAGGGGCACTGGCGCGC
GGTGGAGGTGCGGGTGGCGAAGCGCGCGTCCGCGCGGGCCCGCCGGGTGGCGCCGGCGAAGGCGAAGGCGGCCGGCGCGT
CGGGGGCGCCCCGCGCGCGCGCCGCGGCCGGGGGGGCGCGTCGATGA

Upstream 100 bases:

>100_bases
CGTCTGGTGCGCCGCAGGTCGCGGCCGACCGGGGCAGGCGCGACCCTCGCCATCCAGGGCCTTTTCGTCTATACGAACGG
GTTCCCCGAGGAGTTCCGCC

Downstream 100 bases:

>100_bases
GCCGGCGGGCGGCGGTGAAGACCCCGCGCGCGGGGGCGGCCGCGCGCCGCGGGGCGGTGGCGCGGCGGACCAAGGAGACC
GACGTCGCGGTGGAGCTCCG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MLKLDSRDPGFQEAWARVCARGSDEDEAPVREAAATIVADVRARGDLALLEHTRRHDAWDPGSAAGLALGPADFAAAYRG
LPAAARRALSLAARRIADFHRRETDARVPARRDAAGATLSQVVRPLERVGLYVPGGTARYPSSVLMTAVPARVAGVREIV
VTSPGVKGSGEMDRWTLAACHVAGVARLFKVGGAQAVAALAYGTATVPAVDKICGPGNAYVAAAKRLVFGRVDIDMIAGP
SEILVLADAAADPAEVASDLLAQAEHDVRAVSVLVTPSAALARAALAAVERQLADLPRREIAGRSIEERGAVVVTRGLSE
AVRLADAFAPEHLALHARGAAGLVKRISRAGAVFVGSSTPEAVGDYLAGPSHVLPTAGTARFASPLSVATFRRRMSVLDL
TPAALAALAPSVEALARAEGLEGHWRAVEVRVAKRASARARRVAPAKAKAAGASGAPRARAAAGGARR

Sequences:

>Translated_468_residues
MLKLDSRDPGFQEAWARVCARGSDEDEAPVREAAATIVADVRARGDLALLEHTRRHDAWDPGSAAGLALGPADFAAAYRG
LPAAARRALSLAARRIADFHRRETDARVPARRDAAGATLSQVVRPLERVGLYVPGGTARYPSSVLMTAVPARVAGVREIV
VTSPGVKGSGEMDRWTLAACHVAGVARLFKVGGAQAVAALAYGTATVPAVDKICGPGNAYVAAAKRLVFGRVDIDMIAGP
SEILVLADAAADPAEVASDLLAQAEHDVRAVSVLVTPSAALARAALAAVERQLADLPRREIAGRSIEERGAVVVTRGLSE
AVRLADAFAPEHLALHARGAAGLVKRISRAGAVFVGSSTPEAVGDYLAGPSHVLPTAGTARFASPLSVATFRRRMSVLDL
TPAALAALAPSVEALARAEGLEGHWRAVEVRVAKRASARARRVAPAKAKAAGASGAPRARAAAGGARR
>Mature_468_residues
MLKLDSRDPGFQEAWARVCARGSDEDEAPVREAAATIVADVRARGDLALLEHTRRHDAWDPGSAAGLALGPADFAAAYRG
LPAAARRALSLAARRIADFHRRETDARVPARRDAAGATLSQVVRPLERVGLYVPGGTARYPSSVLMTAVPARVAGVREIV
VTSPGVKGSGEMDRWTLAACHVAGVARLFKVGGAQAVAALAYGTATVPAVDKICGPGNAYVAAAKRLVFGRVDIDMIAGP
SEILVLADAAADPAEVASDLLAQAEHDVRAVSVLVTPSAALARAALAAVERQLADLPRREIAGRSIEERGAVVVTRGLSE
AVRLADAFAPEHLALHARGAAGLVKRISRAGAVFVGSSTPEAVGDYLAGPSHVLPTAGTARFASPLSVATFRRRMSVLDL
TPAALAALAPSVEALARAEGLEGHWRAVEVRVAKRASARARRVAPAKAKAAGASGAPRARAAAGGARR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=401, Percent_Identity=43.8902743142145, Blast_Score=305, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6319819, Length=431, Percent_Identity=39.2111368909513, Blast_Score=291, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48335; Mature: 48335

Theoretical pI: Translated: 10.95; Mature: 10.95

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLDSRDPGFQEAWARVCARGSDEDEAPVREAAATIVADVRARGDLALLEHTRRHDAWD
CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
PGSAAGLALGPADFAAAYRGLPAAARRALSLAARRIADFHRRETDARVPARRDAAGATLS
CCCCCCCEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
QVVRPLERVGLYVPGGTARYPSSVLMTAVPARVAGVREIVVTSPGVKGSGEMDRWTLAAC
HHHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHH
HVAGVARLFKVGGAQAVAALAYGTATVPAVDKICGPGNAYVAAAKRLVFGRVDIDMIAGP
HHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECCC
SEILVLADAAADPAEVASDLLAQAEHDVRAVSVLVTPSAALARAALAAVERQLADLPRRE
CEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCHHH
IAGRSIEERGAVVVTRGLSEAVRLADAFAPEHLALHARGAAGLVKRISRAGAVFVGSSTP
HCCCCHHHCCCEEEECCHHHHHHHHHHCCCCHHEEECCCHHHHHHHHHHCCEEEECCCCH
EAVGDYLAGPSHVLPTAGTARFASPLSVATFRRRMSVLDLTPAALAALAPSVEALARAEG
HHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHCC
LEGHWRAVEVRVAKRASARARRVAPAKAKAAGASGAPRARAAAGGARR
CCCCCEEEEHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MLKLDSRDPGFQEAWARVCARGSDEDEAPVREAAATIVADVRARGDLALLEHTRRHDAWD
CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
PGSAAGLALGPADFAAAYRGLPAAARRALSLAARRIADFHRRETDARVPARRDAAGATLS
CCCCCCCEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
QVVRPLERVGLYVPGGTARYPSSVLMTAVPARVAGVREIVVTSPGVKGSGEMDRWTLAAC
HHHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHH
HVAGVARLFKVGGAQAVAALAYGTATVPAVDKICGPGNAYVAAAKRLVFGRVDIDMIAGP
HHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECCC
SEILVLADAAADPAEVASDLLAQAEHDVRAVSVLVTPSAALARAALAAVERQLADLPRRE
CEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCHHH
IAGRSIEERGAVVVTRGLSEAVRLADAFAPEHLALHARGAAGLVKRISRAGAVFVGSSTP
HCCCCHHHCCCEEEECCHHHHHHHHHHCCCCHHEEECCCHHHHHHHHHHCCEEEECCCCH
EAVGDYLAGPSHVLPTAGTARFASPLSVATFRRRMSVLDLTPAALAALAPSVEALARAEG
HHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHCC
LEGHWRAVEVRVAKRASARARRVAPAKAKAAGASGAPRARAAAGGARR
CCCCCEEEEHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA