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The map label for this gene is fadA [H]

Identifier: 220915508

GI number: 220915508

Start: 438149

End: 439321

Strand: Direct

Name: fadA [H]

Synonym: A2cp1_0389

Alternate gene names: 220915508

Gene position: 438149-439321 (Clockwise)

Preceding gene: 220915507

Following gene: 220915509

Centisome position: 8.71

GC content: 74.94

Gene sequence:

>1173_bases
ATGAGCGCAGCCTACGTCCTCGCAGCGGTGCGGACCCCCGGGTGCAAGGCGAAGAAGGGGAAGCTGAAGGACGTCCGCCC
GGACGACCTGGCCGCCGTCGCCATCCGCGCGCTGCTGGCGCGGACCGGCGTCGACCCGGGGCAGGTGGAGGACGTGATCC
TCGGGTGCGCGTTCCCCGAGGGCGAGCAGGGCATGAACCTCGGGCGCGTCGCGGCGCTCCGGGCCGGGCTGCCGGTGGGC
GTGCCGGGCCAGACGGTGAATCGCTTCTGCGCCTCGGGGCTGCAGACCATCGCCACCGCCGCCGAGCGGATCATGGCCGG
CCAGGCCGACTGCATCGTGGCGGGCGGGGCCGAGAGCATGAGCCTCGTGCCCATGGGCGGCTCGCACTTCAGCGCGAACC
CGGCGCTGGTCGCCTCCTGGCCGGAGTCGTTCGCGGCCATGGGCATCACCGCCGAGCTGGTGGCGGCGCGCGACCAGGTG
AGCCGCGAGGACCAGGACGCGTTCGCGGTGCAGAGCCACGCGCGCGCCGCCCGGGCGCAGGCGGAGGGTCTGTTCGCCGA
CGAGCTCGTCCCCGTCGAGGTGGAGCAGGTCACGCTCGAGAAGGGAAAGCCGGCGCGCCGCACCGAGCAGGTCACGGCCG
ACGACGGCGTGCGCCCGGGCACGAGCCTGGAGGCGCTCGCAAAGCTGAAGCCGGCGTTCAAGATCGACGGCACCGTCACC
GCCGGCAACGCGTCCCAGACCACCGACGGCGCCGCGGCCGCGCTGGTGGTCTCCGAGGCGTTCCTCACCCGCACCGGCCT
CGCGCCGCTGGCGCGCTTCGTCTCCTACGCGGTGCGCGGCGTGCCGCCGGAGATCATGGGCATCGGCCCGGTCGAGGCCA
TCCCGGCGGCGCTGAAGCGCGCCGGCCTGCGCGTCGAGGACGTCGGGCAGATCGAGCTGAACGAGGCGTTCGCGGCGCAG
TCGCTCGCCTGCGTGCGCGCGCTCGGGCTCGATCCGGAGAAGGTGAACCCCACCGGCGGCGCCATCGCGCTCGGGCACCC
GCTCGGCTGCACCGGCGCGAAGCTCACCGCCACGCTGCTGCACGGCATGCGGCGGACCGGCGCGCGGCACGGCATCGTGT
CGATGTGCGTGGGCGGCGGAATGGGCGCGGCGGCGGTGTTCGAGCGCGCCTGA

Upstream 100 bases:

>100_bases
GACGCTCGAGCGCATCCAGCACATGCTGAAGAAGGGCAAGCCGCTCCGGAACTAGCGGTCGAACCGGCGTCGAGCGCGCG
AGCGCGAGAGGAGACCTGGA

Downstream 100 bases:

>100_bases
GGGCGCGCGGGCGGCTCACGGAAGGCGACGAGGAGGAGCGACCATGGCCAGGCTGTTGAAGGGGGCGGAGTACCTGATCT
CCGAGGCGACGAAGGACGAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSAAYVLAAVRTPGCKAKKGKLKDVRPDDLAAVAIRALLARTGVDPGQVEDVILGCAFPEGEQGMNLGRVAALRAGLPVG
VPGQTVNRFCASGLQTIATAAERIMAGQADCIVAGGAESMSLVPMGGSHFSANPALVASWPESFAAMGITAELVAARDQV
SREDQDAFAVQSHARAARAQAEGLFADELVPVEVEQVTLEKGKPARRTEQVTADDGVRPGTSLEALAKLKPAFKIDGTVT
AGNASQTTDGAAAALVVSEAFLTRTGLAPLARFVSYAVRGVPPEIMGIGPVEAIPAALKRAGLRVEDVGQIELNEAFAAQ
SLACVRALGLDPEKVNPTGGAIALGHPLGCTGAKLTATLLHGMRRTGARHGIVSMCVGGGMGAAAVFERA

Sequences:

>Translated_390_residues
MSAAYVLAAVRTPGCKAKKGKLKDVRPDDLAAVAIRALLARTGVDPGQVEDVILGCAFPEGEQGMNLGRVAALRAGLPVG
VPGQTVNRFCASGLQTIATAAERIMAGQADCIVAGGAESMSLVPMGGSHFSANPALVASWPESFAAMGITAELVAARDQV
SREDQDAFAVQSHARAARAQAEGLFADELVPVEVEQVTLEKGKPARRTEQVTADDGVRPGTSLEALAKLKPAFKIDGTVT
AGNASQTTDGAAAALVVSEAFLTRTGLAPLARFVSYAVRGVPPEIMGIGPVEAIPAALKRAGLRVEDVGQIELNEAFAAQ
SLACVRALGLDPEKVNPTGGAIALGHPLGCTGAKLTATLLHGMRRTGARHGIVSMCVGGGMGAAAVFERA
>Mature_389_residues
SAAYVLAAVRTPGCKAKKGKLKDVRPDDLAAVAIRALLARTGVDPGQVEDVILGCAFPEGEQGMNLGRVAALRAGLPVGV
PGQTVNRFCASGLQTIATAAERIMAGQADCIVAGGAESMSLVPMGGSHFSANPALVASWPESFAAMGITAELVAARDQVS
REDQDAFAVQSHARAARAQAEGLFADELVPVEVEQVTLEKGKPARRTEQVTADDGVRPGTSLEALAKLKPAFKIDGTVTA
GNASQTTDGAAAALVVSEAFLTRTGLAPLARFVSYAVRGVPPEIMGIGPVEAIPAALKRAGLRVEDVGQIELNEAFAAQS
LACVRALGLDPEKVNPTGGAIALGHPLGCTGAKLTATLLHGMRRTGARHGIVSMCVGGGMGAAAVFERA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=48.5933503836317, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=42.5, Blast_Score=295, Evalue=4e-80,
Organism=Homo sapiens, GI148539872, Length=384, Percent_Identity=43.75, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=35.0125944584383, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=36.9767441860465, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI194353979, Length=384, Percent_Identity=36.1979166666667, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=45.4545454545455, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=45.343137254902, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1788554, Length=402, Percent_Identity=43.5323383084577, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI87082165, Length=403, Percent_Identity=39.454094292804, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=32.2195704057279, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=382, Percent_Identity=40.0523560209424, Blast_Score=267, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=34.5, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=399, Percent_Identity=35.3383458646617, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=32.7102803738318, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=31.2977099236641, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=40.6565656565657, Blast_Score=275, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=36.1596009975062, Blast_Score=209, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=43.5643564356436, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=40, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24640423, Length=395, Percent_Identity=36.7088607594937, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=33.9578454332553, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 39829; Mature: 39698

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAYVLAAVRTPGCKAKKGKLKDVRPDDLAAVAIRALLARTGVDPGQVEDVILGCAFPE
CCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCC
GEQGMNLGRVAALRAGLPVGVPGQTVNRFCASGLQTIATAAERIMAGQADCIVAGGAESM
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCE
SLVPMGGSHFSANPALVASWPESFAAMGITAELVAARDQVSREDQDAFAVQSHARAARAQ
EEEECCCCCCCCCCCEEEECCHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AEGLFADELVPVEVEQVTLEKGKPARRTEQVTADDGVRPGTSLEALAKLKPAFKIDGTVT
HCCCHHCCCCCCCHHEEECCCCCCCCHHCCCCCCCCCCCCCHHHHHHHCCCCEEECCEEE
AGNASQTTDGAAAALVVSEAFLTRTGLAPLARFVSYAVRGVPPEIMGIGPVEAIPAALKR
ECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHH
AGLRVEDVGQIELNEAFAAQSLACVRALGLDPEKVNPTGGAIALGHPLGCTGAKLTATLL
CCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHH
HGMRRTGARHGIVSMCVGGGMGAAAVFERA
HHHHHCCCCCCHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
SAAYVLAAVRTPGCKAKKGKLKDVRPDDLAAVAIRALLARTGVDPGQVEDVILGCAFPE
CCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCC
GEQGMNLGRVAALRAGLPVGVPGQTVNRFCASGLQTIATAAERIMAGQADCIVAGGAESM
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCE
SLVPMGGSHFSANPALVASWPESFAAMGITAELVAARDQVSREDQDAFAVQSHARAARAQ
EEEECCCCCCCCCCCEEEECCHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AEGLFADELVPVEVEQVTLEKGKPARRTEQVTADDGVRPGTSLEALAKLKPAFKIDGTVT
HCCCHHCCCCCCCHHEEECCCCCCCCHHCCCCCCCCCCCCCHHHHHHHCCCCEEECCEEE
AGNASQTTDGAAAALVVSEAFLTRTGLAPLARFVSYAVRGVPPEIMGIGPVEAIPAALKR
ECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHH
AGLRVEDVGQIELNEAFAAQSLACVRALGLDPEKVNPTGGAIALGHPLGCTGAKLTATLL
CCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHH
HGMRRTGARHGIVSMCVGGGMGAAAVFERA
HHHHHCCCCCCHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]