Click here to switch to the map view.

The map label for this gene is fadN [H]

Identifier: 220915507

GI number: 220915507

Start: 435719

End: 438103

Strand: Direct

Name: fadN [H]

Synonym: A2cp1_0388

Alternate gene names: 220915507

Gene position: 435719-438103 (Clockwise)

Preceding gene: 220915504

Following gene: 220915508

Centisome position: 8.66

GC content: 72.12

Gene sequence:

>2385_bases
ATGGACCGGATCGAGCGGGTGGCGGTGCTGGGGTCGGGCGTGATGGGCAGCACCATCGCCGCGCACCTCGCCAACGCGGG
CTTCGGGGTGCTGCTCCTCGACATCGTCCCGAAGGAGCCGAACGCCGAGGAGCGGGCGGCCGGCCTCGGGCTCGACAGCC
CGGCGGTACGCAACCGCCTCGCGGCCGCGGCGCGCGCGGGCCTCGAGAAGCTGAAGCCGGCGCCGCTCTACCTGCCCTCC
TACGCGTCGCGCATCGACGTGGGCAACCTCGAGGACGACCTCCCGCGGCTCGCGAGCTGCGACTGGGTGGTCGAGGTGGT
GCTCGAGCACCTCGAGGTGAAGCGCCAGCTCCTCGGGCGCATCGCCCCGCACCTCAAGCCGACGGCGGTCCTCACCACGA
ACACGAGCGGCCTCTCGGTGAACGCCATCGCCGACACGTTGCCCGAGGCGCTCCGCCCGCGCTTCCTCGTCACCCACTTC
TTCAACCCGCCGCGCTACATGCGGCTCGTCGAGATCGTCTCGAGCCGGCACACCGACCCGGCCGTCGCGGCGGGCATGGC
CGAGCTCATCCGCGTGCGCCTCGGCAAGGGCATCGTCACCGGCAAGGACACGCCGAACTTCGTGGCGAACCGCATCGGCG
TGTTCGCCATGTGCAACGCCATCCGGCACATGGTGGAGCTCGACCTGACCGTCGAGGAGGTGGACGCCATCGCCGGCCCG
CCCACCGCGCGGCCGAAGAGCGCGACCTTCCGCACCGCCGACCTGGTGGGCCTCGACACGCTCCTGCACGTCGCGAGGAA
CTCCTACGAGCTGCTGCCGGGCGACTCGCGCCGCGACGAGTTCAAGCTGCCCGCCTTCCTCGAGCAGATGGTCGCGAAGG
GGATCCTCGGCAACAAGTCGAGGGGCGGCTTCTTCCGGAAGGAGAAGGGCGAGGGCGGCGGCCTCTCGATCTACGACCAC
CGCAAGGGCGAGTACGTGCCGGCGGCGAAGCCGCGCAGCGCGGCGGTGGAGGCGACGAAGGGGATCGACGACCCGGCCCA
GCGCCTCCGGGCCGCGCTGGCCGGGAAGGACAAGGTCGCCGAGCACGCCTGGCGCAACCTGCGCGACACGCTCCTCTACG
CGTTCGAGCGCATCCCGGAGATCGCCGACGACGTGGTGAACGTGGACGCGGCCATGCGCTGGGGCTTCGGCTGGGACCTC
GGCCCGTTCGAGATGCTCGACGCCATCGGGGTCCCGGCGTTCGTGACCCGGGCCGCGCAGGACGGCGTGGCCGTGCCGGA
GCGGCTCCGCGGCATCGAGCGCTTCTATGCCGAGGAGAACGGGCGGCGCCGCTACCTCGACCTCGCCGGCGGCGGCTACC
GCGACGTGCCGCGCCCGGCCGACCAGATCGACCTCGCGGTGCTGGAGAAGTCCGGCGCGGTGGTGGAGCGGAACGCGGGC
GCCTCGGTGCTGGACCTCGGCGACGGCGTCTTCTGCCTCGAGTTCCACACCAAGATGAACGCGATCGGCCCGGACGTGCT
CGCCATGGTCCACAAGGCGGTGGCGCGCGCCGAGCGCGACGGCCAGGGGCTCGTGATCGCGAACCGCGGCCAGCCGGCGT
TCTCGGCCGGCGCGAACCTGATGCTCATCGCGGTGGCCATCGCCGAGGGCGCGTTCGACGAGATCGCGCTCACCATCCGC
GCGTTCCAGAAGGCGATGATGGCGCTCAAGTACGCGCGGGTGCCGGTGGTGGCGGCGCCGCACGGGCTGGCGCTGGGCGG
CGGCTGCGAGGTGTGCCTGCACGCCACCGCCATGAACCCGCTCGCCGAGACGTACATGGGGCTCGTCGAGATCGGCGTGG
GGCTGCTCCCTGCCGGCGGCGGCACCAAGGAGATGGCGCTCCGGGCGATCCGGCTCGCCGAGAAGTACGAGATCGACGCC
TCGCCGTTCGTGTTCAAGCACTTCAACACCGTCGCGCTCGCGAAGGTGAGCGCCTCCGCCGACGAGCTCGTCGCCATGGG
GATGCTCCGCGAGGGCGACGCGGTGACGCTGTCGCCGGACCGGCTGGTGCACGACGCGAAGCAGAAGGCGCTGGCGCTGG
CCGCGAACTTCCGGCCGGGCACGCCCGCGACCGGCCTGCGCGCGCCGGGCCGCGGCGCGGCGGCGAGCATCGCCTCCCAG
CTCTGGAACATGCGCATGGGCGGCTTCATCACCGAGTACGAGGAGCGGCTCGGCCGCACCATCGCCGGCGTCATGACCGG
CGGCGACGTGCCGGCCGGCACGCTCGTCACCGAGCAGGACCTGCTCGATCTCGAGCGCGAGGCGTTCCTGAAGCTGTGCG
GCGAGCGGAAGACGCTCGAGCGCATCCAGCACATGCTGAAGAAGGGCAAGCCGCTCCGGAACTAG

Upstream 100 bases:

>100_bases
GGGCAGGGGCGATGACGTGGTGCGGCACGTGCAACTTGTGCGCGTCGCGCGGCGGCCGTCAGGGCCGCGCAGCGGACGCG
AACGCACCACGGAGGCCACG

Downstream 100 bases:

>100_bases
CGGTCGAACCGGCGTCGAGCGCGCGAGCGCGAGAGGAGACCTGGAATGAGCGCAGCCTACGTCCTCGCAGCGGTGCGGAC
CCCCGGGTGCAAGGCGAAGA

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 794; Mature: 794

Protein sequence:

>794_residues
MDRIERVAVLGSGVMGSTIAAHLANAGFGVLLLDIVPKEPNAEERAAGLGLDSPAVRNRLAAAARAGLEKLKPAPLYLPS
YASRIDVGNLEDDLPRLASCDWVVEVVLEHLEVKRQLLGRIAPHLKPTAVLTTNTSGLSVNAIADTLPEALRPRFLVTHF
FNPPRYMRLVEIVSSRHTDPAVAAGMAELIRVRLGKGIVTGKDTPNFVANRIGVFAMCNAIRHMVELDLTVEEVDAIAGP
PTARPKSATFRTADLVGLDTLLHVARNSYELLPGDSRRDEFKLPAFLEQMVAKGILGNKSRGGFFRKEKGEGGGLSIYDH
RKGEYVPAAKPRSAAVEATKGIDDPAQRLRAALAGKDKVAEHAWRNLRDTLLYAFERIPEIADDVVNVDAAMRWGFGWDL
GPFEMLDAIGVPAFVTRAAQDGVAVPERLRGIERFYAEENGRRRYLDLAGGGYRDVPRPADQIDLAVLEKSGAVVERNAG
ASVLDLGDGVFCLEFHTKMNAIGPDVLAMVHKAVARAERDGQGLVIANRGQPAFSAGANLMLIAVAIAEGAFDEIALTIR
AFQKAMMALKYARVPVVAAPHGLALGGGCEVCLHATAMNPLAETYMGLVEIGVGLLPAGGGTKEMALRAIRLAEKYEIDA
SPFVFKHFNTVALAKVSASADELVAMGMLREGDAVTLSPDRLVHDAKQKALALAANFRPGTPATGLRAPGRGAAASIASQ
LWNMRMGGFITEYEERLGRTIAGVMTGGDVPAGTLVTEQDLLDLEREAFLKLCGERKTLERIQHMLKKGKPLRN

Sequences:

>Translated_794_residues
MDRIERVAVLGSGVMGSTIAAHLANAGFGVLLLDIVPKEPNAEERAAGLGLDSPAVRNRLAAAARAGLEKLKPAPLYLPS
YASRIDVGNLEDDLPRLASCDWVVEVVLEHLEVKRQLLGRIAPHLKPTAVLTTNTSGLSVNAIADTLPEALRPRFLVTHF
FNPPRYMRLVEIVSSRHTDPAVAAGMAELIRVRLGKGIVTGKDTPNFVANRIGVFAMCNAIRHMVELDLTVEEVDAIAGP
PTARPKSATFRTADLVGLDTLLHVARNSYELLPGDSRRDEFKLPAFLEQMVAKGILGNKSRGGFFRKEKGEGGGLSIYDH
RKGEYVPAAKPRSAAVEATKGIDDPAQRLRAALAGKDKVAEHAWRNLRDTLLYAFERIPEIADDVVNVDAAMRWGFGWDL
GPFEMLDAIGVPAFVTRAAQDGVAVPERLRGIERFYAEENGRRRYLDLAGGGYRDVPRPADQIDLAVLEKSGAVVERNAG
ASVLDLGDGVFCLEFHTKMNAIGPDVLAMVHKAVARAERDGQGLVIANRGQPAFSAGANLMLIAVAIAEGAFDEIALTIR
AFQKAMMALKYARVPVVAAPHGLALGGGCEVCLHATAMNPLAETYMGLVEIGVGLLPAGGGTKEMALRAIRLAEKYEIDA
SPFVFKHFNTVALAKVSASADELVAMGMLREGDAVTLSPDRLVHDAKQKALALAANFRPGTPATGLRAPGRGAAASIASQ
LWNMRMGGFITEYEERLGRTIAGVMTGGDVPAGTLVTEQDLLDLEREAFLKLCGERKTLERIQHMLKKGKPLRN
>Mature_794_residues
MDRIERVAVLGSGVMGSTIAAHLANAGFGVLLLDIVPKEPNAEERAAGLGLDSPAVRNRLAAAARAGLEKLKPAPLYLPS
YASRIDVGNLEDDLPRLASCDWVVEVVLEHLEVKRQLLGRIAPHLKPTAVLTTNTSGLSVNAIADTLPEALRPRFLVTHF
FNPPRYMRLVEIVSSRHTDPAVAAGMAELIRVRLGKGIVTGKDTPNFVANRIGVFAMCNAIRHMVELDLTVEEVDAIAGP
PTARPKSATFRTADLVGLDTLLHVARNSYELLPGDSRRDEFKLPAFLEQMVAKGILGNKSRGGFFRKEKGEGGGLSIYDH
RKGEYVPAAKPRSAAVEATKGIDDPAQRLRAALAGKDKVAEHAWRNLRDTLLYAFERIPEIADDVVNVDAAMRWGFGWDL
GPFEMLDAIGVPAFVTRAAQDGVAVPERLRGIERFYAEENGRRRYLDLAGGGYRDVPRPADQIDLAVLEKSGAVVERNAG
ASVLDLGDGVFCLEFHTKMNAIGPDVLAMVHKAVARAERDGQGLVIANRGQPAFSAGANLMLIAVAIAEGAFDEIALTIR
AFQKAMMALKYARVPVVAAPHGLALGGGCEVCLHATAMNPLAETYMGLVEIGVGLLPAGGGTKEMALRAIRLAEKYEIDA
SPFVFKHFNTVALAKVSASADELVAMGMLREGDAVTLSPDRLVHDAKQKALALAANFRPGTPATGLRAPGRGAAASIASQ
LWNMRMGGFITEYEERLGRTIAGVMTGGDVPAGTLVTEQDLLDLEREAFLKLCGERKTLERIQHMLKKGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=307, Percent_Identity=28.3387622149837, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI296179427, Length=324, Percent_Identity=26.8518518518519, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI261878539, Length=433, Percent_Identity=24.2494226327945, Blast_Score=90, Evalue=1e-17,
Organism=Homo sapiens, GI68989263, Length=433, Percent_Identity=24.2494226327945, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI20127408, Length=308, Percent_Identity=25.974025974026, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1787661, Length=327, Percent_Identity=31.8042813455657, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790281, Length=216, Percent_Identity=26.8518518518519, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1788682, Length=329, Percent_Identity=25.531914893617, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17553560, Length=309, Percent_Identity=29.126213592233, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17549919, Length=310, Percent_Identity=30.9677419354839, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17563036, Length=303, Percent_Identity=29.3729372937294, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71985923, Length=271, Percent_Identity=26.1992619926199, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17508953, Length=320, Percent_Identity=26.25, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=321, Percent_Identity=26.1682242990654, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=338, Percent_Identity=26.0355029585799, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71985930, Length=311, Percent_Identity=25.08038585209, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=263, Percent_Identity=26.2357414448669, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921000, Length=425, Percent_Identity=24.7058823529412, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24583077, Length=425, Percent_Identity=24.7058823529412, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583079, Length=425, Percent_Identity=24.7058823529412, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 85344; Mature: 85344

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIERVAVLGSGVMGSTIAAHLANAGFGVLLLDIVPKEPNAEERAAGLGLDSPAVRNRL
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCCCCHHHHHHH
AAAARAGLEKLKPAPLYLPSYASRIDVGNLEDDLPRLASCDWVVEVVLEHLEVKRQLLGR
HHHHHHHHHHCCCCCEECCCHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
IAPHLKPTAVLTTNTSGLSVNAIADTLPEALRPRFLVTHFFNPPRYMRLVEIVSSRHTDP
HCCCCCCCEEEEECCCCCEEHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCH
AVAAGMAELIRVRLGKGIVTGKDTPNFVANRIGVFAMCNAIRHMVELDLTVEEVDAIAGP
HHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
PTARPKSATFRTADLVGLDTLLHVARNSYELLPGDSRRDEFKLPAFLEQMVAKGILGNKS
CCCCCCCCCEEHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCC
RGGFFRKEKGEGGGLSIYDHRKGEYVPAAKPRSAAVEATKGIDDPAQRLRAALAGKDKVA
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHH
EHAWRNLRDTLLYAFERIPEIADDVVNVDAAMRWGFGWDLGPFEMLDAIGVPAFVTRAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHC
DGVAVPERLRGIERFYAEENGRRRYLDLAGGGYRDVPRPADQIDLAVLEKSGAVVERNAG
CCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHEEECCCCEEECCCC
ASVLDLGDGVFCLEFHTKMNAIGPDVLAMVHKAVARAERDGQGLVIANRGQPAFSAGANL
CCEEECCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHCCCCE
MLIAVAIAEGAFDEIALTIRAFQKAMMALKYARVPVVAAPHGLALGGGCEVCLHATAMNP
EEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCCCEEEEHHHCCH
LAETYMGLVEIGVGLLPAGGGTKEMALRAIRLAEKYEIDASPFVFKHFNTVALAKVSASA
HHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEEEEEECCCH
DELVAMGMLREGDAVTLSPDRLVHDAKQKALALAANFRPGTPATGLRAPGRGAAASIASQ
HHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHH
LWNMRMGGFITEYEERLGRTIAGVMTGGDVPAGTLVTEQDLLDLEREAFLKLCGERKTLE
HHHHHHCCHHHHHHHHHCHHHHHHEECCCCCCCCEECHHHHHHHHHHHHHHHHCCHHHHH
RIQHMLKKGKPLRN
HHHHHHHCCCCCCC
>Mature Secondary Structure
MDRIERVAVLGSGVMGSTIAAHLANAGFGVLLLDIVPKEPNAEERAAGLGLDSPAVRNRL
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCCCCHHHHHHH
AAAARAGLEKLKPAPLYLPSYASRIDVGNLEDDLPRLASCDWVVEVVLEHLEVKRQLLGR
HHHHHHHHHHCCCCCEECCCHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
IAPHLKPTAVLTTNTSGLSVNAIADTLPEALRPRFLVTHFFNPPRYMRLVEIVSSRHTDP
HCCCCCCCEEEEECCCCCEEHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCH
AVAAGMAELIRVRLGKGIVTGKDTPNFVANRIGVFAMCNAIRHMVELDLTVEEVDAIAGP
HHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
PTARPKSATFRTADLVGLDTLLHVARNSYELLPGDSRRDEFKLPAFLEQMVAKGILGNKS
CCCCCCCCCEEHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCC
RGGFFRKEKGEGGGLSIYDHRKGEYVPAAKPRSAAVEATKGIDDPAQRLRAALAGKDKVA
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHH
EHAWRNLRDTLLYAFERIPEIADDVVNVDAAMRWGFGWDLGPFEMLDAIGVPAFVTRAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHC
DGVAVPERLRGIERFYAEENGRRRYLDLAGGGYRDVPRPADQIDLAVLEKSGAVVERNAG
CCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHEEECCCCEEECCCC
ASVLDLGDGVFCLEFHTKMNAIGPDVLAMVHKAVARAERDGQGLVIANRGQPAFSAGANL
CCEEECCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHCCCCE
MLIAVAIAEGAFDEIALTIRAFQKAMMALKYARVPVVAAPHGLALGGGCEVCLHATAMNP
EEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCCCEEEEHHHCCH
LAETYMGLVEIGVGLLPAGGGTKEMALRAIRLAEKYEIDASPFVFKHFNTVALAKVSASA
HHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEEEEEECCCH
DELVAMGMLREGDAVTLSPDRLVHDAKQKALALAANFRPGTPATGLRAPGRGAAASIASQ
HHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHH
LWNMRMGGFITEYEERLGRTIAGVMTGGDVPAGTLVTEQDLLDLEREAFLKLCGERKTLE
HHHHHHCCHHHHHHHHHCHHHHHHEECCCCCCCCEECHHHHHHHHHHHHHHHHCCHHHHH
RIQHMLKKGKPLRN
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]