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The map label for this gene is fadE [H]

Identifier: 220915509

GI number: 220915509

Start: 439365

End: 441140

Strand: Direct

Name: fadE [H]

Synonym: A2cp1_0390

Alternate gene names: 220915509

Gene position: 439365-441140 (Clockwise)

Preceding gene: 220915508

Following gene: 220915510

Centisome position: 8.74

GC content: 70.44

Gene sequence:

>1776_bases
ATGGCCAGGCTGTTGAAGGGGGCGGAGTACCTGATCTCCGAGGCGACGAAGGACGACGTCTTCACCCCGGAGGACTTCAC
CGAGGAGCAGCGCCAGATCGCCGAGACCGCGGAGCAGTTCGCCGAGTCGGAGGCGCTCCCGGCCGAGCACGCGCTCGAGC
AGCACGAGCCGGGCGTGGCCGCGGCGCTCATGCGCAAGGCGGGCGACGCGGGCCTGCTCATGATCGACGCTCCGGAGGCC
TACGGCGGCCTGGCGCTCGACAAGGCCACCAGCATGCTGGCCGCCGAGCGGATGGGCACGGGCGGCGCGTTCTCGGTCTC
CTACGCGGCGCACACCGGCATCGGCACGCTCCCGCTCGTCTACTACGGGACCGACGCGCAGAAGGACCGCTACCTCACGA
AGCTGGTGACCGGCGAGTGGGCCGCCGCGTACTGCCTCACCGAGCCGGAGGCGGGGAGCGACGCCATGGGCGGGAAGGCC
ACCGCCACGCTCTCGCCGGACGGGAAGCACTACCTCCTCGACGGCACCAAGCAGTTCATCACCAACGGCAGCTTCGCGAA
CCTGTTCACGGTGTTCGCGAAGGTGGACCGCAAGCACTTCACCGCCTTCCTGGTGGAGCGCACCTTCCCCGGCGTGACCG
TGGGGCCCGAGGAGAAGAAGCTCGGCATCAAGGGCTCCTCCACCACCTCGGTGATCTTCGAGAGCGCGAAGGTGCCGGTC
GAGAACGTGCTCGGCGAGATCGGCAAGGGGCACAAGATCGCGTTCAACGTGCTGAACGTGGGCCGCTTCAAGCTGGGCGC
GGCGGTCACCGGCGCGGCGAAGCTCGCGCTCGCCACCGGCGCCGCCTACGCGAACGCCCGCAAGCAGTTCGGCACGCCCA
TCGCCCGCTTCGGCGCGATCCGCGAGAAGCTCGCCGACCAGGCCGCCGCCGTCTACGCCTCGGAGTCGCTCATCTACCGC
CTGGCCGGGCTCATCGACGACCGGCTCGCCACGATCCCCGCCGACCAGCCCGGCTACTACGAGGCCTACCAGCAGGGCAT
CGAGGAGTACGCGATCGAGTGCGCCATCGCGAAGGTGTTCTGCAGCGAGGTGCTCGCCGACGTGGTGGACGAGGTGGTGC
AGATCCACGGCGGCTACGGCTTCATCCAGGAGTACCCGGCCGAGAAGTACTACCGCGACGAGCGCATCAACCGGATCTTC
GAGGGCACGAACGAGATCAACCGGCTGCTGGTGCCGGGCACCATCCTGCGCCGCGCGCTGAAGGGTGAGCTGCCGCTGCA
GCGCGAGGTCATGAAGGCGATGGACGCCCTCATGAACCCGTCGCTCGACGAGGCCGATCCGGCGGTGCCGTTCGCGGCCG
AGAAGGCCACCGTGGCCAACCTGAAGCGCGCGTTCCTGGTGGTGGCCGGCGCGGCGGTGCAGAAGTACGGCGAGGCGCTG
AAGGACGAGCAGGAGGTGCTGCTCGCGCTCGCCGACGTCGCCATCCAGGCGTTCGCGGCGGAGAGCGTGGTGCTCCGCGC
CGAGAAGACCGCGTCCACGCAGCCCGAGGCGCGCCGCGCGCTCGCCGCCGCCGCGGTGAAGGTCCACACCTTCGCCGCGG
CCGAGAAGGCCGCCACCGCCGCCCGCCGCGCCGCGTTCTACGTGGGCGAGGGCGACACGCTCACCATCCTGCTCGGCGGC
ATCCGCCGCTTCTCCAAGTACGACGCCGCCGGCCTGCTCCAGGCGAAGCGGCGCCTGGCGGACGCGGTGCTGGAGAGCGA
GCGATATCCGTTCTGA

Upstream 100 bases:

>100_bases
GTGTCGATGTGCGTGGGCGGCGGAATGGGCGCGGCGGCGGTGTTCGAGCGCGCCTGAGGGCGCGCGGGCGGCTCACGGAA
GGCGACGAGGAGGAGCGACC

Downstream 100 bases:

>100_bases
TCTCACGAGGGCTGCGCCCTCGCCCCGCCGCCCTGCGCTTGCCGAAGGGCGGCGGGGCCCCGCTCCTGCTGCGCGGGCCG
GTGACCTCGCGCGCCCGCCT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MARLLKGAEYLISEATKDDVFTPEDFTEEQRQIAETAEQFAESEALPAEHALEQHEPGVAAALMRKAGDAGLLMIDAPEA
YGGLALDKATSMLAAERMGTGGAFSVSYAAHTGIGTLPLVYYGTDAQKDRYLTKLVTGEWAAAYCLTEPEAGSDAMGGKA
TATLSPDGKHYLLDGTKQFITNGSFANLFTVFAKVDRKHFTAFLVERTFPGVTVGPEEKKLGIKGSSTTSVIFESAKVPV
ENVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKLALATGAAYANARKQFGTPIARFGAIREKLADQAAAVYASESLIYR
LAGLIDDRLATIPADQPGYYEAYQQGIEEYAIECAIAKVFCSEVLADVVDEVVQIHGGYGFIQEYPAEKYYRDERINRIF
EGTNEINRLLVPGTILRRALKGELPLQREVMKAMDALMNPSLDEADPAVPFAAEKATVANLKRAFLVVAGAAVQKYGEAL
KDEQEVLLALADVAIQAFAAESVVLRAEKTASTQPEARRALAAAAVKVHTFAAAEKAATAARRAAFYVGEGDTLTILLGG
IRRFSKYDAAGLLQAKRRLADAVLESERYPF

Sequences:

>Translated_591_residues
MARLLKGAEYLISEATKDDVFTPEDFTEEQRQIAETAEQFAESEALPAEHALEQHEPGVAAALMRKAGDAGLLMIDAPEA
YGGLALDKATSMLAAERMGTGGAFSVSYAAHTGIGTLPLVYYGTDAQKDRYLTKLVTGEWAAAYCLTEPEAGSDAMGGKA
TATLSPDGKHYLLDGTKQFITNGSFANLFTVFAKVDRKHFTAFLVERTFPGVTVGPEEKKLGIKGSSTTSVIFESAKVPV
ENVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKLALATGAAYANARKQFGTPIARFGAIREKLADQAAAVYASESLIYR
LAGLIDDRLATIPADQPGYYEAYQQGIEEYAIECAIAKVFCSEVLADVVDEVVQIHGGYGFIQEYPAEKYYRDERINRIF
EGTNEINRLLVPGTILRRALKGELPLQREVMKAMDALMNPSLDEADPAVPFAAEKATVANLKRAFLVVAGAAVQKYGEAL
KDEQEVLLALADVAIQAFAAESVVLRAEKTASTQPEARRALAAAAVKVHTFAAAEKAATAARRAAFYVGEGDTLTILLGG
IRRFSKYDAAGLLQAKRRLADAVLESERYPF
>Mature_590_residues
ARLLKGAEYLISEATKDDVFTPEDFTEEQRQIAETAEQFAESEALPAEHALEQHEPGVAAALMRKAGDAGLLMIDAPEAY
GGLALDKATSMLAAERMGTGGAFSVSYAAHTGIGTLPLVYYGTDAQKDRYLTKLVTGEWAAAYCLTEPEAGSDAMGGKAT
ATLSPDGKHYLLDGTKQFITNGSFANLFTVFAKVDRKHFTAFLVERTFPGVTVGPEEKKLGIKGSSTTSVIFESAKVPVE
NVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKLALATGAAYANARKQFGTPIARFGAIREKLADQAAAVYASESLIYRL
AGLIDDRLATIPADQPGYYEAYQQGIEEYAIECAIAKVFCSEVLADVVDEVVQIHGGYGFIQEYPAEKYYRDERINRIFE
GTNEINRLLVPGTILRRALKGELPLQREVMKAMDALMNPSLDEADPAVPFAAEKATVANLKRAFLVVAGAAVQKYGEALK
DEQEVLLALADVAIQAFAAESVVLRAEKTASTQPEARRALAAAAVKVHTFAAAEKAATAARRAAFYVGEGDTLTILLGGI
RRFSKYDAAGLLQAKRRLADAVLESERYPF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=542, Percent_Identity=36.7158671586716, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI76496475, Length=545, Percent_Identity=36.5137614678899, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI4557235, Length=545, Percent_Identity=36.5137614678899, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI4557233, Length=407, Percent_Identity=35.6265356265356, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI187960098, Length=396, Percent_Identity=34.8484848484849, Blast_Score=206, Evalue=7e-53,
Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=31.4720812182741, Blast_Score=206, Evalue=7e-53,
Organism=Homo sapiens, GI4557231, Length=396, Percent_Identity=34.8484848484849, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI7656849, Length=395, Percent_Identity=30.126582278481, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI226958414, Length=373, Percent_Identity=31.6353887399464, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI4501859, Length=409, Percent_Identity=31.5403422982885, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4501857, Length=405, Percent_Identity=27.6543209876543, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI4503943, Length=419, Percent_Identity=27.2076372315036, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI7669494, Length=308, Percent_Identity=29.8701298701299, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI48976061, Length=414, Percent_Identity=26.8115942028986, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI211971008, Length=414, Percent_Identity=26.8115942028986, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI38505218, Length=413, Percent_Identity=23.2445520581114, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=30.1546391752577, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1786223, Length=399, Percent_Identity=27.0676691729323, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87081702, Length=457, Percent_Identity=26.4770240700219, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082384, Length=298, Percent_Identity=24.1610738255034, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71985184, Length=531, Percent_Identity=35.4048964218456, Blast_Score=281, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI71985192, Length=357, Percent_Identity=38.375350140056, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17570075, Length=429, Percent_Identity=32.8671328671329, Blast_Score=205, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17506239, Length=403, Percent_Identity=33.2506203473945, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=32.25, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17538396, Length=426, Percent_Identity=30.5164319248826, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17534899, Length=410, Percent_Identity=31.7073170731707, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17508101, Length=389, Percent_Identity=32.133676092545, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=391, Percent_Identity=31.4578005115089, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=255, Percent_Identity=36.4705882352941, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71990804, Length=269, Percent_Identity=31.9702602230483, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71982178, Length=292, Percent_Identity=29.4520547945205, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=421, Percent_Identity=26.8408551068884, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=390, Percent_Identity=26.1538461538462, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=361, Percent_Identity=26.5927977839335, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=27.4590163934426, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17540912, Length=478, Percent_Identity=25.5230125523013, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562446, Length=300, Percent_Identity=26.3333333333333, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281363737, Length=385, Percent_Identity=38.961038961039, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI21356377, Length=401, Percent_Identity=35.9102244389027, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24660351, Length=395, Percent_Identity=36.7088607594937, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24646207, Length=401, Percent_Identity=34.9127182044888, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24666513, Length=389, Percent_Identity=31.1053984575836, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21355753, Length=394, Percent_Identity=31.2182741116751, Blast_Score=172, Evalue=8e-43,
Organism=Drosophila melanogaster, GI19920834, Length=409, Percent_Identity=24.6943765281174, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45550141, Length=403, Percent_Identity=26.302729528536, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221473076, Length=403, Percent_Identity=26.302729528536, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652780, Length=269, Percent_Identity=26.7657992565056, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 63420; Mature: 63289

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLLKGAEYLISEATKDDVFTPEDFTEEQRQIAETAEQFAESEALPAEHALEQHEPGVA
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHH
AALMRKAGDAGLLMIDAPEAYGGLALDKATSMLAAERMGTGGAFSVSYAAHTGIGTLPLV
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCEEE
YYGTDAQKDRYLTKLVTGEWAAAYCLTEPEAGSDAMGGKATATLSPDGKHYLLDGTKQFI
EECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCEEEECCHHHHH
TNGSFANLFTVFAKVDRKHFTAFLVERTFPGVTVGPEEKKLGIKGSSTTSVIFESAKVPV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHCCCCCH
ENVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKLALATGAAYANARKQFGTPIARFGAI
HHHHHHHCCCCEEEEEEECCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
REKLADQAAAVYASESLIYRLAGLIDDRLATIPADQPGYYEAYQQGIEEYAIECAIAKVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
CSEVLADVVDEVVQIHGGYGFIQEYPAEKYYRDERINRIFEGTNEINRLLVPGTILRRAL
HHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCHHHHHHEECCHHHHHHHH
KGELPLQREVMKAMDALMNPSLDEADPAVPFAAEKATVANLKRAFLVVAGAAVQKYGEAL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KDEQEVLLALADVAIQAFAAESVVLRAEKTASTQPEARRALAAAAVKVHTFAAAEKAATA
CCHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ARRAAFYVGEGDTLTILLGGIRRFSKYDAAGLLQAKRRLADAVLESERYPF
HHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ARLLKGAEYLISEATKDDVFTPEDFTEEQRQIAETAEQFAESEALPAEHALEQHEPGVA
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHH
AALMRKAGDAGLLMIDAPEAYGGLALDKATSMLAAERMGTGGAFSVSYAAHTGIGTLPLV
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCEEE
YYGTDAQKDRYLTKLVTGEWAAAYCLTEPEAGSDAMGGKATATLSPDGKHYLLDGTKQFI
EECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCEEEECCHHHHH
TNGSFANLFTVFAKVDRKHFTAFLVERTFPGVTVGPEEKKLGIKGSSTTSVIFESAKVPV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHCCCCCH
ENVLGEIGKGHKIAFNVLNVGRFKLGAAVTGAAKLALATGAAYANARKQFGTPIARFGAI
HHHHHHHCCCCEEEEEEECCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
REKLADQAAAVYASESLIYRLAGLIDDRLATIPADQPGYYEAYQQGIEEYAIECAIAKVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
CSEVLADVVDEVVQIHGGYGFIQEYPAEKYYRDERINRIFEGTNEINRLLVPGTILRRAL
HHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHCHHHHHHEECCHHHHHHHH
KGELPLQREVMKAMDALMNPSLDEADPAVPFAAEKATVANLKRAFLVVAGAAVQKYGEAL
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KDEQEVLLALADVAIQAFAAESVVLRAEKTASTQPEARRALAAAAVKVHTFAAAEKAATA
CCHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ARRAAFYVGEGDTLTILLGGIRRFSKYDAAGLLQAKRRLADAVLESERYPF
HHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]