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The map label for this gene is aroE

Identifier: 220915328

GI number: 220915328

Start: 227006

End: 227842

Strand: Direct

Name: aroE

Synonym: A2cp1_0207

Alternate gene names: 220915328

Gene position: 227006-227842 (Clockwise)

Preceding gene: 220915327

Following gene: 220915329

Centisome position: 4.51

GC content: 79.21

Gene sequence:

>837_bases
GTGATCACCGGGCGGACCGCGCTCTACGGCGTCGTCGGCCACCCGGTGGCGCACAGCCGCTCGCCGGAGATGCAGAACGC
GGCGTTCGCGAGGCTGGGCGTGGACGCGGTCTACGTGGCGCTGCCGGTCGCGCCGGAGCGGATCGACGAGGCGCTGCGCG
GCGCGCACGCGCTCGGCTTCCAGGGCCTGAACGTCACCGTGCCGCACAAGCCGCGGGCGGCGTCGCTCTGCCACGCGCTC
GACCCGGTGGCGACCGCGGTGGGCGCCGCGAACACGCTGCGCCGGACCCGCGACGGCTGGGACGGCTTCAACACCGACGC
GCCCGCGTGCCGCACGCTGCTCGAGGCGGCCGGGGTCGTGCGCGGGTCGCGGGCGCTGCTCGTCGGCGCGGGCGGCGCGG
CGCGCGCGGCGGCCTGGGCGCTCGTCCAGCTCGGGACGGAGGTCCGGGTGGCGGCGCGCCGCGAGGAGGCCGCCGCCGAG
CTGTGCCGCGACCTCGCCGCCGCGGTGCCCGGCGCCGACCTGGCCGCCGCCGACTTCGAGGACCTGGAGGCCGAGGCGGA
CGCCGCCGCCGTGGTGGTGAACGGCACGTCGGTGGGGCTGCCCGGGCACGAGGGCCGCCTGCCGCCGCTCCGGTTCCGCG
CCGCCCAGGTGGTGCTCGACTTCGTGTACGGGGACACCGAGCTCGCCCGCGCCGCGCGCGCGGCCGGCGCCCGGCTGGTC
AGCGGCGAGCAGGTGCTGGTGCGCCAGGGCGCGCTCGCGTTCACGATCTGGACCGGCCAGCCCGCCCCCGAGGCGGACAT
GGCCCGCGCGCTCGAGGCGCGCGAGGGAGCACGATGA

Upstream 100 bases:

>100_bases
CGGTGGTGCTCGACGACGTGGCCTGCGTCGCGACCAGCTTCCCGAGCTTCTTCCGGCTGCTCGACCAGGTGTCCGGCCAG
GCGTCCGGCGGAGGCGCGCC

Downstream 100 bases:

>100_bases
CACTTCGGTACCTGACCGCCGGCGAGTCGCACGGCCCGGCGCTGGTCGCCATCGCCGAGGGCTTCCCGGCGGGGCTGGCG
GTGGACTTCGAGGCGGTGGA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MITGRTALYGVVGHPVAHSRSPEMQNAAFARLGVDAVYVALPVAPERIDEALRGAHALGFQGLNVTVPHKPRAASLCHAL
DPVATAVGAANTLRRTRDGWDGFNTDAPACRTLLEAAGVVRGSRALLVGAGGAARAAAWALVQLGTEVRVAARREEAAAE
LCRDLAAAVPGADLAAADFEDLEAEADAAAVVVNGTSVGLPGHEGRLPPLRFRAAQVVLDFVYGDTELARAARAAGARLV
SGEQVLVRQGALAFTIWTGQPAPEADMARALEAREGAR

Sequences:

>Translated_278_residues
MITGRTALYGVVGHPVAHSRSPEMQNAAFARLGVDAVYVALPVAPERIDEALRGAHALGFQGLNVTVPHKPRAASLCHAL
DPVATAVGAANTLRRTRDGWDGFNTDAPACRTLLEAAGVVRGSRALLVGAGGAARAAAWALVQLGTEVRVAARREEAAAE
LCRDLAAAVPGADLAAADFEDLEAEADAAAVVVNGTSVGLPGHEGRLPPLRFRAAQVVLDFVYGDTELARAARAAGARLV
SGEQVLVRQGALAFTIWTGQPAPEADMARALEAREGAR
>Mature_278_residues
MITGRTALYGVVGHPVAHSRSPEMQNAAFARLGVDAVYVALPVAPERIDEALRGAHALGFQGLNVTVPHKPRAASLCHAL
DPVATAVGAANTLRRTRDGWDGFNTDAPACRTLLEAAGVVRGSRALLVGAGGAARAAAWALVQLGTEVRVAARREEAAAE
LCRDLAAAVPGADLAAADFEDLEAEADAAAVVVNGTSVGLPGHEGRLPPLRFRAAQVVLDFVYGDTELARAARAAGARLV
SGEQVLVRQGALAFTIWTGQPAPEADMARALEAREGAR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=278, Percent_Identity=31.294964028777, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789675, Length=257, Percent_Identity=32.295719844358, Blast_Score=94, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_ANAD2 (B8J8W8)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002490632.1
- ProteinModelPortal:   B8J8W8
- SMR:   B8J8W8
- GeneID:   7298442
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_0207
- HOGENOM:   HBG553408
- ProtClustDB:   CLSK944883
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 28740; Mature: 28740

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGRTALYGVVGHPVAHSRSPEMQNAAFARLGVDAVYVALPVAPERIDEALRGAHALGF
CCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCC
QGLNVTVPHKPRAASLCHALDPVATAVGAANTLRRTRDGWDGFNTDAPACRTLLEAAGVV
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
RGSRALLVGAGGAARAAAWALVQLGTEVRVAARREEAAAELCRDLAAAVPGADLAAADFE
CCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
DLEAEADAAAVVVNGTSVGLPGHEGRLPPLRFRAAQVVLDFVYGDTELARAARAAGARLV
HHHCCCCCEEEEEECCEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEE
SGEQVLVRQGALAFTIWTGQPAPEADMARALEAREGAR
CCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITGRTALYGVVGHPVAHSRSPEMQNAAFARLGVDAVYVALPVAPERIDEALRGAHALGF
CCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCC
QGLNVTVPHKPRAASLCHALDPVATAVGAANTLRRTRDGWDGFNTDAPACRTLLEAAGVV
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
RGSRALLVGAGGAARAAAWALVQLGTEVRVAARREEAAAELCRDLAAAVPGADLAAADFE
CCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
DLEAEADAAAVVVNGTSVGLPGHEGRLPPLRFRAAQVVLDFVYGDTELARAARAAGARLV
HHHCCCCCEEEEEECCEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEE
SGEQVLVRQGALAFTIWTGQPAPEADMARALEAREGAR
CCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA