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The map label for this gene is mutL [H]

Identifier: 220905580

GI number: 220905580

Start: 2788254

End: 2790473

Strand: Reverse

Name: mutL [H]

Synonym: Ddes_2319

Alternate gene names: 220905580

Gene position: 2790473-2788254 (Counterclockwise)

Preceding gene: 220905582

Following gene: 220905579

Centisome position: 97.11

GC content: 64.46

Gene sequence:

>2220_bases
ATGCCGCACATGGGCGCATACACTGAAACCATGTCTGAAAAAAATAGTCATATACGCCTGCTGCCACCCGAGCTGCGCAA
CCAGATCGCCGCCGGCGAGGTGGTTGAACGGCCCGCCAGCGTGTTGAAAGAACTGGTGGAAAACAGCCTGGACGCCCAGG
CCGGCCAGATTGATGTTTGCCTTGAAAATGGGGGGCAAAGCCGCATCAGTGTACAGGATGATGGCCGGGGCATCCCTGCG
GAAGATCTGGAGATGGCCGTCACACGTCATGCCACCAGCAAGATACGGTGCCTGGAGGACCTTGAACGCATCCTTTCTTA
CGGCTTTCGGGGCGAGGCCTTGCCGAGCATCGCCTCGGTATCGCGCTTTACCATCACTTCAGCCAGCCAGGACGCTGCGG
GACAGGCCGCGGCACACCGGGTAGAGGTGGAACATGGCCTGCTCAAAAGCTCCGGCCCGGCGGCCCTGCACAAGGGCACG
CTGGTGGAAGTGCGTGATCTTTTTTCCAACATACCAGCCCGGCTGAAGTTTTTAAAGACCCCCTCCACAGAGTTCAGGCG
CGCTCAGGACTGGCTGGCCCGTCTGGCCCTGACACGTCCGCAGGTGGGTTTTTGCCTGTATTCGGGTGAGAGGGAAGCCC
TGCGGTTTCTGCCGGGGCAAACCCTTGCCGAGCGCCTTGCCGTGCTGTGGCCGCGCCTCATCGTGGATGCCCTGCGCCCC
TTTGACGGGCGGCGGCATGGCATCCGCGCGCATGGTCTGGCGGCCCTGCCCAATGTGAGCCAGCCGCGTGGCGACCGCAT
CCTTTTGTATGTCAACGGCCGCTCGGTGACGGACAAGCGCCTGCTGGCCGCCGTGCGCCAGGCCTACAAAGGGCGTATGA
CCAGCAGGGACTACCCGCAGATTGCCCTTTTTGTCGAAATGGACCCGGCCGAGGTGGATGTGAACGTGCACCCGGCCAAA
AGCGAGGTGCGGTTCAGGGATGAATCCGCGGTGTTTTCCGCGGTGCTGCACGCCGTGCAAGGGGCGCTTGTAACATCGTT
TGACGTGGCCGAGGCCGCCTGGCACGAAGGGGCAACGCCTGCCGCTGACGGCAGGGCGTATGGTCAGGCCGGTTCGCCCG
CTTCAGATTCGCCCGCTTCAGATTCGTCTGGTACTTTCGGTTCTCCTGACAAGTCTTATGCTCCGGGCGCGGACCCGGGG
GACCCGGGGGACCCGGCGGGTGCCGCGCCCCGTCCGCAGGGATTCTGGGGGCGGCTGGATAATCCCCCGCTTGTGGAGCG
GCAGGAGCGGGACAGTGCCGCTGACCAGGGCGAATGGCATGTGAGCGCGCCCGCCGCATCTGTGGAAGGAGAGGCCGGGC
ATGCCACGTACGGCACTTTGCCGGGATTTACCGGCCGGGCTGGCTTGTCCGCTCCATCTGGGCTGCCTGGCCCGGATGGC
GCTTCTGATGCGTCCGTTTTTGGTGCGCAGTTTTCTTCTTCGTCTGCCCCTGCGGGAAGCGCCGGTCTGGCCGCTGCCGC
GCAGGAAGGTTTTTTTCTGGAGCAGGAAGACGCCGCCTGCGGCCGCATGGCGGAAGACAGCGGCACATATGCCGCCGGTG
CAGGCGATGCAGCGGATGACCGGGGTGATGTCGCTGCCGGGCATGGCGGAAGCCGTCAGCCCCTGCGCGTTGAAAATATG
GAATACCTGGGGCAGGTGGCAAATACCTATCTGGTGCTGCGCGACAGGGACGGCGCCCTGATCCTGCTGGACCAGCACGC
GGCCCATGAGCGTGTGCTCTATACCCGCATGCGCCGGGGCGGCTTTGCCGGCTCCGGGCAGCTGCTGGCCCTGCCGCTGG
AACTGTCGCTGCATCCGGCGGAGCGCGAGCGGCTGTTTGAGCTGCGGGAAAATCTGGAATCCCTGGGTTTTGTCTTTGAA
AGTTCCGGCGCGGGGCTTGAGGTCAGGGGCATGCCGCCCGTGCTTTCGCGGGCCGAGGCCAGAGATTTTCTGCGTGAAGC
GCTGGCCGGGCGCAAGGACGATCTGGCGGGCATGTTTATTTCCATGTCCTGCAAGGCGGCCATCAAGGCCGGGCAGCGCC
TTACGGATGATGAGGCCGCCGGGCTGCTGCGCCAGTGGCTTGCGGCTCCGGACAGGGAATACTGCCCGCACGGGCGTCCC
TGCGTACTGCGCTGGGATGGCCCTGAGCTGGAAAAAATGTTCAAGCGGCGGCAATCCTGA

Upstream 100 bases:

>100_bases
TTTTCAGCCTTGCCTTCCATACATAAGCACCCCTGGCGGCAAGGCAAGCCCTGCGGCGCCTTGCGGGGGTGTTTTTTCCC
GGCCTGCGCCGCCGCTTGCC

Downstream 100 bases:

>100_bases
TGCTTGGTCCCCACTCCGGTCTCTGTCGCAGGGTGAAGAGAGCCTGAAACCGCTTGCGGGAACATACTGCACTGACGCCG
TGGGTGCACGGGCCAGTACC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MPHMGAYTETMSEKNSHIRLLPPELRNQIAAGEVVERPASVLKELVENSLDAQAGQIDVCLENGGQSRISVQDDGRGIPA
EDLEMAVTRHATSKIRCLEDLERILSYGFRGEALPSIASVSRFTITSASQDAAGQAAAHRVEVEHGLLKSSGPAALHKGT
LVEVRDLFSNIPARLKFLKTPSTEFRRAQDWLARLALTRPQVGFCLYSGEREALRFLPGQTLAERLAVLWPRLIVDALRP
FDGRRHGIRAHGLAALPNVSQPRGDRILLYVNGRSVTDKRLLAAVRQAYKGRMTSRDYPQIALFVEMDPAEVDVNVHPAK
SEVRFRDESAVFSAVLHAVQGALVTSFDVAEAAWHEGATPAADGRAYGQAGSPASDSPASDSSGTFGSPDKSYAPGADPG
DPGDPAGAAPRPQGFWGRLDNPPLVERQERDSAADQGEWHVSAPAASVEGEAGHATYGTLPGFTGRAGLSAPSGLPGPDG
ASDASVFGAQFSSSSAPAGSAGLAAAAQEGFFLEQEDAACGRMAEDSGTYAAGAGDAADDRGDVAAGHGGSRQPLRVENM
EYLGQVANTYLVLRDRDGALILLDQHAAHERVLYTRMRRGGFAGSGQLLALPLELSLHPAERERLFELRENLESLGFVFE
SSGAGLEVRGMPPVLSRAEARDFLREALAGRKDDLAGMFISMSCKAAIKAGQRLTDDEAAGLLRQWLAAPDREYCPHGRP
CVLRWDGPELEKMFKRRQS

Sequences:

>Translated_739_residues
MPHMGAYTETMSEKNSHIRLLPPELRNQIAAGEVVERPASVLKELVENSLDAQAGQIDVCLENGGQSRISVQDDGRGIPA
EDLEMAVTRHATSKIRCLEDLERILSYGFRGEALPSIASVSRFTITSASQDAAGQAAAHRVEVEHGLLKSSGPAALHKGT
LVEVRDLFSNIPARLKFLKTPSTEFRRAQDWLARLALTRPQVGFCLYSGEREALRFLPGQTLAERLAVLWPRLIVDALRP
FDGRRHGIRAHGLAALPNVSQPRGDRILLYVNGRSVTDKRLLAAVRQAYKGRMTSRDYPQIALFVEMDPAEVDVNVHPAK
SEVRFRDESAVFSAVLHAVQGALVTSFDVAEAAWHEGATPAADGRAYGQAGSPASDSPASDSSGTFGSPDKSYAPGADPG
DPGDPAGAAPRPQGFWGRLDNPPLVERQERDSAADQGEWHVSAPAASVEGEAGHATYGTLPGFTGRAGLSAPSGLPGPDG
ASDASVFGAQFSSSSAPAGSAGLAAAAQEGFFLEQEDAACGRMAEDSGTYAAGAGDAADDRGDVAAGHGGSRQPLRVENM
EYLGQVANTYLVLRDRDGALILLDQHAAHERVLYTRMRRGGFAGSGQLLALPLELSLHPAERERLFELRENLESLGFVFE
SSGAGLEVRGMPPVLSRAEARDFLREALAGRKDDLAGMFISMSCKAAIKAGQRLTDDEAAGLLRQWLAAPDREYCPHGRP
CVLRWDGPELEKMFKRRQS
>Mature_738_residues
PHMGAYTETMSEKNSHIRLLPPELRNQIAAGEVVERPASVLKELVENSLDAQAGQIDVCLENGGQSRISVQDDGRGIPAE
DLEMAVTRHATSKIRCLEDLERILSYGFRGEALPSIASVSRFTITSASQDAAGQAAAHRVEVEHGLLKSSGPAALHKGTL
VEVRDLFSNIPARLKFLKTPSTEFRRAQDWLARLALTRPQVGFCLYSGEREALRFLPGQTLAERLAVLWPRLIVDALRPF
DGRRHGIRAHGLAALPNVSQPRGDRILLYVNGRSVTDKRLLAAVRQAYKGRMTSRDYPQIALFVEMDPAEVDVNVHPAKS
EVRFRDESAVFSAVLHAVQGALVTSFDVAEAAWHEGATPAADGRAYGQAGSPASDSPASDSSGTFGSPDKSYAPGADPGD
PGDPAGAAPRPQGFWGRLDNPPLVERQERDSAADQGEWHVSAPAASVEGEAGHATYGTLPGFTGRAGLSAPSGLPGPDGA
SDASVFGAQFSSSSAPAGSAGLAAAAQEGFFLEQEDAACGRMAEDSGTYAAGAGDAADDRGDVAAGHGGSRQPLRVENME
YLGQVANTYLVLRDRDGALILLDQHAAHERVLYTRMRRGGFAGSGQLLALPLELSLHPAERERLFELRENLESLGFVFES
SGAGLEVRGMPPVLSRAEARDFLREALAGRKDDLAGMFISMSCKAAIKAGQRLTDDEAAGLLRQWLAAPDREYCPHGRPC
VLRWDGPELEKMFKRRQS

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=334, Percent_Identity=35.0299401197605, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI189458898, Length=383, Percent_Identity=27.9373368146214, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI189458896, Length=374, Percent_Identity=29.4117647058824, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI4505911, Length=383, Percent_Identity=27.9373368146214, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=28.2857142857143, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=28.2857142857143, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI263191589, Length=240, Percent_Identity=29.5833333333333, Blast_Score=98, Evalue=4e-20,
Organism=Homo sapiens, GI310128480, Length=316, Percent_Identity=25.6329113924051, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI91992162, Length=352, Percent_Identity=23.5795454545455, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI91992160, Length=352, Percent_Identity=23.5795454545455, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1790612, Length=340, Percent_Identity=44.1176470588235, Blast_Score=233, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=33.8557993730408, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=425, Percent_Identity=25.6470588235294, Blast_Score=125, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=34.5132743362832, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=399, Percent_Identity=26.3157894736842, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=201, Percent_Identity=29.3532338308458, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136968, Length=334, Percent_Identity=35.0299401197605, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17136970, Length=183, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 79201; Mature: 79069

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHMGAYTETMSEKNSHIRLLPPELRNQIAAGEVVERPASVLKELVENSLDAQAGQIDVC
CCCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LENGGQSRISVQDDGRGIPAEDLEMAVTRHATSKIRCLEDLERILSYGFRGEALPSIASV
EECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SRFTITSASQDAAGQAAAHRVEVEHGLLKSSGPAALHKGTLVEVRDLFSNIPARLKFLKT
HEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHCCCHHEEEECC
PSTEFRRAQDWLARLALTRPQVGFCLYSGEREALRFLPGQTLAERLAVLWPRLIVDALRP
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
FDGRRHGIRAHGLAALPNVSQPRGDRILLYVNGRSVTDKRLLAAVRQAYKGRMTSRDYPQ
CCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCC
IALFVEMDPAEVDVNVHPAKSEVRFRDESAVFSAVLHAVQGALVTSFDVAEAAWHEGATP
EEEEEEECCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AADGRAYGQAGSPASDSPASDSSGTFGSPDKSYAPGADPGDPGDPAGAAPRPQGFWGRLD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NPPLVERQERDSAADQGEWHVSAPAASVEGEAGHATYGTLPGFTGRAGLSAPSGLPGPDG
CCCCCCCHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ASDASVFGAQFSSSSAPAGSAGLAAAAQEGFFLEQEDAACGRMAEDSGTYAAGAGDAADD
CCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEECCCCHHCCCCCCCCCEECCCCCCCCC
RGDVAAGHGGSRQPLRVENMEYLGQVANTYLVLRDRDGALILLDQHAAHERVLYTRMRRG
CCCEECCCCCCCCCEEEHHHHHHHHHHCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHC
GFAGSGQLLALPLELSLHPAERERLFELRENLESLGFVFESSGAGLEVRGMPPVLSRAEA
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCEEEECCCCCEEECCCCHHHHHHHH
RDFLREALAGRKDDLAGMFISMSCKAAIKAGQRLTDDEAAGLLRQWLAAPDREYCPHGRP
HHHHHHHHCCCCCCHHHEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
CVLRWDGPELEKMFKRRQS
EEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
PHMGAYTETMSEKNSHIRLLPPELRNQIAAGEVVERPASVLKELVENSLDAQAGQIDVC
CCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
LENGGQSRISVQDDGRGIPAEDLEMAVTRHATSKIRCLEDLERILSYGFRGEALPSIASV
EECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SRFTITSASQDAAGQAAAHRVEVEHGLLKSSGPAALHKGTLVEVRDLFSNIPARLKFLKT
HEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHCCCHHEEEECC
PSTEFRRAQDWLARLALTRPQVGFCLYSGEREALRFLPGQTLAERLAVLWPRLIVDALRP
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
FDGRRHGIRAHGLAALPNVSQPRGDRILLYVNGRSVTDKRLLAAVRQAYKGRMTSRDYPQ
CCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCC
IALFVEMDPAEVDVNVHPAKSEVRFRDESAVFSAVLHAVQGALVTSFDVAEAAWHEGATP
EEEEEEECCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AADGRAYGQAGSPASDSPASDSSGTFGSPDKSYAPGADPGDPGDPAGAAPRPQGFWGRLD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NPPLVERQERDSAADQGEWHVSAPAASVEGEAGHATYGTLPGFTGRAGLSAPSGLPGPDG
CCCCCCCHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ASDASVFGAQFSSSSAPAGSAGLAAAAQEGFFLEQEDAACGRMAEDSGTYAAGAGDAADD
CCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEECCCCHHCCCCCCCCCEECCCCCCCCC
RGDVAAGHGGSRQPLRVENMEYLGQVANTYLVLRDRDGALILLDQHAAHERVLYTRMRRG
CCCEECCCCCCCCCEEEHHHHHHHHHHCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHC
GFAGSGQLLALPLELSLHPAERERLFELRENLESLGFVFESSGAGLEVRGMPPVLSRAEA
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCEEEECCCCCEEECCCCHHHHHHHH
RDFLREALAGRKDDLAGMFISMSCKAAIKAGQRLTDDEAAGLLRQWLAAPDREYCPHGRP
HHHHHHHHCCCCCCHHHEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
CVLRWDGPELEKMFKRRQS
EEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA