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The map label for this gene is purE [H]

Identifier: 220905582

GI number: 220905582

Start: 2791398

End: 2791895

Strand: Reverse

Name: purE [H]

Synonym: Ddes_2322

Alternate gene names: 220905582

Gene position: 2791895-2791398 (Counterclockwise)

Preceding gene: 220905583

Following gene: 220905580

Centisome position: 97.16

GC content: 63.05

Gene sequence:

>498_bases
ATGGCTCAAGTGGTTATACTGATGGGGTCCCAGTCTGATGAAGACAAGGTCAGCCCCTGTGTTGAAGTGCTGAAAAGCCT
GGGCATAAGCTGTGTCATCACGGTCAGCTCCGCCCACCGCACCCCTGAACGCACGGAAAAGCTGGTGAGCGAACACGAAG
CCGCCGGTGCGCAGGTTTTCATCTGTGCCGCCGGTATGGCCGCCCATCTGGCTGGAGCCGTGGCGGCGCGCACCACACGC
CCGGTGATCGGCATTCCCGTGTCCAGCGTGGCTCTTGGCGGCATGGATGCCCTGCTTGCCACGGTGCAGATGCCTCCGGG
ATTTCCTGTGGCTACGGTGGCCCTCGACAAGGCCGGCGCGCGCAATGCGGCCTGGCTTGCGGCCCAGATTCTGGCCCTGG
CGGACACTGACCTCAGCCGTAAGCTCGCCGCCGCCCGTGCAAAAATGCGCGAGGATGTGGAAAAGGCCGGTGACGAGATT
ACCCGAAAGTATGCCTGA

Upstream 100 bases:

>100_bases
GGCTAAAGTTGCAACGCAGCCATATGAAAGTGAACCATCGCCGCGCAAAAATGCTGCGGGCGCAATGCGCCGGAGCGGGG
CAGCAAGCAGAGGATATATC

Downstream 100 bases:

>100_bases
ATCACCGTGCCGCAGGTCACGCCTGTCATGTGATCTCGCGACATCTGTGTAACACTGCTTTTGTCGTAAAAAAGATGCCG
CGGGAATTTTTCCGGCGGCA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MAQVVILMGSQSDEDKVSPCVEVLKSLGISCVITVSSAHRTPERTEKLVSEHEAAGAQVFICAAGMAAHLAGAVAARTTR
PVIGIPVSSVALGGMDALLATVQMPPGFPVATVALDKAGARNAAWLAAQILALADTDLSRKLAAARAKMREDVEKAGDEI
TRKYA

Sequences:

>Translated_165_residues
MAQVVILMGSQSDEDKVSPCVEVLKSLGISCVITVSSAHRTPERTEKLVSEHEAAGAQVFICAAGMAAHLAGAVAARTTR
PVIGIPVSSVALGGMDALLATVQMPPGFPVATVALDKAGARNAAWLAAQILALADTDLSRKLAAARAKMREDVEKAGDEI
TRKYA
>Mature_164_residues
AQVVILMGSQSDEDKVSPCVEVLKSLGISCVITVSSAHRTPERTEKLVSEHEAAGAQVFICAAGMAAHLAGAVAARTTRP
VIGIPVSSVALGGMDALLATVQMPPGFPVATVALDKAGARNAAWLAAQILALADTDLSRKLAAARAKMREDVEKAGDEIT
RKYA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220559, Length=144, Percent_Identity=31.25, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI119220557, Length=145, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI5453539, Length=145, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=45.859872611465, Blast_Score=100, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324702, Length=148, Percent_Identity=43.2432432432432, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI18860083, Length=141, Percent_Identity=34.7517730496454, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17063; Mature: 16932

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVVILMGSQSDEDKVSPCVEVLKSLGISCVITVSSAHRTPERTEKLVSEHEAAGAQVF
CCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEE
ICAAGMAAHLAGAVAARTTRPVIGIPVSSVALGGMDALLATVQMPPGFPVATVALDKAGA
EECCCHHHHHHHHHHHHCCCCEEECCHHHHHHCCHHHHHHHHCCCCCCCCCEEEECCCCC
RNAAWLAAQILALADTDLSRKLAAARAKMREDVEKAGDEITRKYA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQVVILMGSQSDEDKVSPCVEVLKSLGISCVITVSSAHRTPERTEKLVSEHEAAGAQVF
CEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEE
ICAAGMAAHLAGAVAARTTRPVIGIPVSSVALGGMDALLATVQMPPGFPVATVALDKAGA
EECCCHHHHHHHHHHHHCCCCEEECCHHHHHHCCHHHHHHHHCCCCCCCCCEEEECCCCC
RNAAWLAAQILALADTDLSRKLAAARAKMREDVEKAGDEITRKYA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]