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The map label for this gene is ywrD [H]

Identifier: 220905289

GI number: 220905289

Start: 2439700

End: 2441358

Strand: Direct

Name: ywrD [H]

Synonym: Ddes_2027

Alternate gene names: 220905289

Gene position: 2439700-2441358 (Clockwise)

Preceding gene: 220905288

Following gene: 220905295

Centisome position: 84.91

GC content: 65.52

Gene sequence:

>1659_bases
ATGCAAGCCAGCCACAGGTATTCCCTTACCCTTTCCACTGCCAGCAACCCGCTGAGCCTGCGGGGCATGGTCACAAGCCC
CCACTACCTGGCCTCCCAGGCGGGGCGCGACATCCTGCGCGCGGGCGGCACCGCCGTGGATGCGGCCATTGCCGCAGCCG
CAGTGCTTTCTGTGGTCTATCCCCACATGTGCGGCATTGGCGGCGATAACTTCTGGCTCATATATGATGCGGCTTCGCAA
CAGATGCGCGCGCTCAACGGCAGCGGCCGCGCCGCGCGGGCAGCCAGCGCAGGCCTGTACGCCGAACGCGGGCACAAGGC
CGTACCCACGCGCGGGGCGCTGGCAGCCGTTACTGTTCCCGGCGCGGTGTCGGGCTGGGCCGCCGCCTTTGATCACAGCA
AAAAACATATGGCTTCGCCCCTGGCCTGGGGTGATCTGCTGGAATCCGCCCGCGAGCATGCCGAAAGCGGCTTTGCCGTG
TCACACTCCCTGGCGGGCAGCCTGACGCTTGTAAGCAGCGGCAAACCCAACTACAGCCTGAACGACTGCCCCGAGTTTCG
CGAGCTTTTCTTTACACCTGAGGGGCATGCCCCGACATTCGCCTCCGTTCTGCGACAGCCGCACCTTGCCCGCACCCTCG
GCCGCCTGGCTGCCGAAGGACCTGAGGATTTTTACTGCGGCGTGACAGCCCGGGCCATTGTGGCCGCCATGCAACGCCAC
GGCGGGCTGCTCTCACAGGAAGACCTGAGCAGCCACACGGCCGACTGGGCCGAGCCGCTGCGCGTGGACTACCGGGGCTA
CACGGCCTGCACACCACCACCCAACTGCCAGGGACTGGCAACACTTGAGATACTTAACATCCTCAACCAGATGGATGTCG
AGGCCCTGGGCGAAGGCACGGCCGACTACTATCATGTCATGGCCGAGGCCACGCGCGAAGCCTTTATTGACCGCCAGCAC
TACCTCACGGATCCGGACTTTGCCGACATCCCCACTGCCAGGCTGCTTTCACCGGCGCATGCACGGCAACAGGCGGCACG
TATCCGCATGGACAAAAGCGCCGGTCCCCTGCCCCCATTGCCTCCTGGCGGCGACACCATCTGGCTTGGCGTGGTGGACG
CGGCCGGCAATGCCGTGTCGCTCATCCAGAGCATTTACCACGAGTTCGGCTCGGGCATTGTGGCGCACGACGCTGGTTTT
GTGCTGCAAAACCGGGGCTGCGCCTTTGCCCTTGAGCCGGGGCATGTCAACAGCCTTCAGCCGGGCAAGCGAACCCTGCA
CACCCTCACGCCGGCCATGCTTCTCAAGGACGGCAGACCCCACCTTGTTTACGGCAGCATGGGCGGCGACGGGCAACCCC
AGACCATTGCGGCCATGACCACCCGTATGGTGGATTTCGGCATGGAGCCGCAGGACGCCGTGAACGCGCCGCGCTGGCTG
CTGGGCCGGAGCTGGGGAGCGGAATCCAACGACCTGAAGCTTGAGGGACGCATCCCAGAAGATGTGGCGCGGGACCTGGA
ACGACGGGGACATGCAGTGCGGCGCATCGCGGACTTTACAGAAATGATGGGGCATGCCGGGGCCATTATGCGGCGGCCGG
GCGATGTTTGGCAGGGCGCCACAGACCCGCGCGGCGACGGCCAGGCAGCAGCGCTGTAG

Upstream 100 bases:

>100_bases
CCTTTGCCCCCTGCCCCTTCCTGTGGCATACTGCCCGCGAACATCCGCCAGCCGCGCCAGCGCGCCGAAAACGGGCGGGA
CAAGCCAGTACGAGGTTCGC

Downstream 100 bases:

>100_bases
CAGGCCTGCCGGGCGCTGCGTCAAATGCGGACCTGGGCGACAAGCGTGTACAGCGGCACGAAACCTGCCCGGCTCTCCAT
GCCCGTGCAACATGGGGGGG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MQASHRYSLTLSTASNPLSLRGMVTSPHYLASQAGRDILRAGGTAVDAAIAAAAVLSVVYPHMCGIGGDNFWLIYDAASQ
QMRALNGSGRAARAASAGLYAERGHKAVPTRGALAAVTVPGAVSGWAAAFDHSKKHMASPLAWGDLLESAREHAESGFAV
SHSLAGSLTLVSSGKPNYSLNDCPEFRELFFTPEGHAPTFASVLRQPHLARTLGRLAAEGPEDFYCGVTARAIVAAMQRH
GGLLSQEDLSSHTADWAEPLRVDYRGYTACTPPPNCQGLATLEILNILNQMDVEALGEGTADYYHVMAEATREAFIDRQH
YLTDPDFADIPTARLLSPAHARQQAARIRMDKSAGPLPPLPPGGDTIWLGVVDAAGNAVSLIQSIYHEFGSGIVAHDAGF
VLQNRGCAFALEPGHVNSLQPGKRTLHTLTPAMLLKDGRPHLVYGSMGGDGQPQTIAAMTTRMVDFGMEPQDAVNAPRWL
LGRSWGAESNDLKLEGRIPEDVARDLERRGHAVRRIADFTEMMGHAGAIMRRPGDVWQGATDPRGDGQAAAL

Sequences:

>Translated_552_residues
MQASHRYSLTLSTASNPLSLRGMVTSPHYLASQAGRDILRAGGTAVDAAIAAAAVLSVVYPHMCGIGGDNFWLIYDAASQ
QMRALNGSGRAARAASAGLYAERGHKAVPTRGALAAVTVPGAVSGWAAAFDHSKKHMASPLAWGDLLESAREHAESGFAV
SHSLAGSLTLVSSGKPNYSLNDCPEFRELFFTPEGHAPTFASVLRQPHLARTLGRLAAEGPEDFYCGVTARAIVAAMQRH
GGLLSQEDLSSHTADWAEPLRVDYRGYTACTPPPNCQGLATLEILNILNQMDVEALGEGTADYYHVMAEATREAFIDRQH
YLTDPDFADIPTARLLSPAHARQQAARIRMDKSAGPLPPLPPGGDTIWLGVVDAAGNAVSLIQSIYHEFGSGIVAHDAGF
VLQNRGCAFALEPGHVNSLQPGKRTLHTLTPAMLLKDGRPHLVYGSMGGDGQPQTIAAMTTRMVDFGMEPQDAVNAPRWL
LGRSWGAESNDLKLEGRIPEDVARDLERRGHAVRRIADFTEMMGHAGAIMRRPGDVWQGATDPRGDGQAAAL
>Mature_552_residues
MQASHRYSLTLSTASNPLSLRGMVTSPHYLASQAGRDILRAGGTAVDAAIAAAAVLSVVYPHMCGIGGDNFWLIYDAASQ
QMRALNGSGRAARAASAGLYAERGHKAVPTRGALAAVTVPGAVSGWAAAFDHSKKHMASPLAWGDLLESAREHAESGFAV
SHSLAGSLTLVSSGKPNYSLNDCPEFRELFFTPEGHAPTFASVLRQPHLARTLGRLAAEGPEDFYCGVTARAIVAAMQRH
GGLLSQEDLSSHTADWAEPLRVDYRGYTACTPPPNCQGLATLEILNILNQMDVEALGEGTADYYHVMAEATREAFIDRQH
YLTDPDFADIPTARLLSPAHARQQAARIRMDKSAGPLPPLPPGGDTIWLGVVDAAGNAVSLIQSIYHEFGSGIVAHDAGF
VLQNRGCAFALEPGHVNSLQPGKRTLHTLTPAMLLKDGRPHLVYGSMGGDGQPQTIAAMTTRMVDFGMEPQDAVNAPRWL
LGRSWGAESNDLKLEGRIPEDVARDLERRGHAVRRIADFTEMMGHAGAIMRRPGDVWQGATDPRGDGQAAAL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=569, Percent_Identity=29.701230228471, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI73915090, Length=569, Percent_Identity=29.701230228471, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI73915096, Length=569, Percent_Identity=29.701230228471, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI73915094, Length=569, Percent_Identity=29.701230228471, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI113429326, Length=549, Percent_Identity=29.3260473588342, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI113429324, Length=549, Percent_Identity=29.5081967213115, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI109148539, Length=554, Percent_Identity=27.6173285198556, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI153266885, Length=562, Percent_Identity=24.9110320284698, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI153266901, Length=563, Percent_Identity=24.866785079929, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1789856, Length=556, Percent_Identity=33.9928057553957, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI193208245, Length=497, Percent_Identity=26.9617706237425, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193208247, Length=497, Percent_Identity=26.9617706237425, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17542894, Length=536, Percent_Identity=25.7462686567164, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17506189, Length=532, Percent_Identity=24.6240601503759, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI212646519, Length=488, Percent_Identity=26.0245901639344, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI72000294, Length=488, Percent_Identity=26.0245901639344, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323330, Length=477, Percent_Identity=21.8029350104822, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077878, Length=523, Percent_Identity=27.5334608030593, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24642670, Length=523, Percent_Identity=27.5334608030593, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24642666, Length=523, Percent_Identity=27.5334608030593, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI45551474, Length=523, Percent_Identity=27.5334608030593, Blast_Score=146, Evalue=5e-35,
Organism=Drosophila melanogaster, GI161077880, Length=523, Percent_Identity=27.5334608030593, Blast_Score=146, Evalue=5e-35,
Organism=Drosophila melanogaster, GI161077496, Length=532, Percent_Identity=24.4360902255639, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI18859893, Length=492, Percent_Identity=25.4065040650407, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI18859741, Length=484, Percent_Identity=23.9669421487603, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58867; Mature: 58867

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQASHRYSLTLSTASNPLSLRGMVTSPHYLASQAGRDILRAGGTAVDAAIAAAAVLSVVY
CCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
PHMCGIGGDNFWLIYDAASQQMRALNGSGRAARAASAGLYAERGHKAVPTRGALAAVTVP
HHHHCCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHCCCHHHCCCCCCCCCCCEEEEECC
GAVSGWAAAFDHSKKHMASPLAWGDLLESAREHAESGFAVSHSLAGSLTLVSSGKPNYSL
CCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCEEEHHCCCCEEEEECCCCCCCC
NDCPEFRELFFTPEGHAPTFASVLRQPHLARTLGRLAAEGPEDFYCGVTARAIVAAMQRH
CCCHHHHHHEECCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHH
GGLLSQEDLSSHTADWAEPLRVDYRGYTACTPPPNCQGLATLEILNILNQMDVEALGEGT
CCCCCHHHHHHCCHHHHHHHEECCCCEEECCCCCCCCCHHHHHHHHHHHHHCHHHHCCCC
ADYYHVMAEATREAFIDRQHYLTDPDFADIPTARLLSPAHARQQAARIRMDKSAGPLPPL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
PPGGDTIWLGVVDAAGNAVSLIQSIYHEFGSGIVAHDAGFVLQNRGCAFALEPGHVNSLQ
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCEEEECCCCCCCCC
PGKRTLHTLTPAMLLKDGRPHLVYGSMGGDGQPQTIAAMTTRMVDFGMEPQDAVNAPRWL
CCHHHHHHHCHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCHHH
LGRSWGAESNDLKLEGRIPEDVARDLERRGHAVRRIADFTEMMGHAGAIMRRPGDVWQGA
HCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHCCC
TDPRGDGQAAAL
CCCCCCCCCCCC
>Mature Secondary Structure
MQASHRYSLTLSTASNPLSLRGMVTSPHYLASQAGRDILRAGGTAVDAAIAAAAVLSVVY
CCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
PHMCGIGGDNFWLIYDAASQQMRALNGSGRAARAASAGLYAERGHKAVPTRGALAAVTVP
HHHHCCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHCCCHHHCCCCCCCCCCCEEEEECC
GAVSGWAAAFDHSKKHMASPLAWGDLLESAREHAESGFAVSHSLAGSLTLVSSGKPNYSL
CCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCEEEHHCCCCEEEEECCCCCCCC
NDCPEFRELFFTPEGHAPTFASVLRQPHLARTLGRLAAEGPEDFYCGVTARAIVAAMQRH
CCCHHHHHHEECCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHH
GGLLSQEDLSSHTADWAEPLRVDYRGYTACTPPPNCQGLATLEILNILNQMDVEALGEGT
CCCCCHHHHHHCCHHHHHHHEECCCCEEECCCCCCCCCHHHHHHHHHHHHHCHHHHCCCC
ADYYHVMAEATREAFIDRQHYLTDPDFADIPTARLLSPAHARQQAARIRMDKSAGPLPPL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
PPGGDTIWLGVVDAAGNAVSLIQSIYHEFGSGIVAHDAGFVLQNRGCAFALEPGHVNSLQ
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCEEEECCCCCCCCC
PGKRTLHTLTPAMLLKDGRPHLVYGSMGGDGQPQTIAAMTTRMVDFGMEPQDAVNAPRWL
CCHHHHHHHCHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCHHH
LGRSWGAESNDLKLEGRIPEDVARDLERRGHAVRRIADFTEMMGHAGAIMRRPGDVWQGA
HCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHCCC
TDPRGDGQAAAL
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]