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The map label for this gene is 220905295

Identifier: 220905295

GI number: 220905295

Start: 2445640

End: 2447250

Strand: Direct

Name: 220905295

Synonym: Ddes_2033

Alternate gene names: NA

Gene position: 2445640-2447250 (Clockwise)

Preceding gene: 220905289

Following gene: 220905296

Centisome position: 85.11

GC content: 58.04

Gene sequence:

>1611_bases
ATGAAGGTCCAATTTCTGGGCGCGGCGCAAACCGTGACCGGTTCCTGCTACATGATTGAAGCATGCGGCAAGCGTTTCTG
CATTGACTGCGGCATGCATCAGGGCAACAAGGCCATTGACGCCCGCAACCGCGAAATCGAAGTCTACCGGCCCACAGACA
TTGACTTTGTGCTTATTACCCACGCGCATATAGACCATTCGGGCCTTTTGCCCCGGATCGTGCGCGACGGCTTCAACAAT
CCCGTATACTGCACCAAGGCCACCAGCGAACTGCTGGACCTCATGCTGCAGGACAGCGCCCACATTCAGGAAATGGAAGC
ACAGTGGGAAGCCAAAAAATACATGCGCCGGGGCCTTAAAAATCCCCCTGCCGCCCTCTATACCGTCGAGGATGCGCAAA
AGGCCGTATCGCTTTTTTCCGCTGTGGACTACCATAAAACTTTTGAGCCTGCTCCTGGCATCCGCGTCACGTACTATGAT
GCGGGGCATATTCTTGGTTCCGGCTCGGTGCGCATCGAGGCCGATGAAGACGGCAAAACCACAAGCCTCATCTTTTCCGG
CGACATAGGCCGCCCGCAGGCCCTCATTGTGCGCAGCCCAGAAAGCCCGCCACAGGCCGACTATGTGTTTATGGAGTCCA
CCTACGGCGACCGCGACCATAAAAACGAAGAAACCAGCGACCAGGAACTGGCCGAAGCCATCGCCTACAGCTACGGCAAG
GGCGAAAAGGTCATTATTCCGGCCTTTGCCGTGGAGCGCACCCAGGAAGTGCTGTACTGCCTGCACACGCTGAGCAAGCA
GGGCAAACTGCCCGAAGACATGCCCGTGTACGTGGACAGCCCCCTGGCCATCCGCGCCACAGAAGTTTTTGAGCGCAACC
GGGAACTTTTTGACGACGCCGCGCAAAAACTGCTCAATAACGGCGACAATCCCTTTGCGCTGCCCAACCTGCGCTACACC
CTGTCTGTGGCGGAATCCCAGGCCATCAACGACTACAAGGGACCGGCCATTGTCATTTCCGCCAGCGGCATGTGCAATGC
GGGCCGCGTGCGCCATCACCTGCGCCATAATATCTGGAAGCCCGGCGCGAGCATCGTCTTTGTGGGCTATCAGGCCGTGG
GTACGCCCGGGCGCAAAATTGTTGAAAAAGCCAAAAAAATAAACCTGTTCGGCGAAGATATGGACGTGGCGGCCCGCATT
TTCACCATTAACGGCTTTTCAGGGCATGCCGGGCAGAGCCAGCTCCTGGACTGGCTGGCCCCCCTGGCCCACAACTGTGC
CCAGGTAGTGCTGACCCACGGCGAAATCAAGGCACAGGAAACACTGGCCGGTCTTATCCGCCAGCGCTTCGGCCTCAAGC
CGCGTATTGCCGCCTACCTTGAAGAGATGGTGCTGGACGGCTGCGAGGTTACCGCCACCGTTACCCACGAAACCAAAGCC
CATCCCAGGGTCGACTGGGGCTTTCTTACCGGCGAAGTGGAACGCAAGTGGGATATGTTCAAGGGCAAGCTGGCTGATGT
TGAAGCCCGCCCCTGGGTGGAACAGACCGACCTGCAGGAAGCCCTGGAAAAAATGGACTATGCCCTCACGCGCCTTATTT
CGCGCATGTAG

Upstream 100 bases:

>100_bases
AAACAGCGTTGCCAAGGCGGAAAAACGGACGCGCAAAAGCCCGCCTGCCGCCTCGGTATATCCGGCGGCCTTTTGCCGCC
AACTCTTACCGGAGGCCATG

Downstream 100 bases:

>100_bases
GAGAATGAAAACACCATGCGCATCATAGCGGGCCGCCTTGGCGGCCGTATTCTGAAGACTGTAGAGGGTGAAGGCTATCG
CCCCGCCATGGGCAGAACCC

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MKVQFLGAAQTVTGSCYMIEACGKRFCIDCGMHQGNKAIDARNREIEVYRPTDIDFVLITHAHIDHSGLLPRIVRDGFNN
PVYCTKATSELLDLMLQDSAHIQEMEAQWEAKKYMRRGLKNPPAALYTVEDAQKAVSLFSAVDYHKTFEPAPGIRVTYYD
AGHILGSGSVRIEADEDGKTTSLIFSGDIGRPQALIVRSPESPPQADYVFMESTYGDRDHKNEETSDQELAEAIAYSYGK
GEKVIIPAFAVERTQEVLYCLHTLSKQGKLPEDMPVYVDSPLAIRATEVFERNRELFDDAAQKLLNNGDNPFALPNLRYT
LSVAESQAINDYKGPAIVISASGMCNAGRVRHHLRHNIWKPGASIVFVGYQAVGTPGRKIVEKAKKINLFGEDMDVAARI
FTINGFSGHAGQSQLLDWLAPLAHNCAQVVLTHGEIKAQETLAGLIRQRFGLKPRIAAYLEEMVLDGCEVTATVTHETKA
HPRVDWGFLTGEVERKWDMFKGKLADVEARPWVEQTDLQEALEKMDYALTRLISRM

Sequences:

>Translated_536_residues
MKVQFLGAAQTVTGSCYMIEACGKRFCIDCGMHQGNKAIDARNREIEVYRPTDIDFVLITHAHIDHSGLLPRIVRDGFNN
PVYCTKATSELLDLMLQDSAHIQEMEAQWEAKKYMRRGLKNPPAALYTVEDAQKAVSLFSAVDYHKTFEPAPGIRVTYYD
AGHILGSGSVRIEADEDGKTTSLIFSGDIGRPQALIVRSPESPPQADYVFMESTYGDRDHKNEETSDQELAEAIAYSYGK
GEKVIIPAFAVERTQEVLYCLHTLSKQGKLPEDMPVYVDSPLAIRATEVFERNRELFDDAAQKLLNNGDNPFALPNLRYT
LSVAESQAINDYKGPAIVISASGMCNAGRVRHHLRHNIWKPGASIVFVGYQAVGTPGRKIVEKAKKINLFGEDMDVAARI
FTINGFSGHAGQSQLLDWLAPLAHNCAQVVLTHGEIKAQETLAGLIRQRFGLKPRIAAYLEEMVLDGCEVTATVTHETKA
HPRVDWGFLTGEVERKWDMFKGKLADVEARPWVEQTDLQEALEKMDYALTRLISRM
>Mature_536_residues
MKVQFLGAAQTVTGSCYMIEACGKRFCIDCGMHQGNKAIDARNREIEVYRPTDIDFVLITHAHIDHSGLLPRIVRDGFNN
PVYCTKATSELLDLMLQDSAHIQEMEAQWEAKKYMRRGLKNPPAALYTVEDAQKAVSLFSAVDYHKTFEPAPGIRVTYYD
AGHILGSGSVRIEADEDGKTTSLIFSGDIGRPQALIVRSPESPPQADYVFMESTYGDRDHKNEETSDQELAEAIAYSYGK
GEKVIIPAFAVERTQEVLYCLHTLSKQGKLPEDMPVYVDSPLAIRATEVFERNRELFDDAAQKLLNNGDNPFALPNLRYT
LSVAESQAINDYKGPAIVISASGMCNAGRVRHHLRHNIWKPGASIVFVGYQAVGTPGRKIVEKAKKINLFGEDMDVAARI
FTINGFSGHAGQSQLLDWLAPLAHNCAQVVLTHGEIKAQETLAGLIRQRFGLKPRIAAYLEEMVLDGCEVTATVTHETKA
HPRVDWGFLTGEVERKWDMFKGKLADVEARPWVEQTDLQEALEKMDYALTRLISRM

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=447, Percent_Identity=27.2930648769575, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI33300633, Length=474, Percent_Identity=25.9493670886076, Blast_Score=138, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32566029, Length=454, Percent_Identity=26.8722466960352, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32564696, Length=476, Percent_Identity=24.3697478991597, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323307, Length=460, Percent_Identity=24.7826086956522, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24648013, Length=438, Percent_Identity=25.7990867579909, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI21358523, Length=476, Percent_Identity=24.7899159663866, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 59794; Mature: 59794

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVQFLGAAQTVTGSCYMIEACGKRFCIDCGMHQGNKAIDARNREIEVYRPTDIDFVLIT
CEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCCEEEEE
HAHIDHSGLLPRIVRDGFNNPVYCTKATSELLDLMLQDSAHIQEMEAQWEAKKYMRRGLK
EEECCCCCCHHHHHHCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
NPPAALYTVEDAQKAVSLFSAVDYHKTFEPAPGIRVTYYDAGHILGSGSVRIEADEDGKT
CCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEECCCCEEEEECCCCCE
TSLIFSGDIGRPQALIVRSPESPPQADYVFMESTYGDRDHKNEETSDQELAEAIAYSYGK
EEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
GEKVIIPAFAVERTQEVLYCLHTLSKQGKLPEDMPVYVDSPLAIRATEVFERNRELFDDA
CCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHH
AQKLLNNGDNPFALPNLRYTLSVAESQAINDYKGPAIVISASGMCNAGRVRHHLRHNIWK
HHHHHHCCCCCEECCCCEEEEEEHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCC
PGASIVFVGYQAVGTPGRKIVEKAKKINLFGEDMDVAARIFTINGFSGHAGQSQLLDWLA
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHH
PLAHNCAQVVLTHGEIKAQETLAGLIRQRFGLKPRIAAYLEEMVLDGCEVTATVTHETKA
HHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
HPRVDWGFLTGEVERKWDMFKGKLADVEARPWVEQTDLQEALEKMDYALTRLISRM
CCCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVQFLGAAQTVTGSCYMIEACGKRFCIDCGMHQGNKAIDARNREIEVYRPTDIDFVLIT
CEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCCEEEEE
HAHIDHSGLLPRIVRDGFNNPVYCTKATSELLDLMLQDSAHIQEMEAQWEAKKYMRRGLK
EEECCCCCCHHHHHHCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
NPPAALYTVEDAQKAVSLFSAVDYHKTFEPAPGIRVTYYDAGHILGSGSVRIEADEDGKT
CCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEECCCCEEEEECCCCCE
TSLIFSGDIGRPQALIVRSPESPPQADYVFMESTYGDRDHKNEETSDQELAEAIAYSYGK
EEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
GEKVIIPAFAVERTQEVLYCLHTLSKQGKLPEDMPVYVDSPLAIRATEVFERNRELFDDA
CCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHH
AQKLLNNGDNPFALPNLRYTLSVAESQAINDYKGPAIVISASGMCNAGRVRHHLRHNIWK
HHHHHHCCCCCEECCCCEEEEEEHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCC
PGASIVFVGYQAVGTPGRKIVEKAKKINLFGEDMDVAARIFTINGFSGHAGQSQLLDWLA
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHH
PLAHNCAQVVLTHGEIKAQETLAGLIRQRFGLKPRIAAYLEEMVLDGCEVTATVTHETKA
HHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
HPRVDWGFLTGEVERKWDMFKGKLADVEARPWVEQTDLQEALEKMDYALTRLISRM
CCCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA