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The map label for this gene is dapA [H]

Identifier: 220904949

GI number: 220904949

Start: 2029043

End: 2029930

Strand: Direct

Name: dapA [H]

Synonym: Ddes_1685

Alternate gene names: 220904949

Gene position: 2029043-2029930 (Clockwise)

Preceding gene: 220904948

Following gene: 220904950

Centisome position: 70.61

GC content: 58.22

Gene sequence:

>888_bases
ATGAACAGTATTCACGGTATTTTCGCTGTTACGGTAACCCATTTCAACAACGACGGCAGCATTGATTACAGCGCCATATC
CAAGCACGTCCAATGGCTGCTCCAATCCGGCGTGCACGGCATCATGCCCGTGGGGGCCACCGGAGAATGGCCGGCGCTTT
CCACACAGGAGCGCAAACAGGTTGCCGAATTTGTCATGAAAGAGGTAGACGGCAAGGTGCCGGTGATCGTGGGGGCCATT
TCCCCCAATGTAGACGTTTCTGTCGACCTGTCGGAACATGCCGGCTCCATCGGCGCGGCGGGCGTCATGATCCTCCCTCC
GCCCGGCGTCCATCCGAGCCAGCACGAAATATACGAATTCTATAAATACATTTCCGGTAAAAGCCCCCTTCCGGTCATGG
TCTACAACAATCCCGGCAGTTGCGGCGTGGCCGTGTCGCCCGAAACGCTGGGCAAGTGCGCCCAGCTGCCCAATATGGGC
TTTCTCAAGGAATCCAGTGGCGACATCATGCGCCTGACCCGGTCTGTGGACGAAGTGGGCGACCGCCTGGTGGTTTTCTG
CGGCTGCGAAAGCCTGGCGTATGAAAGTTTTGTCATGGGGGCCAGAGCATGGGTTTGCGTTCTGGCCAATATCGCCCCGG
CCATGTGCGTCAGGCTTTATGACCTCATCGTCAACAAAGGCAAACTTGACGAGGCCCGGCAGGTGTACCGCCAGATGCTG
CCCCTGCTGCGTCTGCTGGAAGATACCGGGGAACTTTGGCAGGTAGTCAAGCACGCCCTGGTGCTCAAGGGTTTCGGCAG
CGGCAGGCTGCGTATGCCCCGCCAGCCCATTTCAGAAGGTGTGCGCCTTGAGCTTGAACAGGTGCTCAAACAGGCGGACT
TTAGCTGA

Upstream 100 bases:

>100_bases
CGATGCGGCAACAGAAATCACGATTTCTAACCAGAGACAAAAATAAATTGTCGGCAACCCATTTGCCGGAAACAATGCAA
AGCATTTTGACGGAGGTTTC

Downstream 100 bases:

>100_bases
CCCATATACCGGGAGGCGGCCACAGGCCGCCTCCCGTACATGTTTTCATGCAACGAGGAACAGGAGAAACTGCCATGAGC
AGCAAACATGCGGCCGGTGC

Product: dihydrodipicolinate synthetase

Products: NA

Alternate protein names: DHDPS; Vegetative protein 81; VEG81 [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNSIHGIFAVTVTHFNNDGSIDYSAISKHVQWLLQSGVHGIMPVGATGEWPALSTQERKQVAEFVMKEVDGKVPVIVGAI
SPNVDVSVDLSEHAGSIGAAGVMILPPPGVHPSQHEIYEFYKYISGKSPLPVMVYNNPGSCGVAVSPETLGKCAQLPNMG
FLKESSGDIMRLTRSVDEVGDRLVVFCGCESLAYESFVMGARAWVCVLANIAPAMCVRLYDLIVNKGKLDEARQVYRQML
PLLRLLEDTGELWQVVKHALVLKGFGSGRLRMPRQPISEGVRLELEQVLKQADFS

Sequences:

>Translated_295_residues
MNSIHGIFAVTVTHFNNDGSIDYSAISKHVQWLLQSGVHGIMPVGATGEWPALSTQERKQVAEFVMKEVDGKVPVIVGAI
SPNVDVSVDLSEHAGSIGAAGVMILPPPGVHPSQHEIYEFYKYISGKSPLPVMVYNNPGSCGVAVSPETLGKCAQLPNMG
FLKESSGDIMRLTRSVDEVGDRLVVFCGCESLAYESFVMGARAWVCVLANIAPAMCVRLYDLIVNKGKLDEARQVYRQML
PLLRLLEDTGELWQVVKHALVLKGFGSGRLRMPRQPISEGVRLELEQVLKQADFS
>Mature_295_residues
MNSIHGIFAVTVTHFNNDGSIDYSAISKHVQWLLQSGVHGIMPVGATGEWPALSTQERKQVAEFVMKEVDGKVPVIVGAI
SPNVDVSVDLSEHAGSIGAAGVMILPPPGVHPSQHEIYEFYKYISGKSPLPVMVYNNPGSCGVAVSPETLGKCAQLPNMG
FLKESSGDIMRLTRSVDEVGDRLVVFCGCESLAYESFVMGARAWVCVLANIAPAMCVRLYDLIVNKGKLDEARQVYRQML
PLLRLLEDTGELWQVVKHALVLKGFGSGRLRMPRQPISEGVRLELEQVLKQADFS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=216, Percent_Identity=31.4814814814815, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI31543060, Length=295, Percent_Identity=24.0677966101695, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=26.8041237113402, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082415, Length=246, Percent_Identity=29.6747967479675, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786463, Length=279, Percent_Identity=25.8064516129032, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789620, Length=294, Percent_Identity=26.8707482993197, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32178; Mature: 32178

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIHGIFAVTVTHFNNDGSIDYSAISKHVQWLLQSGVHGIMPVGATGEWPALSTQERKQ
CCCCCEEEEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHH
VAEFVMKEVDGKVPVIVGAISPNVDVSVDLSEHAGSIGAAGVMILPPPGVHPSQHEIYEF
HHHHHHHHHCCCCCEEEEEECCCCEEEEEHHHHCCCCCCCCEEEECCCCCCCCHHHHHHH
YKYISGKSPLPVMVYNNPGSCGVAVSPETLGKCAQLPNMGFLKESSGDIMRLTRSVDEVG
HHHHCCCCCCEEEEECCCCCCCEEECHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHC
DRLVVFCGCESLAYESFVMGARAWVCVLANIAPAMCVRLYDLIVNKGKLDEARQVYRQML
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
PLLRLLEDTGELWQVVKHALVLKGFGSGRLRMPRQPISEGVRLELEQVLKQADFS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSIHGIFAVTVTHFNNDGSIDYSAISKHVQWLLQSGVHGIMPVGATGEWPALSTQERKQ
CCCCCEEEEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHH
VAEFVMKEVDGKVPVIVGAISPNVDVSVDLSEHAGSIGAAGVMILPPPGVHPSQHEIYEF
HHHHHHHHHCCCCCEEEEEECCCCEEEEEHHHHCCCCCCCCEEEECCCCCCCCHHHHHHH
YKYISGKSPLPVMVYNNPGSCGVAVSPETLGKCAQLPNMGFLKESSGDIMRLTRSVDEVG
HHHHCCCCCCEEEEECCCCCCCEEECHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHC
DRLVVFCGCESLAYESFVMGARAWVCVLANIAPAMCVRLYDLIVNKGKLDEARQVYRQML
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
PLLRLLEDTGELWQVVKHALVLKGFGSGRLRMPRQPISEGVRLELEQVLKQADFS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8098035; 9384377; 9298659 [H]