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The map label for this gene is uhpC [H]

Identifier: 220904948

GI number: 220904948

Start: 2027589

End: 2028857

Strand: Direct

Name: uhpC [H]

Synonym: Ddes_1684

Alternate gene names: 220904948

Gene position: 2027589-2028857 (Clockwise)

Preceding gene: 220904947

Following gene: 220904949

Centisome position: 70.56

GC content: 53.11

Gene sequence:

>1269_bases
ATGTTAGATTTTTTTAAAGCATCACCTCCGCGTCCGGTTACAAAGAACACTGAAGAGATCAACAGAGACTACAATTATTG
GCGACTGCACCTCATGGCGTCAATCTGGCTTGGATACGCCGTATTTTATTTTACGCGCAACAGCTACAAGTCCATCATGC
CGGCCATGCTCAAAGACCTTGACTGGCAACTTTCCGATGTGGGCATCCTGAGCACCATCTTCTATATCGTCTACGGTTCG
TCCCGCTTTCTGGGTGGCATTATCAGCGACAAATCCAATCCGCGCTACTTCATGGGCGTCGGACTTATCATCACGGGCTT
CATCAATATCGCCTTTGGCATGAGCTCTTCGCTGCCCGCCCTGGCTTTGCTGTGGGGCCTCAATGCCTTTTTTCAGGGAT
GGGGCTGGCCCCCCTGTACCAAGATTCTCACCACATGGTACTCGCACAACGTGGGTGGCGCCATTATTCCCCTGCTGGCA
GGCTGGCTGGCTATCCACTATGGCTGGCGCTACGGCATGATCGTGCCGGGGATCGTCGGCATCTTTGTAGGTATTATTCT
TTGCATCATACTGCGAGACCGGCCGGAATCAATGGGCCTGCCCAGAGTGGGAGAATGGCGTAAGGATCAACTGGAACTGG
AGCAGGTGAAAAAAAGCGAAAACTCGCTCACAACCTGGCAGGTACTGCGACGCTACGTGTTCACCAACAAGTTCATCTGG
CTGCTGGCAGTCTCATATGTGCTTGTTTATGTGGTGCGCATTGGCGTCAATGACTGGGCCAACATGTACCTGGTGAAGGA
ACACGGGGTTGACCTGCTTGTAGCCAACAGCGCCATCACCATGCTTGAAATAGGCGGTTTTATCGGAACCATTGCCGCGG
GCTGGGGTTCGGACAAGCTTTTCAAGGGCAACCGCATACCTATGAACATTATTTTCATGCTGGGCATCATGTTGTCGGTG
GGCGCTCTCTGGCTGCTGCCCCTGACTTCAAAGCTGGCGCTGGGTACGGTTTTCTTTCTCATAGGATTTTTCATTTTCGG
TCCCCAGATGCTCACGGGCATGGCTGCCGCTGAAGTCTGCCACAAGGAATACGCGGGCACAGCCACTGGCTTTGTAGGGC
TTTTCGGCTACATGGGCGCGGCGCTCACGGGCTTGCCACTGGCAATGATCATAGAATCAGCCAGCTGGAACGGGTTTTTC
ATTGTGATGACTGCAGCCTCACTACTCTCAGCGGTGCTCATCATCCCCATTATCGGCGGCAAGAAATAG

Upstream 100 bases:

>100_bases
TGCTCGCCAGCGGCGATAAAAGGCTGCACCAACAGGTTCTGCGTGAAATAGAAAAAAACCGCTAGCCGATGGCTCACCTG
TCACACTACGAGCACACGCC

Downstream 100 bases:

>100_bases
CAAAGGGCTGGCCTGCGCACTCTGGCTCGGCCGCGTCGCAGTGCCGACAGCATAAAAAGCTGCCCTGTATCTTGTTGCAA
CATGACGATGCGGCAACAGA

Product: major facilitator superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLDFFKASPPRPVTKNTEEINRDYNYWRLHLMASIWLGYAVFYFTRNSYKSIMPAMLKDLDWQLSDVGILSTIFYIVYGS
SRFLGGIISDKSNPRYFMGVGLIITGFINIAFGMSSSLPALALLWGLNAFFQGWGWPPCTKILTTWYSHNVGGAIIPLLA
GWLAIHYGWRYGMIVPGIVGIFVGIILCIILRDRPESMGLPRVGEWRKDQLELEQVKKSENSLTTWQVLRRYVFTNKFIW
LLAVSYVLVYVVRIGVNDWANMYLVKEHGVDLLVANSAITMLEIGGFIGTIAAGWGSDKLFKGNRIPMNIIFMLGIMLSV
GALWLLPLTSKLALGTVFFLIGFFIFGPQMLTGMAAAEVCHKEYAGTATGFVGLFGYMGAALTGLPLAMIIESASWNGFF
IVMTAASLLSAVLIIPIIGGKK

Sequences:

>Translated_422_residues
MLDFFKASPPRPVTKNTEEINRDYNYWRLHLMASIWLGYAVFYFTRNSYKSIMPAMLKDLDWQLSDVGILSTIFYIVYGS
SRFLGGIISDKSNPRYFMGVGLIITGFINIAFGMSSSLPALALLWGLNAFFQGWGWPPCTKILTTWYSHNVGGAIIPLLA
GWLAIHYGWRYGMIVPGIVGIFVGIILCIILRDRPESMGLPRVGEWRKDQLELEQVKKSENSLTTWQVLRRYVFTNKFIW
LLAVSYVLVYVVRIGVNDWANMYLVKEHGVDLLVANSAITMLEIGGFIGTIAAGWGSDKLFKGNRIPMNIIFMLGIMLSV
GALWLLPLTSKLALGTVFFLIGFFIFGPQMLTGMAAAEVCHKEYAGTATGFVGLFGYMGAALTGLPLAMIIESASWNGFF
IVMTAASLLSAVLIIPIIGGKK
>Mature_422_residues
MLDFFKASPPRPVTKNTEEINRDYNYWRLHLMASIWLGYAVFYFTRNSYKSIMPAMLKDLDWQLSDVGILSTIFYIVYGS
SRFLGGIISDKSNPRYFMGVGLIITGFINIAFGMSSSLPALALLWGLNAFFQGWGWPPCTKILTTWYSHNVGGAIIPLLA
GWLAIHYGWRYGMIVPGIVGIFVGIILCIILRDRPESMGLPRVGEWRKDQLELEQVKKSENSLTTWQVLRRYVFTNKFIW
LLAVSYVLVYVVRIGVNDWANMYLVKEHGVDLLVANSAITMLEIGGFIGTIAAGWGSDKLFKGNRIPMNIIFMLGIMLSV
GALWLLPLTSKLALGTVFFLIGFFIFGPQMLTGMAAAEVCHKEYAGTATGFVGLFGYMGAALTGLPLAMIIESASWNGFF
IVMTAASLLSAVLIIPIIGGKK

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=406, Percent_Identity=30.7881773399015, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4503847, Length=406, Percent_Identity=30.7881773399015, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI256219483, Length=406, Percent_Identity=30.7881773399015, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI256219543, Length=428, Percent_Identity=29.2056074766355, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI256219564, Length=337, Percent_Identity=32.0474777448071, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI46361976, Length=399, Percent_Identity=23.8095238095238, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082310, Length=435, Percent_Identity=54.9425287356322, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1788573, Length=445, Percent_Identity=33.0337078651685, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI2367259, Length=433, Percent_Identity=27.4826789838337, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17561094, Length=383, Percent_Identity=24.5430809399478, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17542316, Length=461, Percent_Identity=21.4750542299349, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI133901856, Length=439, Percent_Identity=21.6400911161731, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901854, Length=439, Percent_Identity=21.6400911161731, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133930953, Length=438, Percent_Identity=20.5479452054795, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17539138, Length=293, Percent_Identity=26.2798634812287, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24656866, Length=480, Percent_Identity=23.125, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45550478, Length=480, Percent_Identity=23.125, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24656861, Length=480, Percent_Identity=23.125, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46894; Mature: 46894

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFFKASPPRPVTKNTEEINRDYNYWRLHLMASIWLGYAVFYFTRNSYKSIMPAMLKDL
CCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DWQLSDVGILSTIFYIVYGSSRFLGGIISDKSNPRYFMGVGLIITGFINIAFGMSSSLPA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCHH
LALLWGLNAFFQGWGWPPCTKILTTWYSHNVGGAIIPLLAGWLAIHYGWRYGMIVPGIVG
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IFVGIILCIILRDRPESMGLPRVGEWRKDQLELEQVKKSENSLTTWQVLRRYVFTNKFIW
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LLAVSYVLVYVVRIGVNDWANMYLVKEHGVDLLVANSAITMLEIGGFIGTIAAGWGSDKL
HHHHHHHHHHHHHHCCCCHHCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCC
FKGNRIPMNIIFMLGIMLSVGALWLLPLTSKLALGTVFFLIGFFIFGPQMLTGMAAAEVC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKEYAGTATGFVGLFGYMGAALTGLPLAMIIESASWNGFFIVMTAASLLSAVLIIPIIGG
HHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCC
KK
CC
>Mature Secondary Structure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CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]