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The map label for this gene is hisN [H]

Identifier: 220904947

GI number: 220904947

Start: 2026759

End: 2027553

Strand: Direct

Name: hisN [H]

Synonym: Ddes_1683

Alternate gene names: 220904947

Gene position: 2026759-2027553 (Clockwise)

Preceding gene: 220904946

Following gene: 220904948

Centisome position: 70.53

GC content: 57.74

Gene sequence:

>795_bases
ATGCACGAGTATGACGCTTTTCTGGATGTGGCCATGCGTGCCGCAGACATTTCACGCCGGATACTGACAGAACACAGGCA
AAAGTATTTGTGCGGGGCCTATGGATTCAAAACAAAAAGCGACGCCAGCCCCGTGACGGAAACCGATGAACGGGTGGAGC
GCGAGATACGCTCGCTTGTTTCCGGAGCCTTTCCCGATCACGGCATGCTTGGCGAAGAATATGGAGCCGATGCGGCCACA
GCAGAATTTGTATGGGTTATCGACCCCATAGACGGAACCAGGCAATTCATCGCGGGCTATCCGTTTTACGGCACACTTAT
AGCCCTCTGCCGCAACGGCGTGCCGGTGCTCGGCGTCGTGGAAATGCCGGTCATGGCTGAGCGATGGGTGGGAGTGCAGG
GGCGTCAGTCCACAGTCAACGGCCTGCCCATCCGCACCCGCCCACAGACCGACCTGCCTGCTGCTCTGGCAGCCTCAAGC
AATACAGAGTTTGTTTTTGATACTGACAGGGCAGCCTACCAGCGCCTGGTGGCAGCGACCAAGTGGCGCGTCTACGGCGG
GGCCTGTTACGGTTACATGAGCCTTGCCGCAGGCAAAATAGACCTGTGCTTTGACAGCGGCATCATGCAAGAAGTGGATT
ACTGTGCCCTTGTACCCATTGTGGAAGGAGCCGGCGGCGTCATGTCTGACTGGGACGGCAGGCCGCTGACCATGCACTCG
GGAATGCAGGTGCTCGCCAGCGGCGATAAAAGGCTGCACCAACAGGTTCTGCGTGAAATAGAAAAAAACCGCTAG

Upstream 100 bases:

>100_bases
CGTTTCTTCTGCGGGGCAGCAGCACAACAGCACGGAGATCTGGTACGGCATTTCTTGAGGGTACGTGCGCTGCCTACAAC
CTCAAACATCGGAGAAACTG

Downstream 100 bases:

>100_bases
CCGATGGCTCACCTGTCACACTACGAGCACACGCCATGTTAGATTTTTTTAAAGCATCACCTCCGCGTCCGGTTACAAAG
AACACTGAAGAGATCAACAG

Product: Inositol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MHEYDAFLDVAMRAADISRRILTEHRQKYLCGAYGFKTKSDASPVTETDERVEREIRSLVSGAFPDHGMLGEEYGADAAT
AEFVWVIDPIDGTRQFIAGYPFYGTLIALCRNGVPVLGVVEMPVMAERWVGVQGRQSTVNGLPIRTRPQTDLPAALAASS
NTEFVFDTDRAAYQRLVAATKWRVYGGACYGYMSLAAGKIDLCFDSGIMQEVDYCALVPIVEGAGGVMSDWDGRPLTMHS
GMQVLASGDKRLHQQVLREIEKNR

Sequences:

>Translated_264_residues
MHEYDAFLDVAMRAADISRRILTEHRQKYLCGAYGFKTKSDASPVTETDERVEREIRSLVSGAFPDHGMLGEEYGADAAT
AEFVWVIDPIDGTRQFIAGYPFYGTLIALCRNGVPVLGVVEMPVMAERWVGVQGRQSTVNGLPIRTRPQTDLPAALAASS
NTEFVFDTDRAAYQRLVAATKWRVYGGACYGYMSLAAGKIDLCFDSGIMQEVDYCALVPIVEGAGGVMSDWDGRPLTMHS
GMQVLASGDKRLHQQVLREIEKNR
>Mature_264_residues
MHEYDAFLDVAMRAADISRRILTEHRQKYLCGAYGFKTKSDASPVTETDERVEREIRSLVSGAFPDHGMLGEEYGADAAT
AEFVWVIDPIDGTRQFIAGYPFYGTLIALCRNGVPVLGVVEMPVMAERWVGVQGRQSTVNGLPIRTRPQTDLPAALAASS
NTEFVFDTDRAAYQRLVAATKWRVYGGACYGYMSLAAGKIDLCFDSGIMQEVDYCALVPIVEGAGGVMSDWDGRPLTMHS
GMQVLASGDKRLHQQVLREIEKNR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=277, Percent_Identity=29.6028880866426, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI5031789, Length=227, Percent_Identity=28.6343612334802, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI221625487, Length=227, Percent_Identity=28.6343612334802, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1788882, Length=258, Percent_Identity=28.2945736434109, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193202572, Length=229, Percent_Identity=28.82096069869, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193202570, Length=227, Percent_Identity=29.5154185022026, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=204, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357329, Length=267, Percent_Identity=30.3370786516854, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21357303, Length=216, Percent_Identity=31.4814814814815, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664926, Length=167, Percent_Identity=29.3413173652695, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664922, Length=271, Percent_Identity=26.9372693726937, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 29112; Mature: 29112

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEYDAFLDVAMRAADISRRILTEHRQKYLCGAYGFKTKSDASPVTETDERVEREIRSLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
SGAFPDHGMLGEEYGADAATAEFVWVIDPIDGTRQFIAGYPFYGTLIALCRNGVPVLGVV
HCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCEEEEE
EMPVMAERWVGVQGRQSTVNGLPIRTRPQTDLPAALAASSNTEFVFDTDRAAYQRLVAAT
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCHHHHHHHHHHH
KWRVYGGACYGYMSLAAGKIDLCFDSGIMQEVDYCALVPIVEGAGGVMSDWDGRPLTMHS
HHEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHEEEEHHCCCCCCCCCCCCCEEEHHC
GMQVLASGDKRLHQQVLREIEKNR
CHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHEYDAFLDVAMRAADISRRILTEHRQKYLCGAYGFKTKSDASPVTETDERVEREIRSLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
SGAFPDHGMLGEEYGADAATAEFVWVIDPIDGTRQFIAGYPFYGTLIALCRNGVPVLGVV
HCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCEEEEE
EMPVMAERWVGVQGRQSTVNGLPIRTRPQTDLPAALAASSNTEFVFDTDRAAYQRLVAAT
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEECCHHHHHHHHHHH
KWRVYGGACYGYMSLAAGKIDLCFDSGIMQEVDYCALVPIVEGAGGVMSDWDGRPLTMHS
HHEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHEEEEHHCCCCCCCCCCCCCEEEHHC
GMQVLASGDKRLHQQVLREIEKNR
CHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]