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The map label for this gene is pmpM [H]

Identifier: 220904862

GI number: 220904862

Start: 1919650

End: 1920966

Strand: Direct

Name: pmpM [H]

Synonym: Ddes_1596

Alternate gene names: 220904862

Gene position: 1919650-1920966 (Clockwise)

Preceding gene: 220904861

Following gene: 220904863

Centisome position: 66.81

GC content: 61.66

Gene sequence:

>1317_bases
ATGCTCATGATGTACCTTGTGTTCTTCATGGGTTTTGTGGCCGTATGGGTAGCGGGACAAATAAGCGCCGAAGTACAGGC
CGCCCTGGGCATGGTCAACCAGTGCGGCATCTTTCTCATGGTGGTTGCCATGGCCATTTCCAGCGGAGCCACCGCCGCCG
TGAGCCAGTCGCTGGGCGCACTCAAGGTGGCTCGCGCGCAGCGCTATGTGGCAACCACGGTCATAGGCTGCTTTGGCCTT
GGCTTTGTCATGGCCCTGCTGGGCTGGCGCTTTGGCGATGCCATTCTGGGCATGCTCATGGTTCCGGACAGCATCATGCC
TGTGACAAAAGAACTCTGGCAGGTCAGCATGCTGGCCCTGCCCGCCCAATACGTATACGCTGCCACGGGCGTCATGTTTC
GCGCTACGCGCCAGGTCATTCCGCCGTTATGGGTGGCGGCCGTGGTGTGCGCAGCCAATCTGCTGGCCTGTCTCGGCTTC
GGCCTGGGCTGGTTCGGGCTGCCCAACTGGGGTTACATGGGCCTTGCATGGGCCACGGTGGGCGCACAATGCCTCGGTGC
GGTATGCAACTGCGCCCTGCTTGCCCATTCGGGCTACCTGCAACGCCGCACCCTGCCTACCCCCCGCTGGCTCAAGGCTG
GCCTGCCCTATCTTGTCAAGGTGGCCCTGCCCGCAGGAGCCGCGCAGATCGTCTGGCAGTCCGGCTACCTGACCCTTTTC
GTACTGGTAGCCTCATTGCCTTTTGACAGCGTGAACGCCCTGGCCGGACTTACCGCCGGCCTGCGGGTCGAAGCGCTTCT
TTTTTTGCCGGGCATGGCCTTTAACATGAGTGTCGCCGTGCTTGTAGGCAACAGCCTTGGCGCGGGCAAGCCCGCCGAAG
CCAAGAAAGTTGCCCTGTTTATGGTCGGCGCGGCTGCCCTGGCCATGAGCCTTATGGCAGCCCTGCTCTGGCCGTTCAGG
CAGGAGATCGCCCTTATGCTTTCACAGGAGCCTGGCACACAGGCCCAGATTGTGAATTACCTGACCTTTAACCTGCTTTC
CACGCCCTTTTCCATTGCCAGCACCGTCATGGGCGGCGTAATGACCGGGGCGGGAGCTACCAAGTACAATCTGATGATTT
TTGGCGGCACCTTCTGGCTGGTGCGCCTTCCCCTGGGCTGGCTGCTCGGACATATGCTGTGGGGTACGGCCTCGGGCGTT
TTTGTGGCCATGCTCGTTTCCCAATGCCTGCAGACCAGCATCATGCTTTACGTGGTGCTGCGCCGCGACTGGATGCGCTT
TGCCATGAGCAGGATCCGCCAGCCGCACCCTGCCTGA

Upstream 100 bases:

>100_bases
TGCCGTGATCGAACAACGCGGCCTGTCCGCTCCTCAGCTTCGGCCAACCCCCGACCTGAGCACCTCACCCCGCGCCGTAT
GGCGTCTCACATGGCCCCAG

Downstream 100 bases:

>100_bases
CGGCCCGCAGAACCCTTGTGCTTTCCGCGCGGGCCTTTCCAAGGAGAACAACCGTGAGTAAAAAATTCATTCCCGTAAGC
CTGGACGACAGCCAGCGCTA

Product: MATE efflux family protein

Products: NA

Alternate protein names: H(+)/drug antiporter; Multidrug-efflux transporter [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLMMYLVFFMGFVAVWVAGQISAEVQAALGMVNQCGIFLMVVAMAISSGATAAVSQSLGALKVARAQRYVATTVIGCFGL
GFVMALLGWRFGDAILGMLMVPDSIMPVTKELWQVSMLALPAQYVYAATGVMFRATRQVIPPLWVAAVVCAANLLACLGF
GLGWFGLPNWGYMGLAWATVGAQCLGAVCNCALLAHSGYLQRRTLPTPRWLKAGLPYLVKVALPAGAAQIVWQSGYLTLF
VLVASLPFDSVNALAGLTAGLRVEALLFLPGMAFNMSVAVLVGNSLGAGKPAEAKKVALFMVGAAALAMSLMAALLWPFR
QEIALMLSQEPGTQAQIVNYLTFNLLSTPFSIASTVMGGVMTGAGATKYNLMIFGGTFWLVRLPLGWLLGHMLWGTASGV
FVAMLVSQCLQTSIMLYVVLRRDWMRFAMSRIRQPHPA

Sequences:

>Translated_438_residues
MLMMYLVFFMGFVAVWVAGQISAEVQAALGMVNQCGIFLMVVAMAISSGATAAVSQSLGALKVARAQRYVATTVIGCFGL
GFVMALLGWRFGDAILGMLMVPDSIMPVTKELWQVSMLALPAQYVYAATGVMFRATRQVIPPLWVAAVVCAANLLACLGF
GLGWFGLPNWGYMGLAWATVGAQCLGAVCNCALLAHSGYLQRRTLPTPRWLKAGLPYLVKVALPAGAAQIVWQSGYLTLF
VLVASLPFDSVNALAGLTAGLRVEALLFLPGMAFNMSVAVLVGNSLGAGKPAEAKKVALFMVGAAALAMSLMAALLWPFR
QEIALMLSQEPGTQAQIVNYLTFNLLSTPFSIASTVMGGVMTGAGATKYNLMIFGGTFWLVRLPLGWLLGHMLWGTASGV
FVAMLVSQCLQTSIMLYVVLRRDWMRFAMSRIRQPHPA
>Mature_438_residues
MLMMYLVFFMGFVAVWVAGQISAEVQAALGMVNQCGIFLMVVAMAISSGATAAVSQSLGALKVARAQRYVATTVIGCFGL
GFVMALLGWRFGDAILGMLMVPDSIMPVTKELWQVSMLALPAQYVYAATGVMFRATRQVIPPLWVAAVVCAANLLACLGF
GLGWFGLPNWGYMGLAWATVGAQCLGAVCNCALLAHSGYLQRRTLPTPRWLKAGLPYLVKVALPAGAAQIVWQSGYLTLF
VLVASLPFDSVNALAGLTAGLRVEALLFLPGMAFNMSVAVLVGNSLGAGKPAEAKKVALFMVGAAALAMSLMAALLWPFR
QEIALMLSQEPGTQAQIVNYLTFNLLSTPFSIASTVMGGVMTGAGATKYNLMIFGGTFWLVRLPLGWLLGHMLWGTASGV
FVAMLVSQCLQTSIMLYVVLRRDWMRFAMSRIRQPHPA

Specific function: Multidrug efflux pump that functions as an H(+)/drug antiporter. Confers resistance to benzalkonium chloride, fluoroquinolones, ethidium bromide, acriflavine and tetraphenylphosphonium chloride [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=438, Percent_Identity=21.4611872146119, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 46792; Mature: 46792

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]