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The map label for this gene is lysA [H]

Identifier: 220904861

GI number: 220904861

Start: 1918085

End: 1919362

Strand: Direct

Name: lysA [H]

Synonym: Ddes_1595

Alternate gene names: 220904861

Gene position: 1918085-1919362 (Clockwise)

Preceding gene: 220904847

Following gene: 220904862

Centisome position: 66.75

GC content: 58.45

Gene sequence:

>1278_bases
ATGTCCGACATCCGCTCCAGCTACACTGACCAGCTCCAGTTTTACGGCCGTCATACCCCGCGCGAACTGGCCGAAACCTT
CGGCACTCCCCTCTATGTCTATAACGAAAACGTCCTGCGCCAGCGCTGCCGAGACCTCATGGGCCTTTCAAGCCATCCCG
GCTTCGGGGTCAACTATTCCGTCAAGGCCAATTCCAATCCCGTGCTGCTGCGCATGGCGCGCGAAGAAGGCCTGGTAGTA
GACGCCATGAGTCCCGGCGAGCTGCACATGGACCTGCTTGCCGGATTTACGCCCGGGCAGATTCTTTATATCTCCAATAA
CAATTCTGTGGAAGAACTACAGAATGCCCTCAAGCACGGGCTGCTCATCAGCGTGGACTCCGTCGCGCAACTGGACGATC
TCGGCCGTATCAACAAGGGCGGCAAGGTCATGATTCGCTTCAACCCCGGCATTGGCGCAGGGCATCACGCCAAGGTCGTC
ACTGCGGGCAAGGAAACCAAGTTCGGTGTCAATCCAGAACAGATGGACGACGTTTTTGCCCTGCTGCAAAAGCACGACAT
GACACTGGCGGGCATAAACCAGCACATCGGCTCCCTGTTTATGGAGGCCGGAGGCTACCTGGATGCAGCCGAGGTGTTGC
TGCGCCTGGCAGAACAACTGCCCCAGGGCGCGCTGCAACACCTTGAAATCATCGACTTCGGCGGCGGCTTCGGCATCCCA
TACCGCAAGTATGAAGGCCAGCCCCGCCTGGATACAGGCGAACTGGGCAGCCGCCTGCACGCACTCATCAGCGCATGGGC
CAAAAAAACAGGCTATACGGGCCGCTTTCTCATTGAGCCGGGCCGCTACGTGGCTGCCGAATGCGGTGTGCTGCTGGGCC
GCGTGCACGCCGTGAAGAACAACAGCGAAAAGCGCTATGCGGGTACGGACCTTGGCTTCAATGTGCTTGTGCGCCCGGCC
ATGTACGATTCTTTCCACGATGTGGAAATCTACGGCGAAAACAGTCACGAAAAGCGTGAAACCATGGTGCAGACCGTGGT
GGGAAATATCTGCGAAAGCGGCGACATCCTGGCCAAAGACCGTGAATTGCCGGAAATTGTGGAAGGCGATGTGCTCGGCA
TACTTGACGCCGGCGCATATGGCTTTACCATGAGTTCCAACTATAATCAGCGCCTCCGCCCGGCGGAAGTGCTGATTCAG
AGTGACGGCACGGCACGGCTCATCCGCCGGCGCGAATCGCCTGACGATCTGGCCCGCTGCCTTGAAGGGCTTATATAG

Upstream 100 bases:

>100_bases
AGCGTACACCATGACCACGATAATTGTTACTTACCCAAAACGTAGATTGCCGCCCCGCGCGGGCACACCAGAAATTTTTT
GAGGCATCCCCGAGGTACCC

Downstream 100 bases:

>100_bases
GCGCGGTCGCGCGAGATGAAACCCCGGTTCCCTGCCGGGACGCGGCATACCGCCCAAGGATACGACGCACCCCTGCGCAC
CCCGAGCGAACCTGCCGCTG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSDIRSSYTDQLQFYGRHTPRELAETFGTPLYVYNENVLRQRCRDLMGLSSHPGFGVNYSVKANSNPVLLRMAREEGLVV
DAMSPGELHMDLLAGFTPGQILYISNNNSVEELQNALKHGLLISVDSVAQLDDLGRINKGGKVMIRFNPGIGAGHHAKVV
TAGKETKFGVNPEQMDDVFALLQKHDMTLAGINQHIGSLFMEAGGYLDAAEVLLRLAEQLPQGALQHLEIIDFGGGFGIP
YRKYEGQPRLDTGELGSRLHALISAWAKKTGYTGRFLIEPGRYVAAECGVLLGRVHAVKNNSEKRYAGTDLGFNVLVRPA
MYDSFHDVEIYGENSHEKRETMVQTVVGNICESGDILAKDRELPEIVEGDVLGILDAGAYGFTMSSNYNQRLRPAEVLIQ
SDGTARLIRRRESPDDLARCLEGLI

Sequences:

>Translated_425_residues
MSDIRSSYTDQLQFYGRHTPRELAETFGTPLYVYNENVLRQRCRDLMGLSSHPGFGVNYSVKANSNPVLLRMAREEGLVV
DAMSPGELHMDLLAGFTPGQILYISNNNSVEELQNALKHGLLISVDSVAQLDDLGRINKGGKVMIRFNPGIGAGHHAKVV
TAGKETKFGVNPEQMDDVFALLQKHDMTLAGINQHIGSLFMEAGGYLDAAEVLLRLAEQLPQGALQHLEIIDFGGGFGIP
YRKYEGQPRLDTGELGSRLHALISAWAKKTGYTGRFLIEPGRYVAAECGVLLGRVHAVKNNSEKRYAGTDLGFNVLVRPA
MYDSFHDVEIYGENSHEKRETMVQTVVGNICESGDILAKDRELPEIVEGDVLGILDAGAYGFTMSSNYNQRLRPAEVLIQ
SDGTARLIRRRESPDDLARCLEGLI
>Mature_424_residues
SDIRSSYTDQLQFYGRHTPRELAETFGTPLYVYNENVLRQRCRDLMGLSSHPGFGVNYSVKANSNPVLLRMAREEGLVVD
AMSPGELHMDLLAGFTPGQILYISNNNSVEELQNALKHGLLISVDSVAQLDDLGRINKGGKVMIRFNPGIGAGHHAKVVT
AGKETKFGVNPEQMDDVFALLQKHDMTLAGINQHIGSLFMEAGGYLDAAEVLLRLAEQLPQGALQHLEIIDFGGGFGIPY
RKYEGQPRLDTGELGSRLHALISAWAKKTGYTGRFLIEPGRYVAAECGVLLGRVHAVKNNSEKRYAGTDLGFNVLVRPAM
YDSFHDVEIYGENSHEKRETMVQTVVGNICESGDILAKDRELPEIVEGDVLGILDAGAYGFTMSSNYNQRLRPAEVLIQS
DGTARLIRRRESPDDLARCLEGLI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=404, Percent_Identity=34.4059405940594, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17562780, Length=372, Percent_Identity=21.505376344086, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46821; Mature: 46690

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIRSSYTDQLQFYGRHTPRELAETFGTPLYVYNENVLRQRCRDLMGLSSHPGFGVNYS
CCCHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEE
VKANSNPVLLRMAREEGLVVDAMSPGELHMDLLAGFTPGQILYISNNNSVEELQNALKHG
EECCCCCEEEEEECCCCEEEEECCCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCC
LLISVDSVAQLDDLGRINKGGKVMIRFNPGIGAGHHAKVVTAGKETKFGVNPEQMDDVFA
EEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
LLQKHDMTLAGINQHIGSLFMEAGGYLDAAEVLLRLAEQLPQGALQHLEIIDFGGGFGIP
HHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHEEEEECCCCCCCC
YRKYEGQPRLDTGELGSRLHALISAWAKKTGYTGRFLIEPGRYVAAECGVLLGRVHAVKN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCC
NSEKRYAGTDLGFNVLVRPAMYDSFHDVEIYGENSHEKRETMVQTVVGNICESGDILAKD
CCCCEECCCCCCCCEEECHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEECC
RELPEIVEGDVLGILDAGAYGFTMSSNYNQRLRPAEVLIQSDGTARLIRRRESPDDLARC
CCCHHHHCCCEEEEEECCCCEEEECCCCCCCCCHHHEEEECCCHHHHHHCCCCHHHHHHH
LEGLI
HHHCC
>Mature Secondary Structure 
SDIRSSYTDQLQFYGRHTPRELAETFGTPLYVYNENVLRQRCRDLMGLSSHPGFGVNYS
CCHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEE
VKANSNPVLLRMAREEGLVVDAMSPGELHMDLLAGFTPGQILYISNNNSVEELQNALKHG
EECCCCCEEEEEECCCCEEEEECCCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCC
LLISVDSVAQLDDLGRINKGGKVMIRFNPGIGAGHHAKVVTAGKETKFGVNPEQMDDVFA
EEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
LLQKHDMTLAGINQHIGSLFMEAGGYLDAAEVLLRLAEQLPQGALQHLEIIDFGGGFGIP
HHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHEEEEECCCCCCCC
YRKYEGQPRLDTGELGSRLHALISAWAKKTGYTGRFLIEPGRYVAAECGVLLGRVHAVKN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCC
NSEKRYAGTDLGFNVLVRPAMYDSFHDVEIYGENSHEKRETMVQTVVGNICESGDILAKD
CCCCEECCCCCCCCEEECHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEECC
RELPEIVEGDVLGILDAGAYGFTMSSNYNQRLRPAEVLIQSDGTARLIRRRESPDDLARC
CCCHHHHCCCEEEEEECCCCEEEECCCCCCCCCHHHEEEECCCHHHHHHCCCCHHHHHHH
LEGLI
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]