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The map label for this gene is frdB [H]

Identifier: 220904800

GI number: 220904800

Start: 1829606

End: 1830391

Strand: Direct

Name: frdB [H]

Synonym: Ddes_1532

Alternate gene names: 220904800

Gene position: 1829606-1830391 (Clockwise)

Preceding gene: 220904799

Following gene: 220904801

Centisome position: 63.67

GC content: 57.12

Gene sequence:

>786_bases
ATGGGACGTAATCTTACATTTGAAATCTTCCGTTACAATCCGCTGGACCCTCGCTCATTCCCGCATATGCAGACATTCCA
GCTTGAAGAGCACCCCAGCATGACGCTCTTTATCGCGCTGAACCTCATACGCGAAAAGTTTGATGCTTCCCTGCAGTTTG
ACTTCTGCTGCCGGGCGGGCATCTGCGGTTCCTGCGGCATGGTCATCAACGGGCGCCCGGGGCTGGCCTGCCACACGCAA
ACCAGCGATCTGCCGGACCATATCACCCTGCACCCCCTGCCGGTTTTCAAGCTGCTCGGCGACCTCTCGGTAGACACGGG
CACGTGGTTTCGCCAGGTGGGCAAAAAAATCGAATCGTGGATACACACCAATAAAGAGTTTGATCCGGATGCCCAGGAAG
AGCGCATGAGCAACAGCCAGGCTACGGAAATATTTGAACTGGACAGATGTATTGAGTGCGGTTGCTGCGTAGCCGCCTGC
GGTACAGCCCGCATGCGGGAAGACTTTATAGGGGCCACAGCCATCAACCGCATGGCGCGCTTCTATATCGACCCGCGTGA
CAACCGTACTCCTGCGGATTATTATGAACTTATAGGCGATGATAACGGCGTGTTCGGCTGCATGGGCCTGCTGGCCTGCG
ACAGCGTCTGCCCCAAGCAACTGCCCCTGCAAGACCAGCTCGGCATCATGCGGCGTATGGTCAGCATGGAGTCGGTGAGG
GGCATCCTGCCCGAAGCTCTGCGCAAAAAAATGCAGGGCTGCGGTTGCGGTTGCGCCAAAGGCTGA

Upstream 100 bases:

>100_bases
CCCCCGGCGACCGGGGTTACGGCGGCGGCAAGATCATTCCCGGCGACATCAAGGAAGACCAGATCGTTCCTTACGATCAG
AAAGGCTAAGGGAGGGTACC

Downstream 100 bases:

>100_bases
ACCACCGGCATATAGGGTTCAGGCCCGGAACCTGCTGTTCCGGGCCTGAACCGCATACGTCCTGAATGATCTGCCCGGCG
GAGAAAAGCCTCATCCGCCA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MGRNLTFEIFRYNPLDPRSFPHMQTFQLEEHPSMTLFIALNLIREKFDASLQFDFCCRAGICGSCGMVINGRPGLACHTQ
TSDLPDHITLHPLPVFKLLGDLSVDTGTWFRQVGKKIESWIHTNKEFDPDAQEERMSNSQATEIFELDRCIECGCCVAAC
GTARMREDFIGATAINRMARFYIDPRDNRTPADYYELIGDDNGVFGCMGLLACDSVCPKQLPLQDQLGIMRRMVSMESVR
GILPEALRKKMQGCGCGCAKG

Sequences:

>Translated_261_residues
MGRNLTFEIFRYNPLDPRSFPHMQTFQLEEHPSMTLFIALNLIREKFDASLQFDFCCRAGICGSCGMVINGRPGLACHTQ
TSDLPDHITLHPLPVFKLLGDLSVDTGTWFRQVGKKIESWIHTNKEFDPDAQEERMSNSQATEIFELDRCIECGCCVAAC
GTARMREDFIGATAINRMARFYIDPRDNRTPADYYELIGDDNGVFGCMGLLACDSVCPKQLPLQDQLGIMRRMVSMESVR
GILPEALRKKMQGCGCGCAKG
>Mature_260_residues
GRNLTFEIFRYNPLDPRSFPHMQTFQLEEHPSMTLFIALNLIREKFDASLQFDFCCRAGICGSCGMVINGRPGLACHTQT
SDLPDHITLHPLPVFKLLGDLSVDTGTWFRQVGKKIESWIHTNKEFDPDAQEERMSNSQATEIFELDRCIECGCCVAACG
TARMREDFIGATAINRMARFYIDPRDNRTPADYYELIGDDNGVFGCMGLLACDSVCPKQLPLQDQLGIMRRMVSMESVRG
ILPEALRKKMQGCGCGCAKG

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=29.3103448275862, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=37.2881355932203, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790596, Length=219, Percent_Identity=32.4200913242009, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17533915, Length=237, Percent_Identity=29.1139240506329, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322987, Length=219, Percent_Identity=29.6803652968037, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17137106, Length=239, Percent_Identity=28.0334728033473, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24643156, Length=221, Percent_Identity=29.4117647058824, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 29281; Mature: 29150

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00197 2FE2S_FER_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
10.7 %Cys+Met (Translated Protein)
6.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
10.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRNLTFEIFRYNPLDPRSFPHMQTFQLEEHPSMTLFIALNLIREKFDASLQFDFCCRAG
CCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHCCCCEEHHHHCCC
ICGSCGMVINGRPGLACHTQTSDLPDHITLHPLPVFKLLGDLSVDTGTWFRQVGKKIESW
CCCCCCEEEECCCCCEEECCCCCCCCCEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
IHTNKEFDPDAQEERMSNSQATEIFELDRCIECGCCVAACGTARMREDFIGATAINRMAR
HHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
FYIDPRDNRTPADYYELIGDDNGVFGCMGLLACDSVCPKQLPLQDQLGIMRRMVSMESVR
HEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
GILPEALRKKMQGCGCGCAKG
HHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GRNLTFEIFRYNPLDPRSFPHMQTFQLEEHPSMTLFIALNLIREKFDASLQFDFCCRAG
CCCEEEEEEEECCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHCCCCEEHHHHCCC
ICGSCGMVINGRPGLACHTQTSDLPDHITLHPLPVFKLLGDLSVDTGTWFRQVGKKIESW
CCCCCCEEEECCCCCEEECCCCCCCCCEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
IHTNKEFDPDAQEERMSNSQATEIFELDRCIECGCCVAACGTARMREDFIGATAINRMAR
HHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
FYIDPRDNRTPADYYELIGDDNGVFGCMGLLACDSVCPKQLPLQDQLGIMRRMVSMESVR
HEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
GILPEALRKKMQGCGCGCAKG
HHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]