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The map label for this gene is frdA [H]

Identifier: 220904799

GI number: 220904799

Start: 1827738

End: 1829594

Strand: Direct

Name: frdA [H]

Synonym: Ddes_1531

Alternate gene names: 220904799

Gene position: 1827738-1829594 (Clockwise)

Preceding gene: 220904798

Following gene: 220904800

Centisome position: 63.61

GC content: 59.24

Gene sequence:

>1857_bases
ATGCGTATTTTTGAATGTGACGTCTTGTGCATCGGCGCTGGTCTGGCCGGGGAACGTGTGGCGGTTGAAGCGGCTCAGGC
CGGCTTCAGGGTTATCTGTCTTTCCGTTGTGCCTCCCAAGCGTTCGCACTCTTCAGCGGCAATGGGCGGCATGCAGGCGG
CCCTGGGCAACTCCATAATGGGCGAAGGCGACTGCCCCGAAATCCATTTCAATGACACCGTTAAAGGCTCTGACTGGGGC
TGTGACCAGGAAGTGGCGCGGCTTTTTGCCGAGACCGGCCCCATAGCCATGCGTGAAATGGCCTGGATGGGGGTACCCTG
GAGCCGCGTTGTTCCGGGTGAGCATACTTATTACAAGGGCGGCAAGCCCTTTCAGGCCACAGAAAAAAAGGAAAATGAAG
GGCTGATCCATTCCCGCGCCTTTGGCGGCACAGCCAAATGGCGCACCTGCTACACCTCAGACGGCACAGGTCATGCTGTA
CTGTTTACTCTGGACAACCGCCTGTTGCAGCTTGGCGTGGACGTACACGACCGCACCCAGGCCGAAGGGCTTGTACACGA
CGGCCAGCGCTGCATGGGCTGCGTGGCGCGCGACCTGCGCACCGGAGAACTTGTAGGCTACTTCGCCAAGGCAACCCTTA
TTGCTACCGGCGGTTACGGCCGCATTTACCGGGCCACCACCAACGCCATCATCTGCGATGGCGGCGGCCAGATAGCCGCC
CTGGAAACAGGCGTGGTCCCTCTGGGCAATATGGAGGCAGTGCAGTTTCATCCCACGGGAACGGTGCCCACAGACATTCT
GGTTACCGAAGGCTGCCGAGGCGATGGCGGAACCCTGCTGGACGTAAATGAATACCGCTTCATGCCCGACTATGAGCCGG
AAAAGGCTGAACTGGCCTCGCGCGACGTGGTTGCACGCCGCATGACCGAACATATGCGCAAGGGTCTTGGCGTCAAAAGC
CCGTATGGCGATCACCTCTGGCTGGACATCCGCCACCTGGGCGAAAAGCACATTACCACGAACCTGCGTGAGGTATACGA
CATCTCCACGCACTTCCTTGGCGTGAACCCCATACATCAGCTCATTCCGGTACGTCCCACCCACCATTACAGCATGGGCG
GTGTGCGTATCAATAAAGATGGGCACGCTTACGGCCTTGAGGGCCTGTTCTCCGCCGGAGAAGCCGCCTGCTGGGATATG
CACGGCTTCAACCGCCTGGGCGGCAACTCCCTGGCCGAAACCATTGTTTCCGGGCGCATCGTGGGTCAGAAGCTGGTGGA
ATTCCTCAAGGGTTATGAAACCGTCTTTTCCACGGCCGAGATGACTGCGGCCGCCACAAAGGTAAAAGACCGCATCGCCG
CCCTTCTGCGCGGCACAGGTGATGACTGTTACACCCTGCGTAATGAAATGCAGGATGTCATGATGGAACACGTGGGTATT
TTCCGTAACGGCAAAGATCTGGAAGCCGGCGTGACCAAGCTGCAAGACCTGCTGGAGCGTTGCGGTAACATGCGCCTGGC
AAGCGGCAACATACCCGGCCCCAATGCCGAACTTTCCATGGCGTTGCGGGTTCCCGGCATGCTCAAACTGGCCCTGTGCA
CGGCATACGGCGCGCTTATGCGCACAGAAAGCCGCGGTGCTCACGCCCGTGAAGACTACCCTGAACGCAATGACAAGGAC
TGGCTCAACCGCACCCTGGCCTACTGGAAGGAAGGCGACAGCCTGCCCACGCTCAAATATGAACCGGCTACGCCGTACTA
TATTCTGCCCCCCGGCGACCGGGGTTACGGCGGCGGCAAGATCATTCCCGGCGACATCAAGGAAGACCAGATCGTTCCTT
ACGATCAGAAAGGCTAA

Upstream 100 bases:

>100_bases
CCTGCGTGGCGCAAGTGGATATGGATTGTTATGGGCTGTTATCTTTTGCTTGGAACGCTGGCTCTGACCCGCGTCTGGTT
CCTGGGATAGGGGGTGCCGT

Downstream 100 bases:

>100_bases
GGGAGGGTACCATGGGACGTAATCTTACATTTGAAATCTTCCGTTACAATCCGCTGGACCCTCGCTCATTCCCGCATATG
CAGACATTCCAGCTTGAAGA

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MRIFECDVLCIGAGLAGERVAVEAAQAGFRVICLSVVPPKRSHSSAAMGGMQAALGNSIMGEGDCPEIHFNDTVKGSDWG
CDQEVARLFAETGPIAMREMAWMGVPWSRVVPGEHTYYKGGKPFQATEKKENEGLIHSRAFGGTAKWRTCYTSDGTGHAV
LFTLDNRLLQLGVDVHDRTQAEGLVHDGQRCMGCVARDLRTGELVGYFAKATLIATGGYGRIYRATTNAIICDGGGQIAA
LETGVVPLGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELASRDVVARRMTEHMRKGLGVKS
PYGDHLWLDIRHLGEKHITTNLREVYDISTHFLGVNPIHQLIPVRPTHHYSMGGVRINKDGHAYGLEGLFSAGEAACWDM
HGFNRLGGNSLAETIVSGRIVGQKLVEFLKGYETVFSTAEMTAAATKVKDRIAALLRGTGDDCYTLRNEMQDVMMEHVGI
FRNGKDLEAGVTKLQDLLERCGNMRLASGNIPGPNAELSMALRVPGMLKLALCTAYGALMRTESRGAHAREDYPERNDKD
WLNRTLAYWKEGDSLPTLKYEPATPYYILPPGDRGYGGGKIIPGDIKEDQIVPYDQKG

Sequences:

>Translated_618_residues
MRIFECDVLCIGAGLAGERVAVEAAQAGFRVICLSVVPPKRSHSSAAMGGMQAALGNSIMGEGDCPEIHFNDTVKGSDWG
CDQEVARLFAETGPIAMREMAWMGVPWSRVVPGEHTYYKGGKPFQATEKKENEGLIHSRAFGGTAKWRTCYTSDGTGHAV
LFTLDNRLLQLGVDVHDRTQAEGLVHDGQRCMGCVARDLRTGELVGYFAKATLIATGGYGRIYRATTNAIICDGGGQIAA
LETGVVPLGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELASRDVVARRMTEHMRKGLGVKS
PYGDHLWLDIRHLGEKHITTNLREVYDISTHFLGVNPIHQLIPVRPTHHYSMGGVRINKDGHAYGLEGLFSAGEAACWDM
HGFNRLGGNSLAETIVSGRIVGQKLVEFLKGYETVFSTAEMTAAATKVKDRIAALLRGTGDDCYTLRNEMQDVMMEHVGI
FRNGKDLEAGVTKLQDLLERCGNMRLASGNIPGPNAELSMALRVPGMLKLALCTAYGALMRTESRGAHAREDYPERNDKD
WLNRTLAYWKEGDSLPTLKYEPATPYYILPPGDRGYGGGKIIPGDIKEDQIVPYDQKG
>Mature_618_residues
MRIFECDVLCIGAGLAGERVAVEAAQAGFRVICLSVVPPKRSHSSAAMGGMQAALGNSIMGEGDCPEIHFNDTVKGSDWG
CDQEVARLFAETGPIAMREMAWMGVPWSRVVPGEHTYYKGGKPFQATEKKENEGLIHSRAFGGTAKWRTCYTSDGTGHAV
LFTLDNRLLQLGVDVHDRTQAEGLVHDGQRCMGCVARDLRTGELVGYFAKATLIATGGYGRIYRATTNAIICDGGGQIAA
LETGVVPLGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELASRDVVARRMTEHMRKGLGVKS
PYGDHLWLDIRHLGEKHITTNLREVYDISTHFLGVNPIHQLIPVRPTHHYSMGGVRINKDGHAYGLEGLFSAGEAACWDM
HGFNRLGGNSLAETIVSGRIVGQKLVEFLKGYETVFSTAEMTAAATKVKDRIAALLRGTGDDCYTLRNEMQDVMMEHVGI
FRNGKDLEAGVTKLQDLLERCGNMRLASGNIPGPNAELSMALRVPGMLKLALCTAYGALMRTESRGAHAREDYPERNDKD
WLNRTLAYWKEGDSLPTLKYEPATPYYILPPGDRGYGGGKIIPGDIKEDQIVPYDQKG

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=624, Percent_Identity=34.2948717948718, Blast_Score=304, Evalue=2e-82,
Organism=Escherichia coli, GI1786942, Length=610, Percent_Identity=38.1967213114754, Blast_Score=332, Evalue=6e-92,
Organism=Escherichia coli, GI1790597, Length=584, Percent_Identity=36.3013698630137, Blast_Score=318, Evalue=6e-88,
Organism=Escherichia coli, GI1788928, Length=565, Percent_Identity=27.787610619469, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17505833, Length=558, Percent_Identity=35.84229390681, Blast_Score=301, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17550100, Length=554, Percent_Identity=35.0180505415162, Blast_Score=284, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6322701, Length=623, Percent_Identity=35.4735152487961, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6322416, Length=603, Percent_Identity=34.6600331674959, Blast_Score=305, Evalue=1e-83,
Organism=Drosophila melanogaster, GI17137288, Length=559, Percent_Identity=36.6726296958855, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24655642, Length=559, Percent_Identity=36.6726296958855, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24655647, Length=559, Percent_Identity=36.6726296958855, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24663005, Length=618, Percent_Identity=32.8478964401294, Blast_Score=273, Evalue=4e-73,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 67531; Mature: 67531

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIFECDVLCIGAGLAGERVAVEAAQAGFRVICLSVVPPKRSHSSAAMGGMQAALGNSIM
CEEEEEEEEEEECCCCCCCEEHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCC
GEGDCPEIHFNDTVKGSDWGCDQEVARLFAETGPIAMREMAWMGVPWSRVVPGEHTYYKG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHCCCCCCCEECC
GKPFQATEKKENEGLIHSRAFGGTAKWRTCYTSDGTGHAVLFTLDNRLLQLGVDVHDRTQ
CCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCEEEEECCCCCCCHH
AEGLVHDGQRCMGCVARDLRTGELVGYFAKATLIATGGYGRIYRATTNAIICDGGGQIAA
HCCHHHCHHHHHHHHHHHCCCCHHHHEEEEEEEEEECCCCEEEEEECCEEEECCCCEEEE
LETGVVPLGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELAS
EECCCEECCCCEEEEEECCCCCCCCEEEECCCCCCCCCEEEECCEECCCCCCCHHHHHHH
RDVVARRMTEHMRKGLGVKSPYGDHLWLDIRHLGEKHITTNLREVYDISTHFLGVNPIHQ
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHEECCCHHHH
LIPVRPTHHYSMGGVRINKDGHAYGLEGLFSAGEAACWDMHGFNRLGGNSLAETIVSGRI
HCCCCCCCCEECCCEEECCCCCEECHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHH
VGQKLVEFLKGYETVFSTAEMTAAATKVKDRIAALLRGTGDDCYTLRNEMQDVMMEHVGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FRNGKDLEAGVTKLQDLLERCGNMRLASGNIPGPNAELSMALRVPGMLKLALCTAYGALM
HCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
RTESRGAHAREDYPERNDKDWLNRTLAYWKEGDSLPTLKYEPATPYYILPPGDRGYGGGK
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCCCCCE
IIPGDIKEDQIVPYDQKG
ECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRIFECDVLCIGAGLAGERVAVEAAQAGFRVICLSVVPPKRSHSSAAMGGMQAALGNSIM
CEEEEEEEEEEECCCCCCCEEHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCC
GEGDCPEIHFNDTVKGSDWGCDQEVARLFAETGPIAMREMAWMGVPWSRVVPGEHTYYKG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHCCCCCCCEECC
GKPFQATEKKENEGLIHSRAFGGTAKWRTCYTSDGTGHAVLFTLDNRLLQLGVDVHDRTQ
CCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCEEEEECCCCCCCHH
AEGLVHDGQRCMGCVARDLRTGELVGYFAKATLIATGGYGRIYRATTNAIICDGGGQIAA
HCCHHHCHHHHHHHHHHHCCCCHHHHEEEEEEEEEECCCCEEEEEECCEEEECCCCEEEE
LETGVVPLGNMEAVQFHPTGTVPTDILVTEGCRGDGGTLLDVNEYRFMPDYEPEKAELAS
EECCCEECCCCEEEEEECCCCCCCCEEEECCCCCCCCCEEEECCEECCCCCCCHHHHHHH
RDVVARRMTEHMRKGLGVKSPYGDHLWLDIRHLGEKHITTNLREVYDISTHFLGVNPIHQ
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHEECCCHHHH
LIPVRPTHHYSMGGVRINKDGHAYGLEGLFSAGEAACWDMHGFNRLGGNSLAETIVSGRI
HCCCCCCCCEECCCEEECCCCCEECHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHH
VGQKLVEFLKGYETVFSTAEMTAAATKVKDRIAALLRGTGDDCYTLRNEMQDVMMEHVGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FRNGKDLEAGVTKLQDLLERCGNMRLASGNIPGPNAELSMALRVPGMLKLALCTAYGALM
HCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
RTESRGAHAREDYPERNDKDWLNRTLAYWKEGDSLPTLKYEPATPYYILPPGDRGYGGGK
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCCCCCE
IIPGDIKEDQIVPYDQKG
ECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]