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The map label for this gene is prs [H]

Identifier: 220904719

GI number: 220904719

Start: 1739188

End: 1740135

Strand: Direct

Name: prs [H]

Synonym: Ddes_1451

Alternate gene names: 220904719

Gene position: 1739188-1740135 (Clockwise)

Preceding gene: 220904718

Following gene: 220904720

Centisome position: 60.53

GC content: 57.7

Gene sequence:

>948_bases
ATGTTCAGCGATCTTAAGATCGTAACCGGTTCTTCCAATCCGGAATTGGCCAAGGCCATTTGCAACCATCTGGGCTGTCA
GCTCACCCCAACGCTGTCCACCACGTTCAGCGACGGGGAGTTGCGTATTGAAATCGGCGATAATGTCCGCGGCGACGATG
TTTTTGTGGTGCAACCCACTTGTCCGCCCACGGTCAACCGTAACCTTGTTCAGCTGTGCCTTATGCTTGACGCCCTTAAA
AGGGCGAGCGCGGGCCGCATTACAGCCGTTATTCCCTATTACGGCTATGCGCGGCAAGACCGCAAGGTCAGCCCCCGTGC
GCCCATAAGCGCCAAGATGGTGGCCGACTTCATCAGCGTGGCCGGAGCAGAACGCGTGGTGACTATTGATCTGCACGCAG
GGCAGATCCAGGGCTACTTTGATTGCCCTGTGGACAACCTTTTTGCCGTACCTGTAATGCTCGATGCCCTGCGCAAGCTC
GGCGAAGAAAAAATTGTCATCGTCTCGCCCGACGCCGGCGGCGTTGAACGGGCCAGGGCCTACGCCAAGCGCCTTGATGC
GCCCCTGGCTATTGTGGACAAAAGACGCGACAAGCCCAACCAGGCGCAGGCCATGCACGTCATTGGCGACGTGCAGGACC
GGGTAGCCATTGTGGTGGACGACATGATCGACACCGCGGGAACCTTGTGCGCCGGGGCCGAAGTTCTGATGAAAAACGGA
GCGAAAAAGATCGTGGCCTGTGCCACGCATCCGGTGTTGTCCGGTCCGGCCATTGATCGCATCAATGCCACCGAAGCCCT
TTCACAGGTCTTTGTCACCGACACCATCCCGCTGGGCGACAAGCTGGAACGATGCCCGAAACTCGAAGTCATCTCGGTGG
CGGCGATTCTGGGCAAAACCATTCACAACATTCACACCGGTTCTTCGGTCAGCGTGTTGTTTGTTTAG

Upstream 100 bases:

>100_bases
GCATCCGGCCATGGCGGCGACAGGCCAGCCAACTTCGTGACCGGCGGCAGGCAAGGGTGTACAACCTAAATGCTCTTTGA
CGCGCAAGGCGGGGCGGTTC

Downstream 100 bases:

>100_bases
CAAAAACCGTCGGCGCAAAGCCTTCGCGCACGGCCGTACGGCGCACATCCCGCAAGGGAATGGCAAGATACAATAAAGAA
AGCGCTGATCCATGCGGATT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MFSDLKIVTGSSNPELAKAICNHLGCQLTPTLSTTFSDGELRIEIGDNVRGDDVFVVQPTCPPTVNRNLVQLCLMLDALK
RASAGRITAVIPYYGYARQDRKVSPRAPISAKMVADFISVAGAERVVTIDLHAGQIQGYFDCPVDNLFAVPVMLDALRKL
GEEKIVIVSPDAGGVERARAYAKRLDAPLAIVDKRRDKPNQAQAMHVIGDVQDRVAIVVDDMIDTAGTLCAGAEVLMKNG
AKKIVACATHPVLSGPAIDRINATEALSQVFVTDTIPLGDKLERCPKLEVISVAAILGKTIHNIHTGSSVSVLFV

Sequences:

>Translated_315_residues
MFSDLKIVTGSSNPELAKAICNHLGCQLTPTLSTTFSDGELRIEIGDNVRGDDVFVVQPTCPPTVNRNLVQLCLMLDALK
RASAGRITAVIPYYGYARQDRKVSPRAPISAKMVADFISVAGAERVVTIDLHAGQIQGYFDCPVDNLFAVPVMLDALRKL
GEEKIVIVSPDAGGVERARAYAKRLDAPLAIVDKRRDKPNQAQAMHVIGDVQDRVAIVVDDMIDTAGTLCAGAEVLMKNG
AKKIVACATHPVLSGPAIDRINATEALSQVFVTDTIPLGDKLERCPKLEVISVAAILGKTIHNIHTGSSVSVLFV
>Mature_315_residues
MFSDLKIVTGSSNPELAKAICNHLGCQLTPTLSTTFSDGELRIEIGDNVRGDDVFVVQPTCPPTVNRNLVQLCLMLDALK
RASAGRITAVIPYYGYARQDRKVSPRAPISAKMVADFISVAGAERVVTIDLHAGQIQGYFDCPVDNLFAVPVMLDALRKL
GEEKIVIVSPDAGGVERARAYAKRLDAPLAIVDKRRDKPNQAQAMHVIGDVQDRVAIVVDDMIDTAGTLCAGAEVLMKNG
AKKIVACATHPVLSGPAIDRINATEALSQVFVTDTIPLGDKLERCPKLEVISVAAILGKTIHNIHTGSSVSVLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=313, Percent_Identity=48.2428115015974, Blast_Score=304, Evalue=9e-83,
Organism=Homo sapiens, GI4506127, Length=313, Percent_Identity=48.8817891373802, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=47.7848101265823, Blast_Score=298, Evalue=3e-81,
Organism=Homo sapiens, GI28557709, Length=313, Percent_Identity=46.9648562300319, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI194018537, Length=334, Percent_Identity=36.5269461077844, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4506133, Length=339, Percent_Identity=35.3982300884956, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI310128524, Length=148, Percent_Identity=33.7837837837838, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI310115209, Length=148, Percent_Identity=33.7837837837838, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI310118259, Length=148, Percent_Identity=33.7837837837838, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI310119946, Length=148, Percent_Identity=33.7837837837838, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=51.1182108626198, Blast_Score=325, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=44.0894568690096, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17554702, Length=313, Percent_Identity=44.0894568690096, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71989924, Length=313, Percent_Identity=44.0894568690096, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=44.1935483870968, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=33.4310850439883, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321776, Length=300, Percent_Identity=45, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=39.5569620253165, Blast_Score=241, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=38.2165605095541, Blast_Score=232, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6322667, Length=202, Percent_Identity=38.6138613861386, Blast_Score=148, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=36.8421052631579, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=46.6453674121406, Blast_Score=287, Evalue=6e-78,
Organism=Drosophila melanogaster, GI45551540, Length=336, Percent_Identity=43.452380952381, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24651458, Length=357, Percent_Identity=31.6526610644258, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24651456, Length=357, Percent_Identity=31.6526610644258, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI281362873, Length=357, Percent_Identity=31.6526610644258, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24651454, Length=357, Percent_Identity=31.6526610644258, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45552010, Length=376, Percent_Identity=30.0531914893617, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24651462, Length=376, Percent_Identity=30.0531914893617, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24651464, Length=376, Percent_Identity=30.0531914893617, Blast_Score=161, Evalue=5e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33735; Mature: 33735

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSDLKIVTGSSNPELAKAICNHLGCQLTPTLSTTFSDGELRIEIGDNVRGDDVFVVQPT
CCCCEEEEECCCCHHHHHHHHHHCCCEEECCCEEEECCCEEEEEECCCCCCCEEEEECCC
CPPTVNRNLVQLCLMLDALKRASAGRITAVIPYYGYARQDRKVSPRAPISAKMVADFISV
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
AGAERVVTIDLHAGQIQGYFDCPVDNLFAVPVMLDALRKLGEEKIVIVSPDAGGVERARA
CCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
YAKRLDAPLAIVDKRRDKPNQAQAMHVIGDVQDRVAIVVDDMIDTAGTLCAGAEVLMKNG
HHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCC
AKKIVACATHPVLSGPAIDRINATEALSQVFVTDTIPLGDKLERCPKLEVISVAAILGKT
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHH
IHNIHTGSSVSVLFV
HHHCCCCCCEEEEEC
>Mature Secondary Structure
MFSDLKIVTGSSNPELAKAICNHLGCQLTPTLSTTFSDGELRIEIGDNVRGDDVFVVQPT
CCCCEEEEECCCCHHHHHHHHHHCCCEEECCCEEEECCCEEEEEECCCCCCCEEEEECCC
CPPTVNRNLVQLCLMLDALKRASAGRITAVIPYYGYARQDRKVSPRAPISAKMVADFISV
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
AGAERVVTIDLHAGQIQGYFDCPVDNLFAVPVMLDALRKLGEEKIVIVSPDAGGVERARA
CCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
YAKRLDAPLAIVDKRRDKPNQAQAMHVIGDVQDRVAIVVDDMIDTAGTLCAGAEVLMKNG
HHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCC
AKKIVACATHPVLSGPAIDRINATEALSQVFVTDTIPLGDKLERCPKLEVISVAAILGKT
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHH
IHNIHTGSSVSVLFV
HHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA