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The map label for this gene is upp

Identifier: 220904269

GI number: 220904269

Start: 1164998

End: 1165624

Strand: Direct

Name: upp

Synonym: Ddes_0996

Alternate gene names: 220904269

Gene position: 1164998-1165624 (Clockwise)

Preceding gene: 220904255

Following gene: 220904270

Centisome position: 40.54

GC content: 54.7

Gene sequence:

>627_bases
ATGGCCGTTTATGTTGTAGATCATCCCCTTGTGCGCCACAAGATTGGTATTTTGCGTATGGAGTCCACCTCCACCAGCGA
ATTTCGCAGCGTCTCCAACGAAGTGGCCCGCCTGCTTATTTATGAGGCTACCAAGGGGTTTCGTACCGAAAAGCATACTG
TGCAGGGTTGGGCCGGCCCTGTGGAAATTGAAGCCATTTCCGGCAAAAAAGTTACGGTCGTTCCCATTTTGCGCGCCGGT
CTGGGGCTTATGGATGGCGTGCTGGACATGATCCCTGGTGCCAAGATCAGCGTTGTGGGACTGTATCGCAACGAGGAAAC
TCTGGAGCCTGTAGAGTATTACGTCAAGCTTGCCAGCGATATGGACCAGCGCCTTGCCATCATTCTTGATCCCATGCTGG
CCACGGGGGGGTCGCTTATCGCCACCATCGAGCTTCTGAAGCGTCACGGCTGCCGCCAGATATGCAGCCTCAATCTTGTA
TGCGCGCCCGAGGGCATTGCCAAGGTGGAGGCGGCGCATCCTGATGTGGACATATATACCGCCGCCATTGATGATCACCT
CAATGAGCAGGGATATATCATTCCCGGCCTTGGCGATGCCGGAGATCGCATTTTCGGTACCAAATAG

Upstream 100 bases:

>100_bases
CGGCCGGGACGCTTGACAAGATACTCACGCAAGAATAACCTTAATAAGTTTTATGCTTCATGAAAACAGCGGGTTAGCTC
ATGCCCTGCAAGGAGGCTCC

Downstream 100 bases:

>100_bases
CACCGCGCACACCTTTAGAACAATCGAGGCAGGGTATGAGCTTGAGCGGCTCGCGGCGGGAATTTGCGCCCACCGACTAC
AATCTGCGCTTCAGGGATTG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MAVYVVDHPLVRHKIGILRMESTSTSEFRSVSNEVARLLIYEATKGFRTEKHTVQGWAGPVEIEAISGKKVTVVPILRAG
LGLMDGVLDMIPGAKISVVGLYRNEETLEPVEYYVKLASDMDQRLAIILDPMLATGGSLIATIELLKRHGCRQICSLNLV
CAPEGIAKVEAAHPDVDIYTAAIDDHLNEQGYIIPGLGDAGDRIFGTK

Sequences:

>Translated_208_residues
MAVYVVDHPLVRHKIGILRMESTSTSEFRSVSNEVARLLIYEATKGFRTEKHTVQGWAGPVEIEAISGKKVTVVPILRAG
LGLMDGVLDMIPGAKISVVGLYRNEETLEPVEYYVKLASDMDQRLAIILDPMLATGGSLIATIELLKRHGCRQICSLNLV
CAPEGIAKVEAAHPDVDIYTAAIDDHLNEQGYIIPGLGDAGDRIFGTK
>Mature_207_residues
AVYVVDHPLVRHKIGILRMESTSTSEFRSVSNEVARLLIYEATKGFRTEKHTVQGWAGPVEIEAISGKKVTVVPILRAGL
GLMDGVLDMIPGAKISVVGLYRNEETLEPVEYYVKLASDMDQRLAIILDPMLATGGSLIATIELLKRHGCRQICSLNLVC
APEGIAKVEAAHPDVDIYTAAIDDHLNEQGYIIPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=206, Percent_Identity=32.5242718446602, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI57863312, Length=206, Percent_Identity=32.5242718446602, Blast_Score=91, Evalue=5e-19,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=65.8653846153846, Blast_Score=292, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=126, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45550449, Length=195, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=32.512315270936, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=32.512315270936, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=32.512315270936, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_DESDA (B8IZH6)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479581.1
- GeneID:   7284676
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_0996
- HOGENOM:   HBG326432
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22625; Mature: 22493

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYVVDHPLVRHKIGILRMESTSTSEFRSVSNEVARLLIYEATKGFRTEKHTVQGWAGP
CEEEEECCCHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCC
VEIEAISGKKVTVVPILRAGLGLMDGVLDMIPGAKISVVGLYRNEETLEPVEYYVKLASD
EEEEEECCCEEEEEHHHHHCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHC
MDQRLAIILDPMLATGGSLIATIELLKRHGCRQICSLNLVCAPEGIAKVEAAHPDVDIYT
HHHHHHHEECHHHHCCCHHHHHHHHHHHCCCHHHHCCCEEECCCCCCEEECCCCCCEEEE
AAIDDHLNEQGYIIPGLGDAGDRIFGTK
EEHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AVYVVDHPLVRHKIGILRMESTSTSEFRSVSNEVARLLIYEATKGFRTEKHTVQGWAGP
EEEEECCCHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCC
VEIEAISGKKVTVVPILRAGLGLMDGVLDMIPGAKISVVGLYRNEETLEPVEYYVKLASD
EEEEEECCCEEEEEHHHHHCHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHC
MDQRLAIILDPMLATGGSLIATIELLKRHGCRQICSLNLVCAPEGIAKVEAAHPDVDIYT
HHHHHHHEECHHHHCCCHHHHHHHHHHHCCCHHHHCCCEEECCCCCCEEECCCCCCEEEE
AAIDDHLNEQGYIIPGLGDAGDRIFGTK
EEHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA