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The map label for this gene is uraA [H]

Identifier: 220904270

GI number: 220904270

Start: 1165660

End: 1166919

Strand: Direct

Name: uraA [H]

Synonym: Ddes_0997

Alternate gene names: 220904270

Gene position: 1165660-1166919 (Clockwise)

Preceding gene: 220904269

Following gene: 220904271

Centisome position: 40.57

GC content: 57.62

Gene sequence:

>1260_bases
ATGAGCTTGAGCGGCTCGCGGCGGGAATTTGCGCCCACCGACTACAATCTGCGCTTCAGGGATTGCCTGATCGGCGCGCA
GATGCTTTTTGTGGCCTTTGGCGCACTGGTGCTGGTGCCCATACTTACCGGCCTGGACAGCAACGTGGCCCTGTTTACCG
CAGGGGTGGGGACTCTGCTTTTTCAGATATGTACCAGGGGCAAGGTGCCGATCTTTCTGGCATCGTCCTTTGCCTTTATC
GCCCCCATCATCTACGGAGTACAGACCTGGGGTGTCGCCCAGACCCTGGGCGGGCTGGTTTGTTCCGGCTTTGTCTACTT
TATTCTGAGCGGCCTTATCCGCTGGCGCGGCATTGATGTGGTGTTGCGTGTGCTGCCCCCGGTGGTGACCGGCCCTGTTA
TTATGGTCATCGGCCTTATTCTGGCTCCGGTGGCGGTGAACATGGCCCTTGGCAAAACCGGCGATGGCGCGGTGCAGCTG
GTTCCCGAAGAAATGGCCCTGTGGGTTTCGATGACTTCGCTTCTGGTTACGGTGCTGGTTTCGCTTCTGGGGCGGGGGTT
TTTACGGCTCATGCCCATATTGTGCGGTATAACGGCGGGCTTTCTGGTTTCGTTGTATCTGGGGCTCGGCGACTGGACAA
AGGTTGCGGCCACACCCTGGATGAGCCTGCCGCAGTTTACCTTTCCGGAATTTGCCTGGGAACCCATACTCTTTATCATG
CCCATAACCCTTGCACCGGCCATTGAGCATTTTGGCGATGTGGTCGCCATAAGTTCCATCACCGGGCGCGATTATCTCAA
AGACCCGGGCGTGCACACCACCATGTTTGGCGACGGCGTTGCCACCATGGCCGCAGGTTTTGTGGGTGGCCCGCCCTGTA
CCACCTATGCCGAGGTTATCGGCGCGGTGAGCCTGACCCGTGTGTTCAATCCGGCGATCATGACCTGGGCGGCCTTGTGC
GCCATTTTGCTGTCTTTCGTGTCCAAGATCGGGGCTTTTTTGTCGTCCATCCCTGTTCCCGTCATGGGCGGCATAATGAT
CCTGCTTTTCGGGGCCATCATGGTGGTCGGGCTGAATACTCTGGTACGTGCCGGAAAAGACCTGATGGAGCCGAGAAATA
TGATTATCGTGGCTCTCATCATTATTTTCGGTGTGGGTGGAATGCAGTTCAGTATCGGCTCTTTCAAGCTCGGCGGCATA
GGTCTTGCCGCAGTGACGGGCGTGGCGCTCAACCTCTTTTTACCGCGCAGTCGCAGTTGA

Upstream 100 bases:

>100_bases
ATGAGCAGGGATATATCATTCCCGGCCTTGGCGATGCCGGAGATCGCATTTTCGGTACCAAATAGCACCGCGCACACCTT
TAGAACAATCGAGGCAGGGT

Downstream 100 bases:

>100_bases
GCCTGATATAAAAGCGCCTGTCGGTTGTGGCAACTGCCCAGGAAAATACAAAATAGCGGCAGGGCGCGGCGCAGGCAGAT
CCCTGATATGCGAATATTCT

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSLSGSRREFAPTDYNLRFRDCLIGAQMLFVAFGALVLVPILTGLDSNVALFTAGVGTLLFQICTRGKVPIFLASSFAFI
APIIYGVQTWGVAQTLGGLVCSGFVYFILSGLIRWRGIDVVLRVLPPVVTGPVIMVIGLILAPVAVNMALGKTGDGAVQL
VPEEMALWVSMTSLLVTVLVSLLGRGFLRLMPILCGITAGFLVSLYLGLGDWTKVAATPWMSLPQFTFPEFAWEPILFIM
PITLAPAIEHFGDVVAISSITGRDYLKDPGVHTTMFGDGVATMAAGFVGGPPCTTYAEVIGAVSLTRVFNPAIMTWAALC
AILLSFVSKIGAFLSSIPVPVMGGIMILLFGAIMVVGLNTLVRAGKDLMEPRNMIIVALIIIFGVGGMQFSIGSFKLGGI
GLAAVTGVALNLFLPRSRS

Sequences:

>Translated_419_residues
MSLSGSRREFAPTDYNLRFRDCLIGAQMLFVAFGALVLVPILTGLDSNVALFTAGVGTLLFQICTRGKVPIFLASSFAFI
APIIYGVQTWGVAQTLGGLVCSGFVYFILSGLIRWRGIDVVLRVLPPVVTGPVIMVIGLILAPVAVNMALGKTGDGAVQL
VPEEMALWVSMTSLLVTVLVSLLGRGFLRLMPILCGITAGFLVSLYLGLGDWTKVAATPWMSLPQFTFPEFAWEPILFIM
PITLAPAIEHFGDVVAISSITGRDYLKDPGVHTTMFGDGVATMAAGFVGGPPCTTYAEVIGAVSLTRVFNPAIMTWAALC
AILLSFVSKIGAFLSSIPVPVMGGIMILLFGAIMVVGLNTLVRAGKDLMEPRNMIIVALIIIFGVGGMQFSIGSFKLGGI
GLAAVTGVALNLFLPRSRS
>Mature_418_residues
SLSGSRREFAPTDYNLRFRDCLIGAQMLFVAFGALVLVPILTGLDSNVALFTAGVGTLLFQICTRGKVPIFLASSFAFIA
PIIYGVQTWGVAQTLGGLVCSGFVYFILSGLIRWRGIDVVLRVLPPVVTGPVIMVIGLILAPVAVNMALGKTGDGAVQLV
PEEMALWVSMTSLLVTVLVSLLGRGFLRLMPILCGITAGFLVSLYLGLGDWTKVAATPWMSLPQFTFPEFAWEPILFIMP
ITLAPAIEHFGDVVAISSITGRDYLKDPGVHTTMFGDGVATMAAGFVGGPPCTTYAEVIGAVSLTRVFNPAIMTWAALCA
ILLSFVSKIGAFLSSIPVPVMGGIMILLFGAIMVVGLNTLVRAGKDLMEPRNMIIVALIIIFGVGGMQFSIGSFKLGGIG
LAAVTGVALNLFLPRSRS

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=430, Percent_Identity=23.4883720930233, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI44680145, Length=429, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1788843, Length=407, Percent_Identity=37.5921375921376, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87081818, Length=418, Percent_Identity=36.3636363636364, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87082181, Length=448, Percent_Identity=27.9017857142857, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082178, Length=271, Percent_Identity=27.3062730627306, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790087, Length=408, Percent_Identity=23.2843137254902, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356175, Length=176, Percent_Identity=30.6818181818182, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44315; Mature: 44184

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCHHHHCHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SLSGSRREFAPTDYNLRFRDCLIGAQMLFVAFGALVLVPILTGLDSNVALFTAGVGTLL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEHHHHHHHH
FQICTRGKVPIFLASSFAFIAPIIYGVQTWGVAQTLGGLVCSGFVYFILSGLIRWRGIDV
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRVLPPVVTGPVIMVIGLILAPVAVNMALGKTGDGAVQLVPEEMALWVSMTSLLVTVLV
HHHHHCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHH
SLLGRGFLRLMPILCGITAGFLVSLYLGLGDWTKVAATPWMSLPQFTFPEFAWEPILFIM
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHCCHHHHH
PITLAPAIEHFGDVVAISSITGRDYLKDPGVHTTMFGDGVATMAAGFVGGPPCTTYAEVI
HHHHHHHHHHHCCEEEEECCCCCHHHCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHH
GAVSLTRVFNPAIMTWAALCAILLSFVSKIGAFLSSIPVPVMGGIMILLFGAIMVVGLNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LVRAGKDLMEPRNMIIVALIIIFGVGGMQFSIGSFKLGGIGLAAVTGVALNLFLPRSRS
HHHCCHHHHCHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]