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The map label for this gene is dxs [H]

Identifier: 220904229

GI number: 220904229

Start: 1113247

End: 1115181

Strand: Direct

Name: dxs [H]

Synonym: Ddes_0956

Alternate gene names: 220904229

Gene position: 1113247-1115181 (Clockwise)

Preceding gene: 220904228

Following gene: 220904235

Centisome position: 38.74

GC content: 58.19

Gene sequence:

>1935_bases
ATGCCGGAACCTGCCGCGCGGGATGAAAACCCGCCGGCTTCCCTACTTGACGGCATAGAGCGCCCCTCACAGCTTGTGGG
CATGGATGATGTGGCGCTCGCGCAGCTGGCGGGCGAGGTACGTCAGCGCATTATCGACGTGGTTTCGCGTAACGGCGGCC
ATCTGGCGCCGTCTCTTGGTGTGGTGGAACTGACGCTGGCGCTTCTTTCCACCTTCAATATTGAAGAAGACAAGCTCGTG
TGGGACGTGGGGCATCAGGCCTATGCCCACAAACTGCTTACCGGCAGGGCGCAGCAGTTCCATACCCTGCGCTCTTTTGG
CGGTATTTCCGGTTTTCCACGCATGGCTGAAAGCCCTTATGACCATTTTGGCGTGGGGCATTCCTCCACATCCATTTCTG
CCGCCTTGGGCATGGCTTTGGCCCGTGACCTTTCCGGACTCAAGCATCACGTGCTTGCCGTGATCGGCGACGGTTCCCTG
ACGGCCGGAGAAGCCTTTGAAGGGCTTAACCTGGCCGGGCATATGGGACGTCGGCTTATTGTGGTGCTCAATGACAATGA
AATGTCCATTTCGCCCAATGTGGGGGCGCTTTCGCTTTTCCTGAGCCGCACACTTTCGCGGCGCTGGGTGCGGCAGACCC
GCAAAGAAGTGCTCAACTTCCTGCGCTCCATACCCCGTATCGGTCAAAAGCTGGCTGTATACGCCATGCGCGGTGAGTGG
AGCTTCAAGTCTTTCTTTACGCCGGGCATGCTGTTTGAGGCGTTTCGTTTCAACTATATCGGCCCTGTGGACGGGCATGA
CCTGCCGAGCCTGCGCCGCCACCTGCAAATGGCCGCAGCTGTCGAGGACGGCCCCGTGCTGCTGCATGTGCGCACACAAA
AAGGCAAGGGCTATGCCCCGGCAGAAAAAAATCCGACCCTCTATCACGGAGTGGGCCTGTTCACGCCCGAAACCGGTCAG
CCGGTTCCTTCCACGGCCAAAGTACCGTCATTTACCGGAATTTTCAGTAAAACTCTGGTAGAACTTGCTGAAAATGATGA
AAGAGTCATCGCGATTACGGCTGCCATGCCCGAAGGGACCGGTACAGACAGTTTTCGTCAGCGGTTTCCTGACCGCTTTG
TGGACGTGGGCATTTGCGAGCAGCATGCCGTAACCTTTGCCGCCGGGCTTGCCAGTCAGGGATTCAGGCCGGCGCTCGCC
ATCTACTCCACATTTTTGCAACGTGCTTATGATCAGGTGGTGCACGACGTCTGCATACAGAATCTGCCGGTCACGCTTTG
CGTGGACCGTGCAGGGCTTGTGGGCGAGGACGGTGCCACCCATCACGGAGCCTTTGACATCGCCTATCTGCGGCATATCC
CGCAAATGAGCCTGCTGGCTCCCCGCAACGAGGACATGTTGCGGCACTGTCTGTTCACCTCTTTGAATCATGATGGTCCC
TGCGCATTGCGCTATCCCAGAGGGGCGGGCTTTGGTGTGCCTTTTGACGGCCTGCCGCGCCTGCTCACTCCCGGCAGGGG
AGATCTGCTTCAGGATGGAGAAAATATCGCTATTATTGCCGTGGGTAACCGCGCCCACCCCGCGCTGGAGGCGGCGGCGC
AGGCAGAACAGGCGCTGGGCTTCCGTCCGCTGGTTTTTGATCCCGTGTGGCTCAAGCCTTTGCCTGAGGAACAGCTGGCC
TCCATTGCGCGCCGCTTTGACCGCATACTTTTTGTGGAAGAAGGCGTTCTGGCTGGCGGTTTTTCTTCAGCAGTGCTGGA
ATTTTATGCGGATAAGGGGCTGTTGCGTGGTCAGTGCATCAAACGCCTTGGCCTGCCTGACAGTTTTGTGGAACACGGCA
GCCAGTTGCGGTTGCGTGAACTGGTGGGCCTGCGCACAAAAAATATTGCTGCTGCCATTGTGGAACTGGCAGGGCAGAAA
GAGAATGCCATGTGA

Upstream 100 bases:

>100_bases
GCTGACTATACGGTCACCAGGGCGGCCTGACATGCCTGACACACATATAATGACGGCGCAGGATGTTTCTGTGGGAGCCG
GAGCGGCACAGGCTGCCGAT

Downstream 100 bases:

>100_bases
AAACTGTTTAGTTGCAGTAGGATAACGTTTCGTGCGGGCAGGGGACTGATAAAAATATTCTGCCCGCACGGTGTATTTCG
CAACAGGCTTGTTCATGAAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MPEPAARDENPPASLLDGIERPSQLVGMDDVALAQLAGEVRQRIIDVVSRNGGHLAPSLGVVELTLALLSTFNIEEDKLV
WDVGHQAYAHKLLTGRAQQFHTLRSFGGISGFPRMAESPYDHFGVGHSSTSISAALGMALARDLSGLKHHVLAVIGDGSL
TAGEAFEGLNLAGHMGRRLIVVLNDNEMSISPNVGALSLFLSRTLSRRWVRQTRKEVLNFLRSIPRIGQKLAVYAMRGEW
SFKSFFTPGMLFEAFRFNYIGPVDGHDLPSLRRHLQMAAAVEDGPVLLHVRTQKGKGYAPAEKNPTLYHGVGLFTPETGQ
PVPSTAKVPSFTGIFSKTLVELAENDERVIAITAAMPEGTGTDSFRQRFPDRFVDVGICEQHAVTFAAGLASQGFRPALA
IYSTFLQRAYDQVVHDVCIQNLPVTLCVDRAGLVGEDGATHHGAFDIAYLRHIPQMSLLAPRNEDMLRHCLFTSLNHDGP
CALRYPRGAGFGVPFDGLPRLLTPGRGDLLQDGENIAIIAVGNRAHPALEAAAQAEQALGFRPLVFDPVWLKPLPEEQLA
SIARRFDRILFVEEGVLAGGFSSAVLEFYADKGLLRGQCIKRLGLPDSFVEHGSQLRLRELVGLRTKNIAAAIVELAGQK
ENAM

Sequences:

>Translated_644_residues
MPEPAARDENPPASLLDGIERPSQLVGMDDVALAQLAGEVRQRIIDVVSRNGGHLAPSLGVVELTLALLSTFNIEEDKLV
WDVGHQAYAHKLLTGRAQQFHTLRSFGGISGFPRMAESPYDHFGVGHSSTSISAALGMALARDLSGLKHHVLAVIGDGSL
TAGEAFEGLNLAGHMGRRLIVVLNDNEMSISPNVGALSLFLSRTLSRRWVRQTRKEVLNFLRSIPRIGQKLAVYAMRGEW
SFKSFFTPGMLFEAFRFNYIGPVDGHDLPSLRRHLQMAAAVEDGPVLLHVRTQKGKGYAPAEKNPTLYHGVGLFTPETGQ
PVPSTAKVPSFTGIFSKTLVELAENDERVIAITAAMPEGTGTDSFRQRFPDRFVDVGICEQHAVTFAAGLASQGFRPALA
IYSTFLQRAYDQVVHDVCIQNLPVTLCVDRAGLVGEDGATHHGAFDIAYLRHIPQMSLLAPRNEDMLRHCLFTSLNHDGP
CALRYPRGAGFGVPFDGLPRLLTPGRGDLLQDGENIAIIAVGNRAHPALEAAAQAEQALGFRPLVFDPVWLKPLPEEQLA
SIARRFDRILFVEEGVLAGGFSSAVLEFYADKGLLRGQCIKRLGLPDSFVEHGSQLRLRELVGLRTKNIAAAIVELAGQK
ENAM
>Mature_643_residues
PEPAARDENPPASLLDGIERPSQLVGMDDVALAQLAGEVRQRIIDVVSRNGGHLAPSLGVVELTLALLSTFNIEEDKLVW
DVGHQAYAHKLLTGRAQQFHTLRSFGGISGFPRMAESPYDHFGVGHSSTSISAALGMALARDLSGLKHHVLAVIGDGSLT
AGEAFEGLNLAGHMGRRLIVVLNDNEMSISPNVGALSLFLSRTLSRRWVRQTRKEVLNFLRSIPRIGQKLAVYAMRGEWS
FKSFFTPGMLFEAFRFNYIGPVDGHDLPSLRRHLQMAAAVEDGPVLLHVRTQKGKGYAPAEKNPTLYHGVGLFTPETGQP
VPSTAKVPSFTGIFSKTLVELAENDERVIAITAAMPEGTGTDSFRQRFPDRFVDVGICEQHAVTFAAGLASQGFRPALAI
YSTFLQRAYDQVVHDVCIQNLPVTLCVDRAGLVGEDGATHHGAFDIAYLRHIPQMSLLAPRNEDMLRHCLFTSLNHDGPC
ALRYPRGAGFGVPFDGLPRLLTPGRGDLLQDGENIAIIAVGNRAHPALEAAAQAEQALGFRPLVFDPVWLKPLPEEQLAS
IARRFDRILFVEEGVLAGGFSSAVLEFYADKGLLRGQCIKRLGLPDSFVEHGSQLRLRELVGLRTKNIAAAIVELAGQKE
NAM

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=568, Percent_Identity=23.0633802816901, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI205277463, Length=562, Percent_Identity=21.8861209964413, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI4507521, Length=562, Percent_Identity=21.8861209964413, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI225637463, Length=426, Percent_Identity=24.1784037558685, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI225637461, Length=426, Percent_Identity=24.1784037558685, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI225637459, Length=426, Percent_Identity=24.1784037558685, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4557353, Length=253, Percent_Identity=24.5059288537549, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI34101272, Length=253, Percent_Identity=24.5059288537549, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786622, Length=603, Percent_Identity=45.273631840796, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17539652, Length=458, Percent_Identity=23.7991266375546, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24645119, Length=559, Percent_Identity=24.5080500894454, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45551847, Length=559, Percent_Identity=24.3291592128801, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45550715, Length=559, Percent_Identity=24.3291592128801, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24666278, Length=613, Percent_Identity=23.9804241435563, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI160714832, Length=255, Percent_Identity=24.7058823529412, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI160714828, Length=255, Percent_Identity=24.7058823529412, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 70095; Mature: 69964

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPAARDENPPASLLDGIERPSQLVGMDDVALAQLAGEVRQRIIDVVSRNGGHLAPSLG
CCCCCCCCCCCCHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
VVELTLALLSTFNIEEDKLVWDVGHQAYAHKLLTGRAQQFHTLRSFGGISGFPRMAESPY
HHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCC
DHFGVGHSSTSISAALGMALARDLSGLKHHVLAVIGDGSLTAGEAFEGLNLAGHMGRRLI
HHCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCCCCHHHCCCCEEE
VVLNDNEMSISPNVGALSLFLSRTLSRRWVRQTRKEVLNFLRSIPRIGQKLAVYAMRGEW
EEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCC
SFKSFFTPGMLFEAFRFNYIGPVDGHDLPSLRRHLQMAAAVEDGPVLLHVRTQKGKGYAP
CHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
AEKNPTLYHGVGLFTPETGQPVPSTAKVPSFTGIFSKTLVELAENDERVIAITAAMPEGT
CCCCCCEEEECEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
GTDSFRQRFPDRFVDVGICEQHAVTFAAGLASQGFRPALAIYSTFLQRAYDQVVHDVCIQ
CCHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLPVTLCVDRAGLVGEDGATHHGAFDIAYLRHIPQMSLLAPRNEDMLRHCLFTSLNHDGP
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHCCCCCC
CALRYPRGAGFGVPFDGLPRLLTPGRGDLLQDGENIAIIAVGNRAHPALEAAAQAEQALG
EEEECCCCCCCCCCCCCCCHHCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCC
FRPLVFDPVWLKPLPEEQLASIARRFDRILFVEEGVLAGGFSSAVLEFYADKGLLRGQCI
CCCEEECCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHH
KRLGLPDSFVEHGSQLRLRELVGLRTKNIAAAIVELAGQKENAM
HHCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PEPAARDENPPASLLDGIERPSQLVGMDDVALAQLAGEVRQRIIDVVSRNGGHLAPSLG
CCCCCCCCCCCHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
VVELTLALLSTFNIEEDKLVWDVGHQAYAHKLLTGRAQQFHTLRSFGGISGFPRMAESPY
HHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCC
DHFGVGHSSTSISAALGMALARDLSGLKHHVLAVIGDGSLTAGEAFEGLNLAGHMGRRLI
HHCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCCCCHHHCCCCEEE
VVLNDNEMSISPNVGALSLFLSRTLSRRWVRQTRKEVLNFLRSIPRIGQKLAVYAMRGEW
EEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCC
SFKSFFTPGMLFEAFRFNYIGPVDGHDLPSLRRHLQMAAAVEDGPVLLHVRTQKGKGYAP
CHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
AEKNPTLYHGVGLFTPETGQPVPSTAKVPSFTGIFSKTLVELAENDERVIAITAAMPEGT
CCCCCCEEEECEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
GTDSFRQRFPDRFVDVGICEQHAVTFAAGLASQGFRPALAIYSTFLQRAYDQVVHDVCIQ
CCHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLPVTLCVDRAGLVGEDGATHHGAFDIAYLRHIPQMSLLAPRNEDMLRHCLFTSLNHDGP
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHCCCCCC
CALRYPRGAGFGVPFDGLPRLLTPGRGDLLQDGENIAIIAVGNRAHPALEAAAQAEQALG
EEEECCCCCCCCCCCCCCCHHCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCC
FRPLVFDPVWLKPLPEEQLASIARRFDRILFVEEGVLAGGFSSAVLEFYADKGLLRGQCI
CCCEEECCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHH
KRLGLPDSFVEHGSQLRLRELVGLRTKNIAAAIVELAGQKENAM
HHCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA