Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 220904167

GI number: 220904167

Start: 1042336

End: 1042755

Strand: Reverse

Name: ndk

Synonym: Ddes_0894

Alternate gene names: 220904167

Gene position: 1042755-1042336 (Counterclockwise)

Preceding gene: 220904168

Following gene: 220904166

Centisome position: 36.29

GC content: 57.62

Gene sequence:

>420_bases
ATGATGCAATCCACCTTTGCCATAATCAAGCCCGACGCTGTTTCGCGCCAGTTGACCGGTGAAATACTGGCGGCTATGGA
AGCTTCGGGGCTGAAGATCGTGGCCCTTAAAAGGTTGCATCTTTCCAAGGCGCAGGCTGCCGGTTTTTATGCCGTTCACC
GCGAGCGCCCTTTTTTTGACAGCTTGACGGACTACATGTCTTCCGGCCCGGTTGTTTGTGTCGTTTTACGCGGTGAGGAC
GCCGTACCCAGGTGGCGCGCCCTCATGGGAGCCACCAACCCCGCGCAGGCAGAGCCAGGTACCTTGCGCGCCAGGTACGG
CCAGAGCCTTGAGGCCAACGCCGTGCACGGCTCTGACGCGCAGGAAACTGCGGCATTTGAAATCGGCTATTTCTTCAACG
GACTGGAAATTTCGGAGTAA

Upstream 100 bases:

>100_bases
CTTCAATGGGGGGCAGTATCCGGACGGGCGATGCGCCGCAAGGGGCGCACGGGACGCATGCGGCGTCCTGATTTCACCAA
TCTAGCATGAGGAGTACGCC

Downstream 100 bases:

>100_bases
GTTATGACACTGCGCATAGGCTGTGTGGGTTGTGGCAACATGGGCGGGGCCATCATGTCCGGTTTGGCCCGTCCCGGAAC
GCGGAACGAAAACCGGAACA

Product: Nucleoside-diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MMQSTFAIIKPDAVSRQLTGEILAAMEASGLKIVALKRLHLSKAQAAGFYAVHRERPFFDSLTDYMSSGPVVCVVLRGED
AVPRWRALMGATNPAQAEPGTLRARYGQSLEANAVHGSDAQETAAFEIGYFFNGLEISE

Sequences:

>Translated_139_residues
MMQSTFAIIKPDAVSRQLTGEILAAMEASGLKIVALKRLHLSKAQAAGFYAVHRERPFFDSLTDYMSSGPVVCVVLRGED
AVPRWRALMGATNPAQAEPGTLRARYGQSLEANAVHGSDAQETAAFEIGYFFNGLEISE
>Mature_139_residues
MMQSTFAIIKPDAVSRQLTGEILAAMEASGLKIVALKRLHLSKAQAAGFYAVHRERPFFDSLTDYMSSGPVVCVVLRGED
AVPRWRALMGATNPAQAEPGTLRARYGQSLEANAVHGSDAQETAAFEIGYFFNGLEISE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=46.6666666666667, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=40.8759124087591, Blast_Score=113, Evalue=5e-26,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=40.8759124087591, Blast_Score=113, Evalue=5e-26,
Organism=Homo sapiens, GI66392227, Length=138, Percent_Identity=39.8550724637681, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI66392205, Length=138, Percent_Identity=39.8550724637681, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI4505409, Length=138, Percent_Identity=39.8550724637681, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI66392192, Length=138, Percent_Identity=39.8550724637681, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI66392203, Length=138, Percent_Identity=39.8550724637681, Blast_Score=113, Evalue=7e-26,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=37.037037037037, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=35.3383458646617, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=35.3383458646617, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=38.8059701492537, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI30023828, Length=142, Percent_Identity=35.9154929577465, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=35.5555555555556, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI148839372, Length=125, Percent_Identity=35.2, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=55.8823529411765, Blast_Score=156, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=137, Percent_Identity=45.2554744525547, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=38.5185185185185, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=44.4444444444444, Blast_Score=115, Evalue=8e-27,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=33.5820895522388, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645457, Length=142, Percent_Identity=27.4647887323944, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_DESDA (B8IZ74)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479479.1
- GeneID:   7284570
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_0894
- HOGENOM:   HBG445152
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15063; Mature: 15063

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQSTFAIIKPDAVSRQLTGEILAAMEASGLKIVALKRLHLSKAQAAGFYAVHRERPFFD
CCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCEEEEECCCCCHH
SLTDYMSSGPVVCVVLRGEDAVPRWRALMGATNPAQAEPGTLRARYGQSLEANAVHGSDA
HHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCEEHHCCCCCCCCCCCCCCC
QETAAFEIGYFFNGLEISE
CHHHEEEECEEECCEEECC
>Mature Secondary Structure
MMQSTFAIIKPDAVSRQLTGEILAAMEASGLKIVALKRLHLSKAQAAGFYAVHRERPFFD
CCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCEEEEECCCCCHH
SLTDYMSSGPVVCVVLRGEDAVPRWRALMGATNPAQAEPGTLRARYGQSLEANAVHGSDA
HHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCEEHHCCCCCCCCCCCCCCC
QETAAFEIGYFFNGLEISE
CHHHEEEECEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA