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The map label for this gene is proC [H]

Identifier: 220904166

GI number: 220904166

Start: 1041502

End: 1042332

Strand: Reverse

Name: proC [H]

Synonym: Ddes_0893

Alternate gene names: 220904166

Gene position: 1042332-1041502 (Counterclockwise)

Preceding gene: 220904167

Following gene: 220904163

Centisome position: 36.27

GC content: 61.49

Gene sequence:

>831_bases
ATGACACTGCGCATAGGCTGTGTGGGTTGTGGCAACATGGGCGGGGCCATCATGTCCGGTTTGGCCCGTCCCGGAACGCG
GAACGAAAACCGGAACAGCGCCTACACGCTCTGTGGTTACAACCGCACAGCCTCGCGCATGCAGGCCCTGGAAAAAGCCG
GAGTGCGCGTCATGGCGTCCCCACTGGGAGTGGCGGAAAACGCAGATATCATCCTGCTGGCCGTCAAACCCTACCAGATA
CGCGAAATAATGGAGCAGATACGCCCCGCCCTGAACAAGGGCAAGGTCATTCTGTCTGTGGCGGCGGGCATCACCATGCA
CAGCCTGCAACAATGGGCCGAAGCGCTTTGTCCCGTAGTGCGCTGCATGCCCAACACCCCGGCTTTGGTGGGTATGGGCG
TGTTTGCCCTGTGCTTTGACGACCCTGCACTCGGCAATGAACGCAGGCAGGACATTCTGCGGCTTTTCAGCGGTCTCGGG
CAGTGTGTCGAGATGGCCGAGGACAAGTTCACGGCTTTTTCCGCTCTTATCGGCGCAGGCCCGGCATATGTTTTTGCCAT
GATGCAGGGACTTGTGCAGGCCGGGGTAACAATGGGATTTCCCCATGCCCAGGCGCGGCAAATGGTTACAGCACTTTTTG
CCGGCTCGGCGCGCATGGCAGAAGAAGATGCGACGCCATTGGGCCAGTTGCGCGACAATGTGTGCTCACCCGGTGGCCTG
ACCATCGCCGGGGTCAACGCCCTGGACCGCGCGGGCCTCACCGGCCTGCTGGTGGATGCGGTGCTGGCCGCCAGTGCCCG
TGGCGCTGAAATGGAGCGGAATAACGGCTAG

Upstream 100 bases:

>100_bases
GAGCCTTGAGGCCAACGCCGTGCACGGCTCTGACGCGCAGGAAACTGCGGCATTTGAAATCGGCTATTTCTTCAACGGAC
TGGAAATTTCGGAGTAAGTT

Downstream 100 bases:

>100_bases
GGCAGTCTGTCCCTGGATGGGCTGTTGATTTACACCTGCTGTTTTTACGGACGAACGGGCTGACAATGATTTTTTATTGC
CCGCTGCCCGACAGCCAATG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTLRIGCVGCGNMGGAIMSGLARPGTRNENRNSAYTLCGYNRTASRMQALEKAGVRVMASPLGVAENADIILLAVKPYQI
REIMEQIRPALNKGKVILSVAAGITMHSLQQWAEALCPVVRCMPNTPALVGMGVFALCFDDPALGNERRQDILRLFSGLG
QCVEMAEDKFTAFSALIGAGPAYVFAMMQGLVQAGVTMGFPHAQARQMVTALFAGSARMAEEDATPLGQLRDNVCSPGGL
TIAGVNALDRAGLTGLLVDAVLAASARGAEMERNNG

Sequences:

>Translated_276_residues
MTLRIGCVGCGNMGGAIMSGLARPGTRNENRNSAYTLCGYNRTASRMQALEKAGVRVMASPLGVAENADIILLAVKPYQI
REIMEQIRPALNKGKVILSVAAGITMHSLQQWAEALCPVVRCMPNTPALVGMGVFALCFDDPALGNERRQDILRLFSGLG
QCVEMAEDKFTAFSALIGAGPAYVFAMMQGLVQAGVTMGFPHAQARQMVTALFAGSARMAEEDATPLGQLRDNVCSPGGL
TIAGVNALDRAGLTGLLVDAVLAASARGAEMERNNG
>Mature_275_residues
TLRIGCVGCGNMGGAIMSGLARPGTRNENRNSAYTLCGYNRTASRMQALEKAGVRVMASPLGVAENADIILLAVKPYQIR
EIMEQIRPALNKGKVILSVAAGITMHSLQQWAEALCPVVRCMPNTPALVGMGVFALCFDDPALGNERRQDILRLFSGLGQ
CVEMAEDKFTAFSALIGAGPAYVFAMMQGLVQAGVTMGFPHAQARQMVTALFAGSARMAEEDATPLGQLRDNVCSPGGLT
IAGVNALDRAGLTGLLVDAVLAASARGAEMERNNG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=32.967032967033, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=31.5018315018315, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=31.5018315018315, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI198041662, Length=273, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786585, Length=278, Percent_Identity=33.8129496402878, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17569021, Length=272, Percent_Identity=32.3529411764706, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17540664, Length=291, Percent_Identity=25.7731958762887, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=280, Percent_Identity=27.1428571428571, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21358587, Length=270, Percent_Identity=31.1111111111111, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=29.2857142857143, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24647700, Length=166, Percent_Identity=31.9277108433735, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29034; Mature: 28903

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRIGCVGCGNMGGAIMSGLARPGTRNENRNSAYTLCGYNRTASRMQALEKAGVRVMAS
CEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEC
PLGVAENADIILLAVKPYQIREIMEQIRPALNKGKVILSVAAGITMHSLQQWAEALCPVV
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
RCMPNTPALVGMGVFALCFDDPALGNERRQDILRLFSGLGQCVEMAEDKFTAFSALIGAG
HHCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAYVFAMMQGLVQAGVTMGFPHAQARQMVTALFAGSARMAEEDATPLGQLRDNVCSPGGL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCCCCCE
TIAGVNALDRAGLTGLLVDAVLAASARGAEMERNNG
EEECCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TLRIGCVGCGNMGGAIMSGLARPGTRNENRNSAYTLCGYNRTASRMQALEKAGVRVMAS
EEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEC
PLGVAENADIILLAVKPYQIREIMEQIRPALNKGKVILSVAAGITMHSLQQWAEALCPVV
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
RCMPNTPALVGMGVFALCFDDPALGNERRQDILRLFSGLGQCVEMAEDKFTAFSALIGAG
HHCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAYVFAMMQGLVQAGVTMGFPHAQARQMVTALFAGSARMAEEDATPLGQLRDNVCSPGGL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCCCCCE
TIAGVNALDRAGLTGLLVDAVLAASARGAEMERNNG
EEECCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]