Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 220904163

GI number: 220904163

Start: 1037354

End: 1038796

Strand: Reverse

Name: htrA [H]

Synonym: Ddes_0890

Alternate gene names: 220904163

Gene position: 1038796-1037354 (Counterclockwise)

Preceding gene: 220904166

Following gene: 220904162

Centisome position: 36.15

GC content: 60.78

Gene sequence:

>1443_bases
ATGACCCAATCGCTTACAGCCATATACAAAAAAATGCCTTCCGGCATCAGACGGCTTGCCGGACCCAGACATTTTTGCGG
CATCCATCGCACACTGGCCTGGGCCATGTACTGGACCCTGCTGACACTTCTTTCAGGCGGGCTGCTCACTCTGGCCCCTC
TCACGGCAGGAGCGGCCCCGCAGGAAGGCAGCCCGCGCATGACGCCTGTTGTACGCGCAGTTCAGGCAGTTGCGCCGGCA
GTAGTCAATATCACCAGCACGCAGGTAATCCAGGGGCAGACCCTTTCGCCACTGGAACAGTTCTTCGGGCCGGGCCGCGG
GCCGGGCTTTGGCGGCCCGCGCTCGCCCCGCAAGCAAAAACGCGAAAGCCTTGGCTCGGGCGTTATTGTGGACGGCAAGA
AAGGCCTTGTGCTCACTAACGCCCACGTTATCGCGGGCGGCGATGAAGTTATGGTGCGTCTGCTGGACGGCCGCGAATTT
CCCGCCGCCATATGCGGCGCGGACCCGGATTTCGACATAGCCGTGCTGCAGGTCAAAGGTGCCAGCGACCTGCCCTCTGT
GAGCCTGGGCAACTCGGACAACATCCTGCCCGGCGAAACAGCCATCGCCATCGGCAATCCTTTCGGCTTCAGCCACACGG
TGACCACAGGCGTCATTTCTGCCCTGGGGCGCACCATCCGCAGCCGCAACAGCGCTTTTACAGACCTCATCCAGACTGAT
GCCGCCATCAACCCCGGCAACAGCGGCGGCCCCCTGCTGAATCTCGAGGGCGTGCTTATAGGCATCAATACCGCAGTAGA
CGCCCGTGGCGAAGGTATCGGCTTTGCCATACCCGTCAACAAGGCCAGGCGCGTCATGTCTGACCTTATGGACAAAGGCG
GTGTTGCCCCGCTCTGGCTTGGGCTTGACGTGCAGGATGTAGACCCGCACACGGCCATGGCCCTGGGCCTCAGCAGGGCG
CGCGGTGTGCTGGTTACCGCGGTTCTTCCCGGCACTCCGGCTGAAAAGGTCCGCCTGCGTCCCGGCGATATCATAGACAG
CATCAACGCGACGCCCGTGCGCGACAGGCGCGATTACCTCGATATTCTGCGCAACCAGACCGCAGACGCCAAGCTGCGCC
TGAGTCTGCGGCGCGATGGCGAAACTGTGCCGCTGGATATAACACCGGCGCCCTTTACCGATGAAAATGCCCGCAACCTC
ATGCTGAAACGCTGGGGATTCAGGGTGGCGCAAACAGCCGGAAAAGTGACCGTGAGCAGTGTTAACGCCAATGGGCCTTC
GCCCTTTCTGCAAAAAGGCGATATCATCTCCGCAGTGGGGGCGATTCCCGTGCAGGAAGAAAAGGATCTTTTACAGGCTT
TCAGGCGAGAACGCATGTCAGGCCAGGTACTTATGCAAATCACGCGTAACGGCAAAGGCTATTACGCACGGCTTGTTCCG
TAA

Upstream 100 bases:

>100_bases
GGGCCGGGCCTTTTATTCGGCAATCTGCTTCGCGGCCCTTTACGAACAGTTCACGATGGTTATGTATGTGAGGTAAAAAA
GCCCCAAAGGGATACCAAAA

Downstream 100 bases:

>100_bases
GAGAAAACAACAGTCCTGACTGCCCGGAAAACACGGAATTTTGATGCCGATTCTGTATCCTGTCACAGGGCTGATGCTTA
CAAACCGCCGCCGGCAGCCG

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTQSLTAIYKKMPSGIRRLAGPRHFCGIHRTLAWAMYWTLLTLLSGGLLTLAPLTAGAAPQEGSPRMTPVVRAVQAVAPA
VVNITSTQVIQGQTLSPLEQFFGPGRGPGFGGPRSPRKQKRESLGSGVIVDGKKGLVLTNAHVIAGGDEVMVRLLDGREF
PAAICGADPDFDIAVLQVKGASDLPSVSLGNSDNILPGETAIAIGNPFGFSHTVTTGVISALGRTIRSRNSAFTDLIQTD
AAINPGNSGGPLLNLEGVLIGINTAVDARGEGIGFAIPVNKARRVMSDLMDKGGVAPLWLGLDVQDVDPHTAMALGLSRA
RGVLVTAVLPGTPAEKVRLRPGDIIDSINATPVRDRRDYLDILRNQTADAKLRLSLRRDGETVPLDITPAPFTDENARNL
MLKRWGFRVAQTAGKVTVSSVNANGPSPFLQKGDIISAVGAIPVQEEKDLLQAFRRERMSGQVLMQITRNGKGYYARLVP

Sequences:

>Translated_480_residues
MTQSLTAIYKKMPSGIRRLAGPRHFCGIHRTLAWAMYWTLLTLLSGGLLTLAPLTAGAAPQEGSPRMTPVVRAVQAVAPA
VVNITSTQVIQGQTLSPLEQFFGPGRGPGFGGPRSPRKQKRESLGSGVIVDGKKGLVLTNAHVIAGGDEVMVRLLDGREF
PAAICGADPDFDIAVLQVKGASDLPSVSLGNSDNILPGETAIAIGNPFGFSHTVTTGVISALGRTIRSRNSAFTDLIQTD
AAINPGNSGGPLLNLEGVLIGINTAVDARGEGIGFAIPVNKARRVMSDLMDKGGVAPLWLGLDVQDVDPHTAMALGLSRA
RGVLVTAVLPGTPAEKVRLRPGDIIDSINATPVRDRRDYLDILRNQTADAKLRLSLRRDGETVPLDITPAPFTDENARNL
MLKRWGFRVAQTAGKVTVSSVNANGPSPFLQKGDIISAVGAIPVQEEKDLLQAFRRERMSGQVLMQITRNGKGYYARLVP
>Mature_479_residues
TQSLTAIYKKMPSGIRRLAGPRHFCGIHRTLAWAMYWTLLTLLSGGLLTLAPLTAGAAPQEGSPRMTPVVRAVQAVAPAV
VNITSTQVIQGQTLSPLEQFFGPGRGPGFGGPRSPRKQKRESLGSGVIVDGKKGLVLTNAHVIAGGDEVMVRLLDGREFP
AAICGADPDFDIAVLQVKGASDLPSVSLGNSDNILPGETAIAIGNPFGFSHTVTTGVISALGRTIRSRNSAFTDLIQTDA
AINPGNSGGPLLNLEGVLIGINTAVDARGEGIGFAIPVNKARRVMSDLMDKGGVAPLWLGLDVQDVDPHTAMALGLSRAR
GVLVTAVLPGTPAEKVRLRPGDIIDSINATPVRDRRDYLDILRNQTADAKLRLSLRRDGETVPLDITPAPFTDENARNLM
LKRWGFRVAQTAGKVTVSSVNANGPSPFLQKGDIISAVGAIPVQEEKDLLQAFRRERMSGQVLMQITRNGKGYYARLVP

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=289, Percent_Identity=37.3702422145329, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI22129776, Length=360, Percent_Identity=33.8888888888889, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI7019477, Length=282, Percent_Identity=37.5886524822695, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI24308541, Length=279, Percent_Identity=31.5412186379928, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI1789629, Length=365, Percent_Identity=37.8082191780822, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1786356, Length=422, Percent_Identity=35.781990521327, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1789630, Length=381, Percent_Identity=31.758530183727, Blast_Score=154, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24646839, Length=292, Percent_Identity=35.958904109589, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50940; Mature: 50809

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSLTAIYKKMPSGIRRLAGPRHFCGIHRTLAWAMYWTLLTLLSGGLLTLAPLTAGAAP
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCC
QEGSPRMTPVVRAVQAVAPAVVNITSTQVIQGQTLSPLEQFFGPGRGPGFGGPRSPRKQK
CCCCCCHHHHHHHHHHHHHHHEEECCCEEECCCCCCHHHHHCCCCCCCCCCCCCCHHHHH
RESLGSGVIVDGKKGLVLTNAHVIAGGDEVMVRLLDGREFPAAICGADPDFDIAVLQVKG
HHHCCCCEEEECCCCEEEECCEEEECCHHHEEEEECCCCCCHHCCCCCCCCCEEEEEEEC
ASDLPSVSLGNSDNILPGETAIAIGNPFGFSHTVTTGVISALGRTIRSRNSAFTDLIQTD
CCCCCCEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
AAINPGNSGGPLLNLEGVLIGINTAVDARGEGIGFAIPVNKARRVMSDLMDKGGVAPLWL
CCCCCCCCCCCEEEECEEEEEECCEECCCCCCEEEEECHHHHHHHHHHHHHCCCCCEEEE
GLDVQDVDPHTAMALGLSRARGVLVTAVLPGTPAEKVRLRPGDIIDSINATPVRDRRDYL
CCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHEEECCCHHHHCCCCCCCCCHHHHH
DILRNQTADAKLRLSLRRDGETVPLDITPAPFTDENARNLMLKRWGFRVAQTAGKVTVSS
HHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEE
VNANGPSPFLQKGDIISAVGAIPVQEEKDLLQAFRRERMSGQVLMQITRNGKGYYARLVP
ECCCCCCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECC
>Mature Secondary Structure 
TQSLTAIYKKMPSGIRRLAGPRHFCGIHRTLAWAMYWTLLTLLSGGLLTLAPLTAGAAP
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCC
QEGSPRMTPVVRAVQAVAPAVVNITSTQVIQGQTLSPLEQFFGPGRGPGFGGPRSPRKQK
CCCCCCHHHHHHHHHHHHHHHEEECCCEEECCCCCCHHHHHCCCCCCCCCCCCCCHHHHH
RESLGSGVIVDGKKGLVLTNAHVIAGGDEVMVRLLDGREFPAAICGADPDFDIAVLQVKG
HHHCCCCEEEECCCCEEEECCEEEECCHHHEEEEECCCCCCHHCCCCCCCCCEEEEEEEC
ASDLPSVSLGNSDNILPGETAIAIGNPFGFSHTVTTGVISALGRTIRSRNSAFTDLIQTD
CCCCCCEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
AAINPGNSGGPLLNLEGVLIGINTAVDARGEGIGFAIPVNKARRVMSDLMDKGGVAPLWL
CCCCCCCCCCCEEEECEEEEEECCEECCCCCCEEEEECHHHHHHHHHHHHHCCCCCEEEE
GLDVQDVDPHTAMALGLSRARGVLVTAVLPGTPAEKVRLRPGDIIDSINATPVRDRRDYL
CCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHEEECCCHHHHCCCCCCCCCHHHHH
DILRNQTADAKLRLSLRRDGETVPLDITPAPFTDENARNLMLKRWGFRVAQTAGKVTVSS
HHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEE
VNANGPSPFLQKGDIISAVGAIPVQEEKDLLQAFRRERMSGQVLMQITRNGKGYYARLVP
ECCCCCCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]