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The map label for this gene is ytcB [H]

Identifier: 220904053

GI number: 220904053

Start: 913042

End: 913998

Strand: Reverse

Name: ytcB [H]

Synonym: Ddes_0779

Alternate gene names: 220904053

Gene position: 913998-913042 (Counterclockwise)

Preceding gene: 220904064

Following gene: 220904052

Centisome position: 31.81

GC content: 57.37

Gene sequence:

>957_bases
ATGCATCTCCGCAAACGTATACTGGTCACGGGCGGTTCGGGCTTTCTCGGTTCGCACCTGTGTGAAAGACTGCTCAACGA
GGGACATGAAGTCCTTTGCGTGGACAACTTCTTTTCCAGCGCCCGCGCCAATGTGGAGGATTTTCTCGATAACAGAAGAT
TCGAGCTTATCCGCCACGATGTGACCTTTCCCCTGTATGTGGAAGTGGACGAAATCTACAACCTCGCCTGCCCGGCCTCG
CCCATTCACTATCAGCACGACCCGGTGCAGACCATCAAGACCTGCGTTCACGGGGCCATCAATATGCTGGGGCTGGCCAA
GAGGCTCAAGGCGCGCATCTATCAGGCGTCCACCAGTGAAGTGTACGGCGACCCCGAAATACACCCGCAGACCGAGGACT
ACTGGGGGCATGTGAACCCCAACGGCATCCGTTCGTGCTACGATGAAGGCAAGCGCTGCGCCGAAGCCCTGTTTTTCTCT
TACTGGCGCCAGGGCGGCCTGCCCATCAAGGTGGGGCGCATCTTCAATACCTACGGACCCAAAATGCATCCCAACGACGG
GCGCGTGGTATCCAACTTCATCATTCAGGCGCTCAAGGGCCAGCCCATCACCATTTACGGAGACGGCAGCCAGACGCGCT
CTTTCTGCTATGTGGATGACCTGATCGAGTGCATGGTCCGCTTCATGGCTTCGCCCGAAGACTTCATCGGCCCGATGAAT
ATGGGCAACCCCGGCGAATTCACCATTCGCGAACTGGCAGAAAAGGTCGTGGACATGACCGGCAGCAAATCCGTGATCAG
TTACGAACCGCTGCCCGGTGACGACCCCAAACAGCGGCGGCCCGACATTACGCTGGCCCGCGAAAAACTCGGCTGGGAGC
CGCAGGTCAAGCTGGAAGACGGTTTGAAAAAGACCATCGCCTACTTTGACAGCATGTTAAAACTGGGCATGGCCTGA

Upstream 100 bases:

>100_bases
CCCGGCAGCAGCGCCATTGCCAAGACAGGGCAATAGCGCTATGCTGAACTGGTTTTGTTGTCCTACTTTTTGATTTAACA
CCACTTTTTCCGGGGGAAAT

Downstream 100 bases:

>100_bases
CCACTGCCCGAAAGCCACCCTATGCCATGACGCTCTTTATCATAACCCTGCTTGTCCTGGCGGCGGCTGCCGCCGCCATG
GCCCTGTTCGCGCTGCTGCC

Product: NAD-dependent epimerase/dehydratase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MHLRKRILVTGGSGFLGSHLCERLLNEGHEVLCVDNFFSSARANVEDFLDNRRFELIRHDVTFPLYVEVDEIYNLACPAS
PIHYQHDPVQTIKTCVHGAINMLGLAKRLKARIYQASTSEVYGDPEIHPQTEDYWGHVNPNGIRSCYDEGKRCAEALFFS
YWRQGGLPIKVGRIFNTYGPKMHPNDGRVVSNFIIQALKGQPITIYGDGSQTRSFCYVDDLIECMVRFMASPEDFIGPMN
MGNPGEFTIRELAEKVVDMTGSKSVISYEPLPGDDPKQRRPDITLAREKLGWEPQVKLEDGLKKTIAYFDSMLKLGMA

Sequences:

>Translated_318_residues
MHLRKRILVTGGSGFLGSHLCERLLNEGHEVLCVDNFFSSARANVEDFLDNRRFELIRHDVTFPLYVEVDEIYNLACPAS
PIHYQHDPVQTIKTCVHGAINMLGLAKRLKARIYQASTSEVYGDPEIHPQTEDYWGHVNPNGIRSCYDEGKRCAEALFFS
YWRQGGLPIKVGRIFNTYGPKMHPNDGRVVSNFIIQALKGQPITIYGDGSQTRSFCYVDDLIECMVRFMASPEDFIGPMN
MGNPGEFTIRELAEKVVDMTGSKSVISYEPLPGDDPKQRRPDITLAREKLGWEPQVKLEDGLKKTIAYFDSMLKLGMA
>Mature_318_residues
MHLRKRILVTGGSGFLGSHLCERLLNEGHEVLCVDNFFSSARANVEDFLDNRRFELIRHDVTFPLYVEVDEIYNLACPAS
PIHYQHDPVQTIKTCVHGAINMLGLAKRLKARIYQASTSEVYGDPEIHPQTEDYWGHVNPNGIRSCYDEGKRCAEALFFS
YWRQGGLPIKVGRIFNTYGPKMHPNDGRVVSNFIIQALKGQPITIYGDGSQTRSFCYVDDLIECMVRFMASPEDFIGPMN
MGNPGEFTIRELAEKVVDMTGSKSVISYEPLPGDDPKQRRPDITLAREKLGWEPQVKLEDGLKKTIAYFDSMLKLGMA

Specific function: Unknown

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=311, Percent_Identity=57.556270096463, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI7657641, Length=325, Percent_Identity=26.7692307692308, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1788589, Length=344, Percent_Identity=26.7441860465116, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI48994969, Length=340, Percent_Identity=25.8823529411765, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788353, Length=345, Percent_Identity=28.1159420289855, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788366, Length=359, Percent_Identity=27.2980501392758, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788365, Length=341, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786974, Length=254, Percent_Identity=27.5590551181102, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=307, Percent_Identity=57.328990228013, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI115532424, Length=332, Percent_Identity=26.8072289156627, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=330, Percent_Identity=26.969696969697, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71982035, Length=334, Percent_Identity=26.0479041916168, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982038, Length=336, Percent_Identity=26.1904761904762, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21356223, Length=310, Percent_Identity=58.0645161290323, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46

Molecular weight: Translated: 35986; Mature: 35986

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLRKRILVTGGSGFLGSHLCERLLNEGHEVLCVDNFFSSARANVEDFLDNRRFELIRHD
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHCCCHHHHHCCHHHHHHHHC
VTFPLYVEVDEIYNLACPASPIHYQHDPVQTIKTCVHGAINMLGLAKRLKARIYQASTSE
CCCEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VYGDPEIHPQTEDYWGHVNPNGIRSCYDEGKRCAEALFFSYWRQGGLPIKVGRIFNTYGP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHCCCC
KMHPNDGRVVSNFIIQALKGQPITIYGDGSQTRSFCYVDDLIECMVRFMASPEDFIGPMN
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHCCCHHHCCCCC
MGNPGEFTIRELAEKVVDMTGSKSVISYEPLPGDDPKQRRPDITLAREKLGWEPQVKLED
CCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHCCCCCCHHHHHCCCCCCEEHHH
GLKKTIAYFDSMLKLGMA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHLRKRILVTGGSGFLGSHLCERLLNEGHEVLCVDNFFSSARANVEDFLDNRRFELIRHD
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHCCCHHHHHCCHHHHHHHHC
VTFPLYVEVDEIYNLACPASPIHYQHDPVQTIKTCVHGAINMLGLAKRLKARIYQASTSE
CCCEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VYGDPEIHPQTEDYWGHVNPNGIRSCYDEGKRCAEALFFSYWRQGGLPIKVGRIFNTYGP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHCCCC
KMHPNDGRVVSNFIIQALKGQPITIYGDGSQTRSFCYVDDLIECMVRFMASPEDFIGPMN
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHCCCHHHCCCCC
MGNPGEFTIRELAEKVVDMTGSKSVISYEPLPGDDPKQRRPDITLAREKLGWEPQVKLED
CCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHCCCCCCHHHHHCCCCCCEEHHH
GLKKTIAYFDSMLKLGMA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dTDPglucose

Specific reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]