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The map label for this gene is tcrA [H]

Identifier: 220904004

GI number: 220904004

Start: 855429

End: 856208

Strand: Direct

Name: tcrA [H]

Synonym: Ddes_0730

Alternate gene names: 220904004

Gene position: 855429-856208 (Clockwise)

Preceding gene: 220904003

Following gene: 220904005

Centisome position: 29.77

GC content: 63.46

Gene sequence:

>780_bases
ATGTCCTGTTCCCTGCTGCTTGTGGAAGACAACGAGGACATCCTCGCTAACCTGTACGCCTACCTTGAACCGCTGGGCTA
CACGCTGGACTGTGCCCGCAACGGCAAAGCCGGGCTTGAGATGGCTCTCGGGCGCGGTTTTGACTGCATCGTGCTGGACG
TCATGCTGCCCGGCATGGACGGCATAAGCCTGTGCCGCCGCCTGCGGCAGGAATACAGGGTCTCTACTCCCGTCATCATG
CTTACGGCCCGGGATGCCGTTGCCGACAGGGTGGCGGGCCTTGAGGCCGGGGCAGACGATTACCTGGTCAAGCCCTTTGC
CCTTAAGGAGCTTGAAGCCCGCATCCGGGCGCTGCTGCGGCGCGGCCATCTGCAGGGCAGCAACGGCGCAGACGGTCTCT
GGACCTGCGCAGACCTTGTTTTTAATGATGAAGAGCACTGGGCCGAGCGCCGGGGGCAGCGCTTGCGGCTAAGCCCAACG
GGCTTTCGCATCCTCAGGGAACTTTTGCGCGTTGCGCCGGGGCTTGTGCGCCGTCAGGATCTTGAGCGCCTGCTCTGGGG
CAGCGAACCGCCGGAAGGCAGCGCCCTGCGCACGCATATTCATGAGTTACGGCGTGAGCTGGACAAACCCTTCGGCAGGG
CGTTGCTGCATACTGTGCCTCATGTCGGCTACAGGCTGAGTCCGGACGCATCTGAAGAAGACGAAGCACCCGAACCGGGC
ATGCCGGGTGCGGGGAGTGGCTCTTCCGGCATGAAGATAGCCGGCGCGGAGAACACCTGA

Upstream 100 bases:

>100_bases
CATGTGGACTGGAACCGCAAGCGCCCCAATGAGGTAGAGGTGGACGGTCTGGCCATTATCGGCATCATTGACGTGCGGGA
CACGCCCGAGCGCTAAGGCC

Downstream 100 bases:

>100_bases
TGCCTGCCGTTCCGCGTCCGGGGGCCTGCCGTCCGGTTTTTGCGCGCCGTATGCTTATGGCTTTTGTGTTTCTGGCCCTC
GGCATGGGGGCTGCCCTTGG

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSCSLLLVEDNEDILANLYAYLEPLGYTLDCARNGKAGLEMALGRGFDCIVLDVMLPGMDGISLCRRLRQEYRVSTPVIM
LTARDAVADRVAGLEAGADDYLVKPFALKELEARIRALLRRGHLQGSNGADGLWTCADLVFNDEEHWAERRGQRLRLSPT
GFRILRELLRVAPGLVRRQDLERLLWGSEPPEGSALRTHIHELRRELDKPFGRALLHTVPHVGYRLSPDASEEDEAPEPG
MPGAGSGSSGMKIAGAENT

Sequences:

>Translated_259_residues
MSCSLLLVEDNEDILANLYAYLEPLGYTLDCARNGKAGLEMALGRGFDCIVLDVMLPGMDGISLCRRLRQEYRVSTPVIM
LTARDAVADRVAGLEAGADDYLVKPFALKELEARIRALLRRGHLQGSNGADGLWTCADLVFNDEEHWAERRGQRLRLSPT
GFRILRELLRVAPGLVRRQDLERLLWGSEPPEGSALRTHIHELRRELDKPFGRALLHTVPHVGYRLSPDASEEDEAPEPG
MPGAGSGSSGMKIAGAENT
>Mature_258_residues
SCSLLLVEDNEDILANLYAYLEPLGYTLDCARNGKAGLEMALGRGFDCIVLDVMLPGMDGISLCRRLRQEYRVSTPVIML
TARDAVADRVAGLEAGADDYLVKPFALKELEARIRALLRRGHLQGSNGADGLWTCADLVFNDEEHWAERRGQRLRLSPTG
FRILRELLRVAPGLVRRQDLERLLWGSEPPEGSALRTHIHELRRELDKPFGRALLHTVPHVGYRLSPDASEEDEAPEPGM
PGAGSGSSGMKIAGAENT

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=36.6515837104072, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.6681614349776, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=35.8078602620087, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790552, Length=234, Percent_Identity=38.8888888888889, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=36.283185840708, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=38.3259911894273, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.9055793991416, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=33.0508474576271, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=32.7510917030568, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=31.7596566523605, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790860, Length=206, Percent_Identity=33.495145631068, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=28.9592760180996, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=27.8969957081545, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI48994928, Length=114, Percent_Identity=36.8421052631579, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=27.6150627615063, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=122, Percent_Identity=31.1475409836066, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=122, Percent_Identity=32.7868852459016, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1790299, Length=109, Percent_Identity=33.0275229357798, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28569; Mature: 28438

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCSLLLVEDNEDILANLYAYLEPLGYTLDCARNGKAGLEMALGRGFDCIVLDVMLPGMD
CCCEEEEEECCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCEEEEEHHHCCCC
GISLCRRLRQEYRVSTPVIMLTARDAVADRVAGLEAGADDYLVKPFALKELEARIRALLR
HHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHH
RGHLQGSNGADGLWTCADLVFNDEEHWAERRGQRLRLSPTGFRILRELLRVAPGLVRRQD
HCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHCCHHHHHHH
LERLLWGSEPPEGSALRTHIHELRRELDKPFGRALLHTVPHVGYRLSPDASEEDEAPEPG
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
MPGAGSGSSGMKIAGAENT
CCCCCCCCCCCEECCCCCC
>Mature Secondary Structure 
SCSLLLVEDNEDILANLYAYLEPLGYTLDCARNGKAGLEMALGRGFDCIVLDVMLPGMD
CCEEEEEECCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCCEEEEEHHHCCCC
GISLCRRLRQEYRVSTPVIMLTARDAVADRVAGLEAGADDYLVKPFALKELEARIRALLR
HHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHH
RGHLQGSNGADGLWTCADLVFNDEEHWAERRGQRLRLSPTGFRILRELLRVAPGLVRRQD
HCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHCCHHHHHHH
LERLLWGSEPPEGSALRTHIHELRRELDKPFGRALLHTVPHVGYRLSPDASEEDEAPEPG
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
MPGAGSGSSGMKIAGAENT
CCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]