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The map label for this gene is clpP

Identifier: 220903965

GI number: 220903965

Start: 820773

End: 821381

Strand: Direct

Name: clpP

Synonym: Ddes_0691

Alternate gene names: 220903965

Gene position: 820773-821381 (Clockwise)

Preceding gene: 220903964

Following gene: 220903966

Centisome position: 28.56

GC content: 55.99

Gene sequence:

>609_bases
ATGTCGCTTATACCTATGGTTATTGAAACCACCGGCCGTTCCGAACGCGCCTACGATATCTATTCGCGCCTGCTCAAGGA
CCGCATCGTTCTGCTGGGGTCCGAGGTCAACGACACCGTGGCCTCGCTGATCTGCGCCCAGCTGCTTTTTCTTGAATCGC
AGGATCCGGAAAAGGAAATTTCTCTCTATATCAACTCGCCCGGCGGCTCGGTTACCGCTGGTCTTGCCATCTATGACACC
CTGCGCTTCATTTCCGCGCCTGTTTCCACGGTGTGCATGGGGCGTGCTGCCAGCATGGGCGCTTTTTTGCTGGCCGCGGG
CAAACCGGGGCTGCGCTACGCCCTGCCCAACAGCCAGATCATGATTCACCAGCCTTCGGCCGGGTATCAGGGGCAGGCCA
CTGATATAGAGATTCATGCCAAAGAGGTGCTGCGGCTCAAAGAGCGCCTCAACCGCATACTTGCCGAAAATACCGGTCGT
CCTTACAAGGATATTGTCAAGGCGACCGAACGCGATAACTTTTTGACTCCTGAAGAAGCCAAAGACCTGGGCATTATCGA
CCGCGTACTGGTTTCGCGCCAGGACATGGCTCAGGAAAAGAGCGAATAA

Upstream 100 bases:

>100_bases
CAAATAATAATCAGGGAAGGCGGCCTCTGGGCCGCCTTTTGCTTTTTTCGCGGCTCGATGCCGCATATATCGGCCCCCGG
GCCATGTCAGTGAGGCTTTC

Downstream 100 bases:

>100_bases
TCATGGCCAAGAACGATAAGAACAAGGTCAGCGAACCTTTGAGCTGCTCCTTCTGCGGGCGCAGCGAACTGGAGGTGCGC
AACCTCATCGTGCAGGACGG

Product: Endopeptidase Clp

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSLIPMVIETTGRSERAYDIYSRLLKDRIVLLGSEVNDTVASLICAQLLFLESQDPEKEISLYINSPGGSVTAGLAIYDT
LRFISAPVSTVCMGRAASMGAFLLAAGKPGLRYALPNSQIMIHQPSAGYQGQATDIEIHAKEVLRLKERLNRILAENTGR
PYKDIVKATERDNFLTPEEAKDLGIIDRVLVSRQDMAQEKSE

Sequences:

>Translated_202_residues
MSLIPMVIETTGRSERAYDIYSRLLKDRIVLLGSEVNDTVASLICAQLLFLESQDPEKEISLYINSPGGSVTAGLAIYDT
LRFISAPVSTVCMGRAASMGAFLLAAGKPGLRYALPNSQIMIHQPSAGYQGQATDIEIHAKEVLRLKERLNRILAENTGR
PYKDIVKATERDNFLTPEEAKDLGIIDRVLVSRQDMAQEKSE
>Mature_201_residues
SLIPMVIETTGRSERAYDIYSRLLKDRIVLLGSEVNDTVASLICAQLLFLESQDPEKEISLYINSPGGSVTAGLAIYDTL
RFISAPVSTVCMGRAASMGAFLLAAGKPGLRYALPNSQIMIHQPSAGYQGQATDIEIHAKEVLRLKERLNRILAENTGRP
YKDIVKATERDNFLTPEEAKDLGIIDRVLVSRQDMAQEKSE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=58.6387434554974, Blast_Score=241, Evalue=4e-64,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=59.5854922279793, Blast_Score=256, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=57.5268817204301, Blast_Score=225, Evalue=1e-59,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=58.9473684210526, Blast_Score=247, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_DESDA (B8IYM2)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479277.1
- MEROPS:   S14.001
- GeneID:   7284365
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_0691
- HOGENOM:   HBG558421
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22257; Mature: 22126

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIPMVIETTGRSERAYDIYSRLLKDRIVLLGSEVNDTVASLICAQLLFLESQDPEKEI
CCCCCEEEECCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCEE
SLYINSPGGSVTAGLAIYDTLRFISAPVSTVCMGRAASMGAFLLAAGKPGLRYALPNSQI
EEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHCEEEEECCCCCCEEECCCCEE
MIHQPSAGYQGQATDIEIHAKEVLRLKERLNRILAENTGRPYKDIVKATERDNFLTPEEA
EEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHH
KDLGIIDRVLVSRQDMAQEKSE
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLIPMVIETTGRSERAYDIYSRLLKDRIVLLGSEVNDTVASLICAQLLFLESQDPEKEI
CCCCEEEECCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCEE
SLYINSPGGSVTAGLAIYDTLRFISAPVSTVCMGRAASMGAFLLAAGKPGLRYALPNSQI
EEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHCEEEEECCCCCCEEECCCCEE
MIHQPSAGYQGQATDIEIHAKEVLRLKERLNRILAENTGRPYKDIVKATERDNFLTPEEA
EEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHH
KDLGIIDRVLVSRQDMAQEKSE
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA