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The map label for this gene is hgdC [H]

Identifier: 220903823

GI number: 220903823

Start: 658274

End: 659065

Strand: Reverse

Name: hgdC [H]

Synonym: Ddes_0546

Alternate gene names: 220903823

Gene position: 659065-658274 (Counterclockwise)

Preceding gene: 220903824

Following gene: 220903822

Centisome position: 22.94

GC content: 62.37

Gene sequence:

>792_bases
ATGTTTGCAGCCGGAATAGATGTAGGCTCTGTGGCCGCCAAGGCCGTCATTTTTGATACGGCAAGCCGCAGCATGGCGGG
CGGCACTGTGCTGCCCACAGGCTGGAACACGCGGGAAGCGGGCGAACGCGCGCTGGCTGCCGTCTGCGGGCAGGCCGGGG
TGGACCGGGCCGACCTGGCCCGCATCGTGGCCACGGGCTACGGGCGCATCGCCCTGCCCTTTGCCCATAAAACCGTGACG
GAAATCACCTGTCATGCCCGCGGCGCTTCGTGGCTTTTTCCCGGTTCCGGCGTGGTGCTCGATATCGGCGGCCAGGACAG
CAAGGCCATCAGTCTGGATGAAAACGGCGGTGTGCGGGACTTTGTAATGAACGACAAATGCGCGGCAGGCACCGGGCGTT
TTTTGCAGGTACTGGCCGGTATCCTGGGCATGCCGCTGGACGACCTGGGCAAAGCCGCGGTTGGCGGCAGTCCGGTGCCC
ATCTCGAGCATGTGCGCAGTGTTTGCGGAAACAGAAATCGTTGGCCTGCTGGCGCAGGGAACCCCGCCCGCCGATCTGGC
AGCCGGAGTTTTTGTGTCCATAGCAAGACGCATGCGAGGCCTTGCACGCCGTATTTCTTTTACGGGGCAATGTGTTTTTA
CCGGCGGCATGGCTACAAGCCCGGCGTTTTGCGACTTTCTTTCCCGGGAACTGGAAATACCTGTGCGGGTTCCTGACGAA
CCGCAACTGGTGGGCGCCCTGGGCGCTGCCCTGCTTGCAGCGCATCAGCTTGAAAAGAAACATCATGCCTAG

Upstream 100 bases:

>100_bases
ACAGGCACAGCTTGCCCGTGCCTGTTTTGCGGCGAGGATGTCATGAGAATCCTTGTGAAGCGCTCACGCACGGCATGCCC
AATGCCCAGGAGGACAAACG

Downstream 100 bases:

>100_bases
CCGGCCCGGCAAAAGGGCCAAACCGTAACCCAGCAAGGAGCGGATATGAAGTGCGCCAGTTTTGACAGAATCACCACGGC
CTTTGAAAAAAACGTGCTCA

Product: CoA-substrate-specific enzyme activase

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MFAAGIDVGSVAAKAVIFDTASRSMAGGTVLPTGWNTREAGERALAAVCGQAGVDRADLARIVATGYGRIALPFAHKTVT
EITCHARGASWLFPGSGVVLDIGGQDSKAISLDENGGVRDFVMNDKCAAGTGRFLQVLAGILGMPLDDLGKAAVGGSPVP
ISSMCAVFAETEIVGLLAQGTPPADLAAGVFVSIARRMRGLARRISFTGQCVFTGGMATSPAFCDFLSRELEIPVRVPDE
PQLVGALGAALLAAHQLEKKHHA

Sequences:

>Translated_263_residues
MFAAGIDVGSVAAKAVIFDTASRSMAGGTVLPTGWNTREAGERALAAVCGQAGVDRADLARIVATGYGRIALPFAHKTVT
EITCHARGASWLFPGSGVVLDIGGQDSKAISLDENGGVRDFVMNDKCAAGTGRFLQVLAGILGMPLDDLGKAAVGGSPVP
ISSMCAVFAETEIVGLLAQGTPPADLAAGVFVSIARRMRGLARRISFTGQCVFTGGMATSPAFCDFLSRELEIPVRVPDE
PQLVGALGAALLAAHQLEKKHHA
>Mature_263_residues
MFAAGIDVGSVAAKAVIFDTASRSMAGGTVLPTGWNTREAGERALAAVCGQAGVDRADLARIVATGYGRIALPFAHKTVT
EITCHARGASWLFPGSGVVLDIGGQDSKAISLDENGGVRDFVMNDKCAAGTGRFLQVLAGILGMPLDDLGKAAVGGSPVP
ISSMCAVFAETEIVGLLAQGTPPADLAAGVFVSIARRMRGLARRISFTGQCVFTGGMATSPAFCDFLSRELEIPVRVPDE
PQLVGALGAALLAAHQLEKKHHA

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=251, Percent_Identity=39.4422310756972, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 27031; Mature: 27031

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAAGIDVGSVAAKAVIFDTASRSMAGGTVLPTGWNTREAGERALAAVCGQAGVDRADLA
CEECCCCHHHHHHHHHEEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHH
RIVATGYGRIALPFAHKTVTEITCHARGASWLFPGSGVVLDIGGQDSKAISLDENGGVRD
HHHHCCCCCEEEEEHHHHHHHEEEECCCCCEEECCCCEEEEECCCCCCEEEECCCCCEEE
FVMNDKCAAGTGRFLQVLAGILGMPLDDLGKAAVGGSPVPISSMCAVFAETEIVGLLAQG
EEECCCCCCCCHHHHHHHHHHHCCCHHHHCCHHCCCCCCCHHHHHHHHHHHHHEEEEECC
TPPADLAAGVFVSIARRMRGLARRISFTGQCVFTGGMATSPAFCDFLSRELEIPVRVPDE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCEECCCC
PQLVGALGAALLAAHQLEKKHHA
CHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFAAGIDVGSVAAKAVIFDTASRSMAGGTVLPTGWNTREAGERALAAVCGQAGVDRADLA
CEECCCCHHHHHHHHHEEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHH
RIVATGYGRIALPFAHKTVTEITCHARGASWLFPGSGVVLDIGGQDSKAISLDENGGVRD
HHHHCCCCCEEEEEHHHHHHHEEEECCCCCEEECCCCEEEEECCCCCCEEEECCCCCEEE
FVMNDKCAAGTGRFLQVLAGILGMPLDDLGKAAVGGSPVPISSMCAVFAETEIVGLLAQG
EEECCCCCCCCHHHHHHHHHHHCCCHHHHCCHHCCCCCCCHHHHHHHHHHHHHEEEEECC
TPPADLAAGVFVSIARRMRGLARRISFTGQCVFTGGMATSPAFCDFLSRELEIPVRVPDE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCEECCCC
PQLVGALGAALLAAHQLEKKHHA
CHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]