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The map label for this gene is cobH [H]

Identifier: 220903313

GI number: 220903313

Start: 38411

End: 39103

Strand: Reverse

Name: cobH [H]

Synonym: Ddes_0027

Alternate gene names: 220903313

Gene position: 39103-38411 (Counterclockwise)

Preceding gene: 220903314

Following gene: 220903311

Centisome position: 1.36

GC content: 64.21

Gene sequence:

>693_bases
ATGACGTATATTCCTGCGCCGGAACATTCCGTAGAACTGGACCCGGCCTGCACCCCCCAGACCATCGAAGAGCGCTCTTT
TGCCATTATTGATGAAGAAATGCCGCCCCCGCGCCCTTTTGAAGGGCTTTTGTGGCAGGTGGCGCGCCGCTGCGTGCATA
CACTGGGCGATACAGAAATTGTGCATGACCTGTGTCTGAGCCAGACTGCCCTTGAAGCGGGCGTAAACGCCCTGCTGGCG
GGCTGCACTGTGTACACCGACACACGCATGGCTGCGGCAGGATTGCCCCTGCGGCGGCTGACACCCCTTGGCGTTACCGT
TACGCCCATCATGGCCCTGCCCGGGCTTGATGCGCTTGCGCGGGCAAAAAAAACCACACGCTCCCGCGCGGGGCTGGAAT
CCCTCGCCGCGCAGATGCAGGGACATATCATGGTCATCGGCAACGCGCCCACAGCCCTGCTCGGCCTGCTGGACGTGCTG
GAACAGGGCGCGCCGCCCCCGGCCCTTATTGTGGGCATGCCCGTAGGTTTTGTTAATGCGGCGCAGTCCAAAGAACTGCT
CCGCCGCACTGCGTGGCCCCACTTTACCCTGCTGGGGCGCAAGGGCGGCTCGGCGGTGGCGGCGGCCTGCGTCAACGCCC
TGGCAGATATTGCGCTGGCACGGCGCGGCCTGACGCAGGCGGCGGCACTATAA

Upstream 100 bases:

>100_bases
TCCCGACGCTTCTGGCGTACATGGCTCGAAGCAGCGGTAAAAAACAATGGCAGAACGATGTAACGCCGCGAGCGCACACA
CGACCAACCGAGGCTTACCC

Downstream 100 bases:

>100_bases
CCTGCTTTGTCAAACTGCGTTTGCTCAGACCTTTCCGGCTGACCGGCTTTTGGCCTCATTGTCTCCGGTATCTGCAGGAA
CTTCGGCAGATATTTCGGCG

Product: Precorrin-8X methylmutase CbiC/CobH

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MTYIPAPEHSVELDPACTPQTIEERSFAIIDEEMPPPRPFEGLLWQVARRCVHTLGDTEIVHDLCLSQTALEAGVNALLA
GCTVYTDTRMAAAGLPLRRLTPLGVTVTPIMALPGLDALARAKKTTRSRAGLESLAAQMQGHIMVIGNAPTALLGLLDVL
EQGAPPPALIVGMPVGFVNAAQSKELLRRTAWPHFTLLGRKGGSAVAAACVNALADIALARRGLTQAAAL

Sequences:

>Translated_230_residues
MTYIPAPEHSVELDPACTPQTIEERSFAIIDEEMPPPRPFEGLLWQVARRCVHTLGDTEIVHDLCLSQTALEAGVNALLA
GCTVYTDTRMAAAGLPLRRLTPLGVTVTPIMALPGLDALARAKKTTRSRAGLESLAAQMQGHIMVIGNAPTALLGLLDVL
EQGAPPPALIVGMPVGFVNAAQSKELLRRTAWPHFTLLGRKGGSAVAAACVNALADIALARRGLTQAAAL
>Mature_229_residues
TYIPAPEHSVELDPACTPQTIEERSFAIIDEEMPPPRPFEGLLWQVARRCVHTLGDTEIVHDLCLSQTALEAGVNALLAG
CTVYTDTRMAAAGLPLRRLTPLGVTVTPIMALPGLDALARAKKTTRSRAGLESLAAQMQGHIMVIGNAPTALLGLLDVLE
QGAPPPALIVGMPVGFVNAAQSKELLRRTAWPHFTLLGRKGGSAVAAACVNALADIALARRGLTQAAAL

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 24236; Mature: 24104

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYIPAPEHSVELDPACTPQTIEERSFAIIDEEMPPPRPFEGLLWQVARRCVHTLGDTEI
CCCCCCCCCCEECCCCCCCCHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
VHDLCLSQTALEAGVNALLAGCTVYTDTRMAAAGLPLRRLTPLGVTVTPIMALPGLDALA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCHHHHHHHCCCHHHHH
RAKKTTRSRAGLESLAAQMQGHIMVIGNAPTALLGLLDVLEQGAPPPALIVGMPVGFVNA
HHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
AQSKELLRRTAWPHFTLLGRKGGSAVAAACVNALADIALARRGLTQAAAL
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHCC
>Mature Secondary Structure 
TYIPAPEHSVELDPACTPQTIEERSFAIIDEEMPPPRPFEGLLWQVARRCVHTLGDTEI
CCCCCCCCCEECCCCCCCCHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
VHDLCLSQTALEAGVNALLAGCTVYTDTRMAAAGLPLRRLTPLGVTVTPIMALPGLDALA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCHHHHHHHCCCHHHHH
RAKKTTRSRAGLESLAAQMQGHIMVIGNAPTALLGLLDVLEQGAPPPALIVGMPVGFVNA
HHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
AQSKELLRRTAWPHFTLLGRKGGSAVAAACVNALADIALARRGLTQAAAL
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]