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The map label for this gene is aspS [H]

Identifier: 220903296

GI number: 220903296

Start: 14407

End: 16290

Strand: Direct

Name: aspS [H]

Synonym: Ddes_0010

Alternate gene names: 220903296

Gene position: 14407-16290 (Clockwise)

Preceding gene: 220903295

Following gene: 220903297

Centisome position: 0.5

GC content: 60.14

Gene sequence:

>1884_bases
ATGGCGGAGCAGACGGCCCAGGCGGTCGCGCAGGGCCAGGACGTACAGCAGGAACACCAGAAGTATATCACCGGCCTTGG
CGACTGGCACCGCAGCCAGACCTGCGGTGAACTGACCCTTGCCAATAACGGGCAGGAAGTCTGCCTGATGGGCTGGGTGC
AGTACCGGCGCGACCACGGCGGCCTTATTTTTGTAGACCTGCGCGACCGTTCGGGGCTTACCCAGGTGGTCTTCAGCCCT
GATGCCGCCCCGGAAGCCCATAAAAACGCGCATATCCTGCGTTCGGAATACGTGCTGGCCATAAAGGGTCTGGTGCGCCC
GCGCCCCGAGGGCATGGTGAATCCCAACATGGTCACCGGCGAAATCGAGGTTGTGGTGACGGAATGGAAGTTGCTCAATA
CTTCCAAAACCCCGCCCTTTACCATTGAAAACCGTTGTGATGCGGGCGAGAACCTGCGCCTTGCCTGGCGTTATCTTGAT
CTGCGGCGCCCGCGCATGCAGGACAACCTGCGCCTGCGCCACAAGGTGGCCCAGTGCATACGCCGGCATCTGGACGAAGA
CGGTTTTGTGGAAGTGGAAACACCCGTGCTTACCAAGTCCACGCCTGAAGGCGCACGCGATTTTCTGGTTCCCAGCCGTC
TGAATACGGGCGAATTTTACGCCTTGCCGCAATCGCCGCAGCTTTTCAAGCAGTTGCTCATGGTGGCGGGCATGGACCGC
TATTTCCAGATAGTGCGCTGCTTCCGGGATGAAGATCTGCGCGCCGACCGCCAGCCCGAGTTCACCCAGGTGGACATCGA
AATGAGCTTCGCGGACGAAGAAACAGTTATGGGCATGGCAGAAAAGCTCATGGCCCGGGTATTCAGGGACGTTATGGGCA
AGGAACTTTCCCTGCCGTTCCCGCGTATGCCCTGGGACGAGGCCATGGCCCGCTACGGTGTGGACAAGCCCGATACCCGT
TTTGGCTTGGAGCTTGTGGACATTACCGAAATTGTGCGCGGCTCGGGCTTCAAGCTTTTTGCCACGGCTCCGCTGGTCAA
GGGCATGAGGGTTCCCGGCGGCGAAAGTATGACCCGCAAGGAAATAGACGCCTTTACCGAATTTGTGAAAATCTACGGTG
CGCAGGGTCTGGCCTGGATCAAGATCAAGGCCGACGAATGGCAGTCACCCATTGCCAAATTTCTTTCCGACGAGGAGCGC
AAGGGCATTGCCGCGGCGCTGGATCTTCAGGTGGGCGACATTGTCTTTTTCCAGGCGGGCGAACCGGGCATGGTCAATGC
GGCACTGGGCAACCTGCGCGTGCACCTGGCGGACCATATGAACCTCATACCCGAAAACACCTTTAACTTCCTTTGGGTTA
CAGACTTTCCCCTGTACGAATACGATGAGGAAGAAAAGCGCTACGTGGCCTGCCATCACCCCTTTACCTCTCCGGCCCCC
GGGCATATGGAGCTGATGACCAGCGACCCCGCCCGCGCCCGTGCCCGTGCCTATGACATGGTGCTCAACGGAAGTGAGGT
GGGCGGCGGCTCCATCCGCATCCATTCCGGTGAGGTGCAGCGCCGCATGTTTGAAGCTCTGGGCTTCACGCCCGAGCAGG
CCGAAAGCCAGTTCGGCTTCCTTATCCAGGCGTTGGAGCACGGCGCTCCGCCGCACGGCGGCCTTGCTTTCGGGCTTGAC
CGCCTTATCATGTTACTGGCAGGGGCCAGCAGCATCCGCGACGTCATTGCCTTCCCCAAAACGCAAAAAGCCACCTGCCT
CATGACGGACGCGCCTTCGCCCGTGGCGGCCAAACAGTTGCGTGAGCTTGGGTTGCGCCTGCGTGAGCAGCCCGGCGAAA
AAGGCAAGACCGACAAGCCCGGCGAGGCGGAAAAGGCGGAATAA

Upstream 100 bases:

>100_bases
GTAAAAAATCTGGAAAGCGGAGAACAGACCACTGTGCCGCAAGCCCAGGCACTACACATTTTGCAAACGGGAACCAACTG
ACATGACTGAAGAAAGCCAG

Downstream 100 bases:

>100_bases
AATCCGCCCGGCCGGAAGGCCTTGAGCACAAGGAAGCAGCTATGATTCTTGATATTGTTACCTATCCTGATCCGCGCCTC
AAAGAGGTGTGCGAGCCTGT

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MAEQTAQAVAQGQDVQQEHQKYITGLGDWHRSQTCGELTLANNGQEVCLMGWVQYRRDHGGLIFVDLRDRSGLTQVVFSP
DAAPEAHKNAHILRSEYVLAIKGLVRPRPEGMVNPNMVTGEIEVVVTEWKLLNTSKTPPFTIENRCDAGENLRLAWRYLD
LRRPRMQDNLRLRHKVAQCIRRHLDEDGFVEVETPVLTKSTPEGARDFLVPSRLNTGEFYALPQSPQLFKQLLMVAGMDR
YFQIVRCFRDEDLRADRQPEFTQVDIEMSFADEETVMGMAEKLMARVFRDVMGKELSLPFPRMPWDEAMARYGVDKPDTR
FGLELVDITEIVRGSGFKLFATAPLVKGMRVPGGESMTRKEIDAFTEFVKIYGAQGLAWIKIKADEWQSPIAKFLSDEER
KGIAAALDLQVGDIVFFQAGEPGMVNAALGNLRVHLADHMNLIPENTFNFLWVTDFPLYEYDEEEKRYVACHHPFTSPAP
GHMELMTSDPARARARAYDMVLNGSEVGGGSIRIHSGEVQRRMFEALGFTPEQAESQFGFLIQALEHGAPPHGGLAFGLD
RLIMLLAGASSIRDVIAFPKTQKATCLMTDAPSPVAAKQLRELGLRLREQPGEKGKTDKPGEAEKAE

Sequences:

>Translated_627_residues
MAEQTAQAVAQGQDVQQEHQKYITGLGDWHRSQTCGELTLANNGQEVCLMGWVQYRRDHGGLIFVDLRDRSGLTQVVFSP
DAAPEAHKNAHILRSEYVLAIKGLVRPRPEGMVNPNMVTGEIEVVVTEWKLLNTSKTPPFTIENRCDAGENLRLAWRYLD
LRRPRMQDNLRLRHKVAQCIRRHLDEDGFVEVETPVLTKSTPEGARDFLVPSRLNTGEFYALPQSPQLFKQLLMVAGMDR
YFQIVRCFRDEDLRADRQPEFTQVDIEMSFADEETVMGMAEKLMARVFRDVMGKELSLPFPRMPWDEAMARYGVDKPDTR
FGLELVDITEIVRGSGFKLFATAPLVKGMRVPGGESMTRKEIDAFTEFVKIYGAQGLAWIKIKADEWQSPIAKFLSDEER
KGIAAALDLQVGDIVFFQAGEPGMVNAALGNLRVHLADHMNLIPENTFNFLWVTDFPLYEYDEEEKRYVACHHPFTSPAP
GHMELMTSDPARARARAYDMVLNGSEVGGGSIRIHSGEVQRRMFEALGFTPEQAESQFGFLIQALEHGAPPHGGLAFGLD
RLIMLLAGASSIRDVIAFPKTQKATCLMTDAPSPVAAKQLRELGLRLREQPGEKGKTDKPGEAEKAE
>Mature_626_residues
AEQTAQAVAQGQDVQQEHQKYITGLGDWHRSQTCGELTLANNGQEVCLMGWVQYRRDHGGLIFVDLRDRSGLTQVVFSPD
AAPEAHKNAHILRSEYVLAIKGLVRPRPEGMVNPNMVTGEIEVVVTEWKLLNTSKTPPFTIENRCDAGENLRLAWRYLDL
RRPRMQDNLRLRHKVAQCIRRHLDEDGFVEVETPVLTKSTPEGARDFLVPSRLNTGEFYALPQSPQLFKQLLMVAGMDRY
FQIVRCFRDEDLRADRQPEFTQVDIEMSFADEETVMGMAEKLMARVFRDVMGKELSLPFPRMPWDEAMARYGVDKPDTRF
GLELVDITEIVRGSGFKLFATAPLVKGMRVPGGESMTRKEIDAFTEFVKIYGAQGLAWIKIKADEWQSPIAKFLSDEERK
GIAAALDLQVGDIVFFQAGEPGMVNAALGNLRVHLADHMNLIPENTFNFLWVTDFPLYEYDEEEKRYVACHHPFTSPAPG
HMELMTSDPARARARAYDMVLNGSEVGGGSIRIHSGEVQRRMFEALGFTPEQAESQFGFLIQALEHGAPPHGGLAFGLDR
LIMLLAGASSIRDVIAFPKTQKATCLMTDAPSPVAAKQLRELGLRLREQPGEKGKTDKPGEAEKAE

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI40789249, Length=601, Percent_Identity=43.5940099833611, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI5031815, Length=305, Percent_Identity=28.5245901639344, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI194272210, Length=305, Percent_Identity=28.5245901639344, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI4758762, Length=299, Percent_Identity=27.7591973244147, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI45439306, Length=270, Percent_Identity=25.1851851851852, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1788173, Length=587, Percent_Identity=49.5741056218058, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1789256, Length=357, Percent_Identity=27.1708683473389, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1790571, Length=356, Percent_Identity=25.8426966292135, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI32566633, Length=596, Percent_Identity=35.4026845637584, Blast_Score=334, Evalue=7e-92,
Organism=Caenorhabditis elegans, GI71994340, Length=143, Percent_Identity=33.5664335664336, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17535927, Length=143, Percent_Identity=33.5664335664336, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17535925, Length=143, Percent_Identity=33.5664335664336, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71984122, Length=290, Percent_Identity=27.9310344827586, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6325153, Length=635, Percent_Identity=32.9133858267717, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6321807, Length=263, Percent_Identity=26.615969581749, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323011, Length=291, Percent_Identity=27.4914089347079, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=287, Percent_Identity=26.4808362369338, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584738, Length=592, Percent_Identity=40.0337837837838, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24640849, Length=286, Percent_Identity=26.9230769230769, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640851, Length=286, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136276, Length=241, Percent_Identity=28.2157676348548, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921528, Length=235, Percent_Identity=30.6382978723404, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 70434; Mature: 70303

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQTAQAVAQGQDVQQEHQKYITGLGDWHRSQTCGELTLANNGQEVCLMGWVQYRRDHG
CCCHHHHHHHCCCHHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCEEEEEEHHHHHCCCC
GLIFVDLRDRSGLTQVVFSPDAAPEAHKNAHILRSEYVLAIKGLVRPRPEGMVNPNMVTG
CEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHEEHHHCCCCCCCCCCCCEEEC
EIEVVVTEWKLLNTSKTPPFTIENRCDAGENLRLAWRYLDLRRPRMQDNLRLRHKVAQCI
EEEEEEEEEEEECCCCCCCEEECCCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHH
RRHLDEDGFVEVETPVLTKSTPEGARDFLVPSRLNTGEFYALPQSPQLFKQLLMVAGMDR
HHHCCCCCEEEECCCEEECCCCCCHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCHH
YFQIVRCFRDEDLRADRQPEFTQVDIEMSFADEETVMGMAEKLMARVFRDVMGKELSLPF
HHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PRMPWDEAMARYGVDKPDTRFGLELVDITEIVRGSGFKLFATAPLVKGMRVPGGESMTRK
CCCCHHHHHHHCCCCCCCCHHCEEHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCCHHHH
EIDAFTEFVKIYGAQGLAWIKIKADEWQSPIAKFLSDEERKGIAAALDLQVGDIVFFQAG
HHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHCCHHHCCCEEEEEEEECCEEEEECC
EPGMVNAALGNLRVHLADHMNLIPENTFNFLWVTDFPLYEYDEEEKRYVACHHPFTSPAP
CCCEEEEECCCEEEEEHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCC
GHMELMTSDPARARARAYDMVLNGSEVGGGSIRIHSGEVQRRMFEALGFTPEQAESQFGF
CCEEEEECCCHHHHHHHHHEEECCCCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHH
LIQALEHGAPPHGGLAFGLDRLIMLLAGASSIRDVIAFPKTQKATCLMTDAPSPVAAKQL
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCHHHHHH
RELGLRLREQPGEKGKTDKPGEAEKAE
HHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEQTAQAVAQGQDVQQEHQKYITGLGDWHRSQTCGELTLANNGQEVCLMGWVQYRRDHG
CCHHHHHHHCCCHHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCEEEEEEHHHHHCCCC
GLIFVDLRDRSGLTQVVFSPDAAPEAHKNAHILRSEYVLAIKGLVRPRPEGMVNPNMVTG
CEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHEEHHHCCCCCCCCCCCCEEEC
EIEVVVTEWKLLNTSKTPPFTIENRCDAGENLRLAWRYLDLRRPRMQDNLRLRHKVAQCI
EEEEEEEEEEEECCCCCCCEEECCCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHH
RRHLDEDGFVEVETPVLTKSTPEGARDFLVPSRLNTGEFYALPQSPQLFKQLLMVAGMDR
HHHCCCCCEEEECCCEEECCCCCCHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCHH
YFQIVRCFRDEDLRADRQPEFTQVDIEMSFADEETVMGMAEKLMARVFRDVMGKELSLPF
HHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PRMPWDEAMARYGVDKPDTRFGLELVDITEIVRGSGFKLFATAPLVKGMRVPGGESMTRK
CCCCHHHHHHHCCCCCCCCHHCEEHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCCHHHH
EIDAFTEFVKIYGAQGLAWIKIKADEWQSPIAKFLSDEERKGIAAALDLQVGDIVFFQAG
HHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHCCHHHCCCEEEEEEEECCEEEEECC
EPGMVNAALGNLRVHLADHMNLIPENTFNFLWVTDFPLYEYDEEEKRYVACHHPFTSPAP
CCCEEEEECCCEEEEEHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCC
GHMELMTSDPARARARAYDMVLNGSEVGGGSIRIHSGEVQRRMFEALGFTPEQAESQFGF
CCEEEEECCCHHHHHHHHHEEECCCCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHH
LIQALEHGAPPHGGLAFGLDRLIMLLAGASSIRDVIAFPKTQKATCLMTDAPSPVAAKQL
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCHHHHHH
RELGLRLREQPGEKGKTDKPGEAEKAE
HHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA