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The map label for this gene is dys [H]

Identifier: 218883781

GI number: 218883781

Start: 439499

End: 440479

Strand: Reverse

Name: dys [H]

Synonym: DKAM_0470

Alternate gene names: 218883781

Gene position: 440479-439499 (Counterclockwise)

Preceding gene: 218883785

Following gene: 218883780

Centisome position: 32.26

GC content: 50.36

Gene sequence:

>981_bases
ATGCCAGAGGAGTTCAACATAGAGGAGTTGAGAAGCAGACTGCTCGGCGAGGTTGTAAGAGATATCACTATAACACCGGA
GATAACAATCTGCGAGCTCGTGGAGAAGCTCGGGGATGCCCATGGCTTCATGGCCGGGCATGTCTACAGGGCGAGCCAGA
TACTCAATGAGATGACCAGGGATAGTGAGGTAACCCGGTTCCTTGCCTTCACAGGCAACATTGTTTCAACAGGTTTAAGG
GGGTTACTGGCACAGCTGATTAGGGACGGGTTCTTCCATGCTGTGGTGACGACGTGTGGTACGATAGATCATGATATAGC
TAGAGGCACGGGGCACGCATACTACAAGGGGGACTGGATGTATGATGATGCACTACTGAGGAGTGTTGAGATCCATAGGC
TCGGCAACATATTGATCCCCCTGGAGAACTATGGTTTAGCCGTTGAGAAGTTTACAAGGAAACTCCTCGAAGAGATCGGA
GCTATAAAGAAGAAGTGGAGTGTCAGCGAACTCCTCTATGAGGCAGGTAAGAGGATAAGCGATAAAAACAGTATACTACG
CGCCGCTTACGAGAAAAACATACCGGTCTTCGTCCCAGGCATATTCGACGGCAGCTTCGGGTCGCAGATAGTCTTCAACC
ATGCATCCACCGGTGTTGAAGTAGACTTGATAAGCGATGAGAAGAAGATAATAGACATGGTTTTCGCGGCTAAGAGGCTT
GGAGCCTTGATTATCGGCGGGGGGATCAGTAAGCATCACACCATATGGTGGGCCCAGATGAAGGATGGATTAGACTACGC
GGTATACATTACCACTGCTGTAGAGTACGATGGGAGCTTGAGTGGGGCACAACCGAGGGAGGCGATTAGCTGGGGGAAGC
TCAAGCCTACGGGTAAGCATATAGTAGTATACGCTGATGCAACGATAACGCTACCCCTGATAGTAGGAGGTATGCTATGC
CTCGCTAGGAAAGGGGGCTAG

Upstream 100 bases:

>100_bases
CCTATGCCACCATTCACTCTATGATTGCTTGGACTCTATAATGAAACTATAATATACCTGGCTAAAATTATTGAGTGGGT
GGCAGACAATGGTGGATCAT

Downstream 100 bases:

>100_bases
GTAGTGGAGGGCATTAGGCTCCACATAGGGTTAGATGACATTGATTCCCCCACGGGTGGCTGTACAACACATATAGCTGT
CCAAATAGTCCACGAGCTCT

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MPEEFNIEELRSRLLGEVVRDITITPEITICELVEKLGDAHGFMAGHVYRASQILNEMTRDSEVTRFLAFTGNIVSTGLR
GLLAQLIRDGFFHAVVTTCGTIDHDIARGTGHAYYKGDWMYDDALLRSVEIHRLGNILIPLENYGLAVEKFTRKLLEEIG
AIKKKWSVSELLYEAGKRISDKNSILRAAYEKNIPVFVPGIFDGSFGSQIVFNHASTGVEVDLISDEKKIIDMVFAAKRL
GALIIGGGISKHHTIWWAQMKDGLDYAVYITTAVEYDGSLSGAQPREAISWGKLKPTGKHIVVYADATITLPLIVGGMLC
LARKGG

Sequences:

>Translated_326_residues
MPEEFNIEELRSRLLGEVVRDITITPEITICELVEKLGDAHGFMAGHVYRASQILNEMTRDSEVTRFLAFTGNIVSTGLR
GLLAQLIRDGFFHAVVTTCGTIDHDIARGTGHAYYKGDWMYDDALLRSVEIHRLGNILIPLENYGLAVEKFTRKLLEEIG
AIKKKWSVSELLYEAGKRISDKNSILRAAYEKNIPVFVPGIFDGSFGSQIVFNHASTGVEVDLISDEKKIIDMVFAAKRL
GALIIGGGISKHHTIWWAQMKDGLDYAVYITTAVEYDGSLSGAQPREAISWGKLKPTGKHIVVYADATITLPLIVGGMLC
LARKGG
>Mature_325_residues
PEEFNIEELRSRLLGEVVRDITITPEITICELVEKLGDAHGFMAGHVYRASQILNEMTRDSEVTRFLAFTGNIVSTGLRG
LLAQLIRDGFFHAVVTTCGTIDHDIARGTGHAYYKGDWMYDDALLRSVEIHRLGNILIPLENYGLAVEKFTRKLLEEIGA
IKKKWSVSELLYEAGKRISDKNSILRAAYEKNIPVFVPGIFDGSFGSQIVFNHASTGVEVDLISDEKKIIDMVFAAKRLG
ALIIGGGISKHHTIWWAQMKDGLDYAVYITTAVEYDGSLSGAQPREAISWGKLKPTGKHIVVYADATITLPLIVGGMLCL
ARKGG

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=311, Percent_Identity=34.0836012861736, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI7108338, Length=311, Percent_Identity=27.3311897106109, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI7108340, Length=219, Percent_Identity=28.310502283105, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17536927, Length=303, Percent_Identity=36.3036303630363, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321859, Length=278, Percent_Identity=36.3309352517986, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI45550569, Length=262, Percent_Identity=38.5496183206107, Blast_Score=180, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 35998; Mature: 35867

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEEFNIEELRSRLLGEVVRDITITPEITICELVEKLGDAHGFMAGHVYRASQILNEMTR
CCCCCCHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
DSEVTRFLAFTGNIVSTGLRGLLAQLIRDGFFHAVVTTCGTIDHDIARGTGHAYYKGDWM
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCEE
YDDALLRSVEIHRLGNILIPLENYGLAVEKFTRKLLEEIGAIKKKWSVSELLYEAGKRIS
EHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
DKNSILRAAYEKNIPVFVPGIFDGSFGSQIVFNHASTGVEVDLISDEKKIIDMVFAAKRL
CHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHHH
GALIIGGGISKHHTIWWAQMKDGLDYAVYITTAVEYDGSLSGAQPREAISWGKLKPTGKH
CEEEEECCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCHHHHCCCCCCCCCCE
IVVYADATITLPLIVGGMLCLARKGG
EEEEECCEEEHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PEEFNIEELRSRLLGEVVRDITITPEITICELVEKLGDAHGFMAGHVYRASQILNEMTR
CCCCCHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
DSEVTRFLAFTGNIVSTGLRGLLAQLIRDGFFHAVVTTCGTIDHDIARGTGHAYYKGDWM
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCEE
YDDALLRSVEIHRLGNILIPLENYGLAVEKFTRKLLEEIGAIKKKWSVSELLYEAGKRIS
EHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
DKNSILRAAYEKNIPVFVPGIFDGSFGSQIVFNHASTGVEVDLISDEKKIIDMVFAAKRL
CHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHHH
GALIIGGGISKHHTIWWAQMKDGLDYAVYITTAVEYDGSLSGAQPREAISWGKLKPTGKH
CEEEEECCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCHHHHCCCCCCCCCCE
IVVYADATITLPLIVGGMLCLARKGG
EEEEECCEEEHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]