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The map label for this gene is pyrD [H]

Identifier: 218883785

GI number: 218883785

Start: 442270

End: 443178

Strand: Reverse

Name: pyrD [H]

Synonym: DKAM_0474

Alternate gene names: 218883785

Gene position: 443178-442270 (Counterclockwise)

Preceding gene: 218883786

Following gene: 218883781

Centisome position: 32.46

GC content: 48.62

Gene sequence:

>909_bases
GTGGTTGAAGTGCTTGAAACAAGTATAGCTGGGCTAAGGCTGAAGCATCCTGTTATGAATGCAAGCGGTATACTGGGCTC
GGAGCCTGAGCACCTTGAGATACTGGCTAAGCAGGGTTTCTCAGCCCTTGTATCCAAGACTATAACGTTGAATCCTAGGG
AAGGGTATCCCCCACCCATTATTGTTGAGTTAAGGAATAACGGGCTCCTAAACGCAGTAGGCTTAGCGAATCCCGGGGCC
AGAGTGATTCCGGTTCTAGCTAGGAAGGCAAGGGAACTTAGTAAACCACTGATCCTCAGCATCGGCGGCTCCAGTGTGGA
GGAGTTTGTAAAGCTTGCCGAGCTAGCTAGCGAGGCTGGCGTGGATGCAGTCGAGTTAAACCTTAGTTGCCCCCATGCGG
AAGGCTACGGCCTTGAGTTGGGCAGTGATCCCATGCTGGTTTACAGAATAGTAAAGGATGCAGTATCTGTAGCATCCTTA
CCTGTGATAGCTAAGCTAGGGTTAACAGATAGAGTAATCGAGTCAGCTGGTAAAGCCCTCGAGGCAGGCGTGAAAGCCTT
AACGCTGATAAACACTGTGAAAGCTATGAGCATAGATGTATACACTTTAAAGCCTGTGCTGAGTAACAAATATGGAGGCC
TCTCGGGGCCACCGATTCATCCAATAGCTGTGAGAGTGGTATACGACGTATACAGGGAGTACAGGGCTGAGATAATAGGG
GTTGGAGGCGTGTCATCATGGATGGATGTAGCAGAGCTCATACTAGCCGGGGCTAGGGCTGTGCAGGTGGGTACAGCTTT
GATCTGGAATGAGAATATTGTGGATGAAATACTGAGCGGACTCCACAAATGGTTGATTGACTTGGGATATAATAGTTTAA
TGGATCTTGTTGGAATAGCAGTAATGTAG

Upstream 100 bases:

>100_bases
GTTGGGGCATGTGGCTCATGTGTCTTGAAACCCCATTCCCTCCTACTATGCAAGCACGGCCCAGTCTTCAGGTGCCGTGA
TATAGAGGGTTTCCTCAAGG

Downstream 100 bases:

>100_bases
TGAATCGATCCCACCTTCCCTGATCCCCACGATTCATTTTTCACAGGTTACTCTACCTTTATATAGCTGACCGTGATGCC
TAGGGATAAGAATATTAACG

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MVEVLETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPIIVELRNNGLLNAVGLANPGA
RVIPVLARKARELSKPLILSIGGSSVEEFVKLAELASEAGVDAVELNLSCPHAEGYGLELGSDPMLVYRIVKDAVSVASL
PVIAKLGLTDRVIESAGKALEAGVKALTLINTVKAMSIDVYTLKPVLSNKYGGLSGPPIHPIAVRVVYDVYREYRAEIIG
VGGVSSWMDVAELILAGARAVQVGTALIWNENIVDEILSGLHKWLIDLGYNSLMDLVGIAVM

Sequences:

>Translated_302_residues
MVEVLETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPIIVELRNNGLLNAVGLANPGA
RVIPVLARKARELSKPLILSIGGSSVEEFVKLAELASEAGVDAVELNLSCPHAEGYGLELGSDPMLVYRIVKDAVSVASL
PVIAKLGLTDRVIESAGKALEAGVKALTLINTVKAMSIDVYTLKPVLSNKYGGLSGPPIHPIAVRVVYDVYREYRAEIIG
VGGVSSWMDVAELILAGARAVQVGTALIWNENIVDEILSGLHKWLIDLGYNSLMDLVGIAVM
>Mature_302_residues
MVEVLETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPIIVELRNNGLLNAVGLANPGA
RVIPVLARKARELSKPLILSIGGSSVEEFVKLAELASEAGVDAVELNLSCPHAEGYGLELGSDPMLVYRIVKDAVSVASL
PVIAKLGLTDRVIESAGKALEAGVKALTLINTVKAMSIDVYTLKPVLSNKYGGLSGPPIHPIAVRVVYDVYREYRAEIIG
VGGVSSWMDVAELILAGARAVQVGTALIWNENIVDEILSGLHKWLIDLGYNSLMDLVGIAVM

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=205, Percent_Identity=32.1951219512195, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI45006951, Length=319, Percent_Identity=28.5266457680251, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI87082059, Length=319, Percent_Identity=30.0940438871473, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71984108, Length=205, Percent_Identity=33.6585365853659, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322633, Length=323, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640763, Length=173, Percent_Identity=33.5260115606936, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI18858217, Length=173, Percent_Identity=33.5260115606936, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281361352, Length=318, Percent_Identity=27.6729559748428, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137316, Length=318, Percent_Identity=27.6729559748428, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32067; Mature: 32067

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEVLETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPI
CCCHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHCEEEECCCCCCCCCE
IVELRNNGLLNAVGLANPGARVIPVLARKARELSKPLILSIGGSSVEEFVKLAELASEAG
EEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCC
VDAVELNLSCPHAEGYGLELGSDPMLVYRIVKDAVSVASLPVIAKLGLTDRVIESAGKAL
CCEEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EAGVKALTLINTVKAMSIDVYTLKPVLSNKYGGLSGPPIHPIAVRVVYDVYREYRAEIIG
HHHHHHHHHHHHHHHHEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEE
VGGVSSWMDVAELILAGARAVQVGTALIWNENIVDEILSGLHKWLIDLGYNSLMDLVGIA
CCCHHHHHHHHHHHHHCCHHHHHCEEEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
VM
CC
>Mature Secondary Structure
MVEVLETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPI
CCCHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHCEEEECCCCCCCCCE
IVELRNNGLLNAVGLANPGARVIPVLARKARELSKPLILSIGGSSVEEFVKLAELASEAG
EEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCC
VDAVELNLSCPHAEGYGLELGSDPMLVYRIVKDAVSVASLPVIAKLGLTDRVIESAGKAL
CCEEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EAGVKALTLINTVKAMSIDVYTLKPVLSNKYGGLSGPPIHPIAVRVVYDVYREYRAEIIG
HHHHHHHHHHHHHHHHEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEE
VGGVSSWMDVAELILAGARAVQVGTALIWNENIVDEILSGLHKWLIDLGYNSLMDLVGIA
CCCHHHHHHHHHHHHHCCHHHHHCEEEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
VM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]