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The map label for this gene is serS

Identifier: 218883767

GI number: 218883767

Start: 425828

End: 427207

Strand: Reverse

Name: serS

Synonym: DKAM_0456

Alternate gene names: 218883767

Gene position: 427207-425828 (Counterclockwise)

Preceding gene: 218883768

Following gene: 218883766

Centisome position: 31.29

GC content: 49.64

Gene sequence:

>1380_bases
GTGTCTTGGAGTATTTTAACACTACTCAGGGATAACCCTGAGCTATTAAAGGAACACGTTAAGAAGAGGTTCATGGATCC
CAGCCTCGTTGACGAGGCATATAAGTTGGATCTCGAGTGGAGGAGGCTGTTATCACAGGTCCAGGAGCTCAGGCACAGGC
ATAACGTTATAAGCAGGGATATCTCGAAGCTGCCTGAGCCGGAGAGAAGTGCCAGGATAAACGAGGCGAGAGAGCTTCTA
TCCCAAATGGAGGAGCTGGAGAAGAAGTTGAAGGAGATCGAGGATTTAAGGGAGGAGGCGTTGCTGAAGCTACCGAATAT
AGTCCATGAGACGGTGCCAGTGGGCCCCGATGACACGTATAATGTGCCCATTAGGTTCTGGGGTAAGCCAAAGGTGTGGA
GCGGGTATATTGAGCAGTTCATGCAGCAGACCGAGAGATACGGCTTCAAAGTAGAATATGAACTGGTAAACTGGAAGCCT
GTTGGACACGCTGATATGCTTGAATACGTGTTGAGGCTTGGTGACACAGTTAAAGCCGGGGAGGTTGCTGGGAGTAGGTT
CTACTATTTATTCGACGACATAGTCTTCCTGGATATTGCGTTACTGATGTACGCTATAGACAGCTTGACGAGTAAAGGCT
ATAAACTAGTTTTACCACCCTATATGTTACGTCACAAGGTAATGTCCGGCGTTATAGACCTCGCGACGTTCAAGGACGCG
ATCTACAAGATAGAGGGAGAAGACCTCTACCTTATAGCCACAGCTGAGCATTCGCTTGCAGCGCTCCACGCGTTCGAGGA
GATACCTGAGGAGGAGTTGCCATTGAAGTATGTGGGTGTATCCCCCTGCTTCAGGAAGGAGGCTGGAGCCGGCAACAGGG
ATTTAAAGGGTATATTCAGGGTTCACCAGTTCCATAAGGTCGAGCAATACGTTTATGCCAAGCCCGAAGAGAGCTGGGCG
TTAATGGAGGAGTTGATAGGGAATGCTGAAGATCTCTTCAAGGGGCTCGAACTCCCCTACAGGGTGGTCAACATAGCCAG
CGGCGACCTAGGCGCCCCAGCCGCTAAGAAATACGATCTAGAGACATGGATGCCTGCACAGGGGCTCTTCAGAGAGATGG
TCAGCTGCAGTAATACAACTGACTGGCAGTCCTACAGGTTGAAGACGAGGCTTGTACGTAGGAAAGGGATGGTGAAGGAG
TATGTGCATACATTGAATAGCACGGCTATAGCGAGCACGAGGACTATTACATCCATACTTGAGAACCGTCAGAACGAGGA
TGGAACAGTAACTGTACCGAGGGTCCTGAGGAAGTATCTCGAGGTATTCAATAAGGCACCCAGAGACTACATTCACCCGG
TGAAAAGAGAGAGAGCTTAA

Upstream 100 bases:

>100_bases
AACAAGAGAATAGCTTGAATCTTTTTTAATCAAGCCTGTTAAAACACATTTTTATTTTTAAAGATTATTGAATCATGTTG
AGTAGGCATGGTGGATTAAT

Downstream 100 bases:

>100_bases
TAAATCCCGTGCACTGGCTCCCCCATCAGTCATGTTATGTTTATCAGGGATCCATGTAGTACTGTCTCTCCCCGTGTTTA
ATCCGGTTTGTTGAACCAGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSWSILTLLRDNPELLKEHVKKRFMDPSLVDEAYKLDLEWRRLLSQVQELRHRHNVISRDISKLPEPERSARINEARELL
SQMEELEKKLKEIEDLREEALLKLPNIVHETVPVGPDDTYNVPIRFWGKPKVWSGYIEQFMQQTERYGFKVEYELVNWKP
VGHADMLEYVLRLGDTVKAGEVAGSRFYYLFDDIVFLDIALLMYAIDSLTSKGYKLVLPPYMLRHKVMSGVIDLATFKDA
IYKIEGEDLYLIATAEHSLAALHAFEEIPEEELPLKYVGVSPCFRKEAGAGNRDLKGIFRVHQFHKVEQYVYAKPEESWA
LMEELIGNAEDLFKGLELPYRVVNIASGDLGAPAAKKYDLETWMPAQGLFREMVSCSNTTDWQSYRLKTRLVRRKGMVKE
YVHTLNSTAIASTRTITSILENRQNEDGTVTVPRVLRKYLEVFNKAPRDYIHPVKRERA

Sequences:

>Translated_459_residues
MSWSILTLLRDNPELLKEHVKKRFMDPSLVDEAYKLDLEWRRLLSQVQELRHRHNVISRDISKLPEPERSARINEARELL
SQMEELEKKLKEIEDLREEALLKLPNIVHETVPVGPDDTYNVPIRFWGKPKVWSGYIEQFMQQTERYGFKVEYELVNWKP
VGHADMLEYVLRLGDTVKAGEVAGSRFYYLFDDIVFLDIALLMYAIDSLTSKGYKLVLPPYMLRHKVMSGVIDLATFKDA
IYKIEGEDLYLIATAEHSLAALHAFEEIPEEELPLKYVGVSPCFRKEAGAGNRDLKGIFRVHQFHKVEQYVYAKPEESWA
LMEELIGNAEDLFKGLELPYRVVNIASGDLGAPAAKKYDLETWMPAQGLFREMVSCSNTTDWQSYRLKTRLVRRKGMVKE
YVHTLNSTAIASTRTITSILENRQNEDGTVTVPRVLRKYLEVFNKAPRDYIHPVKRERA
>Mature_458_residues
SWSILTLLRDNPELLKEHVKKRFMDPSLVDEAYKLDLEWRRLLSQVQELRHRHNVISRDISKLPEPERSARINEARELLS
QMEELEKKLKEIEDLREEALLKLPNIVHETVPVGPDDTYNVPIRFWGKPKVWSGYIEQFMQQTERYGFKVEYELVNWKPV
GHADMLEYVLRLGDTVKAGEVAGSRFYYLFDDIVFLDIALLMYAIDSLTSKGYKLVLPPYMLRHKVMSGVIDLATFKDAI
YKIEGEDLYLIATAEHSLAALHAFEEIPEEELPLKYVGVSPCFRKEAGAGNRDLKGIFRVHQFHKVEQYVYAKPEESWAL
MEELIGNAEDLFKGLELPYRVVNIASGDLGAPAAKKYDLETWMPAQGLFREMVSCSNTTDWQSYRLKTRLVRRKGMVKEY
VHTLNSTAIASTRTITSILENRQNEDGTVTVPRVLRKYLEVFNKAPRDYIHPVKRERA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=473, Percent_Identity=37.4207188160677, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI8923421, Length=436, Percent_Identity=29.1284403669725, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI225579074, Length=363, Percent_Identity=31.9559228650138, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1787120, Length=458, Percent_Identity=32.5327510917031, Blast_Score=221, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17539260, Length=473, Percent_Identity=37.8435517970402, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17542084, Length=357, Percent_Identity=31.0924369747899, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320226, Length=440, Percent_Identity=40.4545454545455, Blast_Score=279, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6321799, Length=276, Percent_Identity=39.8550724637681, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24581334, Length=474, Percent_Identity=36.2869198312236, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI17737985, Length=263, Percent_Identity=37.6425855513308, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_DESK1 (B8D3V1)

Other databases:

- EMBL:   CP001140
- RefSeq:   YP_002428149.1
- GeneID:   7170692
- GenomeReviews:   CP001140_GR
- KEGG:   dka:DKAM_0456
- HOGENOM:   HBG629391
- OMA:   VPIRFWG
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 53299; Mature: 53168

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 301-301 BINDING 308-308 BINDING 408-408

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWSILTLLRDNPELLKEHVKKRFMDPSLVDEAYKLDLEWRRLLSQVQELRHRHNVISRD
CCCEEEEHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ISKLPEPERSARINEARELLSQMEELEKKLKEIEDLREEALLKLPNIVHETVPVGPDDTY
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NVPIRFWGKPKVWSGYIEQFMQQTERYGFKVEYELVNWKPVGHADMLEYVLRLGDTVKAG
CCCEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCC
EVAGSRFYYLFDDIVFLDIALLMYAIDSLTSKGYKLVLPPYMLRHKVMSGVIDLATFKDA
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
IYKIEGEDLYLIATAEHSLAALHAFEEIPEEELPLKYVGVSPCFRKEAGAGNRDLKGIFR
HEEECCCCEEEEEECCHHHHHHHHHHHCCCHHCCEEEECCCHHHHHHCCCCCCHHHHHHH
VHQFHKVEQYVYAKPEESWALMEELIGNAEDLFKGLELPYRVVNIASGDLGAPAAKKYDL
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCC
ETWMPAQGLFREMVSCSNTTDWQSYRLKTRLVRRKGMVKEYVHTLNSTAIASTRTITSIL
HHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENRQNEDGTVTVPRVLRKYLEVFNKAPRDYIHPVKRERA
HCCCCCCCEEEHHHHHHHHHHHHCCCCHHHHCCHHHCCC
>Mature Secondary Structure 
SWSILTLLRDNPELLKEHVKKRFMDPSLVDEAYKLDLEWRRLLSQVQELRHRHNVISRD
CCEEEEHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ISKLPEPERSARINEARELLSQMEELEKKLKEIEDLREEALLKLPNIVHETVPVGPDDTY
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NVPIRFWGKPKVWSGYIEQFMQQTERYGFKVEYELVNWKPVGHADMLEYVLRLGDTVKAG
CCCEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCC
EVAGSRFYYLFDDIVFLDIALLMYAIDSLTSKGYKLVLPPYMLRHKVMSGVIDLATFKDA
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
IYKIEGEDLYLIATAEHSLAALHAFEEIPEEELPLKYVGVSPCFRKEAGAGNRDLKGIFR
HEEECCCCEEEEEECCHHHHHHHHHHHCCCHHCCEEEECCCHHHHHHCCCCCCHHHHHHH
VHQFHKVEQYVYAKPEESWALMEELIGNAEDLFKGLELPYRVVNIASGDLGAPAAKKYDL
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCC
ETWMPAQGLFREMVSCSNTTDWQSYRLKTRLVRRKGMVKEYVHTLNSTAIASTRTITSIL
HHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENRQNEDGTVTVPRVLRKYLEVFNKAPRDYIHPVKRERA
HCCCCCCCEEEHHHHHHHHHHHHCCCCHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA