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The map label for this gene is ywrD [H]

Identifier: 218883509

GI number: 218883509

Start: 184323

End: 185831

Strand: Direct

Name: ywrD [H]

Synonym: DKAM_0196

Alternate gene names: 218883509

Gene position: 184323-185831 (Clockwise)

Preceding gene: 218883508

Following gene: 218883516

Centisome position: 13.5

GC content: 47.18

Gene sequence:

>1509_bases
ATGCCCGTAGCTAAGCTCGGCATAGGATTTAAGGGTGTAGTAGCTGACCATCCCTTAGCTGTAAAGACCGGGTTAGACGT
GCTGGAGGAAGGAGGCAACGCATTTGATGCATCCATAGCCATTAGCGCTGTTTTATCGGTTGTACAGCCCCAAATGGGTG
GGCCCGGAGGCGATGGATTCCTATTAGGCTTCGTAGGAGACAAGGTTGTTGCCTACGCGTCCTCAGGCCGCTCGCCCAGC
GGATTCAACGCCGATGAATACATTAGGGAAAAACCTCTAAGAGGATCTCTAACAGTAACGATCCCCGGGCTCGTATACCT
ATGGGGTATGGTTAACGAGGAGTATGGAACACTTGATTTAGCGACACTATTGAAGCCAGCAATATCACTGGCATATAATG
GATTTAACGCTGGATATACCCTGGCGAGATCCATTGAGGCGGTTGAAAAAGAATTATCTGGGTTCAAGTGGGCTAAATAC
TATAAAGGGGTTAAACTAGGCAGCAAAATCACCAATAAAGACGCTGCTAGAACCCTTAGGCTAATCGCGTCGAGGGGCTG
GGAAGAATTCTACCAGGGGGAGTTAGCTGAGGAACTAACCAGGGAACTACAGGATCAAGGAGTTAATATAGGGCTTGAAG
ACCTTATGACCCACGAAGGCTTTAAAGTAGATCCCCTCAGGCTAGAGGTGGAAGGAAGAATACTCTATGAGCTCCCGCCA
AACACTCAAGGAGCATCAACGCTCCAGCTGATCAGCGCGCTCTATGAGGAAGAGTTATCCAGGTACGGGTTCCATGATCC
TCAGCGGGCTAGCGCCTGGAGTAAACCAGTTGATATCGTCTACACATTCAGAGACATCTATCTAGGTGACCCCGACTACA
TGGAGATAGATGTAAACGAGTATTTGAGATATAGTAGGGTAAAGAAGCTTATCGAACACAGTGTAAGTCAAAGCAGTACA
CGTGTAAAACATGGAGGAGATACAACATTCTTCATCGTCTCCGATGGAGAATCATTGATCGGATTCATCCAAAGCCTCTT
TCATCCATTCGGCTCAGGGCTAATGATGGGCGGCTTCCCAGTGCAGAATAGAGGAATAGGATTCGCGAAGGAGCATGGAT
TACCTAACAGCCCTGCACCCAGGAAATTACCCCTCCACACGTTATCAATTCTAGGCGTAGTTGAAGACGATAAAAAATAT
ATTATAGGCTGTGTAGGAGGAGACTACAGGCCCCAACTACATCTAAGGGTATATGAAAACATGTTCGTATATGGAATGGA
CCCCGTAAAAGCAGTTGCAGCCCCTCGATTCATCTATGTGGAACCCCGTGGAAGCCAAAGACTCGTCTTAGAGAAACCAC
TTGAGGCTAATACGGTTGGAGGCATAAGTATCGAAGAAGTAGAGTATTTTGGAAGCCATGGACATGTACATGTAGCCATC
CTAGACGATGAAAAATTAATACTTGCCGGCGACCCACGTAGCGAGGGAATAGCTATAGCCATAAACTAG

Upstream 100 bases:

>100_bases
GGAACACACAGTAGAGATACTTCAGGAGCTTGGATACACCCCGGAGGAAATAAGCAGGCTTAAAGAGGCGGGCATCATAT
ATTATCCATAGGAGGTCATC

Downstream 100 bases:

>100_bases
ATTACAGCGTTATTTTTCCTCCACAACCTCGACCCCTTTATTACGTGGTCTAGTAATGAATACCTTCCCGTCGAGTCTTG
GCATCAAATTCTCTAAGATC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MPVAKLGIGFKGVVADHPLAVKTGLDVLEEGGNAFDASIAISAVLSVVQPQMGGPGGDGFLLGFVGDKVVAYASSGRSPS
GFNADEYIREKPLRGSLTVTIPGLVYLWGMVNEEYGTLDLATLLKPAISLAYNGFNAGYTLARSIEAVEKELSGFKWAKY
YKGVKLGSKITNKDAARTLRLIASRGWEEFYQGELAEELTRELQDQGVNIGLEDLMTHEGFKVDPLRLEVEGRILYELPP
NTQGASTLQLISALYEEELSRYGFHDPQRASAWSKPVDIVYTFRDIYLGDPDYMEIDVNEYLRYSRVKKLIEHSVSQSST
RVKHGGDTTFFIVSDGESLIGFIQSLFHPFGSGLMMGGFPVQNRGIGFAKEHGLPNSPAPRKLPLHTLSILGVVEDDKKY
IIGCVGGDYRPQLHLRVYENMFVYGMDPVKAVAAPRFIYVEPRGSQRLVLEKPLEANTVGGISIEEVEYFGSHGHVHVAI
LDDEKLILAGDPRSEGIAIAIN

Sequences:

>Translated_502_residues
MPVAKLGIGFKGVVADHPLAVKTGLDVLEEGGNAFDASIAISAVLSVVQPQMGGPGGDGFLLGFVGDKVVAYASSGRSPS
GFNADEYIREKPLRGSLTVTIPGLVYLWGMVNEEYGTLDLATLLKPAISLAYNGFNAGYTLARSIEAVEKELSGFKWAKY
YKGVKLGSKITNKDAARTLRLIASRGWEEFYQGELAEELTRELQDQGVNIGLEDLMTHEGFKVDPLRLEVEGRILYELPP
NTQGASTLQLISALYEEELSRYGFHDPQRASAWSKPVDIVYTFRDIYLGDPDYMEIDVNEYLRYSRVKKLIEHSVSQSST
RVKHGGDTTFFIVSDGESLIGFIQSLFHPFGSGLMMGGFPVQNRGIGFAKEHGLPNSPAPRKLPLHTLSILGVVEDDKKY
IIGCVGGDYRPQLHLRVYENMFVYGMDPVKAVAAPRFIYVEPRGSQRLVLEKPLEANTVGGISIEEVEYFGSHGHVHVAI
LDDEKLILAGDPRSEGIAIAIN
>Mature_501_residues
PVAKLGIGFKGVVADHPLAVKTGLDVLEEGGNAFDASIAISAVLSVVQPQMGGPGGDGFLLGFVGDKVVAYASSGRSPSG
FNADEYIREKPLRGSLTVTIPGLVYLWGMVNEEYGTLDLATLLKPAISLAYNGFNAGYTLARSIEAVEKELSGFKWAKYY
KGVKLGSKITNKDAARTLRLIASRGWEEFYQGELAEELTRELQDQGVNIGLEDLMTHEGFKVDPLRLEVEGRILYELPPN
TQGASTLQLISALYEEELSRYGFHDPQRASAWSKPVDIVYTFRDIYLGDPDYMEIDVNEYLRYSRVKKLIEHSVSQSSTR
VKHGGDTTFFIVSDGESLIGFIQSLFHPFGSGLMMGGFPVQNRGIGFAKEHGLPNSPAPRKLPLHTLSILGVVEDDKKYI
IGCVGGDYRPQLHLRVYENMFVYGMDPVKAVAAPRFIYVEPRGSQRLVLEKPLEANTVGGISIEEVEYFGSHGHVHVAIL
DDEKLILAGDPRSEGIAIAIN

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=477, Percent_Identity=25.3668763102725, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI73915090, Length=477, Percent_Identity=25.3668763102725, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI73915096, Length=477, Percent_Identity=25.3668763102725, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI73915094, Length=477, Percent_Identity=25.3668763102725, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI113429324, Length=473, Percent_Identity=24.9471458773784, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI113429326, Length=482, Percent_Identity=24.6887966804979, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1789856, Length=529, Percent_Identity=27.2211720226843, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17542894, Length=458, Percent_Identity=24.235807860262, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI72000294, Length=389, Percent_Identity=23.3933161953728, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646519, Length=389, Percent_Identity=23.3933161953728, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193208245, Length=217, Percent_Identity=28.110599078341, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193208247, Length=217, Percent_Identity=28.110599078341, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506189, Length=310, Percent_Identity=24.1935483870968, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45551474, Length=481, Percent_Identity=20.997920997921, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161077878, Length=481, Percent_Identity=20.997920997921, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24642670, Length=481, Percent_Identity=20.997920997921, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24642666, Length=481, Percent_Identity=20.997920997921, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161077880, Length=481, Percent_Identity=20.997920997921, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55023; Mature: 54892

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVAKLGIGFKGVVADHPLAVKTGLDVLEEGGNAFDASIAISAVLSVVQPQMGGPGGDGF
CCCCCCCCCEEEEECCCCEEEHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCE
LLGFVGDKVVAYASSGRSPSGFNADEYIREKPLRGSLTVTIPGLVYLWGMVNEEYGTLDL
EEEEECCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEECHHHHHHHHCCCCCCCCHH
ATLLKPAISLAYNGFNAGYTLARSIEAVEKELSGFKWAKYYKGVKLGSKITNKDAARTLR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHH
LIASRGWEEFYQGELAEELTRELQDQGVNIGLEDLMTHEGFKVDPLRLEVEGRILYELPP
HHHHCCHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCEECCEEEEECCEEEEECCC
NTQGASTLQLISALYEEELSRYGFHDPQRASAWSKPVDIVYTFRDIYLGDPDYMEIDVNE
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEEEEEEEECCCCEEEEEHHH
YLRYSRVKKLIEHSVSQSSTRVKHGGDTTFFIVSDGESLIGFIQSLFHPFGSGLMMGGFP
HHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEECCCC
VQNRGIGFAKEHGLPNSPAPRKLPLHTLSILGVVEDDKKYIIGCVGGDYRPQLHLRVYEN
CCCCCCCCHHHCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEEECCCCCCEEEEEEECC
MFVYGMDPVKAVAAPRFIYVEPRGSQRLVLEKPLEANTVGGISIEEVEYFGSHGHVHVAI
EEEEECCHHHHHCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCEEEEEE
LDDEKLILAGDPRSEGIAIAIN
ECCCEEEEECCCCCCCEEEEEC
>Mature Secondary Structure 
PVAKLGIGFKGVVADHPLAVKTGLDVLEEGGNAFDASIAISAVLSVVQPQMGGPGGDGF
CCCCCCCCEEEEECCCCEEEHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCE
LLGFVGDKVVAYASSGRSPSGFNADEYIREKPLRGSLTVTIPGLVYLWGMVNEEYGTLDL
EEEEECCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEECHHHHHHHHCCCCCCCCHH
ATLLKPAISLAYNGFNAGYTLARSIEAVEKELSGFKWAKYYKGVKLGSKITNKDAARTLR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHH
LIASRGWEEFYQGELAEELTRELQDQGVNIGLEDLMTHEGFKVDPLRLEVEGRILYELPP
HHHHCCHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCEECCEEEEECCEEEEECCC
NTQGASTLQLISALYEEELSRYGFHDPQRASAWSKPVDIVYTFRDIYLGDPDYMEIDVNE
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEEEEEEEECCCCEEEEEHHH
YLRYSRVKKLIEHSVSQSSTRVKHGGDTTFFIVSDGESLIGFIQSLFHPFGSGLMMGGFP
HHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEECCCC
VQNRGIGFAKEHGLPNSPAPRKLPLHTLSILGVVEDDKKYIIGCVGGDYRPQLHLRVYEN
CCCCCCCCHHHCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEEECCCCCCEEEEEEECC
MFVYGMDPVKAVAAPRFIYVEPRGSQRLVLEKPLEANTVGGISIEEVEYFGSHGHVHVAI
EEEEECCHHHHHCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCEEEEEE
LDDEKLILAGDPRSEGIAIAIN
ECCCEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]