Click here to switch to the map view.

The map label for this gene is fixC [C]

Identifier: 218883473

GI number: 218883473

Start: 146530

End: 147900

Strand: Direct

Name: fixC [C]

Synonym: DKAM_0159

Alternate gene names: 218883473

Gene position: 146530-147900 (Clockwise)

Preceding gene: 218883472

Following gene: 218883474

Centisome position: 10.73

GC content: 46.68

Gene sequence:

>1371_bases
TTGAAGTATGATGTAGTAGTTGTGGGAGCTGGTGTTGCTGGATTATACTCCTCATTAGTCTTGGCTTCAAAGGGGTTCAG
GGTCGCGTTAGTGGAGAGTAAGCCAGCCAGTAAAATAGGGGATAAGACATGCGGAGACGCGATAGGTGTACATCATTTCC
AGCACATAGGGTTGAAGCTGCCTGAAGACATCATAGACCATGTCTACAGGGGAGTGAAGATATATAGTCCAAGCGAGAGG
CATGAGATAATTGTTCCCGGTGAGGGAGTAAGCGTTAACAGGGTTAAACTGGGACAATGGCTGCTTAAGCAGGCGTTTGA
CAGGGGTGTGGAATTACTCGACCAGCATAGTGTCATAGGGGTGAATATGATGGGTGATAGGGTAGGTTCTATTATAGCAA
AGAAGGTTGGCGGAGGCACAGTGGAATTAGAGGCAGAAGCATTCATTGATGCAAGCGGCTCAAAACCAGCTTTAAGGAGC
AGGCTTCCCGAGACATGGCCTATTTCTGATAAACCCTATACAACAGACTTCAATATAGCTTATAGAGAGGTAGTAGAGTA
CGATGGCGGTGTAAGGGAGGAGGATAGGGATTACGCTGTAATATACTTGAACACTATTATAGCCCCAGGCGGCTACTGGT
GGCTCTTCCCCAAGTCACGTGATGGCAGGGTGATCAATGTCGGGTTGGGAGTAATATGGAATGGACTCCACAATCCAAGG
CATAACTATGATAAGCACCTCAGACAAAGATTCAATGGTAAAGTGCTGCATGCAGGAGGAGGAATCGTACCTACACGGAG
ACCGCTGCCAACCATGGTCTGGAGGAACGTCGGTGTTGTTGGTGATGCAGCATATACAGTAAACCCTGTGCATGGAGGTG
GTATAGGTTCATCACTGGAGGCAGCTGATATAGTAGCTAGACATGTAGGGGATGCCCTTGAGCAGGGAGAGGTCAGTGAG
AAGACAATGTGGGAGGCAAACATAGAGTATATGAGGGCCTATGGGGCTAAGCAAGCAGGACTAGATATCCTAAGGATGTA
TATGCAGAAGCTCTCCAATGAGGATTTCGAATGGTTGATGGCGAATAAGATCGTTGACGGTGCATCCGTCTATGATATAG
GCGTTAAAGGCGAGTTAGGTGAGAAAATAACTCACATGATACTCTCAGTGTTGAGAGCCTTAAGTAGGCCGAGCCTGCTA
AACCAGTTAAGGATTGTGAGAAACTACATGAAGAAGGCAAGCGAGCTATATCTTGATAAATACCCCTCGACGCCTAACGA
GCTACCAAGCTGGATGAGGATGGTTGAAGACATGGTTGAAGAATACAGGAGGATAATAGGATTCAATAAGGGAGAAAGAG
TTAAATGGTGA

Upstream 100 bases:

>100_bases
CTCTGCCATAGGATAATAGATTATTCATGCCCCTAACCGGAGTGCTTTTTATTTTTATTTAACTATAACATAGTTAAGTA
TTATAAGGGGTGCCAGTGCT

Downstream 100 bases:

>100_bases
TATATGCTGGTATAGATCTAGCTGGTTCACCGAGGAATCCAACAGGCGTAGCATTAATCAAGCACAACGGTAGGACCAGA
ATAGTTTTTATAGGAGTCCT

Product: geranylgeranyl reductase

Products: NA

Alternate protein names: DGGGPL reductase; 2,3-di-O-geranylgeranylglyceryl phosphate reductase; Geranylgeranyl reductase; GGR [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKYDVVVVGAGVAGLYSSLVLASKGFRVALVESKPASKIGDKTCGDAIGVHHFQHIGLKLPEDIIDHVYRGVKIYSPSER
HEIIVPGEGVSVNRVKLGQWLLKQAFDRGVELLDQHSVIGVNMMGDRVGSIIAKKVGGGTVELEAEAFIDASGSKPALRS
RLPETWPISDKPYTTDFNIAYREVVEYDGGVREEDRDYAVIYLNTIIAPGGYWWLFPKSRDGRVINVGLGVIWNGLHNPR
HNYDKHLRQRFNGKVLHAGGGIVPTRRPLPTMVWRNVGVVGDAAYTVNPVHGGGIGSSLEAADIVARHVGDALEQGEVSE
KTMWEANIEYMRAYGAKQAGLDILRMYMQKLSNEDFEWLMANKIVDGASVYDIGVKGELGEKITHMILSVLRALSRPSLL
NQLRIVRNYMKKASELYLDKYPSTPNELPSWMRMVEDMVEEYRRIIGFNKGERVKW

Sequences:

>Translated_456_residues
MKYDVVVVGAGVAGLYSSLVLASKGFRVALVESKPASKIGDKTCGDAIGVHHFQHIGLKLPEDIIDHVYRGVKIYSPSER
HEIIVPGEGVSVNRVKLGQWLLKQAFDRGVELLDQHSVIGVNMMGDRVGSIIAKKVGGGTVELEAEAFIDASGSKPALRS
RLPETWPISDKPYTTDFNIAYREVVEYDGGVREEDRDYAVIYLNTIIAPGGYWWLFPKSRDGRVINVGLGVIWNGLHNPR
HNYDKHLRQRFNGKVLHAGGGIVPTRRPLPTMVWRNVGVVGDAAYTVNPVHGGGIGSSLEAADIVARHVGDALEQGEVSE
KTMWEANIEYMRAYGAKQAGLDILRMYMQKLSNEDFEWLMANKIVDGASVYDIGVKGELGEKITHMILSVLRALSRPSLL
NQLRIVRNYMKKASELYLDKYPSTPNELPSWMRMVEDMVEEYRRIIGFNKGERVKW
>Mature_456_residues
MKYDVVVVGAGVAGLYSSLVLASKGFRVALVESKPASKIGDKTCGDAIGVHHFQHIGLKLPEDIIDHVYRGVKIYSPSER
HEIIVPGEGVSVNRVKLGQWLLKQAFDRGVELLDQHSVIGVNMMGDRVGSIIAKKVGGGTVELEAEAFIDASGSKPALRS
RLPETWPISDKPYTTDFNIAYREVVEYDGGVREEDRDYAVIYLNTIIAPGGYWWLFPKSRDGRVINVGLGVIWNGLHNPR
HNYDKHLRQRFNGKVLHAGGGIVPTRRPLPTMVWRNVGVVGDAAYTVNPVHGGGIGSSLEAADIVARHVGDALEQGEVSE
KTMWEANIEYMRAYGAKQAGLDILRMYMQKLSNEDFEWLMANKIVDGASVYDIGVKGELGEKITHMILSVLRALSRPSLL
NQLRIVRNYMKKASELYLDKYPSTPNELPSWMRMVEDMVEEYRRIIGFNKGERVKW

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011777
- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: NA

Molecular weight: Translated: 50843; Mature: 50843

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYDVVVVGAGVAGLYSSLVLASKGFRVALVESKPASKIGDKTCGDAIGVHHFQHIGLKL
CCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHHCCCCCCCCHHHHHHHHHCCCCC
PEDIIDHVYRGVKIYSPSERHEIIVPGEGVSVNRVKLGQWLLKQAFDRGVELLDQHSVIG
CHHHHHHHHCCEEEECCCCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCEEE
VNMMGDRVGSIIAKKVGGGTVELEAEAFIDASGSKPALRSRLPETWPISDKPYTTDFNIA
EEHHHHHHHHHHHHHCCCCEEEEEHHEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCHH
YREVVEYDGGVREEDRDYAVIYLNTIIAPGGYWWLFPKSRDGRVINVGLGVIWNGLHNPR
HHHHHHHCCCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCEEEEECHHHHCCCCCCCC
HNYDKHLRQRFNGKVLHAGGGIVPTRRPLPTMVWRNVGVVGDAAYTVNPVHGGGIGSSLE
CHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCEEECCCEEECCCCCCCCCCCHH
AADIVARHVGDALEQGEVSEKTMWEANIEYMRAYGAKQAGLDILRMYMQKLSNEDFEWLM
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHH
ANKIVDGASVYDIGVKGELGEKITHMILSVLRALSRPSLLNQLRIVRNYMKKASELYLDK
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
YPSTPNELPSWMRMVEDMVEEYRRIIGFNKGERVKW
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKYDVVVVGAGVAGLYSSLVLASKGFRVALVESKPASKIGDKTCGDAIGVHHFQHIGLKL
CCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHHCCCCCCCCHHHHHHHHHCCCCC
PEDIIDHVYRGVKIYSPSERHEIIVPGEGVSVNRVKLGQWLLKQAFDRGVELLDQHSVIG
CHHHHHHHHCCEEEECCCCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCEEE
VNMMGDRVGSIIAKKVGGGTVELEAEAFIDASGSKPALRSRLPETWPISDKPYTTDFNIA
EEHHHHHHHHHHHHHCCCCEEEEEHHEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCHH
YREVVEYDGGVREEDRDYAVIYLNTIIAPGGYWWLFPKSRDGRVINVGLGVIWNGLHNPR
HHHHHHHCCCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCEEEEECHHHHCCCCCCCC
HNYDKHLRQRFNGKVLHAGGGIVPTRRPLPTMVWRNVGVVGDAAYTVNPVHGGGIGSSLE
CHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHCCCEEECCCEEECCCCCCCCCCCHH
AADIVARHVGDALEQGEVSEKTMWEANIEYMRAYGAKQAGLDILRMYMQKLSNEDFEWLM
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHH
ANKIVDGASVYDIGVKGELGEKITHMILSVLRALSRPSLLNQLRIVRNYMKKASELYLDK
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
YPSTPNELPSWMRMVEDMVEEYRRIIGFNKGERVKW
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a quinone or similar compound as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA