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The map label for this gene is deoA [C]

Identifier: 218883472

GI number: 218883472

Start: 144911

End: 146440

Strand: Direct

Name: deoA [C]

Synonym: DKAM_0158

Alternate gene names: 218883472

Gene position: 144911-146440 (Clockwise)

Preceding gene: 218883470

Following gene: 218883473

Centisome position: 10.61

GC content: 45.1

Gene sequence:

>1530_bases
ATGGGGTTTGAGAGTAAGTCTAAGCTATTTAATGTAAAAATAATTGACCTGGATATACATAGGAATTTAATTATAATGAA
TAGTGGTGATGCTGAGGAATTAGGTGTAGTTACAAACAACATTGTTTTAGTTACTGCTGGAGACTACTCGGCTTACGCAA
TGGTTATAACTAGTAGGACGGTTACTCAACCCGGTGTAGTAGCTTTATCAACGCAGACGGCTTCGACGCTAAGGGTTTCA
GAAGGAGATATGGTTGGTGTTAAACCCATTGGGTTACCGGCTAGCTTCAATGCGTTAAAGAAGAGGATAAGTGGTGTTAA
GCTCTCTGAGAGCGAGATGAAGAGTATTATACAGGATGTTGTGAACGGGATCTATGGCGAGGCTGAGATAGCGGCTTTCC
TCATTAGTCAGCTCTACAATGAGTTAAGCGAGGAGGAATTAAGCTATCTTGTTAAAGCAATGGTTGAAACGGGAAGTAAA
CTCATATTTGAGGAGACGGTATACGATGTGCATAGTATTGGAGGGGTACCTGGTAATAGTAAGGTGGCTTTGATAACAGT
ACCAATAGTTGCCGCTTCAGGGTTATTAATACCTAAAACCAGTAGTAGAGCCATAACGAGCCCGGCTGGCACAGCTGATA
CTATGGAGGTCTTAGCTAGGGTTGATCTAACGATCGATGAGATAGTTGAGATAGCTAGGAAGGTTAAAGGCGTTTTAGCC
TGGGGAGGTAGGCTTAATCTGGCTCCAGCGGACGATATATTTGTTAATATTGAGAGAAGGCTCTCCATAGATCCCGAGCA
ACAAATGGTTGCAAGTATATTATCCAAAAAGCTCGCTATGGGTGTGGAGAGACTAGTGATAGATATACCAGTGGGGCGTG
GGGCAAAGGTTGAAAAGGTTTCTCTTGCTGAAAAATTGGCAGGATTATTCATAAGGCAAGCCGGTTTACTAGGGGTTGCA
ATGAGGGTCGCCTTAACCTATGGTGGGCAACCCATAGGTACATCGGTTGGCCCGGCCCTAGAGGCGAGAGAAGCTCTAGA
AGCCCTTATTGAGAGAAAGGGAAGCAGGAGCCTTATTGATAAAGCCATACTCCTAGCTGGATTAGTTATGGAGTTAAGCG
GGAGGGTTCAGCCTGGGCAGGGTGAGGAGGTGGCTAGGGAGATATTCGTATCCGGTAAGGCATATGAGAAGTTCAAGCAG
ATAATAGAGGCTCAAGGAGGGAACCCTGAGACCAAGCCAAGCGATATACCCATAGGCTCTCACACATATACTCTCACCTC
ACCGCTTGAGGGAGCTGTTACACATATAGATAACACTGCTATCTCTCTAATAGCTAAGGCGTGTGGAGCCCCCTATGATA
AAAGAGCTGGCGTGAAACTCCATGCAAAGGTAGGCTACAGAGTTAACAAGGGTGATCCATTAATAACGTTATATAGTGAC
AGCGCGTCAAGACTTGAGACAGCTGTGAGGCTTCTAAGAGACCTACAGCCAGTGATAGTTGAGGGGATGCTTTTAAGGAC
TCTGCCATAG

Upstream 100 bases:

>100_bases
AACCCTAAAAGACGGGGGCTTTCAATTGTAAATGTTTAAAAACTCTTATGGGTAATCATAGCTCTTTTTGCCCGGTGCAT
GGGATTAGGGTGGGATAGTA

Downstream 100 bases:

>100_bases
GATAATAGATTATTCATGCCCCTAACCGGAGTGCTTTTTATTTTTATTTAACTATAACATAGTTAAGTATTATAAGGGGT
GCCAGTGCTTTGAAGTATGA

Product: AMP phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MGFESKSKLFNVKIIDLDIHRNLIIMNSGDAEELGVVTNNIVLVTAGDYSAYAMVITSRTVTQPGVVALSTQTASTLRVS
EGDMVGVKPIGLPASFNALKKRISGVKLSESEMKSIIQDVVNGIYGEAEIAAFLISQLYNELSEEELSYLVKAMVETGSK
LIFEETVYDVHSIGGVPGNSKVALITVPIVAASGLLIPKTSSRAITSPAGTADTMEVLARVDLTIDEIVEIARKVKGVLA
WGGRLNLAPADDIFVNIERRLSIDPEQQMVASILSKKLAMGVERLVIDIPVGRGAKVEKVSLAEKLAGLFIRQAGLLGVA
MRVALTYGGQPIGTSVGPALEAREALEALIERKGSRSLIDKAILLAGLVMELSGRVQPGQGEEVAREIFVSGKAYEKFKQ
IIEAQGGNPETKPSDIPIGSHTYTLTSPLEGAVTHIDNTAISLIAKACGAPYDKRAGVKLHAKVGYRVNKGDPLITLYSD
SASRLETAVRLLRDLQPVIVEGMLLRTLP

Sequences:

>Translated_509_residues
MGFESKSKLFNVKIIDLDIHRNLIIMNSGDAEELGVVTNNIVLVTAGDYSAYAMVITSRTVTQPGVVALSTQTASTLRVS
EGDMVGVKPIGLPASFNALKKRISGVKLSESEMKSIIQDVVNGIYGEAEIAAFLISQLYNELSEEELSYLVKAMVETGSK
LIFEETVYDVHSIGGVPGNSKVALITVPIVAASGLLIPKTSSRAITSPAGTADTMEVLARVDLTIDEIVEIARKVKGVLA
WGGRLNLAPADDIFVNIERRLSIDPEQQMVASILSKKLAMGVERLVIDIPVGRGAKVEKVSLAEKLAGLFIRQAGLLGVA
MRVALTYGGQPIGTSVGPALEAREALEALIERKGSRSLIDKAILLAGLVMELSGRVQPGQGEEVAREIFVSGKAYEKFKQ
IIEAQGGNPETKPSDIPIGSHTYTLTSPLEGAVTHIDNTAISLIAKACGAPYDKRAGVKLHAKVGYRVNKGDPLITLYSD
SASRLETAVRLLRDLQPVIVEGMLLRTLP
>Mature_508_residues
GFESKSKLFNVKIIDLDIHRNLIIMNSGDAEELGVVTNNIVLVTAGDYSAYAMVITSRTVTQPGVVALSTQTASTLRVSE
GDMVGVKPIGLPASFNALKKRISGVKLSESEMKSIIQDVVNGIYGEAEIAAFLISQLYNELSEEELSYLVKAMVETGSKL
IFEETVYDVHSIGGVPGNSKVALITVPIVAASGLLIPKTSSRAITSPAGTADTMEVLARVDLTIDEIVEIARKVKGVLAW
GGRLNLAPADDIFVNIERRLSIDPEQQMVASILSKKLAMGVERLVIDIPVGRGAKVEKVSLAEKLAGLFIRQAGLLGVAM
RVALTYGGQPIGTSVGPALEAREALEALIERKGSRSLIDKAILLAGLVMELSGRVQPGQGEEVAREIFVSGKAYEKFKQI
IEAQGGNPETKPSDIPIGSHTYTLTSPLEGAVTHIDNTAISLIAKACGAPYDKRAGVKLHAKVGYRVNKGDPLITLYSDS
ASRLETAVRLLRDLQPVIVEGMLLRTLP

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=433, Percent_Identity=27.9445727482679, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4503445, Length=433, Percent_Identity=27.9445727482679, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI166158922, Length=433, Percent_Identity=27.9445727482679, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790842, Length=408, Percent_Identity=28.921568627451, Blast_Score=129, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 54334; Mature: 54203

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFESKSKLFNVKIIDLDIHRNLIIMNSGDAEELGVVTNNIVLVTAGDYSAYAMVITSRT
CCCCCCCCEEEEEEEEEEECCCEEEEECCCCHHCCEEECCEEEEEECCCCEEEEEEEECC
VTQPGVVALSTQTASTLRVSEGDMVGVKPIGLPASFNALKKRISGVKLSESEMKSIIQDV
CCCCCEEEEECCCCCEEEECCCCEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
VNGIYGEAEIAAFLISQLYNELSEEELSYLVKAMVETGSKLIFEETVYDVHSIGGVPGNS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCC
KVALITVPIVAASGLLIPKTSSRAITSPAGTADTMEVLARVDLTIDEIVEIARKVKGVLA
CEEEEEEEHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHEE
WGGRLNLAPADDIFVNIERRLSIDPEQQMVASILSKKLAMGVERLVIDIPVGRGAKVEKV
ECCEEECCCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCCCCHHH
SLAEKLAGLFIRQAGLLGVAMRVALTYGGQPIGTSVGPALEAREALEALIERKGSRSLID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
KAILLAGLVMELSGRVQPGQGEEVAREIFVSGKAYEKFKQIIEAQGGNPETKPSDIPIGS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
HTYTLTSPLEGAVTHIDNTAISLIAKACGAPYDKRAGVKLHAKVGYRVNKGDPLITLYSD
CEEEECCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEEEECEEECCCCEEEEEECC
SASRLETAVRLLRDLQPVIVEGMLLRTLP
CHHHHHHHHHHHHHCHHHHHCCHHHHCCC
>Mature Secondary Structure 
GFESKSKLFNVKIIDLDIHRNLIIMNSGDAEELGVVTNNIVLVTAGDYSAYAMVITSRT
CCCCCCCEEEEEEEEEEECCCEEEEECCCCHHCCEEECCEEEEEECCCCEEEEEEEECC
VTQPGVVALSTQTASTLRVSEGDMVGVKPIGLPASFNALKKRISGVKLSESEMKSIIQDV
CCCCCEEEEECCCCCEEEECCCCEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
VNGIYGEAEIAAFLISQLYNELSEEELSYLVKAMVETGSKLIFEETVYDVHSIGGVPGNS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCC
KVALITVPIVAASGLLIPKTSSRAITSPAGTADTMEVLARVDLTIDEIVEIARKVKGVLA
CEEEEEEEHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHEE
WGGRLNLAPADDIFVNIERRLSIDPEQQMVASILSKKLAMGVERLVIDIPVGRGAKVEKV
ECCEEECCCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCCCCHHH
SLAEKLAGLFIRQAGLLGVAMRVALTYGGQPIGTSVGPALEAREALEALIERKGSRSLID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
KAILLAGLVMELSGRVQPGQGEEVAREIFVSGKAYEKFKQIIEAQGGNPETKPSDIPIGS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
HTYTLTSPLEGAVTHIDNTAISLIAKACGAPYDKRAGVKLHAKVGYRVNKGDPLITLYSD
CEEEECCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCEEEEEEECEEECCCCEEEEEECC
SASRLETAVRLLRDLQPVIVEGMLLRTLP
CHHHHHHHHHHHHHCHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA