Click here to switch to the map view.

The map label for this gene is ubiA

Identifier: 218710910

GI number: 218710910

Start: 3162370

End: 3163224

Strand: Reverse

Name: ubiA

Synonym: VS_3012

Alternate gene names: 218710910

Gene position: 3163224-3162370 (Counterclockwise)

Preceding gene: 218710911

Following gene: 218710909

Centisome position: 95.88

GC content: 46.67

Gene sequence:

>855_bases
ATGCTTGCCACCAAAGCGAAGGCGTACTGGCAATTGACGCGAATGAATCGCCCGATTGGTACTCTGTTACTCCTTTGGCC
GACCTTGTGGTCGCTGATTATTGCTGCGAAAGGCATGCCTGATTTTGATGTCTTGGTTGTTTTCATACTCGGTGTGGTGT
TAATGCGATCGGCTGGCTGTGTGATTAATGATTTTGCTGACCGTAAAGTTGATGGTCATGTCAAACGCACCAAGCAACGT
CCATTACCTTCAGGTTTGGTTTCCAGCAAGGAAGCCATTGTGCTCTTTCTAGTGTTAGCTGTGGTTTCTTTTTTGTTGGT
ACTCACCATGAACCCGCTGACTATTAAGCTCTCTTTTATTGGGGTTGGTCTCGCGTTCATTTATCCTTTCATGAAGCGTT
TTACACACCTTCCACAGTTGTTTCTCGGATTGGCTTTCAGTTGGGCAATACCAATGGCTTGGGCGGCGCAAACCAATGAA
CTGCCAAGCATTGTGTGGTTTATCTTCGTGATTAATGCGTTGTGGACGATAGCCTACGACACGCAATATGCGATGGTTGA
CCGAGATGATGACTTGAAGATTGGCATCAAGTCGACGGCTATTCTGTTTGGTCGTTTTGATAAGCTTATGGTTGGCGCGC
TGCAGTTAGTTACACTGGCGATGTTGATTGCATTGGGCATGCACTACCAACTCGGTGATACTTTCTACTGGGCACTGTTA
GTTTCGGGGAGCTTGTTCGTGTATCAACAGCATCTGATGCGTCACCGCGATCGAGACCTTTGCTTCCAAGCCTTCTTGAA
CAATAACTATGTTGGAATGGCGGTGACTGTAGGCTTGTTCATTACCTTCTGGTAA

Upstream 100 bases:

>100_bases
ACTCGCGCGTCGTTCTCGATTATGGATGAATCATAAACCGATGCTTGTGGCCGAACTTTTTTTACCAACATCCCCCATTT
ACTCTAAGGAGAGTGTGTAA

Downstream 100 bases:

>100_bases
GCATCAGCTTTACAAGTAAACGAACGCTAAAGAAAAAGGCACCCATTGGGTGCCTTTTTTGTTTGTGTGTACCGTCCTAA
ATATGGTTGACACATTTCCA

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLATKAKAYWQLTRMNRPIGTLLLLWPTLWSLIIAAKGMPDFDVLVVFILGVVLMRSAGCVINDFADRKVDGHVKRTKQR
PLPSGLVSSKEAIVLFLVLAVVSFLLVLTMNPLTIKLSFIGVGLAFIYPFMKRFTHLPQLFLGLAFSWAIPMAWAAQTNE
LPSIVWFIFVINALWTIAYDTQYAMVDRDDDLKIGIKSTAILFGRFDKLMVGALQLVTLAMLIALGMHYQLGDTFYWALL
VSGSLFVYQQHLMRHRDRDLCFQAFLNNNYVGMAVTVGLFITFW

Sequences:

>Translated_284_residues
MLATKAKAYWQLTRMNRPIGTLLLLWPTLWSLIIAAKGMPDFDVLVVFILGVVLMRSAGCVINDFADRKVDGHVKRTKQR
PLPSGLVSSKEAIVLFLVLAVVSFLLVLTMNPLTIKLSFIGVGLAFIYPFMKRFTHLPQLFLGLAFSWAIPMAWAAQTNE
LPSIVWFIFVINALWTIAYDTQYAMVDRDDDLKIGIKSTAILFGRFDKLMVGALQLVTLAMLIALGMHYQLGDTFYWALL
VSGSLFVYQQHLMRHRDRDLCFQAFLNNNYVGMAVTVGLFITFW
>Mature_284_residues
MLATKAKAYWQLTRMNRPIGTLLLLWPTLWSLIIAAKGMPDFDVLVVFILGVVLMRSAGCVINDFADRKVDGHVKRTKQR
PLPSGLVSSKEAIVLFLVLAVVSFLLVLTMNPLTIKLSFIGVGLAFIYPFMKRFTHLPQLFLGLAFSWAIPMAWAAQTNE
LPSIVWFIFVINALWTIAYDTQYAMVDRDDDLKIGIKSTAILFGRFDKLMVGALQLVTLAMLIALGMHYQLGDTFYWALL
VSGSLFVYQQHLMRHRDRDLCFQAFLNNNYVGMAVTVGLFITFW

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=279, Percent_Identity=34.4086021505376, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1790473, Length=281, Percent_Identity=58.7188612099644, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1786631, Length=189, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17553718, Length=276, Percent_Identity=37.6811594202899, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI32565247, Length=277, Percent_Identity=35.7400722021661, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17553720, Length=182, Percent_Identity=40.1098901098901, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32565245, Length=139, Percent_Identity=43.8848920863309, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32565243, Length=138, Percent_Identity=43.4782608695652, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324370, Length=295, Percent_Identity=32.8813559322034, Blast_Score=132, Evalue=8e-32,
Organism=Drosophila melanogaster, GI21355567, Length=283, Percent_Identity=37.1024734982332, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_VIBSL (B7VMA0)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002418531.1
- GeneID:   7162477
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_3012
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   PRK12848
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32152; Mature: 32152

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1daf3e1c)-; HASH(0x1c46eb3c)-; HASH(0x1e0a411c)-; HASH(0x1b9348f8)-; HASH(0x1e2fdadc)-; HASH(0x1e65867c)-; HASH(0x1e5cf704)-; HASH(0x1e3b64d8)-; HASH(0x1dc862a8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLATKAKAYWQLTRMNRPIGTLLLLWPTLWSLIIAAKGMPDFDVLVVFILGVVLMRSAGC
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
VINDFADRKVDGHVKRTKQRPLPSGLVSSKEAIVLFLVLAVVSFLLVLTMNPLTIKLSFI
EEEHHHCCCCCCHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH
GVGLAFIYPFMKRFTHLPQLFLGLAFSWAIPMAWAAQTNELPSIVWFIFVINALWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
TQYAMVDRDDDLKIGIKSTAILFGRFDKLMVGALQLVTLAMLIALGMHYQLGDTFYWALL
CEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VSGSLFVYQQHLMRHRDRDLCFQAFLNNNYVGMAVTVGLFITFW
HHCHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCH
>Mature Secondary Structure
MLATKAKAYWQLTRMNRPIGTLLLLWPTLWSLIIAAKGMPDFDVLVVFILGVVLMRSAGC
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
VINDFADRKVDGHVKRTKQRPLPSGLVSSKEAIVLFLVLAVVSFLLVLTMNPLTIKLSFI
EEEHHHCCCCCCHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH
GVGLAFIYPFMKRFTHLPQLFLGLAFSWAIPMAWAAQTNELPSIVWFIFVINALWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
TQYAMVDRDDDLKIGIKSTAILFGRFDKLMVGALQLVTLAMLIALGMHYQLGDTFYWALL
CEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VSGSLFVYQQHLMRHRDRDLCFQAFLNNNYVGMAVTVGLFITFW
HHCHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA